Atlas of Genetics and Cytogenetics in Oncology and Haematology

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FLT4 (fms related tyrosine kinase 4)

Identity

Alias_namesfms-related tyrosine kinase 4
Alias_symbol (synonym)VEGFR3
PCL
Other aliasFLT-4
FLT41
LMPH1A
VEGFR-3
HGNC (Hugo) FLT4
LocusID (NCBI) 2324
Atlas_Id 40612
Location 5q35.3  [Link to chromosome band 5q35]
Location_base_pair Starts at 180601506 and ends at 180649624 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
MGAT1 (5q35.3) / FLT4 (5q35.3)PTPN23 (3p21.31) / FLT4 (5q35.3)TIMP2 (17q25.3) / FLT4 (5q35.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  del(4)(q12q12) FIP1L1/PDGFRA

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 4 ]
  Bone: Angiosarcoma
Soft tissue tumors: an overview
MGAT1/FLT4 (5q35)
Bone: Vascular Tumors

External links

Nomenclature
HGNC (Hugo)FLT4   3767
Cards
Entrez_Gene (NCBI)FLT4  2324  fms related tyrosine kinase 4
AliasesFLT-4; FLT41; LMPH1A; PCL; 
VEGFR-3; VEGFR3
GeneCards (Weizmann)FLT4
Ensembl hg19 (Hinxton)ENSG00000037280 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000037280 [Gene_View]  ENSG00000037280 [Sequence]  chr5:180601506-180649624 [Contig_View]  FLT4 [Vega]
ICGC DataPortalENSG00000037280
TCGA cBioPortalFLT4
AceView (NCBI)FLT4
Genatlas (Paris)FLT4
WikiGenes2324
SOURCE (Princeton)FLT4
Genetics Home Reference (NIH)FLT4
Genomic and cartography
GoldenPath hg38 (UCSC)FLT4  -     chr5:180601506-180649624 -  5q35.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FLT4  -     5q35.3   [Description]    (hg19-Feb_2009)
EnsemblFLT4 - 5q35.3 [CytoView hg19]  FLT4 - 5q35.3 [CytoView hg38]
Mapping of homologs : NCBIFLT4 [Mapview hg19]  FLT4 [Mapview hg38]
OMIM136352   153100   602089   
Gene and transcription
Genbank (Entrez)AB209637 AK291679 AK309910 AY233382 AY233383
RefSeq transcript (Entrez)NM_001354989 NM_002020 NM_182925
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FLT4
Cluster EST : UnigeneHs.646917 [ NCBI ]
CGAP (NCI)Hs.646917
Alternative Splicing GalleryENSG00000037280
Gene ExpressionFLT4 [ NCBI-GEO ]   FLT4 [ EBI - ARRAY_EXPRESS ]   FLT4 [ SEEK ]   FLT4 [ MEM ]
Gene Expression Viewer (FireBrowse)FLT4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2324
GTEX Portal (Tissue expression)FLT4
Human Protein AtlasENSG00000037280-FLT4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP35916   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP35916  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP35916
Splice isoforms : SwissVarP35916
Catalytic activity : Enzyme2.7.10.1 [ Enzyme-Expasy ]   2.7.10.12.7.10.1 [ IntEnz-EBI ]   2.7.10.1 [ BRENDA ]   2.7.10.1 [ KEGG ]   
PhosPhoSitePlusP35916
Domaine pattern : Prosite (Expaxy)IG_LIKE (PS50835)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_TYR (PS00109)    RECEPTOR_TYR_KIN_III (PS00240)   
Domains : Interpro (EBI)Ig-like_dom    Ig-like_dom_sf    Ig-like_fold    Ig_I-set    Ig_sub    Ig_sub2    Kinase-like_dom_sf    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser-Thr/Tyr_kinase_cat_dom    Tyr_kinase_AS    Tyr_kinase_cat_dom    Tyr_kinase_rcpt_3_CS    VEGFR3_rcpt   
Domain families : Pfam (Sanger)I-set (PF07679)    Pkinase_Tyr (PF07714)   
Domain families : Pfam (NCBI)pfam07679    pfam07714   
Domain families : Smart (EMBL)IG (SM00409)  IGc2 (SM00408)  TyrKc (SM00219)  
Conserved Domain (NCBI)FLT4
DMDM Disease mutations2324
Blocks (Seattle)FLT4
PDB (SRS)4BSJ    4BSK   
PDB (PDBSum)4BSJ    4BSK   
PDB (IMB)4BSJ    4BSK   
PDB (RSDB)4BSJ    4BSK   
Structural Biology KnowledgeBase4BSJ    4BSK   
SCOP (Structural Classification of Proteins)4BSJ    4BSK   
CATH (Classification of proteins structures)4BSJ    4BSK   
SuperfamilyP35916
Human Protein Atlas [tissue]ENSG00000037280-FLT4 [tissue]
Peptide AtlasP35916
