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FOS (Fos proto-oncogene, AP-1 transcription factor subunit)

Identity

Alias (NCBI)AP-1
C-FOS
p55
HGNC (Hugo) FOS
HGNC Alias symbc-fos
AP-1
HGNC Previous namev-fos FBJ murine osteosarcoma viral oncogene homolog
 FBJ murine osteosarcoma viral oncogene homolog
LocusID (NCBI) 2353
Atlas_Id 154
Location 14q24.3  [Link to chromosome band 14q24]
Location_base_pair Starts at 75278828 and ends at 75282230 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
BBOX1 (11p14.2) / FOS (14q24.3)FOS (14q24.3) / FOS (14q24.3)FOS (14q24.3) / LGALS3BP (17q25.3)
FOS (14q24.3) / LMNA (1q22)FOS (14q24.3) / MAST2 (1p34.1)FOS (14q24.3) / MBNL1 (3q25.1)
FOS (14q24.3) / SPTBN1 (2p16.2)FOS (14q24.3) / VIM (10p13)LOC100507412 (-) / FOS (14q24.3)
OSBPL10 (3p23) / FOS (14q24.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 3 ]
  t(9;13)(p12;q21) PAX5/DACH1
t(14;16)(q32;q23) IGH/MAF
t(14;19)(q32;q13) IGH/Various Partners

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 4 ]
  Bone: Conventional Osteosarcoma
Liver: Hepatocellular carcinoma
Bone: Osteosarcoma
Bone: Vascular Tumors

