FLT4 (fms related receptor tyrosine kinase 4)

2003-02-01  

Identity

HGNC
LOCATION
5q35.3
LOCUSID
ALIAS
CHTD7,FLT-4,FLT41,LMPH1A,LMPHM1,PCL,VEGFR-3,VEGFR3
FUSION GENES

Other Information

Locus ID:

NCBI: 2324
MIM: 136352
HGNC: 3767
Ensembl: ENSG00000037280

Variants:

dbSNP: 2324
ClinVar: 2324
TCGA: ENSG00000037280
COSMIC: FLT4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000037280ENST00000261937P35916
ENSG00000037280ENST00000393347P35916
ENSG00000037280ENST00000502649E9PD35
ENSG00000037280ENST00000512795D6RFF2
ENSG00000037280ENST00000619105B5A927

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Focal adhesionKEGGko04510
Cytokine-cytokine receptor interactionKEGGhsa04060
Focal adhesionKEGGhsa04510
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
Ras signaling pathwayKEGGhsa04014
Rap1 signaling pathwayKEGGhsa04015
Rap1 signaling pathwayKEGGko04015
Signal TransductionREACTOMER-HSA-162582
Signaling by VEGFREACTOMER-HSA-194138
VEGF ligand-receptor interactionsREACTOMER-HSA-194313
VEGF binds to VEGFR leading to receptor dimerizationREACTOMER-HSA-195399
Breast cancerKEGGko05224
Breast cancerKEGGhsa05224

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA162372840sunitinibChemicalClinicalAnnotation, MultilinkAnnotationassociatedPD19248971, 22015057
PA29444HRASGenePathwayassociated28362716
PA30196KRASGenePathwayassociated28362716
PA31768NRASGenePathwayassociated28362716
PA33304PIK3C2AGenePathwayassociated28362716
PA33305PIK3C2BGenePathwayassociated28362716
PA33308PIK3CAGenePathwayassociated28362716
PA33309PIK3CBGenePathwayassociated28362716
PA33310PIK3CDGenePathwayassociated28362716
PA33311PIK3CGGenePathwayassociated28362716
PA33312PIK3R1GenePathwayassociated28362716
PA33313PIK3R2GenePathwayassociated28362716
PA33314PIK3R3GenePathwayassociated28362716
PA443624Carcinoma, Renal CellDiseaseClinicalAnnotationassociatedPD22015057
PA7000sorafenibChemicalPathwayassociated28362716

References

Pubmed IDYearTitleCitations
185945122008Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation.270
120482692002Suppression of tumor lymphangiogenesis and lymph node metastasis by blocking vascular endothelial growth factor receptor 3 signaling.121
219090982011VEGFR-3 controls tip to stalk conversion at vessel fusion sites by reinforcing Notch signalling.117
289912572017Contribution of rare inherited and de novo variants in 2,871 congenital heart disease probands.109
123937042003VEGFR-3 and CD133 identify a population of CD34+ lymphatic/vascular endothelial precursor cells.97
221798342012Interaction of tumor cells and lymphatic vessels in cancer progression.96
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
128815282003Ligand-induced vascular endothelial growth factor receptor-3 (VEGFR-3) heterodimerization with VEGFR-2 in primary lymphatic endothelial cells regulates tyrosine phosphorylation sites.71
199012622010Inflammation induces lymphangiogenesis through up-regulation of VEGFR-3 mediated by NF-kappaB and Prox1.71
157460842005Angiopoietin-1 promotes lymphatic sprouting and hyperplasia.66

Citation

Dessen P

FLT4 (fms related receptor tyrosine kinase 4)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40612/flt4