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FNTB (farnesyltransferase, CAAX box, beta)

Identity

Alias_symbol (synonym)FPTB
Other alias
HGNC (Hugo) FNTB
LocusID (NCBI) 2342
Atlas_Id 53141
Location 14q23.3  [Link to chromosome band 14q23]
Location_base_pair Starts at 65453507 and ends at 65529370 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
FUT8 (14q23.3) / FNTB (14q23.3)FUT8 14q23.3 / FNTB 14q23.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)FNTB   3785
Cards
Entrez_Gene (NCBI)FNTB  2342  farnesyltransferase, CAAX box, beta
AliasesFPTB
GeneCards (Weizmann)FNTB
Ensembl hg19 (Hinxton)ENSG00000125954 [Gene_View]  chr14:65453507-65529370 [Contig_View]  FNTB [Vega]
Ensembl hg38 (Hinxton)ENSG00000125954 [Gene_View]  chr14:65453507-65529370 [Contig_View]  FNTB [Vega]
ICGC DataPortalENSG00000125954
TCGA cBioPortalFNTB
AceView (NCBI)FNTB
Genatlas (Paris)FNTB
WikiGenes2342
SOURCE (Princeton)FNTB
Genetics Home Reference (NIH)FNTB
Genomic and cartography
GoldenPath hg19 (UCSC)FNTB  -     chr14:65453507-65529370 +  14q23.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)FNTB  -     14q23.3   [Description]    (hg38-Dec_2013)
EnsemblFNTB - 14q23.3 [CytoView hg19]  FNTB - 14q23.3 [CytoView hg38]
Mapping of homologs : NCBIFNTB [Mapview hg19]  FNTB [Mapview hg38]
OMIM134636   
Gene and transcription
Genbank (Entrez)AK093298 AK225917 AK295972 AK315714 AU122768
RefSeq transcript (Entrez)NM_002028
RefSeq genomic (Entrez)NC_000014 NC_018925 NT_026437 NW_004929393
Consensus coding sequences : CCDS (NCBI)FNTB
Cluster EST : UnigeneHs.325531 [ NCBI ]
CGAP (NCI)Hs.325531
Alternative Splicing GalleryENSG00000125954
Gene ExpressionFNTB [ NCBI-GEO ]   FNTB [ EBI - ARRAY_EXPRESS ]   FNTB [ SEEK ]   FNTB [ MEM ]
Gene Expression Viewer (FireBrowse)FNTB [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2342
GTEX Portal (Tissue expression)FNTB
Protein : pattern, domain, 3D structure
UniProt/SwissProtP49356   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP49356  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP49356
Splice isoforms : SwissVarP49356
Catalytic activity : Enzyme2.5.1.58 [ Enzyme-Expasy ]   2.5.1.582.5.1.58 [ IntEnz-EBI ]   2.5.1.58 [ BRENDA ]   2.5.1.58 [ KEGG ]   
PhosPhoSitePlusP49356
Domains : Interpro (EBI)FTB    PFTB_repeat    Terpenoid_cyclase/PrenylTrfase   
Domain families : Pfam (Sanger)Prenyltrans (PF00432)   
Domain families : Pfam (NCBI)pfam00432   
Conserved Domain (NCBI)FNTB
DMDM Disease mutations2342
Blocks (Seattle)FNTB
PDB (SRS)1JCQ    1LD7    1LD8    1MZC    1S63    1SA4    1TN6    2F0Y    2H6F    2H6G    2H6H    2H6I    2IEJ    3E37   
PDB (PDBSum)1JCQ    1LD7    1LD8    1MZC    1S63    1SA4    1TN6    2F0Y    2H6F    2H6G    2H6H    2H6I    2IEJ    3E37   
PDB (IMB)1JCQ    1LD7    1LD8    1MZC    1S63    1SA4    1TN6    2F0Y    2H6F    2H6G    2H6H    2H6I    2IEJ    3E37   
PDB (RSDB)1JCQ    1LD7    1LD8    1MZC    1S63    1SA4    1TN6    2F0Y    2H6F    2H6G    2H6H    2H6I    2IEJ    3E37   
Structural Biology KnowledgeBase1JCQ    1LD7    1LD8    1MZC    1S63    1SA4    1TN6    2F0Y    2H6F    2H6G    2H6H    2H6I    2IEJ    3E37   
SCOP (Structural Classification of Proteins)1JCQ    1LD7    1LD8    1MZC    1S63    1SA4    1TN6    2F0Y    2H6F    2H6G    2H6H    2H6I    2IEJ    3E37   
CATH (Classification of proteins structures)1JCQ    1LD7    1LD8    1MZC    1S63    1SA4    1TN6    2F0Y    2H6F    2H6G    2H6H    2H6I    2IEJ    3E37   
SuperfamilyP49356
Human Protein AtlasENSG00000125954
Peptide AtlasP49356
HPRD00608
