FN1 (fibronectin 1)

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FN1 (fibronectin 1)

Identity

Alias_symbol (synonym)	MSF
	CIG
	LETS
	GFND2
	FINC
Other alias	ED-B
	FN
	FNZ
	GFND
	SMDCF
HGNC (Hugo)	FN1
LocusID (NCBI)	2335
Atlas_Id	40617
Location	2q35 [Link to chromosome band 2q35]
Location_base_pair	Starts at 215360440 and ends at 215436068 bp from pter ( according to hg38-Dec_2013)

Fusion genes
(updated 2017)

Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

AGO4 (1p34.3) / FN1 (2q35)	APPL2 (12q23.3) / FN1 (2q35)	ARNTL (11p15.2) / FN1 (2q35)
CCDC112 (5q22.3) / FN1 (2q35)	CCDC84 (11q23.3) / FN1 (2q35)	CDC27 (17q21.32) / FN1 (2q35)
CSNK1D (17q25.3) / FN1 (2q35)	DENND5A (11p15.4) / FN1 (2q35)	ERCC1 (19q13.32) / FN1 (2q35)
FN1 (2q35) / ACVR2A (2q22.3)	FN1 (2q35) / ALK (2p23.2)	FN1 (2q35) / APOD (3q29)
FN1 (2q35) / CCDC80 (3q13.2)	FN1 (2q35) / CD52 (1p36.11)	FN1 (2q35) / CDKN1B (12p13.1)
FN1 (2q35) / CSH2 (17q23.3)	FN1 (2q35) / DAGLB (7p22.1)	FN1 (2q35) / FGFR1 (8p11.23)
FN1 (2q35) / FN1 (2q35)	FN1 (2q35) / HMGN1 (21q22.2)	FN1 (2q35) / IQCG (3q29)
FN1 (2q35) / KMT2A (11q23.3)	FN1 (2q35) / LDOC1L (22q13.31)	FN1 (2q35) / LYN (8q12.1)
FN1 (2q35) / MAGEA8 (Xq28)	FN1 (2q35) / MED22 (9q34.2)	FN1 (2q35) / NFX1 (9p13.3)
FN1 (2q35) / OPHN1 (Xq12)	FN1 (2q35) / PIGL (17p11.2)	FN1 (2q35) / RNH1 (11p15.5)
FN1 (2q35) / TBC1D8B (Xq22.3)	FN1 (2q35) / TONSL (8q24.3)	FN1 (2q35) / YIPF4 (2p22.3)
FN1 (2q35) / YWHAG (7q11.23)	FN1 (2q35) / ZSCAN12 (6p22.1)	FUT3 (19p13.3) / FN1 (2q35)
KMT2A (11q23.3) / FN1 (2q35)	MCAM (11q23.3) / FN1 (2q35)	MUC5B (11p15.5) / FN1 (2q35)
MYT1L (2p25.3) / FN1 (2q35)	NEMF (14q21.3) / FN1 (2q35)	NUP98 (11p15.4) / FN1 (2q35)
PMS1 (2q32.2) / FN1 (2q35)	PTPRS (19p13.3) / FN1 (2q35)	RACK1 (5q35.3) / FN1 (2q35)
SLC20A1 (2q13) / FN1 (2q35)	SMC3 (10q25.2) / FN1 (2q35)	SNORD6 (11q21) / FN1 (2q35)
SPARC (5q33.1) / FN1 (2q35)	TBC1D20 (20p13) / FN1 (2q35)	TFRC (3q29) / FN1 (2q35)
TNPO3 (7q32.1) / FN1 (2q35)	VASH1 (14q24.3) / FN1 (2q35)	VWF (12p13.31) / FN1 (2q35)
cytochrome_b () / FN1 (2q35)	FN1 2q35 / ALK 2p23.2

Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to How to contribute

DNA/RNA

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 7 ]

inv(2)(p23q35) FN1/ALK
t(2;2)(p23;q35) FN1/ALK
t(2;2)(p23;q35) FN1/ALK
t(2;2)(p23;q35) FN1/ALK
t(2;2)(q22;q35) FN1/ACVR2A
t(2;5)(q35;q31) FN1/FGF1
t(2;8)(q35;p11) FN1/FGFR1

