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FLT3LG (fms related tyrosine kinase 3 ligand)

Identity

Other namesFL
FLT3L
HGNC (Hugo) FLT3LG
LocusID (NCBI) 2323
Atlas_Id 40611
Location 19q13.33
Location_base_pair Starts at 49977466 and ends at 49989488 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
FLT3LG (19q13.33) / ALDH16A1 (19q13.33)FLT3LG (19q13.33) / RPL3 (22q13.1)PRMT1 (19q13.33) / FLT3LG (19q13.33)
PRR12 (19q13.33) / FLT3LG (19q13.33)RPS11 (19q13.33) / FLT3LG (19q13.33)SCAF1 (19q13.33) / FLT3LG (19q13.33)
FLT3LG 19q13.33 / ALDH16A1 19q13.33RPS11 19q13.33 / FLT3LG 19q13.33SCAF1 19q13.33 / FLT3LG 19q13.33

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)FLT3LG   3766
Cards
Entrez_Gene (NCBI)FLT3LG  2323  fms related tyrosine kinase 3 ligand
AliasesFL; FLT3L
GeneCards (Weizmann)FLT3LG
Ensembl hg19 (Hinxton)ENSG00000090554 [Gene_View]  chr19:49977466-49989488 [Contig_View]  FLT3LG [Vega]
Ensembl hg38 (Hinxton)ENSG00000090554 [Gene_View]  chr19:49977466-49989488 [Contig_View]  FLT3LG [Vega]
ICGC DataPortalENSG00000090554
TCGA cBioPortalFLT3LG
AceView (NCBI)FLT3LG
Genatlas (Paris)FLT3LG
WikiGenes2323
SOURCE (Princeton)FLT3LG
Genomic and cartography
GoldenPath hg19 (UCSC)FLT3LG  -     chr19:49977466-49989488 +  19q13.33   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)FLT3LG  -     19q13.33   [Description]    (hg38-Dec_2013)
EnsemblFLT3LG - 19q13.33 [CytoView hg19]  FLT3LG - 19q13.33 [CytoView hg38]
Mapping of homologs : NCBIFLT3LG [Mapview hg19]  FLT3LG [Mapview hg38]
OMIM600007   
Gene and transcription
Genbank (Entrez)AI792400 AK301136 AK308939 BC006331 BC011914
RefSeq transcript (Entrez)NM_001204502 NM_001204503 NM_001278637 NM_001278638 NM_001459
RefSeq genomic (Entrez)NC_000019 NC_018930 NT_011109 NW_004929415
Consensus coding sequences : CCDS (NCBI)FLT3LG
Cluster EST : UnigeneHs.428 [ NCBI ]
CGAP (NCI)Hs.428
Alternative Splicing GalleryENSG00000090554
Gene ExpressionFLT3LG [ NCBI-GEO ]   FLT3LG [ EBI - ARRAY_EXPRESS ]   FLT3LG [ SEEK ]   FLT3LG [ MEM ]
Gene Expression Viewer (FireBrowse)FLT3LG [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2323
GTEX Portal (Tissue expression)FLT3LG
Protein : pattern, domain, 3D structure
UniProt/SwissProtP49771 (Uniprot)
NextProtP49771  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP49771
Splice isoforms : SwissVarP49771 (Swissvar)
PhosPhoSitePlusP49771
Domains : Interpro (EBI)4_helix_cytokine-like_core    4_helix_cytokine_core    Flt3_lig   
Domain families : Pfam (Sanger)Flt3_lig (PF02947)   
Domain families : Pfam (NCBI)pfam02947   
DMDM Disease mutations2323
Blocks (Seattle)FLT3LG
PDB (SRS)1ETE    3QS7    3QS9   
PDB (PDBSum)1ETE    3QS7    3QS9   
PDB (IMB)1ETE    3QS7    3QS9   
PDB (RSDB)1ETE    3QS7    3QS9   
Structural Biology KnowledgeBase1ETE    3QS7    3QS9   
SCOP (Structural Classification of Proteins)1ETE    3QS7    3QS9   
CATH (Classification of proteins structures)1ETE    3QS7    3QS9   
SuperfamilyP49771
Human Protein AtlasENSG00000090554
Peptide AtlasP49771
HPRD02477
IPIIPI00291404   IPI00216372   
Protein Interaction databases
DIP (DOE-UCLA)P49771
IntAct (EBI)P49771
FunCoupENSG00000090554
BioGRIDFLT3LG
STRING (EMBL)FLT3LG
ZODIACFLT3LG
Ontologies - Pathways
QuickGOP49771
