Atlas of Genetics and Cytogenetics in Oncology and Haematology

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FLT4 (fms-related tyrosine kinase 4)

Identity

Other namesFLT41
LMPH1A
PCL
VEGFR3
HGNC (Hugo) FLT4
LocusID (NCBI) 2324
Location 5q35.3
Location_base_pair Starts at 180034753 and ends at 180076624 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas)

Leukemias 11q23ChildAMLID1615

Other Solid tumors implicated (Data extracted from papers in the Atlas)

Solid Tumors AmeloblastomID5945

External links

Nomenclature
HGNC (Hugo)FLT4   3767
Cards
Entrez_Gene (NCBI)FLT4  2324  fms-related tyrosine kinase 4
GeneCards (Weizmann)FLT4
Ensembl hg19 (Hinxton)ENSG00000037280 [Gene_View]  chr5:180034753-180076624 [Contig_View]  FLT4 [Vega]
Ensembl hg38 (Hinxton)ENSG00000037280 [Gene_View]  chr5:180034753-180076624 [Contig_View]  FLT4 [Vega]
ICGC DataPortalENSG00000037280
cBioPortalFLT4
AceView (NCBI)FLT4
Genatlas (Paris)FLT4
WikiGenes2324
SOURCE (Princeton)FLT4
Genomic and cartography
GoldenPath hg19 (UCSC)FLT4  -     chr5:180034753-180076624 -  5q35.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)FLT4  -     5q35.3   [Description]    (hg38-Dec_2013)
EnsemblFLT4 - 5q35.3 [CytoView hg19]  FLT4 - 5q35.3 [CytoView hg38]
Mapping of homologs : NCBIFLT4 [Mapview hg19]  FLT4 [Mapview hg38]
OMIM136352   153100   602089   
Gene and transcription
Genbank (Entrez)AB209637 AK291679 AK309910 AY233382 AY233383
RefSeq transcript (Entrez)NM_002020 NM_182925
RefSeq genomic (Entrez)AC_000137 NC_000005 NC_018916 NG_011536 NT_023133 NW_001838967 NW_004929325
Consensus coding sequences : CCDS (NCBI)FLT4
Cluster EST : UnigeneHs.646917 [ NCBI ]
CGAP (NCI)Hs.646917
Alternative Splicing : Fast-db (Paris)GSHG0025345
Alternative Splicing GalleryENSG00000037280
Gene ExpressionFLT4 [ NCBI-GEO ]     FLT4 [ SEEK ]   FLT4 [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP35916 (Uniprot)
NextProtP35916  [Medical]
With graphics : InterProP35916
Splice isoforms : SwissVarP35916 (Swissvar)
Catalytic activity : Enzyme2.7.10.1 [ Enzyme-Expasy ]   2.7.10.12.7.10.1 [ IntEnz-EBI ]   2.7.10.1 [ BRENDA ]   2.7.10.1 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)IG_LIKE (PS50835)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_TYR (PS00109)    RECEPTOR_TYR_KIN_III (PS00240)   
Domains : Interpro (EBI)Ig-like_dom    Ig-like_fold    Ig_I-set    Ig_sub    Ig_sub2    Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser-Thr/Tyr_kinase_cat_dom    Tyr_kinase_AS    Tyr_kinase_cat_dom    Tyr_kinase_rcpt_3_CS    VEGFR3_rcpt   
Related proteins : CluSTrP35916
Domain families : Pfam (Sanger)I-set (PF07679)    Pkinase_Tyr (PF07714)   
Domain families : Pfam (NCBI)pfam07679    pfam07714   
Domain families : Smart (EMBL)IG (SM00409)  IGc2 (SM00408)  TyrKc (SM00219)  
DMDM Disease mutations2324
Blocks (Seattle)P35916
PDB (SRS)4BSJ    4BSK   
PDB (PDBSum)4BSJ    4BSK   
PDB (IMB)4BSJ    4BSK   
PDB (RSDB)4BSJ    4BSK   
Human Protein AtlasENSG00000037280
Peptide AtlasP35916
HPRD00636
IPIIPI00337568   IPI00293565   IPI00909819   IPI00909224   IPI00555993   IPI00966321   IPI00968257   
Protein Interaction databases
DIP (DOE-UCLA)P35916
IntAct (EBI)P35916
FunCoupENSG00000037280
BioGRIDFLT4
IntegromeDBFLT4
STRING (EMBL)FLT4
Ontologies - Pathways
QuickGOP35916
Ontology : AmiGOpositive regulation of protein phosphorylation  positive regulation of endothelial cell proliferation  vasculature development  lymph vessel development  lymphangiogenesis  lymphangiogenesis  sprouting angiogenesis  transmembrane receptor protein tyrosine kinase activity  vascular endothelial growth factor-activated receptor activity  vascular endothelial growth factor-activated receptor activity  protein binding  ATP binding  extracellular region  nucleus  cytoplasm  plasma membrane  plasma membrane  integral component of plasma membrane  transmembrane receptor protein tyrosine kinase signaling pathway  positive regulation of cell proliferation  positive regulation of cell proliferation  positive regulation vascular endothelial growth factor production  positive regulation of endothelial cell migration  peptidyl-tyrosine phosphorylation  growth factor binding  protein phosphatase binding  cellular response to vascular endothelial