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FOLR1 (folate receptor 1)

Identity

Alias_namesFOLR
folate receptor 1 (adult)
Other aliasFBP
HGNC (Hugo) FOLR1
LocusID (NCBI) 2348
Atlas_Id 40620
Location 11q13.4  [Link to chromosome band 11q13]
Location_base_pair Starts at 72189915 and ends at 72196323 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CTTN (11q13.3) / FOLR1 (11q13.4)NUMA1 (11q13.4) / FOLR1 (11q13.4)CTTN 11q13.3 / FOLR1 11q13.4
NUMA1 11q13.4 / FOLR1 11q13.4

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)FOLR1   3791
Cards
Entrez_Gene (NCBI)FOLR1  2348  folate receptor 1
AliasesFBP; FOLR
GeneCards (Weizmann)FOLR1
Ensembl hg19 (Hinxton)ENSG00000110195 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000110195 [Gene_View]  chr11:72189915-72196323 [Contig_View]  FOLR1 [Vega]
ICGC DataPortalENSG00000110195
TCGA cBioPortalFOLR1
AceView (NCBI)FOLR1
Genatlas (Paris)FOLR1
WikiGenes2348
SOURCE (Princeton)FOLR1
Genetics Home Reference (NIH)FOLR1
Genomic and cartography
GoldenPath hg38 (UCSC)FOLR1  -     chr11:72189915-72196323 +  11q13.4   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FOLR1  -     11q13.4   [Description]    (hg19-Feb_2009)
EnsemblFOLR1 - 11q13.4 [CytoView hg19]  FOLR1 - 11q13.4 [CytoView hg38]
Mapping of homologs : NCBIFOLR1 [Mapview hg19]  FOLR1 [Mapview hg38]
OMIM136430   613068   
Gene and transcription
Genbank (Entrez)AF000381 AH004606 AH004606 AK223527 BC002947
RefSeq transcript (Entrez)NM_000802 NM_016724 NM_016725 NM_016729 NM_016730
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FOLR1
Cluster EST : UnigeneHs.73769 [ NCBI ]
CGAP (NCI)Hs.73769
Alternative Splicing GalleryENSG00000110195
Gene ExpressionFOLR1 [ NCBI-GEO ]   FOLR1 [ EBI - ARRAY_EXPRESS ]   FOLR1 [ SEEK ]   FOLR1 [ MEM ]
Gene Expression Viewer (FireBrowse)FOLR1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2348
GTEX Portal (Tissue expression)FOLR1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP15328   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP15328  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP15328
Splice isoforms : SwissVarP15328
PhosPhoSitePlusP15328
Domains : Interpro (EBI)Folate_rcpt    Folate_rcpt-like    FOLR1   
Domain families : Pfam (Sanger)Folate_rec (PF03024)   
Domain families : Pfam (NCBI)pfam03024   
Conserved Domain (NCBI)FOLR1
DMDM Disease mutations2348
Blocks (Seattle)FOLR1
PDB (SRS)4KM6    4KM7    4KMX    4LRH    5IZQ   
PDB (PDBSum)4KM6    4KM7    4KMX    4LRH    5IZQ   
PDB (IMB)4KM6    4KM7    4KMX    4LRH    5IZQ   
PDB (RSDB)4KM6    4KM7    4KMX    4LRH    5IZQ   
Structural Biology KnowledgeBase4KM6    4KM7    4KMX    4LRH    5IZQ   
SCOP (Structural Classification of Proteins)4KM6    4KM7    4KMX    4LRH    5IZQ   
CATH (Classification of proteins structures)4KM6    4KM7    4KMX    4LRH    5IZQ   
SuperfamilyP15328
Human Protein AtlasENSG00000110195
Peptide AtlasP15328
HPRD00638
IPIIPI00441498   
Protein Interaction databases
DIP (DOE-UCLA)P15328
IntAct (EBI)P15328
FunCoupENSG00000110195
BioGRIDFOLR1
STRING (EMBL)FOLR1
ZODIACFOLR1
Ontologies - Pathways
QuickGOP15328
Ontology : AmiGOGolgi membrane  heart looping  neural crest cell migration involved in heart formation  cardiac neural crest cell migration involved in outflow tract morphogenesis  receptor activity  folic acid binding  folic acid binding  nucleus  endosome  endoplasmic reticulum membrane  plasma membrane  integral component of plasma membrane  ER to Golgi vesicle-mediated transport  receptor-mediated endocytosis  drug binding  folic acid transporter activity  cell surface  ER to Golgi transport vesicle membrane  folic acid transport  membrane  basolateral plasma membrane  apical plasma membrane  regulation of transforming growth factor beta receptor signaling pathway  clathrin-coated vesicle  axon regeneration  anchored component of external side of plasma membrane  brush border membrane  endoplasmic reticulum-Golgi intermediate compartment membrane  folic acid metabolic process  COPII vesicle coating  methotrexate binding  regulation of canonical Wnt signaling pathway  pharyngeal arch artery morphogenesis  anterior neural tube closure  folic acid receptor activity  extracellular exosome  cellular response to folic acid  
