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FN1 (fibronectin 1)

Identity

Alias_symbol (synonym)MSF
CIG
LETS
GFND2
FINC
Other aliasED-B
FN
FNZ
GFND
SMDCF
HGNC (Hugo) FN1
LocusID (NCBI) 2335
Atlas_Id 40617
Location 2q35  [Link to chromosome band 2q35]
Location_base_pair Starts at 215360440 and ends at 215436068 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AGO4 (1p34.3) / FN1 (2q35)APPL2 (12q23.3) / FN1 (2q35)ARNTL (11p15.2) / FN1 (2q35)
CCDC112 (5q22.3) / FN1 (2q35)CCDC84 (11q23.3) / FN1 (2q35)CDC27 (17q21.32) / FN1 (2q35)
CSNK1D (17q25.3) / FN1 (2q35)DENND5A (11p15.4) / FN1 (2q35)ERCC1 (19q13.32) / FN1 (2q35)
FN1 (2q35) / ACVR2A (2q22.3)FN1 (2q35) / ALK (2p23.2)FN1 (2q35) / APOD (3q29)
FN1 (2q35) / CCDC80 (3q13.2)FN1 (2q35) / CD52 (1p36.11)FN1 (2q35) / CDKN1B (12p13.1)
FN1 (2q35) / CSH2 (17q23.3)FN1 (2q35) / DAGLB (7p22.1)FN1 (2q35) / FGFR1 (8p11.23)
FN1 (2q35) / FN1 (2q35)FN1 (2q35) / HMGN1 (21q22.2)FN1 (2q35) / IQCG (3q29)
FN1 (2q35) / KMT2A (11q23.3)FN1 (2q35) / LDOC1L (22q13.31)FN1 (2q35) / LYN (8q12.1)
FN1 (2q35) / MAGEA8 (Xq28)FN1 (2q35) / MED22 (9q34.2)FN1 (2q35) / NFX1 (9p13.3)
FN1 (2q35) / OPHN1 (Xq12)FN1 (2q35) / PIGL (17p11.2)FN1 (2q35) / RNH1 (11p15.5)
FN1 (2q35) / TBC1D8B (Xq22.3)FN1 (2q35) / TONSL (8q24.3)FN1 (2q35) / YIPF4 (2p22.3)
FN1 (2q35) / YWHAG (7q11.23)FN1 (2q35) / ZSCAN12 (6p22.1)FUT3 (19p13.3) / FN1 (2q35)
KMT2A (11q23.3) / FN1 (2q35)MCAM (11q23.3) / FN1 (2q35)MUC5B (11p15.5) / FN1 (2q35)
MYT1L (2p25.3) / FN1 (2q35)NEMF (14q21.3) / FN1 (2q35)NUP98 (11p15.4) / FN1 (2q35)
PMS1 (2q32.2) / FN1 (2q35)PTPRS (19p13.3) / FN1 (2q35)RACK1 (5q35.3) / FN1 (2q35)
SLC20A1 (2q13) / FN1 (2q35)SMC3 (10q25.2) / FN1 (2q35)SNORD6 (11q21) / FN1 (2q35)
SPARC (5q33.1) / FN1 (2q35)TBC1D20 (20p13) / FN1 (2q35)TFRC (3q29) / FN1 (2q35)
TNPO3 (7q32.1) / FN1 (2q35)VASH1 (14q24.3) / FN1 (2q35)VWF (12p13.31) / FN1 (2q35)
cytochrome_b () / FN1 (2q35)FN1 2q35 / ALK 2p23.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 7 ]

Solid Tumors TT_inv02p23q35ID100067 TT_t0202p23q35ID105219 TT_t0202p23q35ID105220 TT_t0202p23q35ID105221 TT_t0202q22q35ID105288
TT_t0205q35q31ID105466 TT_t0208q35p11ID105530

External links

Nomenclature
HGNC (Hugo)FN1   3778
Cards
Entrez_Gene (NCBI)FN1  2335  fibronectin 1
AliasesCIG; ED-B; FINC; FN; 
FNZ; GFND; GFND2; LETS; MSF; SMDCF
GeneCards (Weizmann)FN1
Ensembl hg19 (Hinxton)ENSG00000115414 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000115414 [Gene_View]  ENSG00000115414 [Sequence]  chr2:215360440-215436068 [Contig_View]  FN1 [Vega]
ICGC DataPortalENSG00000115414
TCGA cBioPortalFN1
AceView (NCBI)FN1
Genatlas (Paris)FN1
WikiGenes2335
SOURCE (Princeton)FN1
Genetics Home Reference (NIH)FN1
Genomic and cartography
GoldenPath hg38 (UCSC)FN1  -     chr2:215360440-215436068 -  2q35   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FN1  -     2q35   [Description]    (hg19-Feb_2009)
GoldenPathFN1 - 2q35 [CytoView hg19]  FN1 - 2q35 [CytoView hg38]
ImmunoBaseENSG00000115414
Mapping of homologs : NCBIFN1 [Mapview hg19]  FN1 [Mapview hg38]
OMIM135600   184255   601894   614101   
Gene and transcription
Genbank (Entrez)AB191261 AB209287 AB209840 AF130095 AF312399
RefSeq transcript (Entrez)NM_001306129 NM_001306130 NM_001306131 NM_001306132 NM_001365517 NM_001365518 NM_001365519 NM_001365520 NM_001365521 NM_001365522 NM_001365523 NM_001365524 NM_002026 NM_054034 NM_212474 NM_212475 NM_212476 NM_212478 NM_212482
