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FOLR2 (folate receptor beta)

Identity

Alias (NCBI)BETA-HFR
FBP
FBP/PL-1
FOLR1
FR-BETA
FR-P3
FRbeta
HGNC (Hugo) FOLR2
HGNC Alias symbFR??
HGNC Previous namefolate receptor 2 (fetal)
LocusID (NCBI) 2350
Atlas_Id 46634
Location 11q13.4  [Link to chromosome band 11q13]
Location_base_pair Starts at 72216794 and ends at 72221950 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CDK15 (2q33.1) / FOLR2 (11q13.4)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

Nomenclature
HGNC (Hugo)FOLR2   3793
Cards
Entrez_Gene (NCBI)FOLR2    folate receptor beta
AliasesBETA-HFR; FBP; FBP/PL-1; FOLR1; 
FR-BETA; FR-P3; FRbeta
GeneCards (Weizmann)FOLR2
Ensembl hg19 (Hinxton)ENSG00000165457 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000165457 [Gene_View]  ENSG00000165457 [Sequence]  chr11:72216794-72221950 [Contig_View]  FOLR2 [Vega]
ICGC DataPortalENSG00000165457
TCGA cBioPortalFOLR2
AceView (NCBI)FOLR2
Genatlas (Paris)FOLR2
SOURCE (Princeton)FOLR2
Genetics Home Reference (NIH)FOLR2
Genomic and cartography
GoldenPath hg38 (UCSC)FOLR2  -     chr11:72216794-72221950 +  11q13.4   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FOLR2  -     11q13.4   [Description]    (hg19-Feb_2009)
GoldenPathFOLR2 - 11q13.4 [CytoView hg19]  FOLR2 - 11q13.4 [CytoView hg38]
ImmunoBaseENSG00000165457
genome Data Viewer NCBIFOLR2 [Mapview hg19]  
OMIM136425   
Gene and transcription
Genbank (Entrez)AK222539 AK222643 BC027894 BC058036 BC115366
RefSeq transcript (Entrez)NM_000803 NM_001113534 NM_001113535 NM_001113536
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FOLR2
Alternative Splicing GalleryENSG00000165457
Gene ExpressionFOLR2 [ NCBI-GEO ]   FOLR2 [ EBI - ARRAY_EXPRESS ]   FOLR2 [ SEEK ]   FOLR2 [ MEM ]
Gene Expression Viewer (FireBrowse)FOLR2 [ Firebrowse - Broad ]
GenevisibleExpression of FOLR2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2350
GTEX Portal (Tissue expression)FOLR2
Human Protein AtlasENSG00000165457-FOLR2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP14207   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP14207  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP14207
Splice isoforms : SwissVarP14207
PhosPhoSitePlusP14207
Domains : Interpro (EBI)Folate_rcpt    Folate_rcpt-like    FOLR2   
Domain families : Pfam (Sanger)Folate_rec (PF03024)   
Domain families : Pfam (NCBI)pfam03024   
Conserved Domain (NCBI)FOLR2
Blocks (Seattle)FOLR2
PDB (RSDB)4KMY    4KMZ    4KN0    4KN1    4KN2   
PDB Europe4KMY    4KMZ    4KN0    4KN1    4KN2   
PDB (PDBSum)4KMY    4KMZ    4KN0    4KN1    4KN2   
PDB (IMB)4KMY    4KMZ    4KN0    4KN1    4KN2   
Structural Biology KnowledgeBase4KMY    4KMZ    4KN0    4KN1    4KN2   
SCOP (Structural Classification of Proteins)4KMY    4KMZ    4KN0    4KN1    4KN2   
CATH (Classification of proteins structures)4KMY    4KMZ    4KN0    4KN1    4KN2   
SuperfamilyP14207
Human Protein Atlas [tissue]ENSG00000165457-FOLR2 [tissue]
Peptide AtlasP14207
HPRD00637
IPIIPI00039050   IPI00784257   IPI01010446   IPI01010089   IPI01010086   IPI01009732   IPI01009395   IPI01015880   IPI01015546   IPI01015119   
Protein Interaction databases
DIP (DOE-UCLA)P14207
IntAct (EBI)P14207
BioGRIDFOLR2
STRING (EMBL)FOLR2
ZODIACFOLR2
Ontologies - Pathways
QuickGOP14207
Ontology : AmiGOmonocyte chemotaxis  folic acid binding  extracellular region  plasma membrane  inflammatory response  cell adhesion  fusion of sperm to egg plasma membrane involved in single fertilization  positive regulation of cell population proliferation  cell surface  folic acid transport  anchored component of external side of plasma membrane  anchored component of external side of plasma membrane  sperm-egg recognition  signaling receptor activity  folic acid metabolic process  methotrexate binding  folic acid receptor activity  folic acid receptor activity  cellular response to folic acid  folate import across plasma membrane  
Ontology : EGO-EBImonocyte chemotaxis  folic acid binding  extracellular region  plasma membrane  inflammatory response  cell adhesion  fusion of sperm to egg plasma membrane involved in single fertilization  positive regulation of cell population proliferation  cell surface  folic acid transport  anchored component of external side of plasma membrane  anchored component of external side of plasma membrane  sperm-egg recognition  signaling receptor activity  folic acid metabolic process  methotrexate binding  folic acid receptor activity  folic acid receptor activity  cellular response to folic acid  folate import across plasma membrane  
Pathways : KEGGEndocytosis   
NDEx NetworkFOLR2
Atlas of Cancer Signalling NetworkFOLR2
Wikipedia pathwaysFOLR2
Orthology - Evolution
OrthoDB2350
GeneTree (enSembl)ENSG00000165457
Phylogenetic Trees/Animal Genes : TreeFamFOLR2
HOGENOMP14207
Homologs : HomoloGeneFOLR2
Homology/Alignments : Family Browser (UCSC)FOLR2
Gene fusions - Rearrangements
Fusion : QuiverFOLR2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFOLR2 [hg38]
dbVarFOLR2
ClinVarFOLR2
MonarchFOLR2
1000_GenomesFOLR2 
Exome Variant ServerFOLR2
GNOMAD BrowserENSG00000165457
Varsome BrowserFOLR2
Genomic Variants (DGV)FOLR2 [DGVbeta]
DECIPHERFOLR2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFOLR2 
Mutations
ICGC Data PortalFOLR2 
TCGA Data PortalFOLR2 
Broad Tumor PortalFOLR2
OASIS PortalFOLR2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFOLR2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DFOLR2
Mutations and Diseases : HGMDFOLR2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FOLR2
DgiDB (Drug Gene Interaction Database)FOLR2
DoCM (Curated mutations)FOLR2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FOLR2 (select a term)
intoGenFOLR2
Cancer3DFOLR2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM136425   
Orphanet
DisGeNETFOLR2
MedgenFOLR2
Genetic Testing Registry FOLR2
NextProtP14207 [Medical]
GENETestsFOLR2
Target ValidationFOLR2
Huge Navigator FOLR2 [HugePedia]
ClinGenFOLR2
Clinical trials, drugs, therapy
MyCancerGenomeFOLR2
Protein Interactions : CTD
Pharm GKB GenePA28209
PharosP14207
Clinical trialFOLR2
Miscellaneous
canSAR (ICR)FOLR2 (select the gene name)
HarmonizomeFOLR2
DataMed IndexFOLR2
Probes
Litterature
PubMed49 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXFOLR2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Thu Mar 25 19:21:55 CET 2021

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