FLT3LG (fms related receptor tyrosine kinase 3 ligand)

2003-02-01  

Identity

HGNC
LOCATION
19q13.33
LOCUSID
ALIAS
FL,FLG3L,FLT3L
FUSION GENES

Other Information

Locus ID:

NCBI: 2323
MIM: 600007
HGNC: 3766
Ensembl: ENSG00000090554

Variants:

dbSNP: 2323
ClinVar: 2323
TCGA: ENSG00000090554
COSMIC: FLT3LG

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000090554ENST00000204637P49771
ENSG00000090554ENST00000594009P49771
ENSG00000090554ENST00000595510P49771
ENSG00000090554ENST00000596435M0QYM9
ENSG00000090554ENST00000597551P49771
ENSG00000090554ENST00000597914M0R3A6
ENSG00000090554ENST00000598555M0QXI0
ENSG00000090554ENST00000600084M0R2K0
ENSG00000090554ENST00000600429P49771
ENSG00000090554ENST00000601800M0R2K0

Expression (GTEx)

0
5
10
15
20
25

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Hematopoietic cell lineageKEGGko04640
Cytokine-cytokine receptor interactionKEGGhsa04060
Hematopoietic cell lineageKEGGhsa04640
Pathways in cancerKEGGhsa05200
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147

References

Pubmed IDYearTitleCitations
212631552011FLT3 ligand impedes the efficacy of FLT3 inhibitors in vitro and in vivo.88
118772882002Effects of administration of progenipoietin 1, Flt-3 ligand, granulocyte colony-stimulating factor, and pegylated granulocyte-macrophage colony-stimulating factor on dendritic cell subsets in mice.48
129699632004FLT3 ligand causes autocrine signaling in acute myeloid leukemia cells.47
127594282003Selective induction of dendritic cells using granulocyte macrophage-colony stimulating factor, but not fms-like tyrosine kinase receptor 3-ligand, activates thyroglobulin-specific CD4+/CD25+ T cells and suppresses experimental autoimmune thyroiditis.39
146709162004Thrombopoietin cooperates with FLT3-ligand in the generation of plasmacytoid dendritic cell precursors from human hematopoietic progenitors.33
251352992014Classical Flt3L-dependent dendritic cells control immunity to protein vaccine.31
206286242010Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot".29
215054262011Combined Flt3L/TK gene therapy induces immunological surveillance which mediates an immune response against a surrogate brain tumor neoantigen.29
126767892003Human CD34+ hematopoietic stem cells capable of multilineage engrafting NOD/SCID mice express flt3: distinct flt3 and c-kit expression and response patterns on mouse and candidate human hematopoietic stem cells.27
215161202011Further activation of FLT3 mutants by FLT3 ligand.24

Citation

Dessen P

FLT3LG (fms related receptor tyrosine kinase 3 ligand)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40611/flt3lg