growth factor stimulus  cellular response to vascular endothelial growth factor stimulus  vascular endothelial growth factor signaling pathway  negative regulation of apoptotic process  receptor complex  positive regulation of MAPK cascade  positive regulation of JNK cascade  protein autophosphorylation  vascular endothelial growth factor receptor signaling pathway  vascular endothelial growth factor receptor signaling pathway  vascular endothelial growth factor receptor signaling pathway  vascular endothelial growth factor receptor signaling pathway  blood vessel morphogenesis  regulation of blood vessel remodeling  positive regulation of ERK1 and ERK2 cascade  positive regulation of protein kinase C signaling  
Ontology : EGO-EBIpositive regulation of protein phosphorylation  positive regulation of endothelial cell proliferation  vasculature development  lymph vessel development  lymphangiogenesis  lymphangiogenesis  sprouting angiogenesis  transmembrane receptor protein tyrosine kinase activity  vascular endothelial growth factor-activated receptor activity  vascular endothelial growth factor-activated receptor activity  protein binding  ATP binding  extracellular region  nucleus  cytoplasm  plasma membrane  plasma membrane  integral component of plasma membrane  transmembrane receptor protein tyrosine kinase signaling pathway  positive regulation of cell proliferation  positive regulation of cell proliferation  positive regulation vascular endothelial growth factor production  positive regulation of endothelial cell migration  peptidyl-tyrosine phosphorylation  growth factor binding  protein phosphatase binding  cellular response to vascular endothelial growth factor stimulus  cellular response to vascular endothelial growth factor stimulus  vascular endothelial growth factor signaling pathway  negative regulation of apoptotic process  receptor complex  positive regulation of MAPK cascade  positive regulation of JNK cascade  protein autophosphorylation  vascular endothelial growth factor receptor signaling pathway  vascular endothelial growth factor receptor signaling pathway  vascular endothelial growth factor receptor signaling pathway  vascular endothelial growth factor receptor signaling pathway  blood vessel morphogenesis  regulation of blood vessel remodeling  positive regulation of ERK1 and ERK2 cascade  positive regulation of protein kinase C signaling  
Pathways : BIOCARTAActions of Nitric Oxide in the Heart [Genes]    VEGF, Hypoxia, and Angiogenesis [Genes]   
Pathways : KEGGRas signaling pathway    Rap1 signaling pathway    Cytokine-cytokine receptor interaction    PI3K-Akt signaling pathway    Focal adhesion   
Protein Interaction DatabaseFLT4
DoCM (Curated mutations)FLT4
Wikipedia pathwaysFLT4
Gene fusion - rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerFLT4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FLT4
dbVarFLT4
ClinVarFLT4
1000_GenomesFLT4 
Exome Variant ServerFLT4
SNP (GeneSNP Utah)FLT4
SNP : HGBaseFLT4
Genetic variants : HAPMAPFLT4
Genomic VariantsFLT4  FLT4 [DGVbeta]
Mutations
ICGC Data PortalENSG00000037280 
Somatic Mutations in Cancer : COSMICFLT4 
CONAN: Copy Number AnalysisFLT4 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Mendelian genes
LOVD (Leiden Open Variation Database)Vascular Anomaly and Lymphedema Mutation Database
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)5:180034753-180076624
Mutations and Diseases : HGMDFLT4
OMIM136352    153100    602089   
MedgenFLT4
NextProtP35916 [Medical]
GENETestsFLT4
Disease Genetic AssociationFLT4
Huge Navigator FLT4 [HugePedia]  FLT4 [HugeCancerGEM]
snp3D : Map Gene to Disease2324
DGIdb (Drug Gene Interaction db)FLT4
General knowledge
Homologs : HomoloGeneFLT4
Homology/Alignments : Family Browser (UCSC)FLT4
Phylogenetic Trees/Animal Genes : TreeFamFLT4
Chemical/Protein Interactions : CTD2324
Chemical/Pharm GKB GenePA28183
Clinical trialFLT4
Cancer Resource (Charite)ENSG00000037280
Other databases
Probes
Litterature
PubMed172 Pubmed reference(s) in Entrez
CoreMineFLT4
GoPubMedFLT4
iHOPFLT4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2014Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Dec 20 21:38:31 CET 2014
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