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FN1
Cluster EST : UnigeneHs.203717 [ NCBI ]
CGAP (NCI)Hs.203717
Alternative Splicing GalleryENSG00000115414
Gene ExpressionFN1 [ NCBI-GEO ]   FN1 [ EBI - ARRAY_EXPRESS ]   FN1 [ SEEK ]   FN1 [ MEM ]
Gene Expression Viewer (FireBrowse)FN1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2335
GTEX Portal (Tissue expression)FN1
Human Protein AtlasENSG00000115414-FN1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP02751   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP02751  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP02751
Splice isoforms : SwissVarP02751
PhosPhoSitePlusP02751
Domaine pattern : Prosite (Expaxy)EGF_1 (PS00022)    FN1_1 (PS01253)    FN1_2 (PS51091)    FN2_1 (PS00023)    FN2_2 (PS51092)    FN3 (PS50853)   
Domains : Interpro (EBI)Fibronectin_type1    FN3_dom    FN3_sf    FN_type2_dom    FN_type2_sf    Ig-like_fold    Kringle-like   
Domain families : Pfam (Sanger)fn1 (PF00039)    fn2 (PF00040)    fn3 (PF00041)   
Domain families : Pfam (NCBI)pfam00039    pfam00040    pfam00041   
Domain families : Smart (EMBL)FN1 (SM00058)  FN2 (SM00059)  FN3 (SM00060)  
Conserved Domain (NCBI)FN1
DMDM Disease mutations2335
Blocks (Seattle)FN1
PDB (RSDB)1E88    1E8B    1FBR    1FNA    1FNF    1FNH    1J8K    1O9A    1OWW    1Q38    1QGB    1QO6    1TTF    1TTG    2CG6    2CG7    2CK2    2CKU    2EC3    2FN2    2FNB    2GEE    2H41    2H45    2HA1    2MNU    2N1K    2OCF    2RKY    2RKZ    2RL0    3CAL    3EJH    3GXE    3M7P    3MQL    3R8Q    3T1W    3ZRZ    4GH7    4JE4    4JEG    4LXO    4MMX    4MMY    4MMZ    4PZ5    5DC0    5DC4    5DC9    5DFT    5J6Z    5J7C    5M0A    5N47    5N48   
PDB Europe1E88    1E8B    1FBR    1FNA    1FNF    1FNH    1J8K    1O9A    1OWW    1Q38    1QGB    1QO6    1TTF    1TTG    2CG6    2CG7    2CK2    2CKU    2EC3    2FN2    2FNB    2GEE    2H41    2H45    2HA1    2MNU    2N1K    2OCF    2RKY    2RKZ    2RL0    3CAL    3EJH    3GXE    3M7P    3MQL    3R8Q    3T1W    3ZRZ    4GH7    4JE4    4JEG    4LXO    4MMX    4MMY    4MMZ    4PZ5    5DC0    5DC4    5DC9    5DFT    5J6Z    5J7C    5M0A    5N47    5N48   
PDB (PDBSum)1E88    1E8B    1FBR    1FNA    1FNF    1FNH    1J8K    1O9A    1OWW    1Q38    1QGB    1QO6    1TTF    1TTG    2CG6    2CG7    2CK2    2CKU    2EC3    2FN2    2FNB    2GEE    2H41    2H45    2HA1    2MNU    2N1K    2OCF    2RKY    2RKZ    2RL0    3CAL    3EJH    3GXE    3M7P    3MQL    3R8Q    3T1W    3ZRZ    4GH7    4JE4    4JEG    4LXO    4MMX    4MMY    4MMZ    4PZ5    5DC0    5DC4    5DC9    5DFT    5J6Z    5J7C    5M0A    5N47    5N48   
PDB (IMB)1E88    1E8B    1FBR    1FNA    1FNF    1FNH    1J8K    1O9A    1OWW    1Q38    1QGB    1QO6    1TTF    1TTG    2CG6    2CG7    2CK2    2CKU    2EC3    2FN2    2FNB    2GEE    2H41    2H45    2HA1    2MNU    2N1K    2OCF    2RKY    2RKZ    2RL0    3CAL    3EJH    3GXE    3M7P    3MQL    3R8Q    3T1W    3ZRZ    4GH7    4JE4    4JEG    4LXO    4MMX    4MMY    4MMZ    4PZ5    5DC0    5DC4    5DC9    5DFT    5J6Z    5J7C    5M0A    5N47    5N48   