External links

	Nomenclature
HGNC (Hugo)	FN1 3778
	Cards
Entrez_Gene (NCBI)	FN1 2335 fibronectin 1
Aliases	CIG; ED-B; FINC; FN;
	FNZ; GFND; GFND2; LETS; MSF; SMDCF
GeneCards (Weizmann)	FN1
Ensembl hg19 (Hinxton)	ENSG00000115414 [Gene_View]
Ensembl hg38 (Hinxton)	ENSG00000115414 [Gene_View] ENSG00000115414 [Sequence] chr2:215360440-215436068 [Contig_View] FN1 [Vega]
ICGC DataPortal	ENSG00000115414
TCGA cBioPortal	FN1
AceView (NCBI)	FN1
Genatlas (Paris)	FN1
WikiGenes	2335
SOURCE (Princeton)	FN1
Genetics Home Reference (NIH)	FN1
	Genomic and cartography
GoldenPath hg38 (UCSC)	FN1 - chr2:215360440-215436068 - 2q35 [Description] (hg38-Dec_2013)
GoldenPath hg19 (UCSC)	FN1 - 2q35 [Description] (hg19-Feb_2009)
FN1 - 2q35 [CytoView hg19] FN1 - 2q35 [CytoView hg38]
Mapping of homologs : NCBI	FN1 [Mapview hg19] FN1 [Mapview hg38]
OMIM	135600 184255 601894 614101
	Gene and transcription
Genbank (Entrez)	AB191261 AB209287 AB209840 AF130095 AF312399
RefSeq transcript (Entrez)	NM_001306129 NM_001306130 NM_001306131 NM_001306132 NM_001365517 NM_001365518 NM_001365519 NM_001365520 NM_001365521 NM_001365522 NM_001365523 NM_001365524 NM_002026 NM_054034 NM_212474 NM_212475 NM_212476 NM_212478 NM_212482
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)	FN1
Cluster EST : Unigene	Hs.203717 [ NCBI ]
CGAP (NCI)	Hs.203717
Alternative Splicing Gallery	ENSG00000115414
Gene Expression	FN1 [ NCBI-GEO ] FN1 [ EBI - ARRAY_EXPRESS ] FN1 [ SEEK ] FN1 [ MEM ]
Gene Expression Viewer (FireBrowse)	FN1 [ Firebrowse - Broad ]
SOURCE (Princeton)	Expression in : [Datasets] [Normal Tissue Atlas] [carcinoma Classsification] [NCI60]
Genevestigator	Expression in : [tissues] [cell-lines] [cancer] [perturbations]
BioGPS (Tissue expression)	2335
GTEX Portal (Tissue expression)	FN1
Human Protein Atlas	ENSG00000115414-FN1 [pathology] [cell] [tissue]
	Protein : pattern, domain, 3D structure
UniProt/SwissProt	P02751 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction]
NextProt	P02751 [Sequence] [Exons] [Medical] [Publications]
With graphics : InterPro	P02751
Splice isoforms : SwissVar	P02751
PhosPhoSitePlus	P02751
Domaine pattern : Prosite (Expaxy)	EGF_1 (PS00022) FN1_1 (PS01253) FN1_2 (PS51091) FN2_1 (PS00023) FN2_2 (PS51092) FN3 (PS50853)
Domains : Interpro (EBI)	Fibronectin_type1 FN3_dom FN3_sf FN_type2_dom FN_type2_sf Ig-like_fold Kringle-like
Domain families : Pfam (Sanger)	fn1 (PF00039) fn2 (PF00040) fn3 (PF00041)
Domain families : Pfam (NCBI)	pfam00039 pfam00040 pfam00041
Domain families : Smart (EMBL)	FN1 (SM00058) FN2 (SM00059) FN3 (SM00060)
Conserved Domain (NCBI)	FN1
DMDM Disease mutations	2335
Blocks (Seattle)	FN1
PDB (RSDB)	1E88 1E8B 1FBR 1FNA 1FNF 1FNH 1J8K 1O9A 1OWW 1Q38 1QGB 1QO6 1TTF 1TTG 2CG6 2CG7 2CK2 2CKU 2EC3 2FN2 2FNB 2GEE 2H41 2H45 2HA1 2MNU 2N1K 2OCF 2RKY 2RKZ 2RL0 3CAL 3EJH 3GXE 3M7P 3MQL 3R8Q 3T1W 3ZRZ 4GH7 4JE4 4JEG 4LXO 4MMX 4MMY 4MMZ 4PZ5 5DC0 5DC4 5DC9 5DFT 5J6Z 5J7C 5M0A 5N47 5N48
PDB Europe	1E88 1E8B 1FBR 1FNA 1FNF 1FNH 1J8K 1O9A 1OWW 1Q38 1QGB 1QO6 1TTF 1TTG 2CG6 2CG7 2CK2 2CKU 2EC3 2FN2 2FNB 2GEE 2H41 2H45 2HA1 2MNU 2N1K 2OCF 2RKY 2RKZ 2RL0 3CAL 3EJH 3GXE 3M7P 3MQL 3R8Q 3T1W 3ZRZ 4GH7 4JE4 4JEG 4LXO 4MMX 4MMY 4MMZ 4PZ5 5DC0 5DC4 5DC9 5DFT 5J6Z 5J7C 5M0A 5N47 5N48
PDB (PDBSum)	1E88 1E8B 1FBR 1FNA 1FNF 1FNH 1J8K 1O9A 1OWW 1Q38 1QGB 1QO6 1TTF 1TTG 2CG6 2CG7 2CK2 2CKU 2EC3 2FN2 2FNB 2GEE 2H41 2H45 2HA1 2MNU 2N1K 2OCF 2RKY 2RKZ 2RL0 3CAL 3EJH 3GXE 3M7P 3MQL 3R8Q 3T1W 3ZRZ 4GH7 4JE4 4JEG 4LXO 4MMX 4MMY 4MMZ 4PZ5 5DC0 5DC4 5DC9 5DFT 5J6Z 5J7C 5M0A 5N47 5N48
