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FLOT2 (flotillin 2)

Identity

Alias (NCBI)ECS-1
ECS1
ESA
ESA1
M17S1
HGNC (Hugo) FLOT2
HGNC Alias symbESA
ESA1
ECS-1
ECS1
HGNC Alias nameFlotillin 2 (epidermal surface antigen 1)
 membrane component, chromosome 17, surface marker 1 (35kD protein identified by monoclonal antibody ECS-1)
HGNC Previous nameM17S1
LocusID (NCBI) 2319
Atlas_Id 46114
Location 17q11.2  [Link to chromosome band 17q11]
Location_base_pair Starts at 28879339 and ends at 28897733 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ACTN1 (14q24.1) / FLOT2 (17q11.2)DHRS13 (17q11.2) / FLOT2 (17q11.2)FLOT2 (17q11.2) / FLOT2 (17q11.2)
FLOT2 (17q11.2) / FURIN (15q26.1)FLOT2 (17q11.2) / PEX12 (17q12)FLOT2 (17q11.2) / SEZ6 (17q11.2)
FLOT2 (17q11.2) / SLC23A2 (20p13)FURIN (15q26.1) / FLOT2 (17q11.2)SOCS7 (17q12) / FLOT2 (17q11.2)
TAOK1 (17q11.2) / FLOT2 (17q11.2)FLOT2 17q11.2 / PEX12 17q12SOCS7 17q12 / FLOT2 17q11.2
TAOK1 17q11.2 / FLOT2 17q11.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)FLOT2   3758
Cards
Entrez_Gene (NCBI)FLOT2    flotillin 2
AliasesECS-1; ECS1; ESA; ESA1; 
M17S1
GeneCards (Weizmann)FLOT2
Ensembl hg19 (Hinxton)ENSG00000132589 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000132589 [Gene_View]  ENSG00000132589 [Sequence]  chr17:28879339-28897733 [Contig_View]  FLOT2 [Vega]
ICGC DataPortalENSG00000132589
TCGA cBioPortalFLOT2
AceView (NCBI)FLOT2
Genatlas (Paris)FLOT2
SOURCE (Princeton)FLOT2
Genetics Home Reference (NIH)FLOT2
Genomic and cartography
GoldenPath hg38 (UCSC)FLOT2  -     chr17:28879339-28897733 -  17q11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FLOT2  -     17q11.2   [Description]    (hg19-Feb_2009)
GoldenPathFLOT2 - 17q11.2 [CytoView hg19]  FLOT2 - 17q11.2 [CytoView hg38]
ImmunoBaseENSG00000132589
Genome Data Viewer NCBIFLOT2 [Mapview hg19]  
OMIM131560   
Gene and transcription
Genbank (Entrez)AK225491 BC003683 BC017292 BQ019299 BT019477
RefSeq transcript (Entrez)NM_001330170 NM_004475
Consensus coding sequences : CCDS (NCBI)FLOT2
Gene ExpressionFLOT2 [ NCBI-GEO ]   FLOT2 [ EBI - ARRAY_EXPRESS ]   FLOT2 [ SEEK ]   FLOT2 [ MEM ]
Gene Expression Viewer (FireBrowse)FLOT2 [ Firebrowse - Broad ]
GenevisibleExpression of FLOT2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2319
GTEX Portal (Tissue expression)FLOT2
Human Protein AtlasENSG00000132589-FLOT2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ14254   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ14254  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ14254
PhosPhoSitePlusQ14254
Domains : Interpro (EBI)Band_7    Band_7/SPFH_dom_sf    Flotillin_C    Flotillin_fam   
Domain families : Pfam (Sanger)Band_7 (PF01145)    Flot (PF15975)   
Domain families : Pfam (NCBI)pfam01145    pfam15975   
Domain families : Smart (EMBL)PHB (SM00244)  
Conserved Domain (NCBI)FLOT2
SuperfamilyQ14254
AlphaFold pdb e-kbQ14254   
Human Protein Atlas [tissue]ENSG00000132589-FLOT2 [tissue]
HPRD00580
Protein Interaction databases
DIP (DOE-UCLA)Q14254
IntAct (EBI)Q14254
BioGRIDFLOT2
STRING (EMBL)FLOT2
ZODIACFLOT2
Ontologies - Pathways
QuickGOQ14254
Ontology : AmiGOmembrane raft assembly  uropod  protease binding  acrosomal membrane  protein binding  endosome  plasma membrane  plasma membrane  plasma membrane  plasma membrane  caveola  adherens junction  focal adhesion  cell adhesion  epidermis development  negative regulation of gene expression  membrane  basolateral plasma membrane  apical plasma membrane  flotillin complex  flotillin complex  lamellipodium  endocytic vesicle  cortical actin cytoskeleton  cytoplasmic vesicle  cytoplasmic vesicle  vesicle  dendrite cytoplasm  regulation of heterotypic cell-cell adhesion  regulation of toll-like receptor 3 signaling pathway  ionotropic glutamate receptor binding  intracellular membrane-bounded organelle  cell-cell contact zone  protein localization to plasma membrane raft  regulation of myoblast differentiation  regulation of myoblast differentiation  perinuclear region of cytoplasm  protein stabilization  positive regulation of NF-kappaB transcription factor activity  regulation of necroptotic process  extracellular exosome  protein localization to plasma membrane  protein localization to plasma membrane  anterograde dendritic transport  glutamatergic synapse  anchored component of presynaptic active zone membrane  regulation of postsynaptic membrane neurotransmitter receptor levels  negative regulation of amyloid precursor protein catabolic process  positive regulation of establishment of T cell polarity  
