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FMNL2 (formin like 2)

Identity

Alias_namesFHOD2
formin homology 2 domain containing 2
formin-like 2
Alias_symbol (synonym)KIAA1902
Other alias
HGNC (Hugo) FMNL2
LocusID (NCBI) 114793
Atlas_Id 50600
Location 2q23.3  [Link to chromosome band 2q23]
Location_base_pair Starts at 153191751 and ends at 153506348 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ATG13 (11p11.2) / FMNL2 (2q23.3)FMNL2 (2q23.3) / FBXL17 (5q21.3)FMNL2 (2q23.3) / FMNL2 (2q23.3)
FMNL2 (2q23.3) / GPBAR1 (2q35)FMNL2 (2q23.3) / SEC24C (10q22.2)FMNL2 (2q23.3) / TCF12 (15q21.3)
PROSER1 (13q13.3) / FMNL2 (2q23.3)SREBF2 (22q13.2) / FMNL2 (2q23.3)WDR62 (19q13.12) / FMNL2 (2q23.3)
SREBF2 22q13.2 / FMNL2 2q23.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)FMNL2   18267
Cards
Entrez_Gene (NCBI)FMNL2  114793  formin like 2
AliasesFHOD2
GeneCards (Weizmann)FMNL2
Ensembl hg19 (Hinxton)ENSG00000157827 [Gene_View]  chr2:153191751-153506348 [Contig_View]  FMNL2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000157827 [Gene_View]  chr2:153191751-153506348 [Contig_View]  FMNL2 [Vega]
ICGC DataPortalENSG00000157827
TCGA cBioPortalFMNL2
AceView (NCBI)FMNL2
Genatlas (Paris)FMNL2
WikiGenes114793
SOURCE (Princeton)FMNL2
Genetics Home Reference (NIH)FMNL2
Genomic and cartography
GoldenPath hg19 (UCSC)FMNL2  -     chr2:153191751-153506348 +  2q23.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)FMNL2  -     2q23.3   [Description]    (hg38-Dec_2013)
EnsemblFMNL2 - 2q23.3 [CytoView hg19]  FMNL2 - 2q23.3 [CytoView hg38]
Mapping of homologs : NCBIFMNL2 [Mapview hg19]  FMNL2 [Mapview hg38]
OMIM616285   
Gene and transcription
Genbank (Entrez)AB067489 AI261893 AI498522 AI870367 AI885827
RefSeq transcript (Entrez)NM_001004417 NM_001004421 NM_001004422 NM_052905
RefSeq genomic (Entrez)NC_000002 NC_018913 NT_005403 NW_004929305
Consensus coding sequences : CCDS (NCBI)FMNL2
Cluster EST : UnigeneHs.654630 [ NCBI ]
CGAP (NCI)Hs.654630
Alternative Splicing GalleryENSG00000157827
Gene ExpressionFMNL2 [ NCBI-GEO ]   FMNL2 [ EBI - ARRAY_EXPRESS ]   FMNL2 [ SEEK ]   FMNL2 [ MEM ]
Gene Expression Viewer (FireBrowse)FMNL2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)114793
GTEX Portal (Tissue expression)FMNL2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96PY5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96PY5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96PY5
Splice isoforms : SwissVarQ96PY5
PhosPhoSitePlusQ96PY5
Domaine pattern : Prosite (Expaxy)DAD (PS51231)    FH2 (PS51444)    GBD_FH3 (PS51232)   
Domains : Interpro (EBI)ARM-type_fold    DAD_dom    FH2_Formin    FH3_dom    FMNL2    GBD/FH3_dom    GTPase-bd    Wilms_tumour   
Domain families : Pfam (Sanger)Drf_FH3 (PF06367)    Drf_GBD (PF06371)    FH2 (PF02181)   
Domain families : Pfam (NCBI)pfam06367    pfam06371    pfam02181   
Domain families : Smart (EMBL)FH2 (SM00498)  
Conserved Domain (NCBI)FMNL2
DMDM Disease mutations114793
Blocks (Seattle)FMNL2
