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FOXA2 (forkhead box A2)

Identity

Alias (NCBI)HNF-3-beta
HNF3B
TCF3B
HGNC (Hugo) FOXA2
HGNC Previous nameHNF3B
HGNC Previous namehepatocyte nuclear factor 3, beta
LocusID (NCBI) 3170
Atlas_Id 43740
Location 20p11.21  [Link to chromosome band 20p11]
Location_base_pair Starts at 22581000 and ends at 22585490 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
GOLGA2 (9q34.11) / FOXA2 (20p11.21)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)FOXA2   5022
Cards
Entrez_Gene (NCBI)FOXA2    forkhead box A2
AliasesHNF-3-beta; HNF3B; TCF3B
GeneCards (Weizmann)FOXA2
Ensembl hg19 (Hinxton)ENSG00000125798 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000125798 [Gene_View]  ENSG00000125798 [Sequence]  chr20:22581000-22585490 [Contig_View]  FOXA2 [Vega]
ICGC DataPortalENSG00000125798
TCGA cBioPortalFOXA2
AceView (NCBI)FOXA2
Genatlas (Paris)FOXA2
SOURCE (Princeton)FOXA2
Genetics Home Reference (NIH)FOXA2
Genomic and cartography
GoldenPath hg38 (UCSC)FOXA2  -     chr20:22581000-22585490 -  20p11.21   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FOXA2  -     20p11.21   [Description]    (hg19-Feb_2009)
GoldenPathFOXA2 - 20p11.21 [CytoView hg19]  FOXA2 - 20p11.21 [CytoView hg38]
ImmunoBaseENSG00000125798
Genome Data Viewer NCBIFOXA2 [Mapview hg19]  
OMIM600288   
Gene and transcription
Genbank (Entrez)AA469087 AB028021 AI268650 AI302734 AK301611
RefSeq transcript (Entrez)NM_021784 NM_153675
Consensus coding sequences : CCDS (NCBI)FOXA2
Gene ExpressionFOXA2 [ NCBI-GEO ]   FOXA2 [ EBI - ARRAY_EXPRESS ]   FOXA2 [ SEEK ]   FOXA2 [ MEM ]
Gene Expression Viewer (FireBrowse)FOXA2 [ Firebrowse - Broad ]
GenevisibleExpression of FOXA2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3170
GTEX Portal (Tissue expression)FOXA2
Human Protein AtlasENSG00000125798-FOXA2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y261   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y261  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y261
PhosPhoSitePlusQ9Y261
Domaine pattern : Prosite (Expaxy)FORK_HEAD_1 (PS00657)    FORK_HEAD_2 (PS00658)    FORK_HEAD_3 (PS50039)   
Domains : Interpro (EBI)Fork-head_N    Fork_head_dom    Forkhead_box_C    TF_fork_head_CS_1    TF_fork_head_CS_2    WH-like_DNA-bd_sf    WH_DNA-bd_sf   
Domain families : Pfam (Sanger)Forkhead (PF00250)    Forkhead_N (PF08430)    HNF_C (PF09354)   
Domain families : Pfam (NCBI)pfam00250    pfam08430    pfam09354   
Domain families : Smart (EMBL)FH (SM00339)  
Conserved Domain (NCBI)FOXA2
PDB (RSDB)5X07   
PDB Europe5X07   
PDB (PDBSum)5X07   
PDB (IMB)5X07   
Structural Biology KnowledgeBase5X07   
SCOP (Structural Classification of Proteins)5X07   
CATH (Classification of proteins structures)5X07   
SuperfamilyQ9Y261
AlphaFold pdb e-kbQ9Y261   
Human Protein Atlas [tissue]ENSG00000125798-FOXA2 [tissue]
HPRD02618
Protein Interaction databases
DIP (DOE-UCLA)Q9Y261
IntAct (EBI)Q9Y261
BioGRIDFOXA2
STRING (EMBL)FOXA2
ZODIACFOXA2
Ontologies - Pathways
QuickGOQ9Y261
Ontology : AmiGOpositive regulation of transcription from RNA polymerase II promoter by glucose  chromatin  transcription cis-regulatory region binding  RNA polymerase II cis-regulatory region sequence-specific DNA binding  RNA polymerase II cis-regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  cell fate specification  DNA binding  DNA-binding transcription factor activity  nucleus  nucleoplasm  cytoplasm  chromatin organization  regulation of transcription by RNA polymerase II  regulation of transcription by RNA polymerase II  adult locomotory behavior  anatomical structure morphogenesis  negative regulation of epithelial to mesenchymal transition  protein domain specific binding  cell junction  cell differentiation  regulation of blood coagulation  endocrine pancreas development  negative regulation of glucokinase activity  positive regulation of embryonic development  negative regulation of DNA-binding transcription factor activity  positive regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  regulation of insulin secretion involved in cellular response to glucose stimulus  negative regulation of transcription from RNA polymerase II promoter by glucose  response to interleukin-6  dopaminergic neuron differentiation  dopaminergic neuron differentiation  dopaminergic neuron differentiation  primitive streak formation  sequence-specific double-stranded DNA binding  positive regulation of cell-cell adhesion mediated by cadherin  positive regulation of gastrulation  negative regulation of detection of glucose  
