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FNIP2 (folliculin interacting protein 2)

Identity

Other aliasFNIPL
MAPO1
HGNC (Hugo) FNIP2
LocusID (NCBI) 57600
Atlas_Id 57445
Location 4q32.1  [Link to chromosome band 4q32]
Location_base_pair Starts at 158768995 and ends at 158908050 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
BAZ1B (7q11.23) / FNIP2 (4q32.1)FAM13B (5q31.2) / FNIP2 (4q32.1)FNIP2 (4q32.1) / FAM159A (1p32.3)
FNIP2 (4q32.1) / GDF15 (19p13.11)FNIP2 (4q32.1) / JAG2 (14q32.33)FNIP2 (4q32.1) / LARP7 (4q25)
FNIP2 (4q32.1) / LRBA (4q31.3)FNIP2 (4q32.1) / NPHP3-ACAD11 (3q22.1)LAMP2 (Xq24) / FNIP2 (4q32.1)
UQCRC1 (3p21.31) / FNIP2 (4q32.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 3 ]
  t(3;4)(p21;q32) UQCRC1/FNIP2
t(4;4)(q25;q32) FNIP2/LARP7
t(4;4)(q31;q32) FNIP2/LRBA

External links

Nomenclature
HGNC (Hugo)FNIP2   29280
Cards
Entrez_Gene (NCBI)FNIP2  57600  folliculin interacting protein 2
AliasesFNIPL; MAPO1
GeneCards (Weizmann)FNIP2
Ensembl hg19 (Hinxton)ENSG00000052795 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000052795 [Gene_View]  ENSG00000052795 [Sequence]  chr4:158768995-158908050 [Contig_View]  FNIP2 [Vega]
ICGC DataPortalENSG00000052795
TCGA cBioPortalFNIP2
AceView (NCBI)FNIP2
Genatlas (Paris)FNIP2
WikiGenes57600
SOURCE (Princeton)FNIP2
Genetics Home Reference (NIH)FNIP2
Genomic and cartography
GoldenPath hg38 (UCSC)FNIP2  -     chr4:158768995-158908050 +  4q32.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FNIP2  -     4q32.1   [Description]    (hg19-Feb_2009)
GoldenPathFNIP2 - 4q32.1 [CytoView hg19]  FNIP2 - 4q32.1 [CytoView hg38]
ImmunoBaseENSG00000052795
Mapping of homologs : NCBIFNIP2 [Mapview hg19]  FNIP2 [Mapview hg38]
OMIM612768   
Gene and transcription
Genbank (Entrez)AB040883 AK022968 AK057981 AL713802 BC007861
RefSeq transcript (Entrez)NM_001323916 NM_001346043 NM_001366843 NM_020840
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FNIP2
Cluster EST : UnigeneHs.731810 [ NCBI ]
CGAP (NCI)Hs.731810
Alternative Splicing GalleryENSG00000052795
Gene ExpressionFNIP2 [ NCBI-GEO ]   FNIP2 [ EBI - ARRAY_EXPRESS ]   FNIP2 [ SEEK ]   FNIP2 [ MEM ]
Gene Expression Viewer (FireBrowse)FNIP2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)57600
GTEX Portal (Tissue expression)FNIP2
Human Protein AtlasENSG00000052795-FNIP2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9P278   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9P278  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9P278
Splice isoforms : SwissVarQ9P278
PhosPhoSitePlusQ9P278
Domaine pattern : Prosite (Expaxy)DENN_FNIP12 (PS51836)   
Domains : Interpro (EBI)DENN_FNIP1/2    FNIP_C_dom    FNIP_fam    FNIP_mid_dom    FNIP_N_dom   
Domain families : Pfam (Sanger)FNIP_C (PF14638)    FNIP_M (PF14637)    FNIP_N (PF14636)   
Domain families : Pfam (NCBI)pfam14638    pfam14637    pfam14636   
Conserved Domain (NCBI)FNIP2
DMDM Disease mutations57600
Blocks (Seattle)FNIP2
SuperfamilyQ9P278
Human Protein Atlas [tissue]ENSG00000052795-FNIP2 [tissue]
Peptide AtlasQ9P278
IPIIPI00001790   IPI00885074   IPI00965905   
Protein Interaction databases
DIP (DOE-UCLA)Q9P278
IntAct (EBI)Q9P278
FunCoupENSG00000052795
BioGRIDFNIP2
STRING (EMBL)FNIP2
ZODIACFNIP2
Ontologies - Pathways
QuickGOQ9P278
Ontology : AmiGOnegative regulation of transcription by RNA polymerase II  regulation of protein phosphorylation  protein binding  cytoplasm  protein phosphorylation  mitochondrion organization  intrinsic apoptotic signaling pathway in response to DNA damage  positive regulation of protein complex assembly  positive regulation of peptidyl-serine phosphorylation  TORC1 signaling  ATPase inhibitor activity  negative regulation of catalytic activity  chaperone binding  
Ontology : EGO-EBInegative regulation of transcription by RNA polymerase II  regulation of protein phosphorylation  protein binding  cytoplasm  protein phosphorylation  mitochondrion organization  intrinsic apoptotic signaling pathway in response to DNA damage  positive regulation of protein complex assembly  positive regulation of peptidyl-serine phosphorylation  TORC1 signaling  ATPase inhibitor activity  negative regulation of catalytic activity  chaperone binding  
NDEx NetworkFNIP2
Atlas of Cancer Signalling NetworkFNIP2
Wikipedia pathwaysFNIP2
Orthology - Evolution
OrthoDB57600
GeneTree (enSembl)ENSG00000052795
Phylogenetic Trees/Animal Genes : TreeFamFNIP2
HOGENOMQ9P278
Homologs : HomoloGeneFNIP2
Homology/Alignments : Family Browser (UCSC)FNIP2
Gene fusions - Rearrangements
Fusion : QuiverFNIP2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFNIP2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FNIP2
dbVarFNIP2
ClinVarFNIP2
1000_GenomesFNIP2 
Exome Variant ServerFNIP2
ExAC (Exome Aggregation Consortium)ENSG00000052795
GNOMAD BrowserENSG00000052795
Varsome BrowserFNIP2
Genetic variants : HAPMAP57600
Genomic Variants (DGV)FNIP2 [DGVbeta]
DECIPHERFNIP2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFNIP2 
Mutations
ICGC Data PortalFNIP2 
TCGA Data PortalFNIP2 
Broad Tumor PortalFNIP2
OASIS PortalFNIP2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFNIP2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDFNIP2
BioMutasearch FNIP2
DgiDB (Drug Gene Interaction Database)FNIP2
DoCM (Curated mutations)FNIP2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FNIP2 (select a term)
intoGenFNIP2
Cancer3DFNIP2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM612768   
Orphanet
DisGeNETFNIP2
MedgenFNIP2
Genetic Testing Registry FNIP2
NextProtQ9P278 [Medical]
TSGene57600
GENETestsFNIP2
Target ValidationFNIP2
Huge Navigator FNIP2 [HugePedia]
snp3D : Map Gene to Disease57600
BioCentury BCIQFNIP2
ClinGenFNIP2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD57600
Chemical/Pharm GKB GenePA162388758
Clinical trialFNIP2
Miscellaneous
canSAR (ICR)FNIP2 (select the gene name)
DataMed IndexFNIP2
Probes
Litterature
PubMed14 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFNIP2
EVEXFNIP2
GoPubMedFNIP2
iHOPFNIP2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Jul 8 11:20:31 CEST 2019
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