Atlas of Genetics and Cytogenetics in Oncology and Haematology


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FLT1 (fms related tyrosine kinase 1)

Identity

Alias_namesFLT
fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)
fms-related tyrosine kinase 1
Alias_symbol (synonym)VEGFR1
Other aliasFLT-1
VEGFR-1
HGNC (Hugo) FLT1
LocusID (NCBI) 2321
Atlas_Id 40610
Location 13q12.3  [Link to chromosome band 13q12]
Location_base_pair Starts at 28385551 and ends at 28495128 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
FLT1 (13q12.3) / CTNND1 (11q12.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(4;22)(q12;q11) BCR/PDGFRA
+13,+13 or tetrasomy 13


External links

Nomenclature
HGNC (Hugo)FLT1   3763
LRG (Locus Reference Genomic)LRG_425
Cards
Entrez_Gene (NCBI)FLT1  2321  fms related tyrosine kinase 1
AliasesFLT; FLT-1; VEGFR-1; VEGFR1
GeneCards (Weizmann)FLT1
Ensembl hg19 (Hinxton)ENSG00000102755 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000102755 [Gene_View]  chr13:28385551-28495128 [Contig_View]  FLT1 [Vega]
ICGC DataPortalENSG00000102755
TCGA cBioPortalFLT1
AceView (NCBI)FLT1
Genatlas (Paris)FLT1
WikiGenes2321
SOURCE (Princeton)FLT1
Genetics Home Reference (NIH)FLT1
Genomic and cartography
GoldenPath hg38 (UCSC)FLT1  -     chr13:28385551-28495128 -  13q12.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FLT1  -     13q12.3   [Description]    (hg19-Feb_2009)
EnsemblFLT1 - 13q12.3 [CytoView hg19]  FLT1 - 13q12.3 [CytoView hg38]
Mapping of homologs : NCBIFLT1 [Mapview hg19]  FLT1 [Mapview hg38]
OMIM165070   
Gene and transcription
Genbank (Entrez)###############################################################################################################################################################################################################################################################
RefSeq transcript (Entrez)NM_001159920 NM_001160030 NM_001160031 NM_002019
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FLT1
Cluster EST : UnigeneHs.594454 [ NCBI ]
CGAP (NCI)Hs.594454
Alternative Splicing GalleryENSG00000102755
Gene ExpressionFLT1 [ NCBI-GEO ]   FLT1 [ EBI - ARRAY_EXPRESS ]   FLT1 [ SEEK ]   FLT1 [ MEM ]
Gene Expression Viewer (FireBrowse)FLT1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2321
GTEX Portal (Tissue expression)FLT1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP17948   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP17948  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP17948
Splice isoforms : SwissVarP17948
Catalytic activity : Enzyme2.7.10.1 [ Enzyme-Expasy ]   2.7.10.12.7.10.1 [ IntEnz-EBI ]   2.7.10.1 [ BRENDA ]   2.7.10.1 [ KEGG ]   
PhosPhoSitePlusP17948
Domaine pattern : Prosite (Expaxy)IG_LIKE (PS50835)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_TYR (PS00109)    RECEPTOR_TYR_KIN_III (PS00240)   
Domains : Interpro (EBI)Ig-like_dom    Ig-like_fold    Ig_I-set    Ig_sub    Ig_sub2    Ig_V-set    Immunoglobulin    Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser-Thr/Tyr_kinase_cat_dom    Tyr_kinase_AS    Tyr_kinase_cat_dom    Tyr_kinase_rcpt_3_CS    VEGFR1_rcpt   
Domain families : Pfam (Sanger)I-set (PF07679)    ig (PF00047)    Pkinase_Tyr (PF07714)   
Domain families : Pfam (NCBI)pfam07679    pfam00047    pfam07714   
Domain families : Smart (EMBL)IG (SM00409)  IGc2 (SM00408)  IGv (SM00406)  TyrKc (SM00219)  
Conserved Domain (NCBI)FLT1
DMDM Disease mutations2321
Blocks (Seattle)FLT1
PDB (SRS)1FLT    1QSV    1QSZ    1QTY    1RV6    2XAC    3HNG    4CKV    4CL7    5ABD    5EX3    5T89   
PDB (PDBSum)1FLT    1QSV    1QSZ    1QTY    1RV6    2XAC    3HNG    4CKV    4CL7    5ABD    5EX3    5T89   
PDB (IMB)1FLT    1QSV    1QSZ    1QTY    1RV6    2XAC    3HNG    4CKV    4CL7    5ABD    5EX3    5T89   
PDB (RSDB)1FLT    1QSV    1QSZ    1QTY    1RV6    2XAC    3HNG    4CKV    4CL7    5ABD    5EX3    5T89   
Structural Biology KnowledgeBase1FLT    1QSV    1QSZ    1QTY    1RV6    2XAC    3HNG    4CKV    4CL7    5ABD    5EX3    5T89   
SCOP (Structural Classification of Proteins)1FLT    1QSV    1QSZ    1QTY    1RV6    2XAC    3HNG    4CKV    4CL7    5ABD    5EX3    5T89   
CATH (Classification of proteins structures)1FLT    1QSV    1QSZ    1QTY    1RV6    2XAC    3HNG    4CKV    4CL7    5ABD    5EX3    5T89   
SuperfamilyP17948
Human Protein AtlasENSG00000102755
Peptide AtlasP17948
HPRD01297
IPIIPI00018335   IPI00216043   IPI01010354   IPI01014110   IPI00815971   IPI00816497   IPI01012204   IPI00930254   IPI00930300   
Protein Interaction databases
DIP (DOE-UCLA)P17948
IntAct (EBI)P17948
FunCoupENSG00000102755
BioGRIDFLT1
STRING (EMBL)FLT1
ZODIACFLT1
Ontologies - Pathways
QuickGOP17948