HPRD00636
IPIIPI00337568   IPI00293565   IPI00909819   IPI00909224   IPI00555993   IPI00966321   IPI00968257   
Protein Interaction databases
DIP (DOE-UCLA)P35916
IntAct (EBI)P35916
FunCoupENSG00000037280
BioGRIDFLT4
STRING (EMBL)FLT4
ZODIACFLT4
Ontologies - Pathways
QuickGOP35916
Ontology : AmiGOvasculogenesis  positive regulation of protein phosphorylation  positive regulation of endothelial cell proliferation  vasculature development  lymph vessel development  lymphangiogenesis  lymphangiogenesis  sprouting angiogenesis  sprouting angiogenesis  respiratory system process  MAP kinase kinase kinase activity  protein tyrosine kinase activity  transmembrane receptor protein tyrosine kinase activity  transmembrane receptor protein tyrosine kinase activity  transmembrane signaling receptor activity  vascular endothelial growth factor-activated receptor activity  vascular endothelial growth factor-activated receptor activity  vascular endothelial growth factor-activated receptor activity  protein binding  ATP binding  extracellular region  nucleoplasm  cytoplasm  cytoplasm  plasma membrane  plasma membrane  integral component of plasma membrane  integral component of plasma membrane  transmembrane receptor protein tyrosine kinase signaling pathway  multicellular organism development  positive regulation of cell proliferation  positive regulation of cell proliferation  negative regulation of signal transduction  positive regulation of vascular endothelial growth factor production  positive regulation of endothelial cell migration  peptidyl-tyrosine phosphorylation  growth factor binding  protein phosphatase binding  cell differentiation  mitogen-activated protein kinase kinase binding  positive regulation of kinase activity  cellular response to vascular endothelial growth factor stimulus  cellular response to vascular endothelial growth factor stimulus  VEGF-C-activated receptor activity  vascular endothelial growth factor signaling pathway  protein homodimerization activity  negative regulation of apoptotic process  negative regulation of apoptotic process  receptor complex  receptor complex  positive regulation of MAPK cascade  positive regulation of MAPK cascade  positive regulation of JNK cascade  protein autophosphorylation  vascular endothelial growth factor receptor signaling pathway  vascular endothelial growth factor receptor signaling pathway  vascular endothelial growth factor receptor signaling pathway  vascular endothelial growth factor receptor signaling pathway  lung alveolus development  blood vessel morphogenesis  regulation of blood vessel remodeling  positive regulation of ERK1 and ERK2 cascade  positive regulation of ERK1 and ERK2 cascade  positive regulation of protein kinase C signaling  
Ontology : EGO-EBIvasculogenesis  positive regulation of protein phosphorylation  positive regulation of endothelial cell proliferation  vasculature development  lymph vessel development  lymphangiogenesis  lymphangiogenesis  sprouting angiogenesis  sprouting angiogenesis  respiratory system process  MAP kinase kinase kinase activity  protein tyrosine kinase activity  transmembrane receptor protein tyrosine kinase activity  transmembrane receptor protein tyrosine kinase activity  transmembrane signaling receptor activity  vascular endothelial growth factor-activated receptor activity  vascular endothelial growth factor-activated receptor activity  vascular endothelial growth factor-activated receptor activity  protein binding  ATP binding  extracellular region  nucleoplasm  cytoplasm  cytoplasm  plasma membrane  plasma membrane  integral component of plasma membrane  integral component of plasma membrane  transmembrane receptor protein tyrosine kinase signaling pathway  multicellular organism development  