FMNL2 (formin like 2)

2008-12-01  

Identity

HGNC
LOCATION
2q23.3
LOCUSID
ALIAS
FHOD2
FUSION GENES

Other Information

Locus ID:

NCBI: 114793
MIM: 616285
HGNC: 18267
Ensembl: ENSG00000157827

Variants:

dbSNP: 114793
ClinVar: 114793
TCGA: ENSG00000157827
COSMIC: FMNL2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000157827ENST00000288670Q96PY5
ENSG00000157827ENST00000475377C9IZY8

Expression (GTEx)

0
50
100
150
200
250

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases Activate ForminsREACTOMER-HSA-5663220

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
369794842023Spatiotemporal Regulation of FMNL2 by N-Terminal Myristoylation and C-Terminal Phosphorylation Drives Rapid Filopodia Formation.2
380710362023[Effect of miR-22 Targeting FMNL2 on Cell Migration and Apoptosis in Childhood Acute Myeloid Leukemia].0
369794842023Spatiotemporal Regulation of FMNL2 by N-Terminal Myristoylation and C-Terminal Phosphorylation Drives Rapid Filopodia Formation.2
380710362023[Effect of miR-22 Targeting FMNL2 on Cell Migration and Apoptosis in Childhood Acute Myeloid Leukemia].0
356086972022FMNL2 regulates gliovascular interactions and is associated with vascular risk factors and cerebrovascular pathology in Alzheimer's disease.10
357723912022Formin-Like 2 Is a Potential Biomarker of Poor Prognosis in Nasopharyngeal Carcinoma.1
363351292022LINC00839 promotes malignancy of liver cancer via binding FMNL2 under hypoxia.3
356086972022FMNL2 regulates gliovascular interactions and is associated with vascular risk factors and cerebrovascular pathology in Alzheimer's disease.10
357723912022Formin-Like 2 Is a Potential Biomarker of Poor Prognosis in Nasopharyngeal Carcinoma.1
363351292022LINC00839 promotes malignancy of liver cancer via binding FMNL2 under hypoxia.3
340437222021Characterization of a L136P mutation in Formin-like 2 (FMNL2) from a patient with chronic inflammatory bowel disease.4
340437222021Characterization of a L136P mutation in Formin-like 2 (FMNL2) from a patient with chronic inflammatory bowel disease.4
320468582020CircHIPK3 promotes colorectal cancer cells proliferation and metastasis via modulating of miR-1207-5p/FMNL2 signal.32
322941572020FMNL2 regulates dynamics of fascin in filopodia.20
320468582020CircHIPK3 promotes colorectal cancer cells proliferation and metastasis via modulating of miR-1207-5p/FMNL2 signal.32

Citation

Dessen P

FMNL2 (formin like 2)

Atlas Genet Cytogenet Oncol Haematol. 2008-12-01

Online version: http://atlasgeneticsoncology.org/gene/50600/fmnl2