PDB (SRS)4YC7   
PDB (PDBSum)4YC7   
PDB (IMB)4YC7   
PDB (RSDB)4YC7   
Structural Biology KnowledgeBase4YC7   
SCOP (Structural Classification of Proteins)4YC7   
CATH (Classification of proteins structures)4YC7   
SuperfamilyQ96PY5
Human Protein AtlasENSG00000157827
Peptide AtlasQ96PY5
HPRD13545
IPIIPI00847987   IPI00847755   IPI00816627   IPI00044748   IPI00953446   
Protein Interaction databases
DIP (DOE-UCLA)Q96PY5
IntAct (EBI)Q96PY5
FunCoupENSG00000157827
BioGRIDFMNL2
STRING (EMBL)FMNL2
ZODIACFMNL2
Ontologies - Pathways
QuickGOQ96PY5
Ontology : AmiGOactin binding  cytosol  cytoskeleton organization  Rho GTPase binding  regulation of cell morphogenesis  cortical actin cytoskeleton organization  
Ontology : EGO-EBIactin binding  cytosol  cytoskeleton organization  Rho GTPase binding  regulation of cell morphogenesis  cortical actin cytoskeleton organization  
NDEx NetworkFMNL2
Atlas of Cancer Signalling NetworkFMNL2
Wikipedia pathwaysFMNL2
Orthology - Evolution
OrthoDB114793
GeneTree (enSembl)ENSG00000157827
Phylogenetic Trees/Animal Genes : TreeFamFMNL2
HOVERGENQ96PY5
HOGENOMQ96PY5
Homologs : HomoloGeneFMNL2
Homology/Alignments : Family Browser (UCSC)FMNL2
Gene fusions - Rearrangements
Fusion : MitelmanFMNL2/GPBAR1 [2q23.3/2q35]  
Fusion : MitelmanSREBF2/FMNL2 [22q13.2/2q23.3]  [t(2;22)(q23;q13)]  
Fusion : MitelmanWDR62/FMNL2 [19q13.12/2q23.3]  [t(2;19)(q23;q13)]  
Fusion: TCGASREBF2 22q13.2 FMNL2 2q23.3 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFMNL2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FMNL2
dbVarFMNL2
ClinVarFMNL2
1000_GenomesFMNL2 
Exome Variant ServerFMNL2
ExAC (Exome Aggregation Consortium)FMNL2 (select the gene name)
Genetic variants : HAPMAP114793
Genomic Variants (DGV)FMNL2 [DGVbeta]
DECIPHER (Syndromes)2:153191751-153506348  ENSG00000157827
CONAN: Copy Number AnalysisFMNL2 
Mutations
ICGC Data PortalFMNL2 
TCGA Data PortalFMNL2 
Broad Tumor PortalFMNL2
OASIS PortalFMNL2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFMNL2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDFMNL2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FMNL2
DgiDB (Drug Gene Interaction Database)FMNL2
DoCM (Curated mutations)FMNL2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FMNL2 (select a term)
intoGenFMNL2
Cancer3DFMNL2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM616285   
Orphanet
MedgenFMNL2
Genetic Testing Registry FMNL2
NextProtQ96PY5 [Medical]
TSGene114793
GENETestsFMNL2
Huge Navigator FMNL2 [HugePedia]
snp3D : Map Gene to Disease114793
BioCentury BCIQFMNL2
ClinGenFMNL2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD114793
Chemical/Pharm GKB GenePA28144
Clinical trialFMNL2
Miscellaneous
canSAR (ICR)FMNL2 (select the gene name)
Probes
Litterature
PubMed30 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFMNL2
EVEXFMNL2
GoPubMedFMNL2
iHOPFMNL2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:06:20 CET 2017

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