Ontology : EGO-EBImembrane raft assembly  uropod  protease binding  acrosomal membrane  protein binding  endosome  plasma membrane  plasma membrane  plasma membrane  plasma membrane  caveola  adherens junction  focal adhesion  cell adhesion  epidermis development  negative regulation of gene expression  membrane  basolateral plasma membrane  apical plasma membrane  flotillin complex  flotillin complex  lamellipodium  endocytic vesicle  cortical actin cytoskeleton  cytoplasmic vesicle  cytoplasmic vesicle  vesicle  dendrite cytoplasm  regulation of heterotypic cell-cell adhesion  regulation of toll-like receptor 3 signaling pathway  ionotropic glutamate receptor binding  intracellular membrane-bounded organelle  cell-cell contact zone  protein localization to plasma membrane raft  regulation of myoblast differentiation  regulation of myoblast differentiation  perinuclear region of cytoplasm  protein stabilization  positive regulation of NF-kappaB transcription factor activity  regulation of necroptotic process  extracellular exosome  protein localization to plasma membrane  protein localization to plasma membrane  anterograde dendritic transport  glutamatergic synapse  anchored component of presynaptic active zone membrane  regulation of postsynaptic membrane neurotransmitter receptor levels  negative regulation of amyloid precursor protein catabolic process  positive regulation of establishment of T cell polarity  
Pathways : KEGGInsulin signaling pathway   
NDEx NetworkFLOT2
Atlas of Cancer Signalling NetworkFLOT2
Wikipedia pathwaysFLOT2
Orthology - Evolution
OrthoDB2319
GeneTree (enSembl)ENSG00000132589
Phylogenetic Trees/Animal Genes : TreeFamFLOT2
Homologs : HomoloGeneFLOT2
Homology/Alignments : Family Browser (UCSC)FLOT2
Gene fusions - Rearrangements
Fusion : MitelmanFLOT2/PEX12 [17q11.2/17q12]  
Fusion : MitelmanSOCS7/FLOT2 [17q12/17q11.2]  
Fusion : MitelmanTAOK1/FLOT2 [17q11.2/17q11.2]  
Fusion : QuiverFLOT2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFLOT2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FLOT2
dbVarFLOT2
ClinVarFLOT2
MonarchFLOT2
1000_GenomesFLOT2 
Exome Variant ServerFLOT2
GNOMAD BrowserENSG00000132589
Varsome BrowserFLOT2
ACMGFLOT2 variants
VarityQ14254
Genomic Variants (DGV)FLOT2 [DGVbeta]
DECIPHERFLOT2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFLOT2 
Mutations
ICGC Data PortalFLOT2 
TCGA Data PortalFLOT2 
Broad Tumor PortalFLOT2
OASIS PortalFLOT2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFLOT2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DFLOT2
Mutations and Diseases : HGMDFLOT2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaFLOT2
DgiDB (Drug Gene Interaction Database)FLOT2
DoCM (Curated mutations)FLOT2
CIViC (Clinical Interpretations of Variants in Cancer)FLOT2
Cancer3DFLOT2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM131560   
Orphanet
DisGeNETFLOT2
MedgenFLOT2
Genetic Testing Registry FLOT2
NextProtQ14254 [Medical]
GENETestsFLOT2
Target ValidationFLOT2
Huge Navigator FLOT2 [HugePedia]
ClinGenFLOT2
Clinical trials, drugs, therapy
MyCancerGenomeFLOT2
Protein Interactions : CTDFLOT2
Pharm GKB GenePA28176
PharosQ14254
Clinical trialFLOT2
Miscellaneous
canSAR (ICR)FLOT2
HarmonizomeFLOT2
DataMed IndexFLOT2
Probes
Litterature
PubMed151 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXFLOT2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:09:38 CEST 2021

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