Structural Biology KnowledgeBase1E88    1E8B    1FBR    1FNA    1FNF    1FNH    1J8K    1O9A    1OWW    1Q38    1QGB    1QO6    1TTF    1TTG    2CG6    2CG7    2CK2    2CKU    2EC3    2FN2    2FNB    2GEE    2H41    2H45    2HA1    2MNU    2N1K    2OCF    2RKY    2RKZ    2RL0    3CAL    3EJH    3GXE    3M7P    3MQL    3R8Q    3T1W    3ZRZ    4GH7    4JE4    4JEG    4LXO    4MMX    4MMY    4MMZ    4PZ5    5DC0    5DC4    5DC9    5DFT    5J6Z    5J7C    5M0A    5N47    5N48   
SCOP (Structural Classification of Proteins)1E88    1E8B    1FBR    1FNA    1FNF    1FNH    1J8K    1O9A    1OWW    1Q38    1QGB    1QO6    1TTF    1TTG    2CG6    2CG7    2CK2    2CKU    2EC3    2FN2    2FNB    2GEE    2H41    2H45    2HA1    2MNU    2N1K    2OCF    2RKY    2RKZ    2RL0    3CAL    3EJH    3GXE    3M7P    3MQL    3R8Q    3T1W    3ZRZ    4GH7    4JE4    4JEG    4LXO    4MMX    4MMY    4MMZ    4PZ5    5DC0    5DC4    5DC9    5DFT    5J6Z    5J7C    5M0A    5N47    5N48   
CATH (Classification of proteins structures)1E88    1E8B    1FBR    1FNA    1FNF    1FNH    1J8K    1O9A    1OWW    1Q38    1QGB    1QO6    1TTF    1TTG    2CG6    2CG7    2CK2    2CKU    2EC3    2FN2    2FNB    2GEE    2H41    2H45    2HA1    2MNU    2N1K    2OCF    2RKY    2RKZ    2RL0    3CAL    3EJH    3GXE    3M7P    3MQL    3R8Q    3T1W    3ZRZ    4GH7    4JE4    4JEG    4LXO    4MMX    4MMY    4MMZ    4PZ5    5DC0    5DC4    5DC9    5DFT    5J6Z    5J7C    5M0A    5N47    5N48   
SuperfamilyP02751
Human Protein Atlas [tissue]ENSG00000115414-FN1 [tissue]
Peptide AtlasP02751
HPRD00626
IPIIPI00022418   IPI00479723   IPI00339319   IPI00556632   IPI00867588   IPI00855777   IPI00855785   IPI00411462   IPI00339223   IPI00339224   IPI00339225   IPI00339226   IPI00339227   IPI00339228   IPI00414283   IPI00922213   IPI00873210   IPI00383776   IPI00845263   IPI00983517   
Protein Interaction databases
DIP (DOE-UCLA)P02751
IntAct (EBI)P02751
FunCoupENSG00000115414
BioGRIDFN1
STRING (EMBL)FN1
ZODIACFN1
Ontologies - Pathways
QuickGOP02751
Ontology : AmiGOangiogenesis  regulation of protein phosphorylation  protease binding  platelet degranulation  signaling receptor binding  integrin binding  integrin binding  integrin binding  extracellular matrix structural constituent  extracellular matrix structural constituent  extracellular matrix structural constituent  protein binding  collagen binding  extracellular region  extracellular region  extracellular region  fibrinogen complex  basement membrane  extracellular space  extracellular space  endoplasmic reticulum lumen  endoplasmic reticulum-Golgi intermediate compartment  acute-phase response  cell-substrate junction assembly  cell adhesion  calcium-independent cell-matrix adhesion  protein C-terminus binding  heparin binding  positive regulation of cell proliferation  regulation of cell shape  response to wounding  positive regulation of gene expression  positive regulation of peptidase activity  apical plasma membrane  peptidase activator activity  peptide cross-linking  cytokine-mediated signaling pathway  enzyme binding  extracellular matrix organization  extracellular matrix  platelet alpha granule lumen  integrin activation  substrate adhesion-dependent cell spreading  substrate adhesion-dependent cell spreading  endodermal cell differentiation  wound healing  identical protein binding  proteoglycan binding  post-translational protein modification  cellular protein metabolic