Fusion genes
(updated 2016) | BBOX1 (11p14.2) / FOS (14q24.3) | FOS (14q24.3) / FOS (14q24.3) | FOS (14q24.3) / LGALS3BP (17q25.3) |
| |
FOS (14q24.3) / LMNA (1q22) | FOS (14q24.3) / MAST2 (1p34.1) | FOS (14q24.3) / MBNL1 (3q25.1) |
| |
FOS (14q24.3) / SPTBN1 (2p16.2) | FOS (14q24.3) / VIM (10p13) | LOC100507412 (-) / FOS (14q24.3) |
| |
OSBPL10 (3p23) / FOS (14q24.3) |
| Nomenclature |
|---|
| HGNC (Hugo) | FOS 3796 |
| Cards |
|---|
| Entrez_Gene (NCBI) | FOS 2353 Fos proto-oncogene, AP-1 transcription factor subunit |
| Aliases | AP-1; C-FOS; p55 |
| GeneCards (Weizmann) | FOS |
| Ensembl hg19 (Hinxton) | ENSG00000170345 [Gene_View] |
| Ensembl hg38 (Hinxton) | ENSG00000170345 [Gene_View] chr14:75278778-75282234 [Contig_View] FOS [Vega] |
| ICGC DataPortal | ENSG00000170345 |
| TCGA cBioPortal | FOS |
| AceView (NCBI) | FOS |
| Genatlas (Paris) | FOS |
| WikiGenes | 2353 |
| SOURCE (Princeton) | FOS |
| Genetics Home Reference (NIH) | FOS |
| Genomic and cartography |
|---|
| GoldenPath hg38 (UCSC) | FOS - chr14:75278778-75282234 + 14q24.3 [Description] (hg38-Dec_2013) |
| GoldenPath hg19 (UCSC) | FOS - 14q24.3 [Description] (hg19-Feb_2009) |
| Ensembl | FOS - 14q24.3 [CytoView hg19] FOS - 14q24.3 [CytoView hg38] |
| Mapping of homologs : NCBI | FOS [Mapview hg19] FOS [Mapview hg38] |
| OMIM | 164810 |
| Gene and transcription |
|---|
| Genbank (Entrez) | AH003773 AK097379 AK290907 AK291326 AK298659 |
| RefSeq transcript (Entrez) | NM_005252 |
| RefSeq genomic (Entrez) | |
| Consensus coding sequences : CCDS (NCBI) | FOS |
| Cluster EST : Unigene | Hs.25647 [ NCBI ] |
| CGAP (NCI) | Hs.25647 |
| Alternative Splicing Gallery | ENSG00000170345 |
| Gene Expression | FOS [ NCBI-GEO ] FOS [ EBI - ARRAY_EXPRESS ]
FOS [ SEEK ] FOS [ MEM ] |
| Gene Expression Viewer (FireBrowse) | FOS [ Firebrowse - Broad ] |
| SOURCE (Princeton) | Expression in : [Datasets] [Normal Tissue Atlas] [carcinoma Classsification] [NCI60] |
| Genevisible | Expression in : [tissues] [cell-lines] [cancer] [perturbations] |
| BioGPS (Tissue expression) | 2353 |
| GTEX Portal (Tissue expression) | FOS |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | P01100 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
| NextProt | P01100 [Sequence] [Exons] [Medical] [Publications] |
| With graphics : InterPro | P01100 |
| Splice isoforms : SwissVar | P01100 |
| PhosPhoSitePlus | P01100 |
| Domaine pattern : Prosite (Expaxy) | BZIP (PS50217) BZIP_BASIC (PS00036) |
| Domains : Interpro (EBI) | AP-1 bZIP c-Fos/v-Fos |
| Domain families : Pfam (Sanger) | bZIP_1 (PF00170) |
| Domain families : Pfam (NCBI) | pfam00170 |
| Domain families : Smart (EMBL) | BRLZ (SM00338) |
| Conserved Domain (NCBI) | FOS |
| DMDM Disease mutations | 2353 |
| Blocks (Seattle) | FOS |
| PDB (SRS) | 1A02 1FOS 1S9K |
| PDB (PDBSum) | 1A02 1FOS 1S9K |
| PDB (IMB) | 1A02 1FOS 1S9K |
| PDB (RSDB) | 1A02 1FOS 1S9K |
| Structural Biology KnowledgeBase | 1A02 1FOS 1S9K |
| SCOP (Structural Classification of Proteins) | 1A02 1FOS 1S9K |
| CATH (Classification of proteins structures) | 1A02 1FOS 1S9K |
| Superfamily | P01100 |
| Human Protein Atlas | ENSG00000170345 |
| Peptide Atlas | P01100 |
| HPRD | 01275 |
| IPI | IPI00033008 IPI01013952 IPI01024850 IPI01024729 IPI01025564 IPI01025439 IPI01025006 IPI01026292 IPI01024750 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | P01100 |
| IntAct (EBI) | P01100 |
| FunCoup | ENSG00000170345 |
| BioGRID | FOS |
| STRING (EMBL) | FOS |
| ZODIAC | FOS |
| Ontologies - Pathways |
|---|
| QuickGO | P01100 |
| Ontology : AmiGO | RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II core promoter sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding RNA polymerase II activating transcription factor binding transcriptional activator activity, RNA polymerase II transcription factor binding conditioned taste aversion chromatin binding transcription factor activity, sequence-specific DNA binding protein binding nucleus nucleoplasm nucleoplasm endoplasmic reticulum cytosol DNA methylation regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter inflammatory response transforming growth factor beta receptor signaling pathway nervous system development female pregnancy aging transcription factor binding response to cold response to light stimulus response to gravity response to toxic substance membrane sleep cellular response to extracellular stimulus response to lipopolysaccharide response to progesterone cellular response to hormone stimulus protein-DNA complex response to cytokine cellular response to reactive oxygen species cellular response to reactive oxygen species response to immobilization stress skeletal muscle cell differentiation transcription factor AP-1 complex transcription factor AP-1 complex response to muscle stretch Fc-epsilon receptor signaling pathway response to drug neuron projection transcription regulatory region DNA binding positive regulation of osteoclast differentiation positive regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of transcription from RNA polymerase II promoter positive regulation of transcription from RNA polymerase II promoter protein heterodimerization activity regulation of sequence-specific DNA binding transcription factor activity response to corticosterone response to cAMP SMAD protein signal transduction R-SMAD binding cellular response to cadmium ion cellular response to calcium ion positive regulation of pri-miRNA transcription from RNA polymerase II promoter |
