FLOT2 (flotillin 2)

2007-02-01  

Identity

HGNC
FLOT2
LOCATION
17q11.2
LOCUSID
2319
ALIAS
ECS-1,ECS1,ESA,ESA1,M17S1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2319
MIM: 131560
HGNC: 3758
Ensembl: ENSG00000132589

Variants:

dbSNP: 2319
ClinVar: 2319
TCGA: ENSG00000132589
COSMIC: FLOT2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000132589ENST00000394906E7EMK3
ENSG00000132589ENST00000394908Q14254
ENSG00000132589ENST00000394908A0A024QZ62
ENSG00000132589ENST00000465427K7EKW9
ENSG00000132589ENST00000580805J3QKZ4
ENSG00000132589ENST00000585169J3QLD9
ENSG00000132589ENST00000586827K7EJ47

Expression (GTEx)

0
50
100
150
200
250
300
350
400
450
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Insulin signaling pathwayKEGGko04910
Insulin signaling pathwayKEGGhsa04910
Neuronal SystemREACTOMER-HSA-112316
SALM protein interactions at the synapsesREACTOMER-HSA-8849932
Protein-protein interactions at synapsesREACTOMER-HSA-6794362

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
176007092007Coassembly of flotillins induces formation of membrane microdomains, membrane curvature, and vesicle budding.83
183374182008Flotillin-dependent clustering of the amyloid precursor protein regulates its endocytosis and amyloidogenic processing in neurons.78
220816072012DHHC5 protein palmitoylates flotillin-2 and is rapidly degraded on induction of neuronal differentiation in cultured cells.60
193181232009Hetero-oligomerization of reggie-1/flotillin-2 and reggie-2/flotillin-1 is required for their endocytosis.46
211874332011Flotillins play an essential role in Niemann-Pick C1-like 1-mediated cholesterol uptake.46
182378192008Trafficking of the microdomain scaffolding protein reggie-1/flotillin-2.41
154922572004Up-regulation of Flotillin-2 is associated with melanoma progression and modulates expression of the thrombin receptor protease activated receptor 1.40
228691522013Flotillins as regulators of ErbB2 levels in breast cancer.33
178548032007Linking membrane microdomains to the cytoskeleton: regulation of the lateral mobility of reggie-1/flotillin-2 by interaction with actin.30
173073332007The lipid raft proteins flotillins/reggies interact with Galphaq and are involved in Gq-mediated p38 mitogen-activated protein kinase activation through tyrosine kinase.28

Citation

Dessen P

FLOT2 (flotillin 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46114/flot2