PDB (IMB)	1E88 1E8B 1FBR 1FNA 1FNF 1FNH 1J8K 1O9A 1OWW 1Q38 1QGB 1QO6 1TTF 1TTG 2CG6 2CG7 2CK2 2CKU 2EC3 2FN2 2FNB 2GEE 2H41 2H45 2HA1 2MNU 2N1K 2OCF 2RKY 2RKZ 2RL0 3CAL 3EJH 3GXE 3M7P 3MQL 3R8Q 3T1W 3ZRZ 4GH7 4JE4 4JEG 4LXO 4MMX 4MMY 4MMZ 4PZ5 5DC0 5DC4 5DC9 5DFT 5J6Z 5J7C 5M0A 5N47 5N48
Structural Biology KnowledgeBase	1E88 1E8B 1FBR 1FNA 1FNF 1FNH 1J8K 1O9A 1OWW 1Q38 1QGB 1QO6 1TTF 1TTG 2CG6 2CG7 2CK2 2CKU 2EC3 2FN2 2FNB 2GEE 2H41 2H45 2HA1 2MNU 2N1K 2OCF 2RKY 2RKZ 2RL0 3CAL 3EJH 3GXE 3M7P 3MQL 3R8Q 3T1W 3ZRZ 4GH7 4JE4 4JEG 4LXO 4MMX 4MMY 4MMZ 4PZ5 5DC0 5DC4 5DC9 5DFT 5J6Z 5J7C 5M0A 5N47 5N48
SCOP (Structural Classification of Proteins)	1E88 1E8B 1FBR 1FNA 1FNF 1FNH 1J8K 1O9A 1OWW 1Q38 1QGB 1QO6 1TTF 1TTG 2CG6 2CG7 2CK2 2CKU 2EC3 2FN2 2FNB 2GEE 2H41 2H45 2HA1 2MNU 2N1K 2OCF 2RKY 2RKZ 2RL0 3CAL 3EJH 3GXE 3M7P 3MQL 3R8Q 3T1W 3ZRZ 4GH7 4JE4 4JEG 4LXO 4MMX 4MMY 4MMZ 4PZ5 5DC0 5DC4 5DC9 5DFT 5J6Z 5J7C 5M0A 5N47 5N48
CATH (Classification of proteins structures)	1E88 1E8B 1FBR 1FNA 1FNF 1FNH 1J8K 1O9A 1OWW 1Q38 1QGB 1QO6 1TTF 1TTG 2CG6 2CG7 2CK2 2CKU 2EC3 2FN2 2FNB 2GEE 2H41 2H45 2HA1 2MNU 2N1K 2OCF 2RKY 2RKZ 2RL0 3CAL 3EJH 3GXE 3M7P 3MQL 3R8Q 3T1W 3ZRZ 4GH7 4JE4 4JEG 4LXO 4MMX 4MMY 4MMZ 4PZ5 5DC0 5DC4 5DC9 5DFT 5J6Z 5J7C 5M0A 5N47 5N48
Superfamily	P02751
Human Protein Atlas [tissue]	ENSG00000115414-FN1 [tissue]
Peptide Atlas	P02751
HPRD	00626
IPI	IPI00022418 IPI00479723 IPI00339319 IPI00556632 IPI00867588 IPI00855777 IPI00855785 IPI00411462 IPI00339223 IPI00339224 IPI00339225 IPI00339226 IPI00339227 IPI00339228 IPI00414283 IPI00922213 IPI00873210 IPI00383776 IPI00845263 IPI00983517
	Protein Interaction databases
DIP (DOE-UCLA)	P02751
IntAct (EBI)	P02751
FunCoup	ENSG00000115414
BioGRID	FN1
STRING (EMBL)	FN1
ZODIAC	FN1
	Ontologies - Pathways
QuickGO	P02751
Ontology : AmiGO	angiogenesis regulation of protein phosphorylation protease binding platelet degranulation signaling receptor binding integrin binding integrin binding integrin binding extracellular matrix structural constituent extracellular matrix structural constituent protein binding collagen binding extracellular region extracellular region extracellular region fibrinogen complex basement membrane extracellular space extracellular space endoplasmic reticulum lumen endoplasmic reticulum-Golgi intermediate compartment acute-phase response cell-substrate junction assembly cell adhesion calcium-independent cell-matrix adhesion protein C-terminus binding heparin binding positive regulation of cell proliferation regulation of cell shape response to wounding positive regulation of gene expression positive regulation of peptidase activity apical plasma membrane peptidase activator activity peptide cross-linking cytokine-mediated signaling pathway enzyme binding extracellular matrix organization extracellular matrix platelet alpha granule lumen integrin activation substrate adhesion-dependent cell spreading substrate adhesion-dependent cell spreading endodermal cell differentiation wound healing identical protein binding proteoglycan binding post-translational protein modification cellular protein metabolic process positive regulation of axon extension positive regulation of fibroblast proliferation leukocyte migration chaperone binding interaction with symbiont interaction with other organism via secreted substance