FOSL2 (FOS like 2, AP-1 transcription factor subunit)

2003-02-01  

Identity

HGNC
LOCATION
2p23.2
LOCUSID
ALIAS
FRA2
FUSION GENES

Other Information

Locus ID:

NCBI: 2355
MIM: 601575
HGNC: 3798
Ensembl: ENSG00000075426

Variants:

dbSNP: 2355
ClinVar: 2355
TCGA: ENSG00000075426
COSMIC: FOSL2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000075426ENST00000264716P15408
ENSG00000075426ENST00000379619P15408
ENSG00000075426ENST00000436647C9JCN8

Expression (GTEx)

0
50
100
150
200
250

Pathways

PathwaySourceExternal ID
Osteoclast differentiationKEGGko04380
Osteoclast differentiationKEGGhsa04380

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA283MAPK8GenePathwayassociated23922006
PA30621MAPK14GenePathwayassociated23922006

References

Pubmed IDYearTitleCitations
198745742009Genetical genomic determinants of alcohol consumption in rats and humans.93
186411272008Development of pulmonary fibrosis through a pathway involving the transcription factor Fra-2/AP-1.48
193217462009Gene deregulation and spatial genome reorganization near breakpoints prior to formation of translocations in anaplastic large cell lymphoma.39
208377722010Fra-2/AP-1 controls bone formation by regulating osteoblast differentiation and collagen production.29
223269522012FOSL2 promotes leptin gene expression in human and mouse adipocytes.27
199339342009Transcription factor fos-related antigen-2 induces progressive peripheral vasculopathy in mice closely resembling human systemic sclerosis.21
293304622018miR-143-3p inhibits the proliferation, migration and invasion in osteosarcoma by targeting FOSL2.20
173932992008Role of Fra-2 in breast cancer: influence on tumor cell invasion and motility.18
200394272010The transcription factor Fra-2 regulates the production of extracellular matrix in systemic sclerosis.18
225234312012Fra-2 transgenic mice as a novel model of pulmonary hypertension associated with systemic sclerosis.17

Citation

Dessen P

FOSL2 (FOS like 2, AP-1 transcription factor subunit)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40623/fosl2