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FLRT2 (fibronectin leucine rich transmembrane protein 2)

Identity

Other alias-
HGNC (Hugo) FLRT2
LocusID (NCBI) 23768
Atlas_Id 63540
Location 14q31.3  [Link to chromosome band 14q31]
Location_base_pair Starts at 85533322 and ends at 85628696 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
KCNIP4 (4p15.31) / FLRT2 (14q31.3)TSPAN3 (15q24.3) / FLRT2 (14q31.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)FLRT2   3761
Cards
Entrez_Gene (NCBI)FLRT2  23768  fibronectin leucine rich transmembrane protein 2
Aliases
GeneCards (Weizmann)FLRT2
Ensembl hg19 (Hinxton) [Gene_View]
Ensembl hg38 (Hinxton) [Gene_View]  chr14:85533322-85628696 [Contig_View]  FLRT2 [Vega]
TCGA cBioPortalFLRT2
AceView (NCBI)FLRT2
Genatlas (Paris)FLRT2
WikiGenes23768
SOURCE (Princeton)FLRT2
Genetics Home Reference (NIH)FLRT2
Genomic and cartography
GoldenPath hg38 (UCSC)FLRT2  -     chr14:85533322-85628696 +  14q31.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FLRT2  -     14q31.3   [Description]    (hg19-Feb_2009)
EnsemblFLRT2 - 14q31.3 [CytoView hg19]  FLRT2 - 14q31.3 [CytoView hg38]
Mapping of homologs : NCBIFLRT2 [Mapview hg19]  FLRT2 [Mapview hg38]
OMIM604807   
Gene and transcription
Genbank (Entrez)AA442817 AF169676 AK056649 AL040720 AY358287
RefSeq transcript (Entrez)NM_001346143 NM_001346144 NM_001346145 NM_001346146 NM_013231
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FLRT2
Cluster EST : UnigeneHs.744139 [ NCBI ]
CGAP (NCI)Hs.744139
Gene ExpressionFLRT2 [ NCBI-GEO ]   FLRT2 [ EBI - ARRAY_EXPRESS ]   FLRT2 [ SEEK ]   FLRT2 [ MEM ]
Gene Expression Viewer (FireBrowse)FLRT2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23768
GTEX Portal (Tissue expression)FLRT2
Protein : pattern, domain, 3D structure
UniProt/SwissProtO43155   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO43155  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO43155
Splice isoforms : SwissVarO43155
PhosPhoSitePlusO43155
Domaine pattern : Prosite (Expaxy)FN3 (PS50853)   
Domains : Interpro (EBI)Cys-rich_flank_reg_C    FN3_dom    Ig-like_fold    L_dom-like    Leu-rich_rpt    Leu-rich_rpt_typical-subtyp    LRRNT   
Domain families : Pfam (Sanger)fn3 (PF00041)    LRR_8 (PF13855)    LRRCT (PF01463)   
Domain families : Pfam (NCBI)pfam00041    pfam13855    pfam01463   
Domain families : Smart (EMBL)LRR_TYP (SM00369)  LRRCT (SM00082)  LRRNT (SM00013)  
Conserved Domain (NCBI)FLRT2
DMDM Disease mutations23768
Blocks (Seattle)FLRT2
SuperfamilyO43155
Peptide AtlasO43155
HPRD05312
IPIIPI00001633   IPI01014880   
Protein Interaction databases
DIP (DOE-UCLA)O43155
IntAct (EBI)O43155
BioGRIDFLRT2
STRING (EMBL)FLRT2
ZODIACFLRT2
Ontologies - Pathways
QuickGOO43155
Ontology : AmiGOheart morphogenesis  protein kinase inhibitor activity  signal transducer activity, downstream of receptor  fibroblast growth factor receptor binding  proteinaceous extracellular matrix  extracellular space  cytoplasm  endoplasmic reticulum membrane  plasma membrane  integral component of plasma membrane  integral component of plasma membrane  cell-cell junction  focal adhesion  focal adhesion  negative regulation of protein kinase activity  axon guidance  biological_process  fibroblast growth factor receptor signaling pathway  fibroblast growth factor receptor signaling pathway  cytokine-mediated signaling pathway  protein binding, bridging  organelle membrane  neuron projection  synapse  chemorepellent activity  negative regulation of JAK-STAT cascade  negative chemotaxis  positive regulation of synapse assembly  cell adhesion involved in heart morphogenesis  extracellular exosome  basement membrane organization  regulation of neuron migration  
Ontology : EGO-EBIheart morphogenesis  protein kinase inhibitor activity  signal transducer activity, downstream of receptor  fibroblast growth factor receptor binding  proteinaceous extracellular matrix  extracellular space  cytoplasm  endoplasmic reticulum membrane  plasma membrane  integral component of plasma membrane  integral component of plasma membrane  cell-cell junction  focal adhesion  focal adhesion  negative regulation of protein kinase activity  axon guidance  biological_process  fibroblast growth factor receptor signaling pathway  fibroblast growth factor receptor signaling pathway  cytokine-mediated signaling pathway  protein binding, bridging  organelle membrane  neuron projection  synapse  chemorepellent activity  negative regulation of JAK-STAT cascade  negative chemotaxis  positive regulation of synapse assembly  cell adhesion involved in heart morphogenesis  extracellular exosome  basement membrane organization  regulation of neuron migration  
NDEx NetworkFLRT2
Atlas of Cancer Signalling NetworkFLRT2
Wikipedia pathwaysFLRT2
Orthology - Evolution
OrthoDB23768
Phylogenetic Trees/Animal Genes : TreeFamFLRT2
HOVERGENO43155
HOGENOMO43155
Homologs : HomoloGeneFLRT2
Homology/Alignments : Family Browser (UCSC)FLRT2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFLRT2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FLRT2
dbVarFLRT2
ClinVarFLRT2
1000_GenomesFLRT2 
Exome Variant ServerFLRT2
ExAC (Exome Aggregation Consortium)FLRT2 (select the gene name)
Genetic variants : HAPMAP23768
Genomic Variants (DGV)FLRT2 [DGVbeta]
DECIPHERFLRT2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFLRT2 
Mutations
ICGC Data PortalFLRT2 
TCGA Data PortalFLRT2 
Broad Tumor PortalFLRT2
OASIS PortalFLRT2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFLRT2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDFLRT2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FLRT2
DgiDB (Drug Gene Interaction Database)FLRT2
DoCM (Curated mutations)FLRT2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FLRT2 (select a term)
intoGenFLRT2
Cancer3DFLRT2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604807   
Orphanet
MedgenFLRT2
Genetic Testing Registry FLRT2
NextProtO43155 [Medical]
TSGene23768
GENETestsFLRT2
Target ValidationFLRT2
Huge Navigator FLRT2 [HugePedia]
snp3D : Map Gene to Disease23768
BioCentury BCIQFLRT2
ClinGenFLRT2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD23768
Chemical/Pharm GKB GenePA28178
Clinical trialFLRT2
Miscellaneous
canSAR (ICR)FLRT2 (select the gene name)
Probes
Litterature
PubMed25 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFLRT2
EVEXFLRT2
GoPubMedFLRT2
iHOPFLRT2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 15:49:41 CEST 2017

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