involved in symbiotic interaction collagen-containing extracellular matrix collagen-containing extracellular matrix collagen-containing extracellular matrix collagen-containing extracellular matrix extracellular exosome extracellular exosome regulation of ERK1 and ERK2 cascade blood microparticle disordered domain specific binding neural crest cell migration involved in autonomic nervous system development positive regulation of substrate-dependent cell migration, cell attachment to substrate negative regulation of transforming growth factor-beta secretion
Ontology : EGO-EBI	angiogenesis regulation of protein phosphorylation protease binding platelet degranulation signaling receptor binding integrin binding integrin binding integrin binding extracellular matrix structural constituent extracellular matrix structural constituent protein binding collagen binding extracellular region extracellular region extracellular region fibrinogen complex basement membrane extracellular space extracellular space endoplasmic reticulum lumen endoplasmic reticulum-Golgi intermediate compartment acute-phase response cell-substrate junction assembly cell adhesion calcium-independent cell-matrix adhesion protein C-terminus binding heparin binding positive regulation of cell proliferation regulation of cell shape response to wounding positive regulation of gene expression positive regulation of peptidase activity apical plasma membrane peptidase activator activity peptide cross-linking cytokine-mediated signaling pathway enzyme binding extracellular matrix organization extracellular matrix platelet alpha granule lumen integrin activation substrate adhesion-dependent cell spreading substrate adhesion-dependent cell spreading endodermal cell differentiation wound healing identical protein binding proteoglycan binding post-translational protein modification cellular protein metabolic process positive regulation of axon extension positive regulation of fibroblast proliferation leukocyte migration chaperone binding interaction with symbiont interaction with other organism via secreted substance involved in symbiotic interaction collagen-containing extracellular matrix collagen-containing extracellular matrix collagen-containing extracellular matrix collagen-containing extracellular matrix extracellular exosome extracellular exosome regulation of ERK1 and ERK2 cascade blood microparticle disordered domain specific binding neural crest cell migration involved in autonomic nervous system development positive regulation of substrate-dependent cell migration, cell attachment to substrate negative regulation of transforming growth factor-beta secretion
Pathways : KEGG	PI3K-Akt signaling pathway Focal adhesion ECM-receptor interaction Regulation of actin cytoskeleton Bacterial invasion of epithelial cells Amoebiasis Pathways in cancer Proteoglycans in cancer Small cell lung cancer
NDEx Network	FN1
Atlas of Cancer Signalling Network	FN1
Wikipedia pathways	FN1
	Orthology - Evolution
OrthoDB	2335
GeneTree (enSembl)	ENSG00000115414
Phylogenetic Trees/Animal Genes : TreeFam	FN1
HOGENOM	P02751
Homologs : HomoloGene	FN1
Homology/Alignments : Family Browser (UCSC)	FN1
	Gene fusions - Rearrangements
Fusion : Mitelman	FN1/ALK [2q35/2p23.2]
Fusion : Mitelman	FN1/FGFR1 [2q35/8p11.23] [t(2;8)(q35;p11)]
Fusion Cancer (Beijing)	APPL2 [12q23.3] - FN1 [2q35] [FUSC003617]