positive regulation of cell proliferation  positive regulation of cell proliferation  negative regulation of signal transduction  positive regulation of vascular endothelial growth factor production  positive regulation of endothelial cell migration  peptidyl-tyrosine phosphorylation  growth factor binding  protein phosphatase binding  cell differentiation  mitogen-activated protein kinase kinase binding  positive regulation of kinase activity  cellular response to vascular endothelial growth factor stimulus  cellular response to vascular endothelial growth factor stimulus  VEGF-C-activated receptor activity  vascular endothelial growth factor signaling pathway  protein homodimerization activity  negative regulation of apoptotic process  negative regulation of apoptotic process  receptor complex  receptor complex  positive regulation of MAPK cascade  positive regulation of MAPK cascade  positive regulation of JNK cascade  protein autophosphorylation  vascular endothelial growth factor receptor signaling pathway  vascular endothelial growth factor receptor signaling pathway  vascular endothelial growth factor receptor signaling pathway  vascular endothelial growth factor receptor signaling pathway  lung alveolus development  blood vessel morphogenesis  regulation of blood vessel remodeling  positive regulation of ERK1 and ERK2 cascade  positive regulation of ERK1 and ERK2 cascade  positive regulation of protein kinase C signaling  
Pathways : KEGGRas signaling pathway    Rap1 signaling pathway    Cytokine-cytokine receptor interaction    PI3K-Akt signaling pathway    Focal adhesion   
NDEx NetworkFLT4
Atlas of Cancer Signalling NetworkFLT4
Wikipedia pathwaysFLT4
Orthology - Evolution
OrthoDB2324
GeneTree (enSembl)ENSG00000037280
Phylogenetic Trees/Animal Genes : TreeFamFLT4
HOVERGENP35916
HOGENOMP35916
Homologs : HomoloGeneFLT4
Homology/Alignments : Family Browser (UCSC)FLT4
Gene fusions - Rearrangements
Fusion : MitelmanMGAT1/FLT4 [5q35.3/5q35.3]  [t(5;5)(q35;q35)]  
Fusion : QuiverFLT4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFLT4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FLT4
dbVarFLT4
ClinVarFLT4
1000_GenomesFLT4 
Exome Variant ServerFLT4
ExAC (Exome Aggregation Consortium)ENSG00000037280
GNOMAD BrowserENSG00000037280
Varsome BrowserFLT4
Genetic variants : HAPMAP2324
Genomic Variants (DGV)FLT4 [DGVbeta]
DECIPHERFLT4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFLT4 
Mutations
ICGC Data PortalFLT4 
TCGA Data PortalFLT4 
Broad Tumor PortalFLT4
OASIS PortalFLT4 [ Somatic mutations - Copy number]
Cancer Gene: CensusFLT4 
Somatic Mutations in Cancer : COSMICFLT4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDFLT4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Mendelian genes
LOVD (Leiden Open Variation Database)Vascular Anomaly and Lymphedema Mutation Database
BioMutasearch FLT4
DgiDB (Drug Gene Interaction Database)FLT4
DoCM (Curated mutations)FLT4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FLT4 (select a term)
intoGenFLT4
Cancer3DFLT4(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM136352    153100    602089   
Orphanet11478   
DisGeNETFLT4
MedgenFLT4
Genetic Testing Registry FLT4
NextProtP35916 [Medical]
TSGene2324
GENETestsFLT4
Target ValidationFLT4
Huge Navigator FLT4 [HugePedia]
snp3D : Map Gene to Disease2324
BioCentury BCIQFLT4
ClinGenFLT4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2324
Chemical/Pharm GKB GenePA28183
Clinical trialFLT4
Miscellaneous
canSAR (ICR)FLT4 (select the gene name)
Probes
Litterature
PubMed226 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFLT4
EVEXFLT4
GoPubMedFLT4
iHOPFLT4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Aug 27 11:23:17 CEST 2018
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