External links

Nomenclature
HGNC (Hugo)FOS   3796
Cards
Entrez_Gene (NCBI)FOS  2353  Fos proto-oncogene, AP-1 transcription factor subunit
AliasesAP-1; C-FOS; p55
GeneCards (Weizmann)FOS
Ensembl hg19 (Hinxton)ENSG00000170345 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000170345 [Gene_View]  ENSG00000170345 [Sequence]  chr14:75278828-75282230 [Contig_View]  FOS [Vega]
ICGC DataPortalENSG00000170345
TCGA cBioPortalFOS
AceView (NCBI)FOS
Genatlas (Paris)FOS
WikiGenes2353
SOURCE (Princeton)FOS
Genetics Home Reference (NIH)FOS
Genomic and cartography
GoldenPath hg38 (UCSC)FOS  -     chr14:75278828-75282230 +  14q24.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FOS  -     14q24.3   [Description]    (hg19-Feb_2009)
GoldenPathFOS - 14q24.3 [CytoView hg19]  FOS - 14q24.3 [CytoView hg38]
ImmunoBaseENSG00000170345
genome Data Viewer NCBIFOS [Mapview hg19]  
OMIM164810   
Gene and transcription
Genbank (Entrez)AH003773 AK097379 AK290907 AK291326 AK298659
RefSeq transcript (Entrez)NM_005252
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FOS
Alternative Splicing GalleryENSG00000170345
Gene ExpressionFOS [ NCBI-GEO ]   FOS [ EBI - ARRAY_EXPRESS ]   FOS [ SEEK ]   FOS [ MEM ]
Gene Expression Viewer (FireBrowse)FOS [ Firebrowse - Broad ]
GenevisibleExpression of FOS in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2353
GTEX Portal (Tissue expression)FOS
Human Protein AtlasENSG00000170345-FOS [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP01100   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP01100  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP01100
Splice isoforms : SwissVarP01100
PhosPhoSitePlusP01100
Domaine pattern : Prosite (Expaxy)BZIP (PS50217)    BZIP_BASIC (PS00036)   
Domains : Interpro (EBI)AP-1    bZIP    c-Fos/v-Fos   
Domain families : Pfam (Sanger)bZIP_1 (PF00170)   
Domain families : Pfam (NCBI)pfam00170   
Domain families : Smart (EMBL)BRLZ (SM00338)  
Conserved Domain (NCBI)FOS
DMDM Disease mutations2353
Blocks (Seattle)FOS
PDB (RSDB)1A02    1FOS    1S9K   
PDB Europe1A02    1FOS    1S9K   
PDB (PDBSum)1A02    1FOS    1S9K   
PDB (IMB)1A02    1FOS    1S9K   
Structural Biology KnowledgeBase1A02    1FOS    1S9K   
SCOP (Structural Classification of Proteins)1A02    1FOS    1S9K   
CATH (Classification of proteins structures)1A02    1FOS    1S9K   
SuperfamilyP01100
Human Protein Atlas [tissue]ENSG00000170345-FOS [tissue]
Peptide AtlasP01100
HPRD01275
IPIIPI00033008   IPI01013952   IPI01024850   IPI01024729   IPI01025564   IPI01025439   IPI01025006   IPI01026292   IPI01024750   
Protein Interaction databases
DIP (DOE-UCLA)P01100
IntAct (EBI)P01100
FunCoupENSG00000170345
BioGRIDFOS
STRING (EMBL)FOS
ZODIACFOS
Ontologies - Pathways
QuickGOP01100
Ontology : AmiGOnuclear chromatin  transcription regulatory region sequence-specific DNA binding  RNA polymerase II proximal promoter sequence-specific DNA binding  RNA polymerase II core promoter sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  RNA polymerase II activating transcription factor binding  DNA-binding transcription activator activity, RNA polymerase II-specific  conditioned taste aversion  chromatin binding  DNA-binding transcription factor activity  DNA-binding transcription factor activity  protein binding  nucleus  nucleus  nucleoplasm  nucleoplasm  endoplasmic reticulum  cytosol  DNA methylation  regulation of transcription by RNA polymerase II  transcription by RNA polymerase II  inflammatory response  transforming growth factor beta receptor signaling pathway  nervous system development  female pregnancy  aging  transcription factor binding  response to cold  response to light stimulus  response to gravity  response to toxic substance  membrane  cytokine-mediated signaling pathway  sleep  cellular response to extracellular stimulus  response to lipopolysaccharide  response to progesterone  cellular response to hormone stimulus  protein-DNA complex  cellular response to reactive oxygen species  cellular response to reactive oxygen species  response to immobilization stress  skeletal muscle cell differentiation  transcription factor AP-1 complex  transcription factor AP-1 complex  response to muscle stretch  Fc-epsilon receptor signaling pathway  neuron projection  protein-containing complex binding  positive regulation of osteoclast differentiation  positive regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  regulation of DNA-binding transcription factor activity  response to corticosterone  response to cAMP  SMAD protein signal transduction  R-SMAD binding  cellular response to cadmium ion  cellular response to calcium ion  positive regulation of neuron death  positive regulation of pri-miRNA transcription by RNA polymerase II  
Ontology : EGO-EBInuclear chromatin  transcription regulatory region sequence-specific DNA binding  RNA polymerase II proximal promoter sequence-specific DNA binding  RNA polymerase II core promoter sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  RNA polymerase II activating transcription factor binding  DNA-binding transcription activator activity, RNA polymerase II-specific  conditioned taste aversion  chromatin binding  DNA-binding transcription factor activity  DNA-binding transcription factor activity  protein binding  nucleus  nucleus  nucleoplasm  nucleoplasm  endoplasmic reticulum  cytosol  DNA methylation  regulation of transcription by RNA polymerase II  transcription by RNA polymerase II  inflammatory response  transforming growth factor beta receptor signaling pathway  nervous system development  female pregnancy  aging  transcription factor binding  response to cold  response to light stimulus  response to gravity  response to toxic substance  membrane  cytokine-mediated signaling pathway  sleep  cellular response to extracellular stimulus  response to lipopolysaccharide  response to progesterone  cellular response to hormone stimulus  protein-DNA complex  cellular response to reactive oxygen species  cellular response to reactive oxygen species  response to immobilization stress  skeletal muscle cell differentiation  transcription factor AP-1 complex  transcription factor AP-1 complex  response to muscle stretch  Fc-epsilon receptor signaling pathway  neuron projection  protein-containing complex binding  positive regulation of osteoclast differentiation  positive regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  regulation of DNA-binding transcription factor activity  response to corticosterone  response to cAMP  SMAD protein signal transduction  R-SMAD binding  cellular response to cadmium ion  cellular response to calcium ion  positive regulation of neuron death  positive regulation of pri-miRNA transcription by RNA polymerase II  
Pathways : KEGGMAPK signaling pathway    Osteoclast differentiation    Toll-like receptor signaling pathway    T cell receptor signaling pathway    B cell receptor signaling pathway    TNF signaling pathway    Circadian entrainment    Cholinergic synapse    Dopaminergic synapse    Estrogen signaling pathway    Prolactin signaling pathway    Amphetamine addiction    Salmonella infection    Pertussis    Leishmaniasis    Chagas disease (American trypanosomiasis)    Hepatitis B    HTLV-I infection    Herpes simplex infection    Pathways in cancer    Colorectal cancer    Rheumatoid arthritis   
NDEx NetworkFOS
Atlas of Cancer Signalling NetworkFOS
Wikipedia pathwaysFOS
Orthology - Evolution
OrthoDB2353
GeneTree (enSembl)ENSG00000170345
Phylogenetic Trees/Animal Genes : TreeFamFOS
HOGENOMP01100
Homologs : HomoloGeneFOS
Homology/Alignments : Family Browser (UCSC)FOS
Gene fusions - Rearrangements
Fusion : QuiverFOS
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFOS [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FOS
dbVarFOS
ClinVarFOS
1000_GenomesFOS 
Exome Variant ServerFOS
GNOMAD BrowserENSG00000170345
Varsome BrowserFOS
Genetic variants : HAPMAP2353
Genomic Variants (DGV)FOS [DGVbeta]
DECIPHERFOS [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFOS 
Mutations
ICGC Data PortalFOS 
TCGA Data PortalFOS 
Broad Tumor PortalFOS
OASIS PortalFOS [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFOS  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DFOS
Mutations and Diseases : HGMDFOS
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FOS
DgiDB (Drug Gene Interaction Database)FOS
DoCM (Curated mutations)FOS (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FOS (select a term)
intoGenFOS
Cancer3DFOS(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM164810   
Orphanet1007   
DisGeNETFOS
MedgenFOS
Genetic Testing Registry FOS
NextProtP01100 [Medical]
TSGene2353
GENETestsFOS
Target ValidationFOS
Huge Navigator FOS [HugePedia]
snp3D : Map Gene to Disease2353
BioCentury BCIQFOS
ClinGenFOS
Clinical trials, drugs, therapy
Protein Interactions : CTD2353
Pharm GKB GenePA28212
Pharm GKB PathwaysPA162356267   PA165985892   
Clinical trialFOS
Miscellaneous
canSAR (ICR)FOS (select the gene name)
HarmonizomeFOS
DataMed IndexFOS
Probes
Litterature
PubMed456 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFOS
EVEXFOS
GoPubMedFOS
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Jul 16 15:13:47 CEST 2020
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