Fusion Cancer (Beijing)	ARNTL [11p15.2] - FN1 [2q35] [FUSC003415]
Fusion Cancer (Beijing)	DENND5A [11p15.4] - FN1 [2q35] [FUSC003432]
Fusion Cancer (Beijing)	FN1 [2q35] - CCDC80 [3q13.2] [FUSC002713]
Fusion Cancer (Beijing)	FN1 [2q35] - HMGN1 [21q22.2] [FUSC003437]
Fusion Cancer (Beijing)	FN1 [2q35] - LDOC1L [22q13.31] [FUSC002149]
Fusion Cancer (Beijing)	FN1 [2q35] - MAGEA8 [Xq28] [FUSC002252] [FUSC002252]
Fusion Cancer (Beijing)	FN1 [2q35] - MED22 [9q34.2] [FUSC002150] [FUSC002150]
Fusion Cancer (Beijing)	FN1 [2q35] - NFX1 [9p13.3] [FUSC003438]
Fusion Cancer (Beijing)	FN1 [2q35] - TBC1D8B [Xq22.3] [FUSC003441]
Fusion Cancer (Beijing)	FN1 [2q35] - TONSL [8q24.3] [FUSC002153]
Fusion Cancer (Beijing)	FN1 [2q35] - ZSCAN12 [6p22.1] [FUSC002992]
Fusion Cancer (Beijing)	FUT3 [19p13.3] - FN1 [2q35] [FUSC002154]
Fusion Cancer (Beijing)	MUC5B [11p15.5] - FN1 [2q35] [FUSC002173]
Fusion Cancer (Beijing)	MYT1L [2p25.3] - FN1 [2q35] [FUSC002878]
Fusion Cancer (Beijing)	PTPRS [19p13.3] - FN1 [2q35] [FUSC003475]
Fusion Cancer (Beijing)	SNORD6 [11q21] - FN1 [2q35] [FUSC002204] [FUSC002204] [FUSC002204]
Fusion Cancer (Beijing)	VASH1 [14q24.3] - FN1 [2q35] [FUSC003504]
Fusion Cancer (Beijing)	cytochrome_b [FN1] - 2q35 [FUSC002834]
Fusion : Quiver	FN1
	Polymorphisms : SNP and Copy number variants
NCBI Variation Viewer	FN1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)	FN1
dbVar	FN1
ClinVar	FN1
1000_Genomes	FN1
Exome Variant Server	FN1
ExAC (Exome Aggregation Consortium)	ENSG00000115414
GNOMAD Browser	ENSG00000115414
Varsome Browser	FN1
Genetic variants : HAPMAP	2335
Genomic Variants (DGV)	FN1 [DGVbeta]
DECIPHER	FN1 [patients] [syndromes] [variants] [genes]
CONAN: Copy Number Analysis	FN1
	Mutations
ICGC Data Portal	FN1
TCGA Data Portal	FN1
Broad Tumor Portal	FN1
OASIS Portal	FN1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMIC	FN1 [overview] [genome browser] [tissue] [distribution]
Mutations and Diseases : HGMD	FN1
intOGen Portal	FN1
LOVD (Leiden Open Variation Database)	Whole genome datasets
LOVD (Leiden Open Variation Database)	LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)	LOVD 3.0 shared installation
BioMuta	search FN1
DgiDB (Drug Gene Interaction Database)	FN1
DoCM (Curated mutations)	FN1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)	FN1 (select a term)
intoGen	FN1
Cancer3D	FN1(select the gene name)
Impact of mutations	[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
	Diseases
OMIM	135600 184255 601894 614101
Orphanet	11615
DisGeNET	FN1
Medgen	FN1
Genetic Testing Registry	FN1
NextProt	P02751 [Medical]
TSGene	2335
GENETests	FN1
Target Validation	FN1
Huge Navigator	FN1 [HugePedia]
snp3D : Map Gene to Disease	2335
BioCentury BCIQ	FN1
ClinGen	FN1
	Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD	2335
Chemical/Pharm GKB Gene	PA28194
Clinical trial	FN1
	Miscellaneous
canSAR (ICR)	FN1 (select the gene name)
DataMed Index	FN1
	Probes
	Litterature
PubMed	499 Pubmed reference(s) in Entrez
GeneRIFs	Gene References Into Functions (Entrez)
CoreMine	FN1
EVEX	FN1
GoPubMed	FN1
iHOP	FN1

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI NCBI

indexed on : Thu Mar 21 15:46:42 CET 2019

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Atlas of Genetics and Cytogenetics in Oncology and Haematology

FN1 (fibronectin 1)

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to How to contribute

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to How to contribute