Ontology : AmiGOpositive regulation of protein phosphorylation  receptor binding  cytokine activity  extracellular region  extracellular space  signal transduction  positive regulation of cell proliferation  membrane  integral component of membrane  lymphocyte differentiation  regulation of myeloid dendritic cell activation  receptor tyrosine kinase binding  intrinsic component of external side of plasma membrane  positive regulation of natural killer cell differentiation  embryonic hemopoiesis  protein homodimerization activity  positive regulation of myoblast differentiation  positive regulation of cell cycle  positive regulation of transcription from RNA polymerase II promoter  homeostasis of number of cells within a tissue  positive regulation of cell proliferation in bone marrow  negative regulation of apoptotic process in bone marrow  positive regulation of osteoclast proliferation  positive regulation of myoblast fusion  
Ontology : EGO-EBIpositive regulation of protein phosphorylation  receptor binding  cytokine activity  extracellular region  extracellular space  signal transduction  positive regulation of cell proliferation  membrane  integral component of membrane  lymphocyte differentiation  regulation of myeloid dendritic cell activation  receptor tyrosine kinase binding  intrinsic component of external side of plasma membrane  positive regulation of natural killer cell differentiation  embryonic hemopoiesis  protein homodimerization activity  positive regulation of myoblast differentiation  positive regulation of cell cycle  positive regulation of transcription from RNA polymerase II promoter  homeostasis of number of cells within a tissue  positive regulation of cell proliferation in bone marrow  negative regulation of apoptotic process in bone marrow  positive regulation of osteoclast proliferation  positive regulation of myoblast fusion  
Pathways : KEGGCytokine-cytokine receptor interaction    Hematopoietic cell lineage    Pathways in cancer   
NDEx Network
Atlas of Cancer Signalling NetworkFLT3LG
Wikipedia pathwaysFLT3LG
Orthology - Evolution
OrthoDB2323
GeneTree (enSembl)ENSG00000090554
Phylogenetic Trees/Animal Genes : TreeFamFLT3LG
Homologs : HomoloGeneFLT3LG
Homology/Alignments : Family Browser (UCSC)FLT3LG
Gene fusions - Rearrangements
Fusion: TCGAFLT3LG 19q13.33 ALDH16A1 19q13.33 HNSC
Fusion: TCGARPS11 19q13.33 FLT3LG 19q13.33 LAML
Fusion: TCGASCAF1 19q13.33 FLT3LG 19q13.33 HNSC
Polymorphisms : SNP, variants
NCBI Variation ViewerFLT3LG [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FLT3LG
dbVarFLT3LG
ClinVarFLT3LG
1000_GenomesFLT3LG 
Exome Variant ServerFLT3LG
ExAC (Exome Aggregation Consortium)FLT3LG (select the gene name)
Genetic variants : HAPMAP2323
Genomic Variants (DGV)FLT3LG [DGVbeta]
Mutations
ICGC Data PortalFLT3LG 
TCGA Data PortalFLT3LG 
Broad Tumor PortalFLT3LG
OASIS PortalFLT3LG [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFLT3LG 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FLT3LG
DgiDB (Drug Gene Interaction Database)FLT3LG
DoCM (Curated mutations)FLT3LG (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FLT3LG (select a term)
intoGenFLT3LG
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)19:49977466-49989488  ENSG00000090554
CONAN: Copy Number AnalysisFLT3LG 
Mutations and Diseases : HGMDFLT3LG
OMIM600007   
MedgenFLT3LG
Genetic Testing Registry FLT3LG
NextProtP49771 [Medical]
TSGene2323
GENETestsFLT3LG
Huge Navigator FLT3LG [HugePedia]
snp3D : Map Gene to Disease2323
BioCentury BCIQFLT3LG
ClinGenFLT3LG
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2323
Chemical/Pharm GKB GenePA28182
Clinical trialFLT3LG
Miscellaneous
canSAR (ICR)FLT3LG (select the gene name)
Probes
Litterature
PubMed53 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFLT3LG
EVEXFLT3LG
GoPubMedFLT3LG
iHOPFLT3LG
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sat May 28 11:02:58 CEST 2016

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