FOLR2 (folate receptor beta)

2007-04-01  

Identity

HGNC
LOCATION
11q13.4
LOCUSID
ALIAS
BETA-HFR,FBP,FBP/PL-1,FOLR1,FR-BETA,FR-P3,FRbeta
FUSION GENES

Other Information

Locus ID:

NCBI: 2350
MIM: 136425
HGNC: 3793
Ensembl: ENSG00000165457

Variants:

dbSNP: 2350
ClinVar: 2350
TCGA: ENSG00000165457
COSMIC: FOLR2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000165457ENST00000298223P14207
ENSG00000165457ENST00000321324E7EU04
ENSG00000165457ENST00000449475J3KQP4
ENSG00000165457ENST00000454954J3KR13
ENSG00000165457ENST00000535625F5H4Z6
ENSG00000165457ENST00000536778F5H3Z4
ENSG00000165457ENST00000538353F5GXV3
ENSG00000165457ENST00000539412F5GZ45
ENSG00000165457ENST00000541003F5H5L8
ENSG00000165457ENST00000619261A0A087WWY2

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Post-translational modification: synthesis of GPI-anchored proteinsREACTOMER-HSA-163125
MetabolismREACTOMER-HSA-1430728
Metabolism of vitamins and cofactorsREACTOMER-HSA-196854
Metabolism of water-soluble vitamins and cofactorsREACTOMER-HSA-196849
Metabolism of folate and pterinesREACTOMER-HSA-196757
Antifolate resistanceKEGGko01523
Antifolate resistanceKEGGhsa01523

References

Pubmed IDYearTitleCitations
199519912009Folate receptor beta is expressed by tumor-associated macrophages and constitutes a marker for M2 anti-inflammatory/regulatory macrophages.99
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
194933492009118 SNPs of folate-related genes and risks of spina bifida and conotruncal heart defects.62
170351412006Neural tube defects and folate pathway genes: family-based association tests of gene-gene and gene-environment interactions.38
191611602009An association study of 45 folate-related genes in spina bifida: Involvement of cubilin (CUBN) and tRNA aspartic acid methyltransferase 1 (TRDMT1).30
223505992012Clinical significance of folate receptor β-expressing tumor-associated macrophages in pancreatic cancer.29
222113582012Functional folate receptor beta-expressing macrophages in osteoarthritis synovium and their M1/M2 expression profiles.26
190486312009Oral facial clefts and gene polymorphisms in metabolism of folate/one-carbon and vitamin A: a pathway-wide association study.20
206348912010Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia.18
206839052010Association of folate receptor (FOLR1, FOLR2, FOLR3) and reduced folate carrier (SLC19A1) genes with meningomyelocele.16

Citation

Dessen P

FOLR2 (folate receptor beta)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46634/folr2