Ontology : AmiGOangiogenesis  monocyte chemotaxis  transmembrane receptor protein tyrosine kinase activity  vascular endothelial growth factor-activated receptor activity  vascular endothelial growth factor-activated receptor activity  protein binding  ATP binding  extracellular space  endosome  plasma membrane  plasma membrane  integral component of plasma membrane  focal adhesion  transmembrane receptor protein tyrosine kinase signaling pathway  positive regulation of cell proliferation  positive regulation of phospholipase C activity  positive regulation of phosphatidylinositol 3-kinase signaling  actin cytoskeleton  cell migration  peptidyl-tyrosine phosphorylation  growth factor binding  cell differentiation  positive regulation of cell migration  positive regulation of vascular endothelial growth factor receptor signaling pathway  cellular response to vascular endothelial growth factor stimulus  vascular endothelial growth factor receptor-1 signaling pathway  VEGF-A-activated receptor activity  VEGF-B-activated receptor activity  placental growth factor-activated receptor activity  vascular endothelial growth factor signaling pathway  receptor complex  positive regulation of MAP kinase activity  positive regulation of MAPK cascade  positive regulation of phosphatidylinositol 3-kinase activity  positive regulation of angiogenesis  protein autophosphorylation  vascular endothelial growth factor receptor signaling pathway  vascular endothelial growth factor receptor signaling pathway  vascular endothelial growth factor receptor signaling pathway  blood vessel morphogenesis  embryonic morphogenesis  
Ontology : EGO-EBIangiogenesis  monocyte chemotaxis  transmembrane receptor protein tyrosine kinase activity  vascular endothelial growth factor-activated receptor activity  vascular endothelial growth factor-activated receptor activity  protein binding  ATP binding  extracellular space  endosome  plasma membrane  plasma membrane  integral component of plasma membrane  focal adhesion  transmembrane receptor protein tyrosine kinase signaling pathway  positive regulation of cell proliferation  positive regulation of phospholipase C activity  positive regulation of phosphatidylinositol 3-kinase signaling  actin cytoskeleton  cell migration  peptidyl-tyrosine phosphorylation  growth factor binding  cell differentiation  positive regulation of cell migration  positive regulation of vascular endothelial growth factor receptor signaling pathway  cellular response to vascular endothelial growth factor stimulus  vascular endothelial growth factor receptor-1 signaling pathway  VEGF-A-activated receptor activity  VEGF-B-activated receptor activity  placental growth factor-activated receptor activity  vascular endothelial growth factor signaling pathway  receptor complex  positive regulation of MAP kinase activity  positive regulation of MAPK cascade  positive regulation of phosphatidylinositol 3-kinase activity  positive regulation of angiogenesis  protein autophosphorylation  vascular endothelial growth factor receptor signaling pathway  vascular endothelial growth factor receptor signaling pathway  vascular endothelial growth factor receptor signaling pathway  blood vessel morphogenesis  embryonic morphogenesis  
Pathways : BIOCARTAActions of Nitric Oxide in the Heart [Genes]    VEGF, Hypoxia, and Angiogenesis [Genes]   
Pathways : KEGG   
NDEx NetworkFLT1
Atlas of Cancer Signalling NetworkFLT1
Wikipedia pathwaysFLT1
Orthology - Evolution
OrthoDB2321
GeneTree (enSembl)ENSG00000102755
Phylogenetic Trees/Animal Genes : TreeFamFLT1
HOVERGENP17948
HOGENOMP17948
Homologs : HomoloGeneFLT1
Homology/Alignments : Family Browser (UCSC)FLT1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFLT1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FLT1
dbVarFLT1
ClinVarFLT1
1000_GenomesFLT1 
Exome Variant ServerFLT1
ExAC (Exome Aggregation Consortium)FLT1 (select the gene name)
Genetic variants : HAPMAP2321
Genomic Variants (DGV)FLT1 [DGVbeta]
DECIPHERFLT1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFLT1 
Mutations
ICGC Data PortalFLT1 
TCGA Data PortalFLT1 
Broad Tumor PortalFLT1
OASIS PortalFLT1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFLT1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDFLT1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)The Globin Gene Server
BioMutasearch FLT1
DgiDB (Drug Gene Interaction Database)FLT1
DoCM (Curated mutations)FLT1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FLT1 (select a term)
intoGenFLT1
Cancer3DFLT1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM165070   
Orphanet
MedgenFLT1
Genetic Testing Registry FLT1
NextProtP17948 [Medical]
TSGene2321
GENETestsFLT1
Target ValidationFLT1
Huge Navigator FLT1 [HugePedia]
snp3D : Map Gene to Disease2321
BioCentury BCIQFLT1
ClinGenFLT1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2321
Chemical/Pharm GKB GenePA28180
Clinical trialFLT1
Miscellaneous
canSAR (ICR)FLT1 (select the gene name)
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFLT1
EVEXFLT1
GoPubMedFLT1
iHOPFLT1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:34:05 CEST 2017

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