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FNDC5 (fibronectin type III domain containing 5)

Identity

Alias_symbol (synonym)FRCP2
Other aliasirisin
HGNC (Hugo) FNDC5
LocusID (NCBI) 252995
Atlas_Id 55118
Location 1p35.1  [Link to chromosome band 1p35]
Location_base_pair Starts at 33327869 and ends at 33336414 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
FNDC5 (1p35.1) / FNDC5 (1p35.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)FNDC5   20240
Cards
Entrez_Gene (NCBI)FNDC5  252995  fibronectin type III domain containing 5
AliasesFRCP2; irisin
GeneCards (Weizmann)FNDC5
Ensembl hg19 (Hinxton)ENSG00000160097 [Gene_View]  chr1:33327869-33336414 [Contig_View]  FNDC5 [Vega]
Ensembl hg38 (Hinxton)ENSG00000160097 [Gene_View]  chr1:33327869-33336414 [Contig_View]  FNDC5 [Vega]
ICGC DataPortalENSG00000160097
TCGA cBioPortalFNDC5
AceView (NCBI)FNDC5
Genatlas (Paris)FNDC5
WikiGenes252995
SOURCE (Princeton)FNDC5
Genetics Home Reference (NIH)FNDC5
Genomic and cartography
GoldenPath hg19 (UCSC)FNDC5  -     chr1:33327869-33336414 -  1p35.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)FNDC5  -     1p35.1   [Description]    (hg38-Dec_2013)
EnsemblFNDC5 - 1p35.1 [CytoView hg19]  FNDC5 - 1p35.1 [CytoView hg38]
Mapping of homologs : NCBIFNDC5 [Mapview hg19]  FNDC5 [Mapview hg38]
OMIM611906   
Gene and transcription
Genbank (Entrez)AK092102 BC007548 BC033123 BC062297 BE502835
RefSeq transcript (Entrez)NM_001171940 NM_001171941 NM_153756
RefSeq genomic (Entrez)NC_000001 NC_018912 NT_032977 NW_004929290
Consensus coding sequences : CCDS (NCBI)FNDC5
Cluster EST : UnigeneHs.524234 [ NCBI ]
CGAP (NCI)Hs.524234
Alternative Splicing GalleryENSG00000160097
Gene ExpressionFNDC5 [ NCBI-GEO ]   FNDC5 [ EBI - ARRAY_EXPRESS ]   FNDC5 [ SEEK ]   FNDC5 [ MEM ]
Gene Expression Viewer (FireBrowse)FNDC5 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)252995
GTEX Portal (Tissue expression)FNDC5
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8NAU1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8NAU1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8NAU1
Splice isoforms : SwissVarQ8NAU1
PhosPhoSitePlusQ8NAU1
Domaine pattern : Prosite (Expaxy)FN3 (PS50853)   
Domains : Interpro (EBI)FN3_dom    FNDC5_C    Ig-like_fold   
Domain families : Pfam (Sanger)DUF4808 (PF16066)    fn3 (PF00041)   
Domain families : Pfam (NCBI)pfam16066    pfam00041   
Domain families : Smart (EMBL)FN3 (SM00060)  
Conserved Domain (NCBI)FNDC5
DMDM Disease mutations252995
Blocks (Seattle)FNDC5
PDB (SRS)4LSD   
PDB (PDBSum)4LSD   
PDB (IMB)4LSD   
PDB (RSDB)4LSD   
Structural Biology KnowledgeBase4LSD   
SCOP (Structural Classification of Proteins)4LSD   
CATH (Classification of proteins structures)4LSD   
SuperfamilyQ8NAU1
Human Protein AtlasENSG00000160097
Peptide AtlasQ8NAU1
HPRD17009
IPIIPI00854598   IPI00514152   IPI00385341   IPI00889652   
Protein Interaction databases
DIP (DOE-UCLA)Q8NAU1
IntAct (EBI)Q8NAU1
FunCoupENSG00000160097
BioGRIDFNDC5
STRING (EMBL)FNDC5
ZODIACFNDC5
Ontologies - Pathways
QuickGOQ8NAU1
Ontology : AmiGOmolecular_function  hormone activity  extracellular region  peroxisomal membrane  endoplasmic reticulum  plasma membrane  biological_process  response to muscle activity  integral component of membrane  positive regulation of brown fat cell differentiation  
Ontology : EGO-EBImolecular_function  hormone activity  extracellular region  peroxisomal membrane  endoplasmic reticulum  plasma membrane  biological_process  response to muscle activity  integral component of membrane  positive regulation of brown fat cell differentiation  
NDEx NetworkFNDC5
Atlas of Cancer Signalling NetworkFNDC5
Wikipedia pathwaysFNDC5
Orthology - Evolution
OrthoDB252995
GeneTree (enSembl)ENSG00000160097
Phylogenetic Trees/Animal Genes : TreeFamFNDC5
HOVERGENQ8NAU1
HOGENOMQ8NAU1
Homologs : HomoloGeneFNDC5
Homology/Alignments : Family Browser (UCSC)FNDC5
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFNDC5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FNDC5
dbVarFNDC5
ClinVarFNDC5
1000_GenomesFNDC5 
Exome Variant ServerFNDC5
ExAC (Exome Aggregation Consortium)FNDC5 (select the gene name)
Genetic variants : HAPMAP252995
Genomic Variants (DGV)FNDC5 [DGVbeta]
DECIPHER (Syndromes)1:33327869-33336414  ENSG00000160097
CONAN: Copy Number AnalysisFNDC5 
Mutations
ICGC Data PortalFNDC5 
TCGA Data PortalFNDC5 
Broad Tumor PortalFNDC5
OASIS PortalFNDC5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFNDC5  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDFNDC5
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FNDC5
DgiDB (Drug Gene Interaction Database)FNDC5
DoCM (Curated mutations)FNDC5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FNDC5 (select a term)
intoGenFNDC5
Cancer3DFNDC5(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611906   
Orphanet
MedgenFNDC5
Genetic Testing Registry FNDC5
NextProtQ8NAU1 [Medical]
TSGene252995
GENETestsFNDC5
Huge Navigator FNDC5 [HugePedia]
snp3D : Map Gene to Disease252995
BioCentury BCIQFNDC5
ClinGenFNDC5
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD252995
Chemical/Pharm GKB GenePA134924607
Clinical trialFNDC5
Miscellaneous
canSAR (ICR)FNDC5 (select the gene name)
Probes
Litterature
PubMed76 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFNDC5
EVEXFNDC5
GoPubMedFNDC5
iHOPFNDC5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:01:28 CEST 2017

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