| Ontology : EGO-EBI | RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II core promoter sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding RNA polymerase II activating transcription factor binding transcriptional activator activity, RNA polymerase II transcription factor binding conditioned taste aversion chromatin binding transcription factor activity, sequence-specific DNA binding protein binding nucleus nucleoplasm nucleoplasm endoplasmic reticulum cytosol DNA methylation regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter inflammatory response transforming growth factor beta receptor signaling pathway nervous system development female pregnancy aging transcription factor binding response to cold response to light stimulus response to gravity response to toxic substance membrane sleep cellular response to extracellular stimulus response to lipopolysaccharide response to progesterone cellular response to hormone stimulus protein-DNA complex response to cytokine cellular response to reactive oxygen species cellular response to reactive oxygen species response to immobilization stress skeletal muscle cell differentiation transcription factor AP-1 complex transcription factor AP-1 complex response to muscle stretch Fc-epsilon receptor signaling pathway response to drug neuron projection transcription regulatory region DNA binding positive regulation of osteoclast differentiation positive regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of transcription from RNA polymerase II promoter positive regulation of transcription from RNA polymerase II promoter protein heterodimerization activity regulation of sequence-specific DNA binding transcription factor activity response to corticosterone response to cAMP SMAD protein signal transduction R-SMAD binding cellular response to cadmium ion cellular response to calcium ion positive regulation of pri-miRNA transcription from RNA polymerase II promoter |
| Pathways : BIOCARTA | [Genes] |
| Pathways : KEGG | |
| NDEx Network | FOS |
| Atlas of Cancer Signalling Network | FOS |
| Wikipedia pathways | FOS |
| Orthology - Evolution |
|---|
| OrthoDB | 2353 |
| GeneTree (enSembl) | ENSG00000170345 |
| Phylogenetic Trees/Animal Genes : TreeFam | FOS |
| HOVERGEN | P01100 |
| HOGENOM | P01100 |
| Homologs : HomoloGene | FOS |
| Homology/Alignments : Family Browser (UCSC) | FOS |
| Gene fusions - Rearrangements |
|---|
| Polymorphisms : SNP and Copy number variants |
|---|
| NCBI Variation Viewer | FOS [hg38] |
| dbSNP Single Nucleotide Polymorphism (NCBI) | FOS |
| dbVar | FOS |
| ClinVar | FOS |
| 1000_Genomes | FOS |
| Exome Variant Server | FOS |
| ExAC (Exome Aggregation Consortium) | FOS (select the gene name) |
| Genetic variants : HAPMAP | 2353 |
| Genomic Variants (DGV) | FOS [DGVbeta] |
| DECIPHER | FOS [patients] [syndromes] [variants] [genes] |
| CONAN: Copy Number Analysis | FOS |
| Mutations |
|---|
| ICGC Data Portal | FOS |
| TCGA Data Portal | FOS |
| Broad Tumor Portal | FOS |
| OASIS Portal | FOS [ Somatic mutations - Copy number] |
| Somatic Mutations in Cancer : COSMIC | FOS [overview] [genome browser] [tissue] [distribution] |
| Mutations and Diseases : HGMD | FOS |
| LOVD (Leiden Open Variation Database) | Whole genome datasets |
| LOVD (Leiden Open Variation Database) | LOVD - Leiden Open Variation Database |
| LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
| BioMuta | search FOS |
| DgiDB (Drug Gene Interaction Database) | FOS |
| DoCM (Curated mutations) | FOS (select the gene name) |
| CIViC (Clinical Interpretations of Variants in Cancer) | FOS (select a term) |
| intoGen | FOS |
| Cancer3D | FOS(select the gene name) |
| Impact of mutations | [PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
|---|
| OMIM | 164810 |
| Orphanet | 1007 |
| Medgen | FOS |
| Genetic Testing Registry | FOS
|
| NextProt | P01100 [Medical] |
| TSGene | 2353 |
| GENETests | FOS |
| Target Validation | FOS |
| Huge Navigator |
FOS [HugePedia] |
| snp3D : Map Gene to Disease | 2353 |
| BioCentury BCIQ | FOS |
| ClinGen | FOS |
| Clinical trials, drugs, therapy |
|---|
| Chemical/Protein Interactions : CTD | 2353 |
| Chemical/Pharm GKB Gene | PA28212 |
| Clinical trial | FOS |
| Miscellaneous |
|---|
| canSAR (ICR) | FOS (select the gene name) |
| Probes |
|---|
| Litterature |
|---|
| PubMed | 404 Pubmed reference(s) in Entrez |
| GeneRIFs | Gene References Into Functions (Entrez) |
| CoreMine | FOS |
| EVEX | FOS |
| GoPubMed | FOS |
| iHOP | FOS |
