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FOSB (FosB proto-oncogene, AP-1 transcription factor subunit)

Identity

Alias_namesFBJ murine osteosarcoma viral oncogene homolog B
Alias_symbol (synonym)G0S3
GOSB
GOS3
AP-1
MGC42291
DKFZp686C0818
Other alias
HGNC (Hugo) FOSB
LocusID (NCBI) 2354
Atlas_Id 40621
Location 19q13.32  [Link to chromosome band 19q13]
Location_base_pair Starts at 45467995 and ends at 45475179 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
LMNA (1q22) / FOSB (19q13.32)SERPINE1 (7q22.1) / FOSB (19q13.32)WWTR1 (3q25.1) / FOSB (19q13.32)
ZFP36 (19q13.2) / FOSB (19q13.32)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  Pseudomyogenic hemangioendothelioma: t(7;19)(q22;q13) SERPINE1/FOSB
Bone: Vascular Tumors


External links

Nomenclature
HGNC (Hugo)FOSB   3797
Cards
Entrez_Gene (NCBI)FOSB  2354  FosB proto-oncogene, AP-1 transcription factor subunit
AliasesAP-1; G0S3; GOS3; GOSB
GeneCards (Weizmann)FOSB
Ensembl hg19 (Hinxton)ENSG00000125740 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000125740 [Gene_View]  chr19:45467995-45475179 [Contig_View]  FOSB [Vega]
ICGC DataPortalENSG00000125740
TCGA cBioPortalFOSB
AceView (NCBI)FOSB
Genatlas (Paris)FOSB
WikiGenes2354
SOURCE (Princeton)FOSB
Genetics Home Reference (NIH)FOSB
Genomic and cartography
GoldenPath hg38 (UCSC)FOSB  -     chr19:45467995-45475179 +  19q13.32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FOSB  -     19q13.32   [Description]    (hg19-Feb_2009)
EnsemblFOSB - 19q13.32 [CytoView hg19]  FOSB - 19q13.32 [CytoView hg38]
Mapping of homologs : NCBIFOSB [Mapview hg19]  FOSB [Mapview hg38]
OMIM164772   
Gene and transcription
Genbank (Entrez)AF432216 AK225070 AK292720 BC036724 BC040197
RefSeq transcript (Entrez)NM_001114171 NM_006732
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FOSB
Cluster EST : UnigeneHs.590958 [ NCBI ]
CGAP (NCI)Hs.590958
Alternative Splicing GalleryENSG00000125740
Gene ExpressionFOSB [ NCBI-GEO ]   FOSB [ EBI - ARRAY_EXPRESS ]   FOSB [ SEEK ]   FOSB [ MEM ]
Gene Expression Viewer (FireBrowse)FOSB [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2354
GTEX Portal (Tissue expression)FOSB
Protein : pattern, domain, 3D structure
UniProt/SwissProtP53539   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP53539  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP53539
Splice isoforms : SwissVarP53539
PhosPhoSitePlusP53539
Domaine pattern : Prosite (Expaxy)BZIP (PS50217)    BZIP_BASIC (PS00036)   
Domains : Interpro (EBI)AP-1    bZIP    FosB   
Domain families : Pfam (Sanger)bZIP_1 (PF00170)   
Domain families : Pfam (NCBI)pfam00170   
Domain families : Smart (EMBL)BRLZ (SM00338)  
Conserved Domain (NCBI)FOSB
DMDM Disease mutations2354
Blocks (Seattle)FOSB
SuperfamilyP53539
Human Protein AtlasENSG00000125740
Peptide AtlasP53539
HPRD01270
IPIIPI00295556   IPI00878153   IPI00979546   IPI00879624   IPI00879189   IPI00879011   IPI00877591   
Protein Interaction databases
DIP (DOE-UCLA)P53539
IntAct (EBI)P53539
FunCoupENSG00000125740
BioGRIDFOSB
STRING (EMBL)FOSB
ZODIACFOSB
Ontologies - Pathways
QuickGOP53539
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  RNA polymerase II core promoter proximal region sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding  DNA binding  nucleus  nucleoplasm  transcription from RNA polymerase II promoter  female pregnancy  transcription factor binding  response to mechanical stimulus  response to progesterone  cellular response to hormone stimulus  response to drug  intracellular membrane-bounded organelle  response to morphine  positive regulation of transcription from RNA polymerase II promoter  response to corticosterone  response to cAMP  cellular response to calcium ion  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  RNA polymerase II core promoter proximal region sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding  DNA binding  nucleus  nucleoplasm  transcription from RNA polymerase II promoter  female pregnancy  transcription factor binding  response to mechanical stimulus  response to progesterone  cellular response to hormone stimulus  response to drug  intracellular membrane-bounded organelle  response to morphine  positive regulation of transcription from RNA polymerase II promoter  response to corticosterone  response to cAMP  cellular response to calcium ion  
Pathways : BIOCARTAFOSB gene expression and drug abuse [Genes]   
Pathways : KEGGOsteoclast differentiation    Cocaine addiction    Amphetamine addiction    Alcoholism   
NDEx NetworkFOSB
Atlas of Cancer Signalling NetworkFOSB
Wikipedia pathwaysFOSB
Orthology - Evolution
OrthoDB2354
GeneTree (enSembl)ENSG00000125740
Phylogenetic Trees/Animal Genes : TreeFamFOSB
HOVERGENP53539
HOGENOMP53539
Homologs : HomoloGeneFOSB
Homology/Alignments : Family Browser (UCSC)FOSB
Gene fusions - Rearrangements
Fusion : MitelmanLMNA/FOSB [1q22/19q13.32]  [t(1;19)(q22;q13)]  
Fusion : MitelmanSERPINE1/FOSB [7q22.1/19q13.32]  [t(7;19)(q22;q13)]  
Fusion : MitelmanWWTR1/FOSB [3q25.1/19q13.32]  [t(3;19)(q25;q13)]  
Fusion : MitelmanZFP36/FOSB [19q13.2/19q13.32]  [t(19;19)(q13;q13)]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFOSB [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FOSB
dbVarFOSB
ClinVarFOSB
1000_GenomesFOSB 
Exome Variant ServerFOSB
ExAC (Exome Aggregation Consortium)FOSB (select the gene name)
Genetic variants : HAPMAP2354
Genomic Variants (DGV)FOSB [DGVbeta]
DECIPHERFOSB [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFOSB 
Mutations
ICGC Data PortalFOSB 
TCGA Data PortalFOSB 
Broad Tumor PortalFOSB
OASIS PortalFOSB [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFOSB  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDFOSB
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FOSB
DgiDB (Drug Gene Interaction Database)FOSB
DoCM (Curated mutations)FOSB (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FOSB (select a term)
intoGenFOSB
Cancer3DFOSB(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM164772   
Orphanet
MedgenFOSB
Genetic Testing Registry FOSB
NextProtP53539 [Medical]
TSGene2354
GENETestsFOSB
Target ValidationFOSB
Huge Navigator FOSB [HugePedia]
snp3D : Map Gene to Disease2354
BioCentury BCIQFOSB
ClinGenFOSB
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2354
Chemical/Pharm GKB GenePA28213
Clinical trialFOSB
Miscellaneous
canSAR (ICR)FOSB (select the gene name)
Probes
Litterature
PubMed53 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFOSB
EVEXFOSB
GoPubMedFOSB
iHOPFOSB
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:34:12 CEST 2017

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