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FLNB (filamin B, beta)

Identity

Other namesABP-278
ABP-280
AOI
FH1
FLN-B
FLN1L
LRS1
SCT
TABP
TAP
HGNC (Hugo) FLNB
LocusID (NCBI) 2317
Location 3p14.3
Location_base_pair Starts at 57994127 and ends at 58157982 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)FLNB   3755
Cards
Entrez_Gene (NCBI)FLNB  2317  filamin B, beta
GeneCards (Weizmann)FLNB
Ensembl hg19 (Hinxton)ENSG00000136068 [Gene_View]  chr3:57994127-58157982 [Contig_View]  FLNB [Vega]
Ensembl hg38 (Hinxton)ENSG00000136068 [Gene_View]  chr3:57994127-58157982 [Contig_View]  FLNB [Vega]
ICGC DataPortalENSG00000136068
cBioPortalFLNB
AceView (NCBI)FLNB
Genatlas (Paris)FLNB
WikiGenes2317
SOURCE (Princeton)FLNB
Genomic and cartography
GoldenPath hg19 (UCSC)FLNB  -     chr3:57994127-58157982 +  3p14.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)FLNB  -     3p14.3   [Description]    (hg38-Dec_2013)
EnsemblFLNB - 3p14.3 [CytoView hg19]  FLNB - 3p14.3 [CytoView hg38]
Mapping of homologs : NCBIFLNB [Mapview hg19]  FLNB [Mapview hg38]
OMIM108720   108721   112310   150250   272460   603381   
Gene and transcription
Genbank (Entrez)AB191258 AB209889 AB371580 AB371581 AB371582
RefSeq transcript (Entrez)NM_001164317 NM_001164318 NM_001164319 NM_001457
RefSeq genomic (Entrez)AC_000135 NC_000003 NC_018914 NG_012801 NT_022517 NW_001838877 NW_004929309
Consensus coding sequences : CCDS (NCBI)FLNB
Cluster EST : UnigeneHs.476448 [ NCBI ]
CGAP (NCI)Hs.476448
Alternative Splicing : Fast-db (Paris)GSHG0020878
Alternative Splicing GalleryENSG00000136068
Gene ExpressionFLNB [ NCBI-GEO ]     FLNB [ SEEK ]   FLNB [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO75369 (Uniprot)
NextProtO75369  [Medical]
With graphics : InterProO75369
Splice isoforms : SwissVarO75369 (Swissvar)
Domaine pattern : Prosite (Expaxy)ACTININ_1 (PS00019)    ACTININ_2 (PS00020)    CH (PS50021)    FILAMIN_REPEAT (PS50194)   
Domains : Interpro (EBI)Actinin_actin-bd_CS    CH-domain    Filamin/ABP280_repeat-like    Filamin/ABP280_rpt    Ig-like_fold    Ig_E-set   
Related proteins : CluSTrO75369
Domain families : Pfam (Sanger)CH (PF00307)    Filamin (PF00630)   
Domain families : Pfam (NCBI)pfam00307    pfam00630   
Domain families : Smart (EMBL)CH (SM00033)  IG_FLMN (SM00557)  
DMDM Disease mutations2317
Blocks (Seattle)O75369
PDB (SRS)2DI8    2DI9    2DIA    2DIB    2DIC    2DJ4    2DLG    2DMB    2DMC    2E9I    2E9J    2EE6    2EE9    2EEA    2EEB    2EEC    2EED    2WA5    2WA6    2WA7    3FER    4B7L   
PDB (PDBSum)2DI8    2DI9    2DIA    2DIB    2DIC    2DJ4    2DLG    2DMB    2DMC    2E9I    2E9J    2EE6    2EE9    2EEA    2EEB    2EEC    2EED    2WA5    2WA6    2WA7    3FER    4B7L   
PDB (IMB)2DI8    2DI9    2DIA    2DIB    2DIC    2DJ4    2DLG    2DMB    2DMC    2E9I    2E9J    2EE6    2EE9    2EEA    2EEB    2EEC    2EED    2WA5    2WA6    2WA7    3FER    4B7L   
PDB (RSDB)2DI8    2DI9    2DIA    2DIB    2DIC    2DJ4    2DLG    2DMB    2DMC    2E9I    2E9J    2EE6    2EE9    2EEA    2EEB    2EEC    2EED    2WA5    2WA6    2WA7    3FER    4B7L   
Human Protein AtlasENSG00000136068
Peptide AtlasO75369
HPRD04543
IPIIPI00289334   IPI00943563   IPI00382697   IPI00382698   IPI00382699   IPI00953109   IPI00940093   IPI00900293   IPI00477536   
Protein Interaction databases
DIP (DOE-UCLA)O75369
IntAct (EBI)O75369
FunCoupENSG00000136068
BioGRIDFLNB
IntegromeDBFLNB
STRING (EMBL)FLNB
Ontologies - Pathways
QuickGOO75369
Ontology : AmiGOstress fiber  actin binding  protein binding  cytoplasm  cytosol  plasma membrane  focal adhesion  cell cortex  cytoskeletal anchoring at plasma membrane  signal transduction  skeletal muscle tissue development  actin cytoskeleton  integral component of membrane  cytokine-mediated signaling pathway  Z disc  actin cytoskeleton organization  cell differentiation  identical protein binding  poly(A) RNA binding  extracellular vesicular exosome  
Ontology : EGO-EBIstress fiber  actin binding  protein binding  cytoplasm  cytosol  plasma membrane  focal adhesion  cell cortex  cytoskeletal anchoring at plasma membrane  signal transduction  skeletal muscle tissue development  actin cytoskeleton  integral component of membrane  cytokine-mediated signaling pathway  Z disc  actin cytoskeleton organization  cell differentiation  identical protein binding  poly(A) RNA binding  extracellular vesicular exosome  
Pathways : KEGGMAPK signaling pathway    Focal adhesion    Salmonella infection    Proteoglycans in cancer   
Protein Interaction DatabaseFLNB
DoCM (Curated mutations)FLNB
Wikipedia pathwaysFLNB
Gene fusion - rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerFLNB [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FLNB
dbVarFLNB
ClinVarFLNB
1000_GenomesFLNB 
Exome Variant ServerFLNB
SNP (GeneSNP Utah)FLNB
SNP : HGBaseFLNB
Genetic variants : HAPMAPFLNB
Genomic VariantsFLNB  FLNB [DGVbeta]
Mutations
ICGC Data PortalENSG00000136068 
Somatic Mutations in Cancer : COSMICFLNB 
CONAN: Copy Number AnalysisFLNB 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Mendelian genes
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)3:57994127-58157982
Mutations and Diseases : HGMDFLNB
OMIM108720    108721    112310    150250    272460    603381   
MedgenFLNB
NextProtO75369 [Medical]
GENETestsFLNB
Disease Genetic AssociationFLNB
Huge Navigator FLNB [HugePedia]  FLNB [HugeCancerGEM]
snp3D : Map Gene to Disease2317
DGIdb (Drug Gene Interaction db)FLNB
General knowledge
Homologs : HomoloGeneFLNB
Homology/Alignments : Family Browser (UCSC)FLNB
Phylogenetic Trees/Animal Genes : TreeFamFLNB
Chemical/Protein Interactions : CTD2317
Chemical/Pharm GKB GenePA28173
Clinical trialFLNB
Cancer Resource (Charite)ENSG00000136068
Other databases
Probes
Litterature
PubMed87 Pubmed reference(s) in Entrez
CoreMineFLNB
GoPubMedFLNB
iHOPFLNB
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2014Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Dec 20 21:38:22 CET 2014

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