Atlas of Genetics and Cytogenetics in Oncology and Haematology

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FOLR1 (folate receptor alpha)

Identity

Alias (NCBI)FBP
FOLR
FRalpha
NCFTD
HGNC (Hugo) FOLR1
HGNC Alias symbFR??
HGNC Previous nameFOLR
HGNC Previous namefolate receptor 1 (adult)
 folate receptor 1
LocusID (NCBI) 2348
Atlas_Id 40620
Location 11q13.4  [Link to chromosome band 11q13]
Location_base_pair Starts at 72192140 and ends at 72196299 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CTTN (11q13.3) / FOLR1 (11q13.4)NUMA1 (11q13.4) / FOLR1 (11q13.4)CTTN 11q13.3 / FOLR1 11q13.4
NUMA1 11q13.4 / FOLR1 11q13.4

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)FOLR1   3791
Cards
Entrez_Gene (NCBI)FOLR1    folate receptor alpha
AliasesFBP; FOLR; FRalpha; NCFTD
GeneCards (Weizmann)FOLR1
Ensembl hg19 (Hinxton)ENSG00000110195 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000110195 [Gene_View]  ENSG00000110195 [Sequence]  chr11:72192140-72196299 [Contig_View]  FOLR1 [Vega]
ICGC DataPortalENSG00000110195
TCGA cBioPortalFOLR1
AceView (NCBI)FOLR1
Genatlas (Paris)FOLR1
SOURCE (Princeton)FOLR1
Genetics Home Reference (NIH)FOLR1
Genomic and cartography
GoldenPath hg38 (UCSC)FOLR1  -     chr11:72192140-72196299 +  11q13.4   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FOLR1  -     11q13.4   [Description]    (hg19-Feb_2009)
GoldenPathFOLR1 - 11q13.4 [CytoView hg19]  FOLR1 - 11q13.4 [CytoView hg38]
ImmunoBaseENSG00000110195
genome Data Viewer NCBIFOLR1 [Mapview hg19]  
OMIM136430   613068   
Gene and transcription
Genbank (Entrez)AF000381 AH004606 AH004606 AK223527 BC002947
RefSeq transcript (Entrez)NM_000802 NM_016724 NM_016725 NM_016729 NM_016730
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FOLR1
Alternative Splicing GalleryENSG00000110195
Gene ExpressionFOLR1 [ NCBI-GEO ]   FOLR1 [ EBI - ARRAY_EXPRESS ]   FOLR1 [ SEEK ]   FOLR1 [ MEM ]
Gene Expression Viewer (FireBrowse)FOLR1 [ Firebrowse - Broad ]
GenevisibleExpression of FOLR1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2348
GTEX Portal (Tissue expression)FOLR1
Human Protein AtlasENSG00000110195-FOLR1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP15328   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP15328  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP15328
Splice isoforms : SwissVarP15328
PhosPhoSitePlusP15328
Domains : Interpro (EBI)Folate_rcpt    Folate_rcpt-like    FOLR1   
Domain families : Pfam (Sanger)Folate_rec (PF03024)   
Domain families : Pfam (NCBI)pfam03024   
Conserved Domain (NCBI)FOLR1
Blocks (Seattle)FOLR1
PDB (RSDB)4KM6    4KM7    4KMX    4LRH    5IZQ   
PDB Europe4KM6    4KM7    4KMX    4LRH    5IZQ   
PDB (PDBSum)4KM6    4KM7    4KMX    4LRH    5IZQ   
PDB (IMB)4KM6    4KM7    4KMX    4LRH    5IZQ   
Structural Biology KnowledgeBase4KM6    4KM7    4KMX    4LRH    5IZQ   
SCOP (Structural Classification of Proteins)4KM6    4KM7    4KMX    4LRH    5IZQ   
CATH (Classification of proteins structures)4KM6    4KM7    4KMX    4LRH    5IZQ   
SuperfamilyP15328
Human Protein Atlas [tissue]ENSG00000110195-FOLR1 [tissue]
Peptide AtlasP15328
HPRD00638
IPIIPI00441498   
Protein Interaction databases
DIP (DOE-UCLA)P15328
IntAct (EBI)P15328
BioGRIDFOLR1
STRING (EMBL)FOLR1
ZODIACFOLR1
Ontologies - Pathways
QuickGOP15328
Ontology : AmiGOGolgi membrane  heart looping  neural crest cell migration involved in heart formation  cardiac neural crest cell migration involved in outflow tract morphogenesis  protein binding  folic acid binding  folic acid binding  nucleus  endosome  endoplasmic reticulum membrane  plasma membrane  endoplasmic reticulum to Golgi vesicle-mediated transport  receptor-mediated endocytosis  cell adhesion  fusion of sperm to egg plasma membrane involved in single fertilization  cell surface  ER to Golgi transport vesicle membrane  folic acid transport  membrane  basolateral plasma membrane  apical plasma membrane  regulation of transforming growth factor beta receptor signaling pathway  transport vesicle  clathrin-coated vesicle  axon