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FOSL2 (FOS like 2, AP-1 transcription factor subunit)

Identity

Alias (NCBI)FRA2
HGNC (Hugo) FOSL2
HGNC Alias symbFRA2
FLJ23306
HGNC Previous nameFOS like antigen 2
LocusID (NCBI) 2355
Atlas_Id 40623
Location 2p23.2  [Link to chromosome band 2p23]
Location_base_pair Starts at 28392858 and ends at 28417317 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
FOSL2 (2p23.2) / BRE (2p23.2)FOSL2 (2p23.2) / FOSL2 (2p23.2)FOSL2 (2p23.2) / INTS10 (8p21.3)
TAF1B (2p25.1) / FOSL2 (2p23.2)FOSL2 2p23.2 / BRE 2p23.2TAF1B 2p25.1 / FOSL2 2p23.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(14;19)(q32;q13) IGH/Various Partners


External links

 

Nomenclature
HGNC (Hugo)FOSL2   3798
Cards
Entrez_Gene (NCBI)FOSL2    FOS like 2, AP-1 transcription factor subunit
AliasesFRA2
GeneCards (Weizmann)FOSL2
Ensembl hg19 (Hinxton)ENSG00000075426 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000075426 [Gene_View]  ENSG00000075426 [Sequence]  chr2:28392858-28417317 [Contig_View]  FOSL2 [Vega]
ICGC DataPortalENSG00000075426
TCGA cBioPortalFOSL2
AceView (NCBI)FOSL2
Genatlas (Paris)FOSL2
SOURCE (Princeton)FOSL2
Genetics Home Reference (NIH)FOSL2
Genomic and cartography
GoldenPath hg38 (UCSC)FOSL2  -     chr2:28392858-28417317 +  2p23.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FOSL2  -     2p23.2   [Description]    (hg19-Feb_2009)
GoldenPathFOSL2 - 2p23.2 [CytoView hg19]  FOSL2 - 2p23.2 [CytoView hg38]
ImmunoBaseENSG00000075426
Genome Data Viewer NCBIFOSL2 [Mapview hg19]  
OMIM601575   
Gene and transcription
Genbank (Entrez)AK026959 AK055579 AK302622 AK315415 BC008899
RefSeq transcript (Entrez)NM_005253
Consensus coding sequences : CCDS (NCBI)FOSL2
Gene ExpressionFOSL2 [ NCBI-GEO ]   FOSL2 [ EBI - ARRAY_EXPRESS ]   FOSL2 [ SEEK ]   FOSL2 [ MEM ]
Gene Expression Viewer (FireBrowse)FOSL2 [ Firebrowse - Broad ]
GenevisibleExpression of FOSL2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2355
GTEX Portal (Tissue expression)FOSL2
Human Protein AtlasENSG00000075426-FOSL2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP15408   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP15408  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP15408
PhosPhoSitePlusP15408
Domaine pattern : Prosite (Expaxy)BZIP (PS50217)    BZIP_BASIC (PS00036)   
Domains : Interpro (EBI)AP-1    bZIP    Fra2   
Domain families : Pfam (Sanger)bZIP_1 (PF00170)   
Domain families : Pfam (NCBI)pfam00170   
Domain families : Smart (EMBL)BRLZ (SM00338)  
Conserved Domain (NCBI)FOSL2
SuperfamilyP15408
AlphaFold pdb e-kbP15408   
Human Protein Atlas [tissue]ENSG00000075426-FOSL2 [tissue]
HPRD03343
Protein Interaction databases
DIP (DOE-UCLA)P15408
IntAct (EBI)P15408
BioGRIDFOSL2
STRING (EMBL)FOSL2
ZODIACFOSL2
Ontologies - Pathways
QuickGOP15408
Ontology : AmiGOchromatin  RNA polymerase II transcription regulatory region sequence-specific DNA binding  RNA polymerase II cis-regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription activator activity, RNA polymerase II-specific  keratinocyte development  chromatin binding  DNA-binding transcription factor activity  protein binding  nucleus  nucleoplasm  regulation of transcription by RNA polymerase II  cell death  positive regulation of transcription by RNA polymerase II  positive regulation of fibroblast proliferation  
Ontology : EGO-EBIchromatin  RNA polymerase II transcription regulatory region sequence-specific DNA binding  RNA polymerase II cis-regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription activator activity, RNA polymerase II-specific  keratinocyte development  chromatin binding  DNA-binding transcription factor activity  protein binding  nucleus  nucleoplasm  regulation of transcription by RNA polymerase II  cell death  positive regulation of transcription by RNA polymerase II  positive regulation of fibroblast proliferation  
Pathways : BIOCARTABone Remodelling [Genes]   
Pathways : KEGGOsteoclast differentiation   
NDEx NetworkFOSL2
Atlas of Cancer Signalling NetworkFOSL2
Wikipedia pathwaysFOSL2
Orthology - Evolution
OrthoDB2355
GeneTree (enSembl)ENSG00000075426
Phylogenetic Trees/Animal Genes : TreeFamFOSL2
Homologs : HomoloGeneFOSL2
Homology/Alignments : Family Browser (UCSC)FOSL2
Gene fusions - Rearrangements
Fusion : MitelmanFOSL2/BRE [2p23.2/2p23.2]  
Fusion : MitelmanTAF1B/FOSL2 [2p25.1/2p23.2]  
Fusion : QuiverFOSL2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFOSL2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FOSL2
dbVarFOSL2
ClinVarFOSL2
MonarchFOSL2
1000_GenomesFOSL2 
Exome Variant ServerFOSL2
GNOMAD BrowserENSG00000075426
Varsome BrowserFOSL2
ACMGFOSL2 variants
VarityP15408
Genomic Variants (DGV)FOSL2 [DGVbeta]
DECIPHERFOSL2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFOSL2 
Mutations
ICGC Data PortalFOSL2 
TCGA Data PortalFOSL2 
Broad Tumor PortalFOSL2
OASIS PortalFOSL2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFOSL2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DFOSL2
Mutations and Diseases : HGMDFOSL2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaFOSL2
DgiDB (Drug Gene Interaction Database)FOSL2
DoCM (Curated mutations)FOSL2
CIViC (Clinical Interpretations of Variants in Cancer)FOSL2
Cancer3DFOSL2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601575   
Orphanet
DisGeNETFOSL2
MedgenFOSL2
Genetic Testing Registry FOSL2
NextProtP15408 [Medical]
GENETestsFOSL2
Target ValidationFOSL2
Huge Navigator FOSL2 [HugePedia]
ClinGenFOSL2
Clinical trials, drugs, therapy
MyCancerGenomeFOSL2
Protein Interactions : CTDFOSL2
Pharm GKB GenePA28215
Pharm GKB PathwaysPA165985892   
PharosP15408
Clinical trialFOSL2
Miscellaneous
canSAR (ICR)FOSL2
HarmonizomeFOSL2
DataMed IndexFOSL2
Probes
Litterature
PubMed72 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXFOSL2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Oct 4 15:09:46 CEST 2021

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