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FMO4 (flavin containing dimethylaniline monoxygenase 4)

Identity

Alias_namesFMO2
flavin containing monooxygenase 4
Other alias
HGNC (Hugo) FMO4
LocusID (NCBI) 2329
Atlas_Id 46842
Location 1q24.3  [Link to chromosome band 1q24]
Location_base_pair Starts at 171314183 and ends at 171342084 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DDR2 (1q23.3) / FMO4 (1q24.3)HECA (6q24.1) / FMO4 (1q24.3)DDR2 1q23.3 / FMO4 1q24.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(1;1)(q23;q24) DDR2/FMO4

External links

Nomenclature
HGNC (Hugo)FMO4   3772
Cards
Entrez_Gene (NCBI)FMO4  2329  flavin containing dimethylaniline monoxygenase 4
AliasesFMO2
GeneCards (Weizmann)FMO4
Ensembl hg19 (Hinxton)ENSG00000076258 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000076258 [Gene_View]  ENSG00000076258 [Sequence]  chr1:171314183-171342084 [Contig_View]  FMO4 [Vega]
ICGC DataPortalENSG00000076258
TCGA cBioPortalFMO4
AceView (NCBI)FMO4
Genatlas (Paris)FMO4
WikiGenes2329
SOURCE (Princeton)FMO4
Genetics Home Reference (NIH)FMO4
Genomic and cartography
GoldenPath hg38 (UCSC)FMO4  -     chr1:171314183-171342084 +  1q24.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FMO4  -     1q24.3   [Description]    (hg19-Feb_2009)
GoldenPathFMO4 - 1q24.3 [CytoView hg19]  FMO4 - 1q24.3 [CytoView hg38]
Genome Data Viewer NCBIFMO4 [Mapview hg19]  
OMIM136131   
Gene and transcription
Genbank (Entrez)BC002780 BT007444 BX495448 Z11737
RefSeq transcript (Entrez)NM_002022
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FMO4
Alternative Splicing GalleryENSG00000076258
Gene ExpressionFMO4 [ NCBI-GEO ]   FMO4 [ EBI - ARRAY_EXPRESS ]   FMO4 [ SEEK ]   FMO4 [ MEM ]
Gene Expression Viewer (FireBrowse)FMO4 [ Firebrowse - Broad ]
GenevisibleExpression of FMO4 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2329
GTEX Portal (Tissue expression)FMO4
Human Protein AtlasENSG00000076258-FMO4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP31512   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP31512  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP31512
Splice isoforms : SwissVarP31512
Catalytic activity : Enzyme1.14.13.8 [ Enzyme-Expasy ]   1.14.13.81.14.13.8 [ IntEnz-EBI ]   1.14.13.8 [ BRENDA ]   1.14.13.8 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusP31512
Domains : Interpro (EBI)FAD/NAD-bd_sf    Flavin_mOase    Flavin_mOase-like    Flavin_mOase_4   
Domain families : Pfam (Sanger)FMO-like (PF00743)   
Domain families : Pfam (NCBI)pfam00743   
Conserved Domain (NCBI)FMO4
DMDM Disease mutations2329
SuperfamilyP31512
Human Protein Atlas [tissue]ENSG00000076258-FMO4 [tissue]
Peptide AtlasP31512
HPRD00632
IPIIPI00219008   
Protein Interaction databases
DIP (DOE-UCLA)P31512
IntAct (EBI)P31512
FunCoupENSG00000076258
BioGRIDFMO4
STRING (EMBL)FMO4
ZODIACFMO4
Ontologies - Pathways
QuickGOP31512
Ontology : AmiGOmonooxygenase activity  N,N-dimethylaniline monooxygenase activity  endoplasmic reticulum membrane  integral component of membrane  drug catabolic process  flavin adenine dinucleotide binding  NADP binding  oxidation-reduction process  
Ontology : EGO-EBImonooxygenase activity  N,N-dimethylaniline monooxygenase activity  endoplasmic reticulum membrane  integral component of membrane  drug catabolic process  flavin adenine dinucleotide binding  NADP binding  oxidation-reduction process  
Pathways : KEGGDrug metabolism - cytochrome P450   
NDEx NetworkFMO4
Atlas of Cancer Signalling NetworkFMO4
Wikipedia pathwaysFMO4
Orthology - Evolution
OrthoDB2329
GeneTree (enSembl)ENSG00000076258
Phylogenetic Trees/Animal Genes : TreeFamFMO4
HOGENOMP31512
Homologs : HomoloGeneFMO4
Homology/Alignments : Family Browser (UCSC)FMO4
Gene fusions - Rearrangements
Fusion : MitelmanDDR2/FMO4 [1q23.3/1q24.3]  
Fusion PortalDDR2 1q23.3 FMO4 1q24.3 SKCM
Fusion : QuiverFMO4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFMO4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FMO4
dbVarFMO4
ClinVarFMO4
1000_GenomesFMO4 
Exome Variant ServerFMO4
GNOMAD BrowserENSG00000076258
Varsome BrowserFMO4
Genetic variants : HAPMAP2329
Genomic Variants (DGV)FMO4 [DGVbeta]
DECIPHERFMO4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFMO4 
Mutations
ICGC Data PortalFMO4 
TCGA Data PortalFMO4 
Broad Tumor PortalFMO4
OASIS PortalFMO4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFMO4  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DFMO4
Mutations and Diseases : HGMDFMO4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutaselect FMO4
DgiDB (Drug Gene Interaction Database)FMO4
DoCM (Curated mutations)FMO4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FMO4 (select a term)
intoGenFMO4
Cancer3DFMO4 (select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM136131   
Orphanet
DisGeNETFMO4
MedgenFMO4
Genetic Testing Registry FMO4
NextProtP31512 [Medical]
TSGene2329
GENETestsFMO4
Open Targets GeneticsENSG00000076258  [validation]
snp3D : Map Gene to Disease2329
BioCentury BCIQFMO4
ClinGenFMO4
Clinical trials, drugs, therapy
Protein Interactions : CTD2329
Pharm GKB GenePA28188
Pharm GKB PathwaysPA165374494   
Clinical trialFMO4
Miscellaneous
canSAR (ICR)FMO4 (select the gene name)
HarmonizomeFMO4
DataMed IndexFMO4
Probes
Litterature
PubMed15 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFMO4
EVEXFMO4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sat Jul 11 19:49:15 CEST 2020
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