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FLOT2 (flotillin 2)

Identity

Alias_namesM17S1
Alias_symbol (synonym)ESA
ESA1
ECS-1
ECS1
Other alias
HGNC (Hugo) FLOT2
LocusID (NCBI) 2319
Atlas_Id 46114
Location 17q11.2  [Link to chromosome band 17q11]
Location_base_pair Starts at 27206357 and ends at 27224715 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ACTN1 (14q24.1) / FLOT2 (17q11.2)DHRS13 (17q11.2) / FLOT2 (17q11.2)FLOT2 (17q11.2) / FLOT2 (17q11.2)
FLOT2 (17q11.2) / FURIN (15q26.1)FLOT2 (17q11.2) / PEX12 (17q12)FLOT2 (17q11.2) / SEZ6 (17q11.2)
FLOT2 (17q11.2) / SLC23A2 (20p13)FURIN (15q26.1) / FLOT2 (17q11.2)SOCS7 (17q12) / FLOT2 (17q11.2)
TAOK1 (17q11.2) / FLOT2 (17q11.2)FLOT2 17q11.2 / PEX12 17q12SOCS7 17q12 / FLOT2 17q11.2
TAOK1 17q11.2 / FLOT2 17q11.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)FLOT2   3758
Cards
Entrez_Gene (NCBI)FLOT2  2319  flotillin 2
AliasesECS-1; ECS1; ESA; ESA1; 
M17S1
GeneCards (Weizmann)FLOT2
Ensembl hg19 (Hinxton)ENSG00000132589 [Gene_View]  chr17:27206357-27224715 [Contig_View]  FLOT2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000132589 [Gene_View]  chr17:27206357-27224715 [Contig_View]  FLOT2 [Vega]
ICGC DataPortalENSG00000132589
TCGA cBioPortalFLOT2
AceView (NCBI)FLOT2
Genatlas (Paris)FLOT2
WikiGenes2319
SOURCE (Princeton)FLOT2
Genetics Home Reference (NIH)FLOT2
Genomic and cartography
GoldenPath hg19 (UCSC)FLOT2  -     chr17:27206357-27224715 -  17q11.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)FLOT2  -     17q11.2   [Description]    (hg38-Dec_2013)
EnsemblFLOT2 - 17q11.2 [CytoView hg19]  FLOT2 - 17q11.2 [CytoView hg38]
Mapping of homologs : NCBIFLOT2 [Mapview hg19]  FLOT2 [Mapview hg38]
OMIM131560   
Gene and transcription
Genbank (Entrez)AK225491 BC003683 BC017292 BT019477 BT019478
RefSeq transcript (Entrez)NM_004475
RefSeq genomic (Entrez)NC_000017 NC_018928 NT_010783 NW_004929407
Consensus coding sequences : CCDS (NCBI)FLOT2
Cluster EST : UnigeneHs.514038 [ NCBI ]
CGAP (NCI)Hs.514038
Alternative Splicing GalleryENSG00000132589
Gene ExpressionFLOT2 [ NCBI-GEO ]   FLOT2 [ EBI - ARRAY_EXPRESS ]   FLOT2 [ SEEK ]   FLOT2 [ MEM ]
Gene Expression Viewer (FireBrowse)FLOT2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2319
GTEX Portal (Tissue expression)FLOT2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ14254   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ14254  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ14254
Splice isoforms : SwissVarQ14254
PhosPhoSitePlusQ14254
Domains : Interpro (EBI)Band_7    Flotillin_C    Flotillin_fam   
Domain families : Pfam (Sanger)Band_7 (PF01145)    Flot (PF15975)   
Domain families : Pfam (NCBI)pfam01145    pfam15975   
Domain families : Smart (EMBL)PHB (SM00244)  
Conserved Domain (NCBI)FLOT2
DMDM Disease mutations2319
Blocks (Seattle)FLOT2
SuperfamilyQ14254
Human Protein AtlasENSG00000132589
Peptide AtlasQ14254
HPRD00580
IPIIPI00789008   IPI00795979   
Protein Interaction databases
DIP (DOE-UCLA)Q14254
IntAct (EBI)Q14254
FunCoupENSG00000132589
BioGRIDFLOT2
STRING (EMBL)FLOT2
ZODIACFLOT2
Ontologies - Pathways
QuickGOQ14254
Ontology : AmiGOmembrane raft assembly  uropod  protease binding  acrosomal membrane  protein binding  endosome  plasma membrane  plasma membrane  caveola  cell-cell adherens junction  focal adhesion  cell adhesion  synaptic transmission  epidermis development  negative regulation of gene expression  membrane  basolateral plasma membrane  apical plasma membrane  flotillin complex  lamellipodium  endocytic vesicle  cortical actin cytoskeleton  cytoplasmic vesicle  vesicle  regulation of heterotypic cell-cell adhesion  regulation of toll-like receptor 3 signaling pathway  ionotropic glutamate receptor binding  cell-cell contact zone  protein localization to plasma membrane raft  regulation of myoblast differentiation  protein heterodimerization activity  perinuclear region of cytoplasm  protein stabilization  extracellular exosome  establishment of protein localization to plasma membrane  negative regulation of amyloid precursor protein catabolic process  positive regulation of establishment of T cell polarity  
