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FMN2 (formin 2)

Identity

Other alias-
HGNC (Hugo) FMN2
LocusID (NCBI) 56776
Atlas_Id 53299
Location 1q43  [Link to chromosome band 1q43]
Location_base_pair Starts at 240091885 and ends at 240475189 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
FMN2 (1q43) / DDX59 (1q32.1)NVL (1q42.11) / FMN2 (1q43)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)FMN2   14074
Cards
Entrez_Gene (NCBI)FMN2  56776  formin 2
Aliases
GeneCards (Weizmann)FMN2
Ensembl hg19 (Hinxton)ENSG00000155816 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000155816 [Gene_View]  chr1:240091885-240475189 [Contig_View]  FMN2 [Vega]
ICGC DataPortalENSG00000155816
TCGA cBioPortalFMN2
AceView (NCBI)FMN2
Genatlas (Paris)FMN2
WikiGenes56776
SOURCE (Princeton)FMN2
Genetics Home Reference (NIH)FMN2
Genomic and cartography
GoldenPath hg38 (UCSC)FMN2  -     chr1:240091885-240475189 +  1q43   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FMN2  -     1q43   [Description]    (hg19-Feb_2009)
EnsemblFMN2 - 1q43 [CytoView hg19]  FMN2 - 1q43 [CytoView hg38]
Mapping of homologs : NCBIFMN2 [Mapview hg19]  FMN2 [Mapview hg38]
OMIM606373   616193   
Gene and transcription
Genbank (Entrez)AB209153 AF218941 AF218942 AF225426 AK297716
RefSeq transcript (Entrez)NM_001305424 NM_001348094 NM_020066
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FMN2
Cluster EST : UnigeneHs.24889 [ NCBI ]
CGAP (NCI)Hs.24889
Alternative Splicing GalleryENSG00000155816
Gene ExpressionFMN2 [ NCBI-GEO ]   FMN2 [ EBI - ARRAY_EXPRESS ]   FMN2 [ SEEK ]   FMN2 [ MEM ]
Gene Expression Viewer (FireBrowse)FMN2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)56776
GTEX Portal (Tissue expression)FMN2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NZ56   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NZ56  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NZ56
Splice isoforms : SwissVarQ9NZ56
PhosPhoSitePlusQ9NZ56
Domaine pattern : Prosite (Expaxy)FH2 (PS51444)   
Domains : Interpro (EBI)DEP_dom    FH2_Formin    Formin_homology_1   
Domain families : Pfam (Sanger)Drf_FH1 (PF06346)    FH2 (PF02181)   
Domain families : Pfam (NCBI)pfam06346    pfam02181   
Domain families : Smart (EMBL)FH2 (SM00498)  
Conserved Domain (NCBI)FMN2
DMDM Disease mutations56776
Blocks (Seattle)FMN2
PDB (SRS)2YLE    3R7G   
PDB (PDBSum)2YLE    3R7G   
PDB (IMB)2YLE    3R7G   
PDB (RSDB)2YLE    3R7G   
Structural Biology KnowledgeBase2YLE    3R7G   
SCOP (Structural Classification of Proteins)2YLE    3R7G   
CATH (Classification of proteins structures)2YLE    3R7G   
SuperfamilyQ9NZ56
Human Protein AtlasENSG00000155816
Peptide AtlasQ9NZ56
HPRD10449
IPIIPI00936831   IPI01015399   IPI00921870   IPI00719756   IPI00387079   IPI01010443   IPI00643331   
Protein Interaction databases
DIP (DOE-UCLA)Q9NZ56
IntAct (EBI)Q9NZ56
FunCoupENSG00000155816
BioGRIDFMN2
STRING (EMBL)FMN2
ZODIACFMN2
Ontologies - Pathways
QuickGOQ9NZ56
Ontology : AmiGOmolecular_function  actin binding  nucleolus  endoplasmic reticulum membrane  spindle  cytosol  plasma membrane  microvillus  cell cortex  cellular response to DNA damage stimulus  multicellular organism development  protein transport  actin cytoskeleton  vesicle-mediated transport  cytoplasmic vesicle membrane  intracellular signal transduction  polar body extrusion after meiotic divisions  negative regulation of protein catabolic process  negative regulation of apoptotic process  intracellular transport  perinuclear region of cytoplasm  oogenesis  establishment of meiotic spindle localization  homologous chromosome movement towards spindle pole involved in homologous chromosome segregation  formin-nucleated actin cable assembly  cellular response to hypoxia  
Ontology : EGO-EBImolecular_function  actin binding  nucleolus  endoplasmic reticulum membrane  spindle  cytosol  plasma membrane  microvillus  cell cortex  cellular response to DNA damage stimulus  multicellular organism development  protein transport  actin cytoskeleton  vesicle-mediated transport  cytoplasmic vesicle membrane  intracellular signal transduction  polar body extrusion after meiotic divisions  negative regulation of protein catabolic process  negative regulation of apoptotic process  intracellular transport  perinuclear region of cytoplasm  oogenesis  establishment of meiotic spindle localization  homologous chromosome movement towards spindle pole involved in homologous chromosome segregation  formin-nucleated actin cable assembly  cellular response to hypoxia  
Pathways : KEGGDorso-ventral axis formation   
NDEx NetworkFMN2
Atlas of Cancer Signalling NetworkFMN2
Wikipedia pathwaysFMN2
Orthology - Evolution
OrthoDB56776
GeneTree (enSembl)ENSG00000155816
Phylogenetic Trees/Animal Genes : TreeFamFMN2
HOVERGENQ9NZ56
HOGENOMQ9NZ56
Homologs : HomoloGeneFMN2
Homology/Alignments : Family Browser (UCSC)FMN2
Gene fusions - Rearrangements
Fusion : MitelmanNVL/FMN2 [1q42.11/1q43]  [t(1;1)(q42;q43)]  
Fusion Cancer (Beijing)FMN2 [1q43]  -  DDX59 [1q32.1]  [FUSC004606]
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFMN2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FMN2
dbVarFMN2
ClinVarFMN2
1000_GenomesFMN2 
Exome Variant ServerFMN2
ExAC (Exome Aggregation Consortium)FMN2 (select the gene name)
Genetic variants : HAPMAP56776
Genomic Variants (DGV)FMN2 [DGVbeta]
DECIPHERFMN2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFMN2 
Mutations
ICGC Data PortalFMN2 
TCGA Data PortalFMN2 
Broad Tumor PortalFMN2
OASIS PortalFMN2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFMN2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDFMN2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FMN2
DgiDB (Drug Gene Interaction Database)FMN2
DoCM (Curated mutations)FMN2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FMN2 (select a term)
intoGenFMN2
Cancer3DFMN2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606373    616193   
Orphanet11804   
MedgenFMN2
Genetic Testing Registry FMN2
NextProtQ9NZ56 [Medical]
TSGene56776
GENETestsFMN2
Target ValidationFMN2
Huge Navigator FMN2 [HugePedia]
snp3D : Map Gene to Disease56776
BioCentury BCIQFMN2
ClinGenFMN2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD56776
Chemical/Pharm GKB GenePA28185
Clinical trialFMN2
Miscellaneous
canSAR (ICR)FMN2 (select the gene name)
Probes
Litterature
PubMed29 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFMN2
EVEXFMN2
GoPubMedFMN2
iHOPFMN2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 1 17:01:22 CEST 2017

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