IPIIPI00026817   IPI01025132   
Protein Interaction databases
DIP (DOE-UCLA)P49356
IntAct (EBI)P49356
FunCoupENSG00000125954
BioGRIDFNTB
STRING (EMBL)FNTB
ZODIACFNTB
Ontologies - Pathways
QuickGOP49356
Ontology : AmiGOfarnesyltranstransferase activity  protein farnesyltransferase activity  protein farnesyltransferase activity  protein binding  cytosol  microtubule associated complex  protein farnesyltransferase complex  drug binding  zinc ion binding  negative regulation of cell proliferation  response to inorganic substance  response to organic cyclic compound  protein farnesylation  isoprenoid binding  regulation of rhodopsin mediated signaling pathway  response to cytokine  wound healing  peptide binding  positive regulation of cell cycle  positive regulation of fibroblast proliferation  positive regulation of nitric-oxide synthase biosynthetic process  
Ontology : EGO-EBIfarnesyltranstransferase activity  protein farnesyltransferase activity  protein farnesyltransferase activity  protein binding  cytosol  microtubule associated complex  protein farnesyltransferase complex  drug binding  zinc ion binding  negative regulation of cell proliferation  response to inorganic substance  response to organic cyclic compound  protein farnesylation  isoprenoid binding  regulation of rhodopsin mediated signaling pathway  response to cytokine  wound healing  peptide binding  positive regulation of cell cycle  positive regulation of fibroblast proliferation  positive regulation of nitric-oxide synthase biosynthetic process  
Pathways : KEGGTerpenoid backbone biosynthesis   
NDEx NetworkFNTB
Atlas of Cancer Signalling NetworkFNTB
Wikipedia pathwaysFNTB
Orthology - Evolution
OrthoDB2342
GeneTree (enSembl)ENSG00000125954
Phylogenetic Trees/Animal Genes : TreeFamFNTB
HOVERGENP49356
HOGENOMP49356
Homologs : HomoloGeneFNTB
Homology/Alignments : Family Browser (UCSC)FNTB
Gene fusions - Rearrangements
Fusion : MitelmanFUT8/FNTB [14q23.3/14q23.3]  [t(14;14)(q23;q23)]  
Fusion: TCGAFUT8 14q23.3 FNTB 14q23.3 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFNTB [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FNTB
dbVarFNTB
ClinVarFNTB
1000_GenomesFNTB 
Exome Variant ServerFNTB
ExAC (Exome Aggregation Consortium)FNTB (select the gene name)
Genetic variants : HAPMAP2342
Genomic Variants (DGV)FNTB [DGVbeta]
DECIPHER (Syndromes)14:65453507-65529370  ENSG00000125954
CONAN: Copy Number AnalysisFNTB 
Mutations
ICGC Data PortalFNTB 
TCGA Data PortalFNTB 
Broad Tumor PortalFNTB
OASIS PortalFNTB [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFNTB  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDFNTB
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FNTB
DgiDB (Drug Gene Interaction Database)FNTB
DoCM (Curated mutations)FNTB (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FNTB (select a term)
intoGenFNTB
Cancer3DFNTB(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM134636   
Orphanet
MedgenFNTB
Genetic Testing Registry FNTB
NextProtP49356 [Medical]
TSGene2342
GENETestsFNTB
Huge Navigator FNTB [HugePedia]
snp3D : Map Gene to Disease2342
BioCentury BCIQFNTB
ClinGenFNTB
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2342
Chemical/Pharm GKB GenePA28202
Clinical trialFNTB
Miscellaneous
canSAR (ICR)FNTB (select the gene name)
Probes
Litterature
PubMed39 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFNTB
EVEXFNTB
GoPubMedFNTB
iHOPFNTB
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:01:29 CEST 2017

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