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FLNC (filamin C, gamma)

Identity

Other namesABP-280
ABP280A
ABPA
ABPL
FLN2
MFM5
MPD4
HGNC (Hugo) FLNC
LocusID (NCBI) 2318
Location 7q32.1
Location_base_pair Starts at 128470483 and ends at 128499328 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)FLNC   3756
Cards
Entrez_Gene (NCBI)FLNC  2318  filamin C, gamma
GeneCards (Weizmann)FLNC
Ensembl (Hinxton)ENSG00000128591 [Gene_View]  chr7:128470483-128499328 [Contig_View]  FLNC [Vega]
ICGC DataPortalENSG00000128591
AceView (NCBI)FLNC
Genatlas (Paris)FLNC
WikiGenes2318
SOURCE (Princeton)NM_001127487 NM_001458
Genomic and cartography
GoldenPath (UCSC)FLNC  -  7q32.1   chr7:128470483-128499328 +  7q32.1   [Description]    (hg19-Feb_2009)
EnsemblFLNC - 7q32.1 [CytoView]
Mapping of homologs : NCBIFLNC [Mapview]
OMIM102565   609524   614065   
Gene and transcription
Genbank (Entrez)AB208865 AB371585 AF089841 AF146692 AJ012737
RefSeq transcript (Entrez)NM_001127487 NM_001458
RefSeq genomic (Entrez)AC_000139 NC_000007 NC_018918 NG_011807 NT_007933 NW_001839071 NW_004929332
Consensus coding sequences : CCDS (NCBI)FLNC
Cluster EST : UnigeneHs.58414 [ NCBI ]
CGAP (NCI)Hs.58414
Alternative Splicing : Fast-db (Paris)GSHG0027706
Alternative Splicing GalleryENSG00000128591
Gene ExpressionFLNC [ NCBI-GEO ]     FLNC [ SEEK ]   FLNC [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ14315 (Uniprot)
NextProtQ14315  [Medical]
With graphics : InterProQ14315
Splice isoforms : SwissVarQ14315 (Swissvar)
Domaine pattern : Prosite (Expaxy)ACTININ_1 (PS00019)    ACTININ_2 (PS00020)    CH (PS50021)    FILAMIN_REPEAT (PS50194)   
Domains : Interpro (EBI)Actinin_actin-bd_CS    CH-domain    Fibronectin_type3    Filamin/ABP280_repeat-like    Filamin/ABP280_rpt    FLN    Ig-like_fold    Ig_E-set   
Related proteins : CluSTrQ14315
Domain families : Pfam (Sanger)CH (PF00307)    Filamin (PF00630)   
Domain families : Pfam (NCBI)pfam00307    pfam00630   
Domain families : Smart (EMBL)CH (SM00033)  FN3 (SM00060)  IG_FLMN (SM00557)  
DMDM Disease mutations2318
Blocks (Seattle)Q14315
PDB (SRS)1V05    2D7M    2D7N    2D7O    2D7P    2D7Q    2K9U    2NQC    3V8O    4MGX   
PDB (PDBSum)1V05    2D7M    2D7N    2D7O    2D7P    2D7Q    2K9U    2NQC    3V8O    4MGX   
PDB (IMB)1V05    2D7M    2D7N    2D7O    2D7P    2D7Q    2K9U    2NQC    3V8O    4MGX   
PDB (RSDB)1V05    2D7M    2D7N    2D7O    2D7P    2D7Q    2K9U    2NQC    3V8O    4MGX   
Human Protein AtlasENSG00000128591
Peptide AtlasQ14315
HPRD00018
IPIIPI00178352   IPI00413958   
Protein Interaction databases
DIP (DOE-UCLA)Q14315
IntAct (EBI)Q14315
FunCoupENSG00000128591
BioGRIDFLNC
InParanoidQ14315
Interologous Interaction database Q14315
IntegromeDBFLNC
STRING (EMBL)FLNC
Ontologies - Pathways
Ontology : AmiGOactin binding  protein binding  cytoplasm  cytosol  cytoskeleton  plasma membrane  cytoskeletal protein binding  sarcoplasm  Z disc  ankyrin binding  cell junction assembly  sarcolemma  costamere  muscle fiber development  
Ontology : EGO-EBIactin binding  protein binding  cytoplasm  cytosol  cytoskeleton  plasma membrane  cytoskeletal protein binding  sarcoplasm  Z disc  ankyrin binding  cell junction assembly  sarcolemma  costamere  muscle fiber development  
Pathways : KEGGMAPK signaling pathway    Focal adhesion    Salmonella infection    Proteoglycans in cancer   
Protein Interaction DatabaseFLNC
Wikipedia pathwaysFLNC
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)FLNC
SNP (GeneSNP Utah)FLNC
SNP : HGBaseFLNC
Genetic variants : HAPMAPFLNC
1000_GenomesFLNC 
ICGC programENSG00000128591 
CONAN: Copy Number AnalysisFLNC 
Somatic Mutations in Cancer : COSMICFLNC 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)Leiden Muscular Dystrophy pages
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Mutations and Diseases : HGMDFLNC
OMIM102565    609524    614065   
MedgenFLNC
GENETestsFLNC
Disease Genetic AssociationFLNC
Huge Navigator FLNC [HugePedia]  FLNC [HugeCancerGEM]
Genomic VariantsFLNC  FLNC [DGVbeta]
Exome VariantFLNC
dbVarFLNC
ClinVarFLNC
snp3D : Map Gene to Disease2318
General knowledge
Homologs : HomoloGeneFLNC
Homology/Alignments : Family Browser (UCSC)FLNC
Phylogenetic Trees/Animal Genes : TreeFamFLNC
Chemical/Protein Interactions : CTD2318
Chemical/Pharm GKB GenePA28174
Clinical trialFLNC
Cancer Resource (Charite)ENSG00000128591
Other databases
Probes
Litterature
PubMed87 Pubmed reference(s) in Entrez
CoreMineFLNC
iHOPFLNC
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 13 12:46:46 CEST 2014

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