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FLOT1 (flotillin 1)

Identity

Other alias-
HGNC (Hugo) FLOT1
LocusID (NCBI) 10211
Atlas_Id 51013
Location 6p21.33  [Link to chromosome band 6p21]
Location_base_pair Starts at 30727709 and ends at 30742851 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
APP (21q21.3) / FLOT1 (6p21.33)FLOT1 (6p21.33) / TTC19 (17p12)GNL1 (6p21.33) / FLOT1 (6p21.33)
KIF13B (8p12) / FLOT1 (6p21.33)LIG3 (17q12) / FLOT1 (6p21.33)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)FLOT1   3757
Cards
Entrez_Gene (NCBI)FLOT1  10211  flotillin 1
Aliases
GeneCards (Weizmann)FLOT1
Ensembl hg19 (Hinxton)ENSG00000137312 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000137312 [Gene_View]  ENSG00000137312 [Sequence]  chr6:30727709-30742851 [Contig_View]  FLOT1 [Vega]
ICGC DataPortalENSG00000137312
TCGA cBioPortalFLOT1
AceView (NCBI)FLOT1
Genatlas (Paris)FLOT1
WikiGenes10211
SOURCE (Princeton)FLOT1
Genetics Home Reference (NIH)FLOT1
Genomic and cartography
GoldenPath hg38 (UCSC)FLOT1  -     chr6:30727709-30742851 -  6p21.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FLOT1  -     6p21.33   [Description]    (hg19-Feb_2009)
EnsemblFLOT1 - 6p21.33 [CytoView hg19]  FLOT1 - 6p21.33 [CytoView hg38]
Mapping of homologs : NCBIFLOT1 [Mapview hg19]  FLOT1 [Mapview hg38]
OMIM606998   
Gene and transcription
Genbank (Entrez)AF085357 AF089750 AF117234 AK000816 AK222530
RefSeq transcript (Entrez)NM_001318875 NM_005803
RefSeq genomic (Entrez)NC_000006 NT_113891 NT_167244 NT_167245 NT_167246 NT_167247 NT_167248 NT_167249
Consensus coding sequences : CCDS (NCBI)FLOT1
Cluster EST : UnigeneHs.179986 [ NCBI ]
CGAP (NCI)Hs.179986
Alternative Splicing GalleryENSG00000137312
Gene ExpressionFLOT1 [ NCBI-GEO ]   FLOT1 [ EBI - ARRAY_EXPRESS ]   FLOT1 [ SEEK ]   FLOT1 [ MEM ]
Gene Expression Viewer (FireBrowse)FLOT1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10211
GTEX Portal (Tissue expression)FLOT1
Human Protein AtlasENSG00000137312-FLOT1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO75955   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO75955  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO75955
Splice isoforms : SwissVarO75955
PhosPhoSitePlusO75955
Domains : Interpro (EBI)Band_7    Band_7/SPFH_dom_sf    Flotillin_C    Flotillin_fam   
Domain families : Pfam (Sanger)Band_7 (PF01145)    Flot (PF15975)   
Domain families : Pfam (NCBI)pfam01145    pfam15975   
Domain families : Smart (EMBL)PHB (SM00244)  
Conserved Domain (NCBI)FLOT1
DMDM Disease mutations10211
Blocks (Seattle)FLOT1
SuperfamilyO75955
Human Protein Atlas [tissue]ENSG00000137312-FLOT1 [tissue]
Peptide AtlasO75955
HPRD06105
IPIIPI00027438   IPI00892872   IPI01021929   IPI00893518   IPI00894029   IPI00893621   IPI00893832   IPI00894145   IPI00894385   IPI00894525   IPI00892989   IPI00892615   IPI00892740   IPI00893347   IPI00893481   IPI00893081   IPI00792079   IPI00791583   IPI00793401   IPI00827631   IPI00941052   IPI00789691   
Protein Interaction databases
DIP (DOE-UCLA)O75955
IntAct (EBI)O75955
FunCoupENSG00000137312
BioGRIDFLOT1
STRING (EMBL)FLOT1
ZODIACFLOT1
Ontologies - Pathways
QuickGOO75955
Ontology : AmiGOmembrane raft assembly  positive regulation of cytokine production  uropod  positive regulation of protein phosphorylation  protease binding  regulation of receptor internalization  protein binding  lysosomal membrane  endosome  early endosome  microtubule organizing center  plasma membrane  plasma membrane  plasma membrane  caveola  cell-cell junction  cell-cell adherens junction  focal adhesion  axonogenesis  COP9 signalosome  external side of plasma membrane  membrane  basolateral plasma membrane  apical plasma membrane  flotillin complex  extracellular matrix disassembly  lamellipodium  cortical actin cytoskeleton  cytoplasmic vesicle  positive regulation of protein binding  positive regulation of synaptic transmission, dopaminergic  positive regulation of interferon-beta production  dsRNA transport  positive regulation of heterotypic cell-cell adhesion  positive regulation of toll-like receptor 3 signaling pathway  regulation of toll-like receptor 4 signaling pathway  centriolar satellite  response to endoplasmic reticulum stress  regulation of Rho protein signal transduction  ionotropic glutamate receptor binding  sarcolemma  melanosome  cell-cell contact zone  plasma membrane raft assembly  membrane raft  positive regulation of endocytosis  protein heterodimerization activity  positive regulation of skeletal muscle tissue development  presynaptic active zone  protein stabilization  protein homooligomerization  regulation of neurotransmitter uptake  regulation of neurotransmitter uptake  regulation of neurotransmitter uptake  positive regulation of cell adhesion molecule production  extracellular exosome  protein kinase C signaling  cellular response to exogenous dsRNA  protein localization to plasma membrane  dopaminergic synapse  dopaminergic synapse  dopaminergic synapse  glutamatergic synapse  GABA-ergic synapse  positive regulation of myoblast fusion  positive regulation of cell junction assembly  protein localization to membrane raft  positive regulation of cell-cell adhesion mediated by cadherin  
