FNDC5 (fibronectin type III domain containing 5)

2015-03-01  

Identity

HGNC
FNDC5
LOCATION
1p35.1
LOCUSID
252995
ALIAS
FRCP2,irisin
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 252995
MIM: 611906
HGNC: 20240
Ensembl: ENSG00000160097

Variants:

dbSNP: 252995
ClinVar: 252995
TCGA: ENSG00000160097
COSMIC: FNDC5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000160097ENST00000373471A0A0A0MRR6
ENSG00000160097ENST00000496770Q8NAU1
ENSG00000160097ENST00000649537A0A3B3ITP1

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
245068712014Irisin and FGF21 are cold-induced endocrine activators of brown fat function in humans.202
242379622014The effects of acute and chronic exercise on PGC-1α, irisin and browning of subcutaneous adipose tissue in humans.103
267698302015Crossfit training changes brain-derived neurotrophic factor and irisin levels at rest, after wingate and progressive tests, and improves aerobic capacity and body composition of young physically active men and women.28
250606902014Circulating irisin, omentin-1, and lipoprotein subparticles in adults at higher cardiovascular risk.20
288671872017Irisin stimulates cell proliferation and invasion by targeting the PI3K/AKT pathway in human hepatocellular carcinoma.14
283853282017Adiponectin profile and Irisin expression in Italian obese children: Association with insulin-resistance.13
291089002018Irisin and leptin concentrations in relation to obesity, and developing type 2 diabetes: A cross sectional and a prospective case-control study nested in the Normative Aging Study.12
266111022016Does PGC1α/FNDC5/BDNF Elicit the Beneficial Effects of Exercise on Neurodegenerative Disorders?10
280773412017Serum Irisin and Oxytocin Levels as Predictors of Metabolic Parameters in Obese Children.8
287325652017Circulating irisin levels are lower in patients with either stable coronary artery disease (CAD) or myocardial infarction (MI) versus healthy controls, whereas follistatin and activin A levels are higher and can discriminate MI from CAD with similar to CK-MB accuracy.8

Citation

Dessen P

FNDC5 (fibronectin type III domain containing 5)

Atlas Genet Cytogenet Oncol Haematol. 2015-03-01

Online version: http://atlasgeneticsoncology.org/gene/55118/fndc5