Ontology : EGO-EBImembrane raft assembly  uropod  protease binding  acrosomal membrane  protein binding  endosome  plasma membrane  plasma membrane  caveola  cell-cell adherens junction  focal adhesion  cell adhesion  synaptic transmission  epidermis development  negative regulation of gene expression  membrane  basolateral plasma membrane  apical plasma membrane  flotillin complex  lamellipodium  endocytic vesicle  cortical actin cytoskeleton  cytoplasmic vesicle  vesicle  regulation of heterotypic cell-cell adhesion  regulation of toll-like receptor 3 signaling pathway  ionotropic glutamate receptor binding  cell-cell contact zone  protein localization to plasma membrane raft  regulation of myoblast differentiation  protein heterodimerization activity  perinuclear region of cytoplasm  protein stabilization  extracellular exosome  establishment of protein localization to plasma membrane  negative regulation of amyloid precursor protein catabolic process  positive regulation of establishment of T cell polarity  
Pathways : KEGGInsulin signaling pathway   
NDEx NetworkFLOT2
Atlas of Cancer Signalling NetworkFLOT2
Wikipedia pathwaysFLOT2
Orthology - Evolution
OrthoDB2319
GeneTree (enSembl)ENSG00000132589
Phylogenetic Trees/Animal Genes : TreeFamFLOT2
HOVERGENQ14254
HOGENOMQ14254
Homologs : HomoloGeneFLOT2
Homology/Alignments : Family Browser (UCSC)FLOT2
Gene fusions - Rearrangements
Fusion : MitelmanFLOT2/PEX12 [17q11.2/17q12]  
Fusion : MitelmanSOCS7/FLOT2 [17q12/17q11.2]  [t(17;17)(q11;q12)]  
Fusion : MitelmanTAOK1/FLOT2 [17q11.2/17q11.2]  [t(17;17)(q11;q11)]  
Fusion: TCGAFLOT2 17q11.2 PEX12 17q12 BRCA
Fusion: TCGASOCS7 17q12 FLOT2 17q11.2 BRCA
Fusion: TCGATAOK1 17q11.2 FLOT2 17q11.2 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFLOT2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FLOT2
dbVarFLOT2
ClinVarFLOT2
1000_GenomesFLOT2 
Exome Variant ServerFLOT2
ExAC (Exome Aggregation Consortium)FLOT2 (select the gene name)
Genetic variants : HAPMAP2319
Genomic Variants (DGV)FLOT2 [DGVbeta]
DECIPHER (Syndromes)17:27206357-27224715  ENSG00000132589
CONAN: Copy Number AnalysisFLOT2 
Mutations
ICGC Data PortalFLOT2 
TCGA Data PortalFLOT2 
Broad Tumor PortalFLOT2
OASIS PortalFLOT2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFLOT2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDFLOT2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FLOT2
DgiDB (Drug Gene Interaction Database)FLOT2
DoCM (Curated mutations)FLOT2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FLOT2 (select a term)
intoGenFLOT2
Cancer3DFLOT2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM131560   
Orphanet
MedgenFLOT2
Genetic Testing Registry FLOT2
NextProtQ14254 [Medical]
TSGene2319
GENETestsFLOT2
Huge Navigator FLOT2 [HugePedia]
snp3D : Map Gene to Disease2319
BioCentury BCIQFLOT2
ClinGenFLOT2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2319
Chemical/Pharm GKB GenePA28176
Clinical trialFLOT2
Miscellaneous
canSAR (ICR)FLOT2 (select the gene name)
Probes
Litterature
PubMed88 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFLOT2
EVEXFLOT2
GoPubMedFLOT2
iHOPFLOT2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:06:18 CET 2017

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