Ontology : EGO-EBImembrane raft assembly  positive regulation of cytokine production  uropod  positive regulation of protein phosphorylation  protease binding  regulation of receptor internalization  protein binding  lysosomal membrane  endosome  early endosome  microtubule organizing center  plasma membrane  plasma membrane  plasma membrane  caveola  cell-cell junction  cell-cell adherens junction  focal adhesion  axonogenesis  COP9 signalosome  external side of plasma membrane  membrane  basolateral plasma membrane  apical plasma membrane  flotillin complex  extracellular matrix disassembly  lamellipodium  cortical actin cytoskeleton  cytoplasmic vesicle  positive regulation of protein binding  positive regulation of synaptic transmission, dopaminergic  positive regulation of interferon-beta production  dsRNA transport  positive regulation of heterotypic cell-cell adhesion  positive regulation of toll-like receptor 3 signaling pathway  regulation of toll-like receptor 4 signaling pathway  centriolar satellite  response to endoplasmic reticulum stress  regulation of Rho protein signal transduction  ionotropic glutamate receptor binding  sarcolemma  melanosome  cell-cell contact zone  plasma membrane raft assembly  membrane raft  positive regulation of endocytosis  protein heterodimerization activity  positive regulation of skeletal muscle tissue development  presynaptic active zone  protein stabilization  protein homooligomerization  regulation of neurotransmitter uptake  regulation of neurotransmitter uptake  regulation of neurotransmitter uptake  positive regulation of cell adhesion molecule production  extracellular exosome  protein kinase C signaling  cellular response to exogenous dsRNA  protein localization to plasma membrane  dopaminergic synapse  dopaminergic synapse  dopaminergic synapse  glutamatergic synapse  GABA-ergic synapse  positive regulation of myoblast fusion  positive regulation of cell junction assembly  protein localization to membrane raft  positive regulation of cell-cell adhesion mediated by cadherin  
Pathways : KEGGInsulin signaling pathway   
NDEx NetworkFLOT1
Atlas of Cancer Signalling NetworkFLOT1
Wikipedia pathwaysFLOT1
Orthology - Evolution
OrthoDB10211
GeneTree (enSembl)ENSG00000137312
Phylogenetic Trees/Animal Genes : TreeFamFLOT1
HOVERGENO75955
HOGENOMO75955
Homologs : HomoloGeneFLOT1
Homology/Alignments : Family Browser (UCSC)FLOT1
Gene fusions - Rearrangements
Fusion : QuiverFLOT1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFLOT1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FLOT1
dbVarFLOT1
ClinVarFLOT1
1000_GenomesFLOT1 
Exome Variant ServerFLOT1
ExAC (Exome Aggregation Consortium)ENSG00000137312
GNOMAD BrowserENSG00000137312
Varsome BrowserFLOT1
Genetic variants : HAPMAP10211
Genomic Variants (DGV)FLOT1 [DGVbeta]
DECIPHERFLOT1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFLOT1 
Mutations
ICGC Data PortalFLOT1 
TCGA Data PortalFLOT1 
Broad Tumor PortalFLOT1
OASIS PortalFLOT1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFLOT1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDFLOT1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FLOT1
DgiDB (Drug Gene Interaction Database)FLOT1
DoCM (Curated mutations)FLOT1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FLOT1 (select a term)
intoGenFLOT1
Cancer3DFLOT1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606998   
Orphanet
DisGeNETFLOT1
MedgenFLOT1
Genetic Testing Registry FLOT1
NextProtO75955 [Medical]
TSGene10211
GENETestsFLOT1
Target ValidationFLOT1
Huge Navigator FLOT1 [HugePedia]
snp3D : Map Gene to Disease10211
BioCentury BCIQFLOT1
ClinGenFLOT1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10211
Chemical/Pharm GKB GenePA28175
Clinical trialFLOT1
Miscellaneous
canSAR (ICR)FLOT1 (select the gene name)
Probes
Litterature
PubMed132 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFLOT1
EVEXFLOT1
GoPubMedFLOT1
iHOPFLOT1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 11:06:49 CET 2018

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