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FOLR2 (folate receptor beta)

Identity

Alias_namesfolate receptor 2 (fetal)
Other aliasBETA-HFR
FBP
FBP/PL-1
FR-BETA
FR-P3
HGNC (Hugo) FOLR2
LocusID (NCBI) 2350
Atlas_Id 46634
Location 11q13.4  [Link to chromosome band 11q13]
Location_base_pair Starts at 72216775 and ends at 72221950 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CDK15 (2q33.1) / FOLR2 (11q13.4)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)FOLR2   3793
Cards
Entrez_Gene (NCBI)FOLR2  2350  folate receptor beta
AliasesBETA-HFR; FBP; FBP/PL-1; FR-BETA; 
FR-P3
GeneCards (Weizmann)FOLR2
Ensembl hg19 (Hinxton)ENSG00000165457 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000165457 [Gene_View]  chr11:72216775-72221950 [Contig_View]  FOLR2 [Vega]
ICGC DataPortalENSG00000165457
TCGA cBioPortalFOLR2
AceView (NCBI)FOLR2
Genatlas (Paris)FOLR2
WikiGenes2350
SOURCE (Princeton)FOLR2
Genetics Home Reference (NIH)FOLR2
Genomic and cartography
GoldenPath hg38 (UCSC)FOLR2  -     chr11:72216775-72221950 +  11q13.4   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FOLR2  -     11q13.4   [Description]    (hg19-Feb_2009)
EnsemblFOLR2 - 11q13.4 [CytoView hg19]  FOLR2 - 11q13.4 [CytoView hg38]
Mapping of homologs : NCBIFOLR2 [Mapview hg19]  FOLR2 [Mapview hg38]
OMIM136425   
Gene and transcription
Genbank (Entrez)AK222539 AK222643 BC027894 BC058036 BC115366
RefSeq transcript (Entrez)NM_000803 NM_001113534 NM_001113535 NM_001113536
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FOLR2
Cluster EST : UnigeneHs.433159 [ NCBI ]
CGAP (NCI)Hs.433159
Alternative Splicing GalleryENSG00000165457
Gene ExpressionFOLR2 [ NCBI-GEO ]   FOLR2 [ EBI - ARRAY_EXPRESS ]   FOLR2 [ SEEK ]   FOLR2 [ MEM ]
Gene Expression Viewer (FireBrowse)FOLR2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2350
GTEX Portal (Tissue expression)FOLR2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP14207   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP14207  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP14207
Splice isoforms : SwissVarP14207
PhosPhoSitePlusP14207
Domains : Interpro (EBI)Folate_rcpt    Folate_rcpt-like    FOLR2   
Domain families : Pfam (Sanger)Folate_rec (PF03024)   
Domain families : Pfam (NCBI)pfam03024   
Conserved Domain (NCBI)FOLR2
DMDM Disease mutations2350
Blocks (Seattle)FOLR2
PDB (SRS)4KMY    4KMZ    4KN0    4KN1    4KN2   
PDB (PDBSum)4KMY    4KMZ    4KN0    4KN1    4KN2   
PDB (IMB)4KMY    4KMZ    4KN0    4KN1    4KN2   
PDB (RSDB)4KMY    4KMZ    4KN0    4KN1    4KN2   
Structural Biology KnowledgeBase4KMY    4KMZ    4KN0    4KN1    4KN2   
SCOP (Structural Classification of Proteins)4KMY    4KMZ    4KN0    4KN1    4KN2   
CATH (Classification of proteins structures)4KMY    4KMZ    4KN0    4KN1    4KN2   
SuperfamilyP14207
Human Protein AtlasENSG00000165457
Peptide AtlasP14207
HPRD00637
IPIIPI00039050   IPI00784257   IPI01010446   IPI01010089   IPI01010086   IPI01009732   IPI01009395   IPI01015880   IPI01015546   IPI01015119   
Protein Interaction databases
DIP (DOE-UCLA)P14207
IntAct (EBI)P14207
FunCoupENSG00000165457
BioGRIDFOLR2
STRING (EMBL)FOLR2
ZODIACFOLR2
Ontologies - Pathways
QuickGOP14207
Ontology : AmiGOmonocyte chemotaxis  folic acid binding  extracellular region  plasma membrane  C-terminal protein lipidation  receptor-mediated endocytosis  inflammatory response  drug binding  positive regulation of cell proliferation  folic acid transporter activity  cell surface  folic acid transport  membrane  anchored component of external side of plasma membrane  folic acid metabolic process  regulation of thymidylate synthase biosynthetic process  methotrexate binding  folic acid receptor activity  cellular response to folic acid  
Ontology : EGO-EBImonocyte chemotaxis  folic acid binding  extracellular region  plasma membrane  C-terminal protein lipidation  receptor-mediated endocytosis  inflammatory response  drug binding  positive regulation of cell proliferation  folic acid transporter activity  cell surface  folic acid transport  membrane  anchored component of external side of plasma membrane  folic acid metabolic process  regulation of thymidylate synthase biosynthetic process  methotrexate binding  folic acid receptor activity  cellular response to folic acid  
Pathways : KEGGEndocytosis   
NDEx NetworkFOLR2
Atlas of Cancer Signalling NetworkFOLR2
Wikipedia pathwaysFOLR2
Orthology - Evolution
OrthoDB2350
GeneTree (enSembl)ENSG00000165457
Phylogenetic Trees/Animal Genes : TreeFamFOLR2
HOVERGENP14207
HOGENOMP14207
Homologs : HomoloGeneFOLR2
Homology/Alignments : Family Browser (UCSC)FOLR2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFOLR2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FOLR2
dbVarFOLR2
ClinVarFOLR2
1000_GenomesFOLR2 
Exome Variant ServerFOLR2
ExAC (Exome Aggregation Consortium)FOLR2 (select the gene name)
Genetic variants : HAPMAP2350
Genomic Variants (DGV)FOLR2 [DGVbeta]
DECIPHERFOLR2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFOLR2 
Mutations
ICGC Data PortalFOLR2 
TCGA Data PortalFOLR2 
Broad Tumor PortalFOLR2
OASIS PortalFOLR2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFOLR2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDFOLR2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FOLR2
DgiDB (Drug Gene Interaction Database)FOLR2
DoCM (Curated mutations)FOLR2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FOLR2 (select a term)
intoGenFOLR2
Cancer3DFOLR2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM136425   
Orphanet
MedgenFOLR2
Genetic Testing Registry FOLR2
NextProtP14207 [Medical]
TSGene2350
GENETestsFOLR2
Target ValidationFOLR2
Huge Navigator FOLR2 [HugePedia]
snp3D : Map Gene to Disease2350
BioCentury BCIQFOLR2
ClinGenFOLR2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2350
Chemical/Pharm GKB GenePA28209
Clinical trialFOLR2
Miscellaneous
canSAR (ICR)FOLR2 (select the gene name)
Probes
Litterature
PubMed41 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFOLR2
EVEXFOLR2
GoPubMedFOLR2
iHOPFOLR2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:34:12 CEST 2017

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