Ontology : EGO-EBIGolgi membrane  heart looping  neural crest cell migration involved in heart formation  cardiac neural crest cell migration involved in outflow tract morphogenesis  receptor activity  folic acid binding  folic acid binding  nucleus  endosome  endoplasmic reticulum membrane  plasma membrane  integral component of plasma membrane  ER to Golgi vesicle-mediated transport  receptor-mediated endocytosis  drug binding  folic acid transporter activity  cell surface  ER to Golgi transport vesicle membrane  folic acid transport  membrane  basolateral plasma membrane  apical plasma membrane  regulation of transforming growth factor beta receptor signaling pathway  clathrin-coated vesicle  axon regeneration  anchored component of external side of plasma membrane  brush border membrane  endoplasmic reticulum-Golgi intermediate compartment membrane  folic acid metabolic process  COPII vesicle coating  methotrexate binding  regulation of canonical Wnt signaling pathway  pharyngeal arch artery morphogenesis  anterior neural tube closure  folic acid receptor activity  extracellular exosome  cellular response to folic acid  
Pathways : KEGGEndocytosis   
NDEx NetworkFOLR1
Atlas of Cancer Signalling NetworkFOLR1
Wikipedia pathwaysFOLR1
Orthology - Evolution
OrthoDB2348
GeneTree (enSembl)ENSG00000110195
Phylogenetic Trees/Animal Genes : TreeFamFOLR1
HOVERGENP15328
HOGENOMP15328
Homologs : HomoloGeneFOLR1
Homology/Alignments : Family Browser (UCSC)FOLR1
Gene fusions - Rearrangements
Fusion : MitelmanCTTN/FOLR1 [11q13.3/11q13.4]  [t(11;11)(q13;q13)]  
Fusion : MitelmanNUMA1/FOLR1 [11q13.4/11q13.4]  [t(11;11)(q13;q13)]  
Fusion: TCGACTTN 11q13.3 FOLR1 11q13.4 BRCA LGG
Fusion: TCGANUMA1 11q13.4 FOLR1 11q13.4 LGG
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFOLR1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FOLR1
dbVarFOLR1
ClinVarFOLR1
1000_GenomesFOLR1 
Exome Variant ServerFOLR1
ExAC (Exome Aggregation Consortium)FOLR1 (select the gene name)
Genetic variants : HAPMAP2348
Genomic Variants (DGV)FOLR1 [DGVbeta]
DECIPHERFOLR1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFOLR1 
Mutations
ICGC Data PortalFOLR1 
TCGA Data PortalFOLR1 
Broad Tumor PortalFOLR1
OASIS PortalFOLR1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFOLR1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDFOLR1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FOLR1
DgiDB (Drug Gene Interaction Database)FOLR1
DoCM (Curated mutations)FOLR1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FOLR1 (select a term)
intoGenFOLR1
Cancer3DFOLR1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM136430    613068   
Orphanet18851   
MedgenFOLR1
Genetic Testing Registry FOLR1
NextProtP15328 [Medical]
TSGene2348
GENETestsFOLR1
Target ValidationFOLR1
Huge Navigator FOLR1 [HugePedia]
snp3D : Map Gene to Disease2348
BioCentury BCIQFOLR1
ClinGenFOLR1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2348
Chemical/Pharm GKB GenePA28207
Clinical trialFOLR1
Miscellaneous
canSAR (ICR)FOLR1 (select the gene name)
Probes
Litterature
PubMed118 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFOLR1
EVEXFOLR1
GoPubMedFOLR1
iHOPFOLR1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 13:53:38 CEST 2017

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