process  positive regulation of axon extension  positive regulation of fibroblast proliferation  leukocyte migration  chaperone binding  interaction with symbiont  interaction with other organism via secreted substance involved in symbiotic interaction  collagen-containing extracellular matrix  collagen-containing extracellular matrix  collagen-containing extracellular matrix  collagen-containing extracellular matrix  extracellular exosome  extracellular exosome  regulation of ERK1 and ERK2 cascade  blood microparticle  disordered domain specific binding  neural crest cell migration involved in autonomic nervous system development  positive regulation of substrate-dependent cell migration, cell attachment to substrate  negative regulation of transforming growth factor-beta secretion  
Ontology : EGO-EBIangiogenesis  regulation of protein phosphorylation  protease binding  platelet degranulation  signaling receptor binding  integrin binding  integrin binding  integrin binding  extracellular matrix structural constituent  extracellular matrix structural constituent  extracellular matrix structural constituent  protein binding  collagen binding  extracellular region  extracellular region  extracellular region  fibrinogen complex  basement membrane  extracellular space  extracellular space  endoplasmic reticulum lumen  endoplasmic reticulum-Golgi intermediate compartment  acute-phase response  cell-substrate junction assembly  cell adhesion  calcium-independent cell-matrix adhesion  protein C-terminus binding  heparin binding  positive regulation of cell proliferation  regulation of cell shape  response to wounding  positive regulation of gene expression  positive regulation of peptidase activity  apical plasma membrane  peptidase activator activity  peptide cross-linking  cytokine-mediated signaling pathway  enzyme binding  extracellular matrix organization  extracellular matrix  platelet alpha granule lumen  integrin activation  substrate adhesion-dependent cell spreading  substrate adhesion-dependent cell spreading  endodermal cell differentiation  wound healing  identical protein binding  proteoglycan binding  post-translational protein modification  cellular protein metabolic process  positive regulation of axon extension  positive regulation of fibroblast proliferation  leukocyte migration  chaperone binding  interaction with symbiont  interaction with other organism via secreted substance involved in symbiotic interaction  collagen-containing extracellular matrix  collagen-containing extracellular matrix  collagen-containing extracellular matrix  collagen-containing extracellular matrix  extracellular exosome  extracellular exosome  regulation of ERK1 and ERK2 cascade  blood microparticle  disordered domain specific binding  neural crest cell migration involved in autonomic nervous system development  positive regulation of substrate-dependent cell migration, cell attachment to substrate  negative regulation of transforming growth factor-beta secretion  
Pathways : KEGGPI3K-Akt signaling pathway    Focal adhesion    ECM-receptor interaction    Regulation of actin cytoskeleton    Bacterial invasion of epithelial cells    Amoebiasis    Pathways in cancer    Proteoglycans in cancer    Small cell lung cancer   
NDEx NetworkFN1
Atlas of Cancer Signalling NetworkFN1