Ontology : EGO-EBIpositive regulation of transcription from RNA polymerase II promoter by glucose  chromatin  transcription cis-regulatory region binding  RNA polymerase II cis-regulatory region sequence-specific DNA binding  RNA polymerase II cis-regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  cell fate specification  DNA binding  DNA-binding transcription factor activity  nucleus  nucleoplasm  cytoplasm  chromatin organization  regulation of transcription by RNA polymerase II  regulation of transcription by RNA polymerase II  adult locomotory behavior  anatomical structure morphogenesis  negative regulation of epithelial to mesenchymal transition  protein domain specific binding  cell junction  cell differentiation  regulation of blood coagulation  endocrine pancreas development  negative regulation of glucokinase activity  positive regulation of embryonic development  negative regulation of DNA-binding transcription factor activity  positive regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  regulation of insulin secretion involved in cellular response to glucose stimulus  negative regulation of transcription from RNA polymerase II promoter by glucose  response to interleukin-6  dopaminergic neuron differentiation  dopaminergic neuron differentiation  dopaminergic neuron differentiation  primitive streak formation  sequence-specific double-stranded DNA binding  positive regulation of cell-cell adhesion mediated by cadherin  positive regulation of gastrulation  negative regulation of detection of glucose  
Pathways : KEGGMaturity onset diabetes of the young   
NDEx NetworkFOXA2
Atlas of Cancer Signalling NetworkFOXA2
Wikipedia pathwaysFOXA2
Orthology - Evolution
OrthoDB3170
GeneTree (enSembl)ENSG00000125798
Phylogenetic Trees/Animal Genes : TreeFamFOXA2
Homologs : HomoloGeneFOXA2
Homology/Alignments : Family Browser (UCSC)FOXA2
Gene fusions - Rearrangements
Fusion : QuiverFOXA2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFOXA2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FOXA2
dbVarFOXA2
ClinVarFOXA2
MonarchFOXA2
1000_GenomesFOXA2 
Exome Variant ServerFOXA2
GNOMAD BrowserENSG00000125798
Varsome BrowserFOXA2
ACMGFOXA2 variants
VarityQ9Y261
Genomic Variants (DGV)FOXA2 [DGVbeta]
DECIPHERFOXA2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFOXA2 
Mutations
ICGC Data PortalFOXA2 
TCGA Data PortalFOXA2 
Broad Tumor PortalFOXA2
OASIS PortalFOXA2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFOXA2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DFOXA2
Mutations and Diseases : HGMDFOXA2
intOGen PortalFOXA2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaFOXA2
DgiDB (Drug Gene Interaction Database)FOXA2
DoCM (Curated mutations)FOXA2
CIViC (Clinical Interpretations of Variants in Cancer)FOXA2
Cancer3DFOXA2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600288   
Orphanet
DisGeNETFOXA2
MedgenFOXA2
Genetic Testing Registry FOXA2
NextProtQ9Y261 [Medical]
GENETestsFOXA2
Target ValidationFOXA2
Huge Navigator FOXA2 [HugePedia]
ClinGenFOXA2
Clinical trials, drugs, therapy
MyCancerGenomeFOXA2
Protein Interactions : CTDFOXA2
Pharm GKB GenePA201091
PharosQ9Y261
Clinical trialFOXA2
Miscellaneous
canSAR (ICR)FOXA2
HarmonizomeFOXA2
DataMed IndexFOXA2
Probes
Litterature
PubMed158 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXFOXA2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Oct 4 15:09:46 CEST 2021

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