regeneration  anchored component of external side of plasma membrane  anchored component of external side of plasma membrane  brush border membrane  endoplasmic reticulum-Golgi intermediate compartment membrane  sperm-egg recognition  signaling receptor activity  folic acid metabolic process  COPII vesicle coating  methotrexate binding  regulation of canonical Wnt signaling pathway  pharyngeal arch artery morphogenesis  anterior neural tube closure  folic acid receptor activity  folic acid receptor activity  extracellular exosome  cellular response to folic acid  folate import across plasma membrane  
Ontology : EGO-EBIGolgi membrane  heart looping  neural crest cell migration involved in heart formation  cardiac neural crest cell migration involved in outflow tract morphogenesis  protein binding  folic acid binding  folic acid binding  nucleus  endosome  endoplasmic reticulum membrane  plasma membrane  endoplasmic reticulum to Golgi vesicle-mediated transport  receptor-mediated endocytosis  cell adhesion  fusion of sperm to egg plasma membrane involved in single fertilization  cell surface  ER to Golgi transport vesicle membrane  folic acid transport  membrane  basolateral plasma membrane  apical plasma membrane  regulation of transforming growth factor beta receptor signaling pathway  transport vesicle  clathrin-coated vesicle  axon regeneration  anchored component of external side of plasma membrane  anchored component of external side of plasma membrane  brush border membrane  endoplasmic reticulum-Golgi intermediate compartment membrane  sperm-egg recognition  signaling receptor activity  folic acid metabolic process  COPII vesicle coating  methotrexate binding  regulation of canonical Wnt signaling pathway  pharyngeal arch artery morphogenesis  anterior neural tube closure  folic acid receptor activity  folic acid receptor activity  extracellular exosome  cellular response to folic acid  folate import across plasma membrane  
Pathways : KEGGEndocytosis   
NDEx NetworkFOLR1
Atlas of Cancer Signalling NetworkFOLR1
Wikipedia pathwaysFOLR1
Orthology - Evolution
OrthoDB2348
GeneTree (enSembl)ENSG00000110195
Phylogenetic Trees/Animal Genes : TreeFamFOLR1
HOGENOMP15328
Homologs : HomoloGeneFOLR1
Homology/Alignments : Family Browser (UCSC)FOLR1
Gene fusions - Rearrangements
Fusion : MitelmanCTTN/FOLR1 [11q13.3/11q13.4]  
Fusion : MitelmanNUMA1/FOLR1 [11q13.4/11q13.4]  
Fusion PortalCTTN 11q13.3 FOLR1 11q13.4 BRCA LGG
Fusion PortalNUMA1 11q13.4 FOLR1 11q13.4 LGG
Fusion : QuiverFOLR1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFOLR1 [hg38]
dbVarFOLR1
ClinVarFOLR1
MonarchFOLR1
1000_GenomesFOLR1 
Exome Variant ServerFOLR1
GNOMAD BrowserENSG00000110195
Varsome BrowserFOLR1
Genomic Variants (DGV)FOLR1 [DGVbeta]
DECIPHERFOLR1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFOLR1 
Mutations
ICGC Data PortalFOLR1 
TCGA Data PortalFOLR1 
Broad Tumor PortalFOLR1
OASIS PortalFOLR1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFOLR1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DFOLR1
Mutations and Diseases : HGMDFOLR1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FOLR1
DgiDB (Drug Gene Interaction Database)FOLR1
DoCM (Curated mutations)FOLR1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FOLR1 (select a term)
intoGenFOLR1
Cancer3DFOLR1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM136430    613068   
Orphanet18851   
DisGeNETFOLR1
MedgenFOLR1
Genetic Testing Registry FOLR1
NextProtP15328 [Medical]
GENETestsFOLR1
Target ValidationFOLR1
Huge Navigator FOLR1 [HugePedia]
ClinGenFOLR1
Clinical trials, drugs, therapy
MyCancerGenomeFOLR1
Protein Interactions : CTD
Pharm GKB GenePA28207
Pharm GKB PathwaysPA165816349   
PharosP15328
Clinical trialFOLR1
Miscellaneous
canSAR (ICR)FOLR1 (select the gene name)
HarmonizomeFOLR1
DataMed IndexFOLR1
Probes
Litterature
PubMed148 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXFOLR1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Mar 25 19:21:55 CET 2021
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