Wikipedia pathwaysFN1
Orthology - Evolution
OrthoDB2335
GeneTree (enSembl)ENSG00000115414
Phylogenetic Trees/Animal Genes : TreeFamFN1
HOGENOMP02751
Homologs : HomoloGeneFN1
Homology/Alignments : Family Browser (UCSC)FN1
Gene fusions - Rearrangements
Fusion : MitelmanFN1/ALK [2q35/2p23.2]  
Fusion : MitelmanFN1/FGFR1 [2q35/8p11.23]  [t(2;8)(q35;p11)]  
Fusion Cancer (Beijing)APPL2 [12q23.3]  -  FN1 [2q35]  [FUSC003617]
Fusion Cancer (Beijing)ARNTL [11p15.2]  -  FN1 [2q35]  [FUSC003415]
Fusion Cancer (Beijing)DENND5A [11p15.4]  -  FN1 [2q35]  [FUSC003432]
Fusion Cancer (Beijing)FN1 [2q35]  -  CCDC80 [3q13.2]  [FUSC002713]
Fusion Cancer (Beijing)FN1 [2q35]  -  HMGN1 [21q22.2]  [FUSC003437]
Fusion Cancer (Beijing)FN1 [2q35]  -  LDOC1L [22q13.31]  [FUSC002149]
Fusion Cancer (Beijing)FN1 [2q35]  -  MAGEA8 [Xq28]  [FUSC002252]  [FUSC002252]
Fusion Cancer (Beijing)FN1 [2q35]  -  MED22 [9q34.2]  [FUSC002150]  [FUSC002150]
Fusion Cancer (Beijing)FN1 [2q35]  -  NFX1 [9p13.3]  [FUSC003438]
Fusion Cancer (Beijing)FN1 [2q35]  -  TBC1D8B [Xq22.3]  [FUSC003441]
Fusion Cancer (Beijing)FN1 [2q35]  -  TONSL [8q24.3]  [FUSC002153]
Fusion Cancer (Beijing)FN1 [2q35]  -  ZSCAN12 [6p22.1]  [FUSC002992]
Fusion Cancer (Beijing)FUT3 [19p13.3]  -  FN1 [2q35]  [FUSC002154]
Fusion Cancer (Beijing)MUC5B [11p15.5]  -  FN1 [2q35]  [FUSC002173]
Fusion Cancer (Beijing)MYT1L [2p25.3]  -  FN1 [2q35]  [FUSC002878]
Fusion Cancer (Beijing)PTPRS [19p13.3]  -  FN1 [2q35]  [FUSC003475]
Fusion Cancer (Beijing)SNORD6 [11q21]  -  FN1 [2q35]  [FUSC002204]  [FUSC002204]  [FUSC002204]
Fusion Cancer (Beijing)VASH1 [14q24.3]  -  FN1 [2q35]  [FUSC003504]
Fusion Cancer (Beijing)cytochrome_b [FN1]  -  2q35 [FUSC002834]
Fusion : QuiverFN1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFN1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FN1
dbVarFN1
ClinVarFN1
1000_GenomesFN1 
Exome Variant ServerFN1
ExAC (Exome Aggregation Consortium)ENSG00000115414
GNOMAD BrowserENSG00000115414
Varsome BrowserFN1
Genetic variants : HAPMAP2335
Genomic Variants (DGV)FN1 [DGVbeta]
DECIPHERFN1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFN1 
Mutations
ICGC Data PortalFN1 
TCGA Data PortalFN1 
Broad Tumor PortalFN1
OASIS PortalFN1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFN1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DFN1
Mutations and Diseases : HGMDFN1
intOGen PortalFN1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FN1
DgiDB (Drug Gene Interaction Database)FN1
DoCM (Curated mutations)FN1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FN1 (select a term)
intoGenFN1
Cancer3DFN1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM135600    184255    601894    614101   
Orphanet11615   
DisGeNETFN1
MedgenFN1
Genetic Testing Registry FN1
NextProtP02751 [Medical]
TSGene2335
GENETestsFN1
Target ValidationFN1
Huge Navigator FN1 [HugePedia]
snp3D : Map Gene to Disease2335
BioCentury BCIQFN1
ClinGenFN1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2335
Chemical/Pharm GKB GenePA28194
Clinical trialFN1
Miscellaneous
canSAR (ICR)FN1 (select the gene name)
DataMed IndexFN1
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFN1
EVEXFN1
GoPubMedFN1
iHOPFN1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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