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FOSL2 (FOS like 2, AP-1 transcription factor subunit)

Identity

Alias_namesFOS like antigen 2
Alias_symbol (synonym)FRA2
FLJ23306
Other alias
HGNC (Hugo) FOSL2
LocusID (NCBI) 2355
Atlas_Id 40623
Location 2p23.2  [Link to chromosome band 2p23]
Location_base_pair Starts at 28392912 and ends at 28414649 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
FOSL2 (2p23.2) / BRE (2p23.2)FOSL2 (2p23.2) / FOSL2 (2p23.2)FOSL2 (2p23.2) / INTS10 (8p21.3)
TAF1B (2p25.1) / FOSL2 (2p23.2)FOSL2 2p23.2 / BRE 2p23.2TAF1B 2p25.1 / FOSL2 2p23.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)FOSL2   3798
Cards
Entrez_Gene (NCBI)FOSL2  2355  FOS like 2, AP-1 transcription factor subunit
AliasesFRA2
GeneCards (Weizmann)FOSL2
Ensembl hg19 (Hinxton)ENSG00000075426 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000075426 [Gene_View]  chr2:28392912-28414649 [Contig_View]  FOSL2 [Vega]
ICGC DataPortalENSG00000075426
TCGA cBioPortalFOSL2
AceView (NCBI)FOSL2
Genatlas (Paris)FOSL2
WikiGenes2355
SOURCE (Princeton)FOSL2
Genetics Home Reference (NIH)FOSL2
Genomic and cartography
GoldenPath hg38 (UCSC)FOSL2  -     chr2:28392912-28414649 +  2p23.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FOSL2  -     2p23.2   [Description]    (hg19-Feb_2009)
EnsemblFOSL2 - 2p23.2 [CytoView hg19]  FOSL2 - 2p23.2 [CytoView hg38]
Mapping of homologs : NCBIFOSL2 [Mapview hg19]  FOSL2 [Mapview hg38]
OMIM601575   
Gene and transcription
Genbank (Entrez)AK026959 AK055579 AK302622 AK315415 BC008899
RefSeq transcript (Entrez)NM_005253
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FOSL2
Cluster EST : UnigeneHs.596972 [ NCBI ]
CGAP (NCI)Hs.596972
Alternative Splicing GalleryENSG00000075426
Gene ExpressionFOSL2 [ NCBI-GEO ]   FOSL2 [ EBI - ARRAY_EXPRESS ]   FOSL2 [ SEEK ]   FOSL2 [ MEM ]
Gene Expression Viewer (FireBrowse)FOSL2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2355
GTEX Portal (Tissue expression)FOSL2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP15408   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP15408  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP15408
Splice isoforms : SwissVarP15408
PhosPhoSitePlusP15408
Domaine pattern : Prosite (Expaxy)BZIP (PS50217)    BZIP_BASIC (PS00036)   
Domains : Interpro (EBI)AP-1    bZIP    Fra2   
Domain families : Pfam (Sanger)bZIP_1 (PF00170)   
Domain families : Pfam (NCBI)pfam00170   
Domain families : Smart (EMBL)BRLZ (SM00338)  
Conserved Domain (NCBI)FOSL2
DMDM Disease mutations2355
Blocks (Seattle)FOSL2
SuperfamilyP15408
Human Protein AtlasENSG00000075426
Peptide AtlasP15408
HPRD03343
IPIIPI00011593   IPI00657842   IPI00893858   IPI00002169   
Protein Interaction databases
DIP (DOE-UCLA)P15408
IntAct (EBI)P15408
FunCoupENSG00000075426
BioGRIDFOSL2
STRING (EMBL)FOSL2
ZODIACFOSL2
Ontologies - Pathways
QuickGOP15408
Ontology : AmiGORNA polymerase II regulatory region sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding  keratinocyte development  chromatin binding  transcription factor activity, sequence-specific DNA binding  protein binding  nucleus  nucleoplasm  regulation of transcription from RNA polymerase II promoter  transcription from RNA polymerase II promoter  cell death  positive regulation of transcription from RNA polymerase II promoter  positive regulation of fibroblast proliferation  
Ontology : EGO-EBIRNA polymerase II regulatory region sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding  keratinocyte development  chromatin binding  transcription factor activity, sequence-specific DNA binding  protein binding  nucleus  nucleoplasm  regulation of transcription from RNA polymerase II promoter  transcription from RNA polymerase II promoter  cell death  positive regulation of transcription from RNA polymerase II promoter  positive regulation of fibroblast proliferation  
Pathways : BIOCARTABone Remodelling [Genes]   
Pathways : KEGGOsteoclast differentiation   
NDEx NetworkFOSL2
Atlas of Cancer Signalling NetworkFOSL2
Wikipedia pathwaysFOSL2
Orthology - Evolution
OrthoDB2355
GeneTree (enSembl)ENSG00000075426
Phylogenetic Trees/Animal Genes : TreeFamFOSL2
HOVERGENP15408
HOGENOMP15408
Homologs : HomoloGeneFOSL2
Homology/Alignments : Family Browser (UCSC)FOSL2
Gene fusions - Rearrangements
Fusion : MitelmanFOSL2/BRE [2p23.2/2p23.2]  
Fusion : MitelmanTAF1B/FOSL2 [2p25.1/2p23.2]  [t(2;2)(p23;p25)]  
Fusion: TCGAFOSL2 2p23.2 BRE 2p23.2 BRCA LUSC
Fusion: TCGATAF1B 2p25.1 FOSL2 2p23.2 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFOSL2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FOSL2
dbVarFOSL2
ClinVarFOSL2
1000_GenomesFOSL2 
Exome Variant ServerFOSL2
ExAC (Exome Aggregation Consortium)FOSL2 (select the gene name)
Genetic variants : HAPMAP2355
Genomic Variants (DGV)FOSL2 [DGVbeta]
DECIPHERFOSL2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFOSL2 
Mutations
ICGC Data PortalFOSL2 
TCGA Data PortalFOSL2 
Broad Tumor PortalFOSL2
OASIS PortalFOSL2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFOSL2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDFOSL2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FOSL2
DgiDB (Drug Gene Interaction Database)FOSL2
DoCM (Curated mutations)FOSL2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FOSL2 (select a term)
intoGenFOSL2
Cancer3DFOSL2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601575   
Orphanet
MedgenFOSL2
Genetic Testing Registry FOSL2
NextProtP15408 [Medical]
TSGene2355
GENETestsFOSL2
Target ValidationFOSL2
Huge Navigator FOSL2 [HugePedia]
snp3D : Map Gene to Disease2355
BioCentury BCIQFOSL2
ClinGenFOSL2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2355
Chemical/Pharm GKB GenePA28215
Clinical trialFOSL2
Miscellaneous
canSAR (ICR)FOSL2 (select the gene name)
Probes
Litterature
PubMed48 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFOSL2
EVEXFOSL2
GoPubMedFOSL2
iHOPFOSL2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 13:53:39 CEST 2017

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