Atlas of Genetics and Cytogenetics in Oncology and Haematology

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FMNL3 (formin like 3)

Identity

Alias_namesformin-like 3
Alias_symbol (synonym)DKFZp762B245
MGC45819
WBP3
Other aliasFHOD3
FRL2
WBP-3
HGNC (Hugo) FMNL3
LocusID (NCBI) 91010
Atlas_Id 54318
Location 12q13.12  [Link to chromosome band 12q13]
Location_base_pair Starts at 49637941 and ends at 49707414 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
COL1A1 (17q21.33) / FMNL3 (12q13.12)FMNL3 (12q13.12) / REPS1 (6q24.1)FMNL3 (12q13.12) / RNF44 (5q35.2)
SLC25A1 (22q11.21) / FMNL3 (12q13.12)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(12;17)(q13;q21) COL1A1/FMNL3

External links

Nomenclature
HGNC (Hugo)FMNL3   23698
Cards
Entrez_Gene (NCBI)FMNL3  91010  formin like 3
AliasesFHOD3; FRL2; WBP-3; WBP3
GeneCards (Weizmann)FMNL3
Ensembl hg19 (Hinxton)ENSG00000161791 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000161791 [Gene_View]  ENSG00000161791 [Sequence]  chr12:49637941-49707414 [Contig_View]  FMNL3 [Vega]
ICGC DataPortalENSG00000161791
TCGA cBioPortalFMNL3
AceView (NCBI)FMNL3
Genatlas (Paris)FMNL3
WikiGenes91010
SOURCE (Princeton)FMNL3
Genetics Home Reference (NIH)FMNL3
Genomic and cartography
GoldenPath hg38 (UCSC)FMNL3  -     chr12:49637941-49707414 -  12q13.12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FMNL3  -     12q13.12   [Description]    (hg19-Feb_2009)
GoldenPathFMNL3 - 12q13.12 [CytoView hg19]  FMNL3 - 12q13.12 [CytoView hg38]
ImmunoBaseENSG00000161791
Mapping of homologs : NCBIFMNL3 [Mapview hg19]  FMNL3 [Mapview hg38]
OMIM616288   
Gene and transcription
Genbank (Entrez)AB095934 AK095874 AK127200 AK128195 AL162062
RefSeq transcript (Entrez)NM_001367835 NM_175736 NM_198900
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FMNL3
Cluster EST : UnigeneHs.179838 [ NCBI ]
CGAP (NCI)Hs.179838
Alternative Splicing GalleryENSG00000161791
Gene ExpressionFMNL3 [ NCBI-GEO ]   FMNL3 [ EBI - ARRAY_EXPRESS ]   FMNL3 [ SEEK ]   FMNL3 [ MEM ]
Gene Expression Viewer (FireBrowse)FMNL3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)91010
GTEX Portal (Tissue expression)FMNL3
Human Protein AtlasENSG00000161791-FMNL3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8IVF7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8IVF7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8IVF7
Splice isoforms : SwissVarQ8IVF7
PhosPhoSitePlusQ8IVF7
Domaine pattern : Prosite (Expaxy)FH2 (PS51444)    GBD_FH3 (PS51232)   
Domains : Interpro (EBI)ARM-type_fold    FH2_Formin    FH3_dom    Fmnl3    GBD/FH3_dom    GTPase-bd   
Domain families : Pfam (Sanger)Drf_FH3 (PF06367)    Drf_GBD (PF06371)    FH2 (PF02181)   
Domain families : Pfam (NCBI)pfam06367    pfam06371    pfam02181   
Domain families : Smart (EMBL)Drf_FH3 (SM01139)  Drf_GBD (SM01140)  FH2 (SM00498)  
Conserved Domain (NCBI)FMNL3
DMDM Disease mutations91010
Blocks (Seattle)FMNL3
SuperfamilyQ8IVF7
Human Protein Atlas [tissue]ENSG00000161791-FMNL3 [tissue]
Peptide AtlasQ8IVF7
HPRD17007
IPIIPI00847544   IPI00418767   IPI00411979   IPI01021503   IPI01020836   
Protein Interaction databases
DIP (DOE-UCLA)Q8IVF7
IntAct (EBI)Q8IVF7
FunCoupENSG00000161791
BioGRIDFMNL3
STRING (EMBL)FMNL3
ZODIACFMNL3
Ontologies - Pathways
QuickGOQ8IVF7
Ontology : AmiGOangiogenesis  actin binding  cytoplasm  Golgi apparatus  cytosol  cytosol  cytosol  plasma membrane  cytoskeleton organization  regulation of cell shape  regulation of cell shape  cell migration  Rho GTPase binding  cortical actin cytoskeleton organization  GTPase activating protein binding  GTPase activating protein binding  intracellular membrane-bounded organelle  
Ontology : EGO-EBIangiogenesis  actin binding  cytoplasm  Golgi apparatus  cytosol  cytosol  cytosol  plasma membrane  cytoskeleton organization  regulation of cell shape  regulation of cell shape  cell migration  Rho GTPase binding  cortical actin cytoskeleton organization  GTPase activating protein binding  GTPase activating protein binding  intracellular membrane-bounded organelle  
NDEx NetworkFMNL3
Atlas of Cancer Signalling NetworkFMNL3
Wikipedia pathwaysFMNL3
Orthology - Evolution
OrthoDB91010
GeneTree (enSembl)ENSG00000161791
Phylogenetic Trees/Animal Genes : TreeFamFMNL3
HOGENOMQ8IVF7
Homologs : HomoloGeneFMNL3
Homology/Alignments : Family Browser (UCSC)FMNL3
Gene fusions - Rearrangements
Fusion : MitelmanCOL1A1/FMNL3 [17q21.33/12q13.12]  [t(12;17)(q13;q21)]  
Fusion : QuiverFMNL3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFMNL3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FMNL3
dbVarFMNL3
ClinVarFMNL3
1000_GenomesFMNL3 
Exome Variant ServerFMNL3
ExAC (Exome Aggregation Consortium)ENSG00000161791
GNOMAD BrowserENSG00000161791
Varsome BrowserFMNL3
Genetic variants : HAPMAP91010
Genomic Variants (DGV)FMNL3 [DGVbeta]
DECIPHERFMNL3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFMNL3 
Mutations
ICGC Data PortalFMNL3 
TCGA Data PortalFMNL3 
Broad Tumor PortalFMNL3
OASIS PortalFMNL3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFMNL3  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DFMNL3
Mutations and Diseases : HGMDFMNL3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FMNL3
DgiDB (Drug Gene Interaction Database)FMNL3
DoCM (Curated mutations)FMNL3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FMNL3 (select a term)
intoGenFMNL3
Cancer3DFMNL3(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM616288   
Orphanet
DisGeNETFMNL3
MedgenFMNL3
Genetic Testing Registry FMNL3
NextProtQ8IVF7 [Medical]
TSGene91010
GENETestsFMNL3
Target ValidationFMNL3
Huge Navigator FMNL3 [HugePedia]
snp3D : Map Gene to Disease91010
BioCentury BCIQFMNL3
ClinGenFMNL3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD91010
Chemical/Pharm GKB GenePA134992328
Clinical trialFMNL3
Miscellaneous
canSAR (ICR)FMNL3 (select the gene name)
DataMed IndexFMNL3
Probes
Litterature
PubMed24 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFMNL3
EVEXFMNL3
GoPubMedFMNL3
iHOPFMNL3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Nov 13 17:43:40 CET 2019
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