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FOXA2 (forkhead box A2)

Identity

Alias_namesHNF3B
hepatocyte nuclear factor 3
Other aliasTCF3B
HGNC (Hugo) FOXA2
LocusID (NCBI) 3170
Atlas_Id 43740
Location 20p11.21  [Link to chromosome band 20p11]
Location_base_pair Starts at 22561642 and ends at 22565101 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
GOLGA2 (9q34.11) / FOXA2 (20p11.21)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)FOXA2   5022
Cards
Entrez_Gene (NCBI)FOXA2  3170  forkhead box A2
AliasesHNF3B; TCF3B
GeneCards (Weizmann)FOXA2
Ensembl hg19 (Hinxton)ENSG00000125798 [Gene_View]  chr20:22561642-22565101 [Contig_View]  FOXA2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000125798 [Gene_View]  chr20:22561642-22565101 [Contig_View]  FOXA2 [Vega]
ICGC DataPortalENSG00000125798
TCGA cBioPortalFOXA2
AceView (NCBI)FOXA2
Genatlas (Paris)FOXA2
WikiGenes3170
SOURCE (Princeton)FOXA2
Genetics Home Reference (NIH)FOXA2
Genomic and cartography
GoldenPath hg19 (UCSC)FOXA2  -     chr20:22561642-22565101 -  20p11.21   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)FOXA2  -     20p11.21   [Description]    (hg38-Dec_2013)
EnsemblFOXA2 - 20p11.21 [CytoView hg19]  FOXA2 - 20p11.21 [CytoView hg38]
Mapping of homologs : NCBIFOXA2 [Mapview hg19]  FOXA2 [Mapview hg38]
OMIM600288   
Gene and transcription
Genbank (Entrez)AA469087 AB028021 AI268650 AI302734 AK301611
RefSeq transcript (Entrez)NM_021784 NM_153675
RefSeq genomic (Entrez)NC_000020 NC_018931 NT_011387 NW_004929416
Consensus coding sequences : CCDS (NCBI)FOXA2
Cluster EST : UnigeneHs.155651 [ NCBI ]
CGAP (NCI)Hs.155651
Alternative Splicing GalleryENSG00000125798
Gene ExpressionFOXA2 [ NCBI-GEO ]   FOXA2 [ EBI - ARRAY_EXPRESS ]   FOXA2 [ SEEK ]   FOXA2 [ MEM ]
Gene Expression Viewer (FireBrowse)FOXA2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3170
GTEX Portal (Tissue expression)FOXA2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y261   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y261  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y261
Splice isoforms : SwissVarQ9Y261
PhosPhoSitePlusQ9Y261
Domaine pattern : Prosite (Expaxy)FORK_HEAD_1 (PS00657)    FORK_HEAD_2 (PS00658)    FORK_HEAD_3 (PS50039)   
Domains : Interpro (EBI)Fork-head_N    Fork_head_dom    Forkhead_box_C    TF_fork_head_CS_1    TF_fork_head_CS_2    WHTH_DNA-bd_dom   
Domain families : Pfam (Sanger)Forkhead (PF00250)    Forkhead_N (PF08430)    HNF_C (PF09354)   
Domain families : Pfam (NCBI)pfam00250    pfam08430    pfam09354   
Domain families : Smart (EMBL)FH (SM00339)  
Conserved Domain (NCBI)FOXA2
DMDM Disease mutations3170
Blocks (Seattle)FOXA2
SuperfamilyQ9Y261
Human Protein AtlasENSG00000125798
Peptide AtlasQ9Y261
HPRD02618
IPIIPI00031773   IPI00908346   IPI00910912   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y261
IntAct (EBI)Q9Y261
FunCoupENSG00000125798
BioGRIDFOXA2
STRING (EMBL)FOXA2
ZODIACFOXA2
Ontologies - Pathways
QuickGOQ9Y261
Ontology : AmiGOpositive regulation of transcription from RNA polymerase II promoter by glucose  negative regulation of transcription from RNA polymerase II promoter by glucose  RNA polymerase II core promoter proximal region sequence-specific DNA binding  RNA polymerase II transcription factor activity, sequence-specific DNA binding  cell fate specification  DNA binding  transcription factor activity, sequence-specific DNA binding  nucleus  nucleoplasm  cytoplasm  transcription, DNA-templated  regulation of transcription from RNA polymerase II promoter  transcription factor binding  adult locomotory behavior  negative regulation of epithelial to mesenchymal transition  chromatin modification  protein domain specific binding  cell junction  regulation of blood coagulation  endocrine pancreas development  negative regulation of glucokinase activity  positive regulation of embryonic development  negative regulation of sequence-specific DNA binding transcription factor activity  transcription regulatory region DNA binding  positive regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  positive regulation of transcription from RNA polymerase II promoter  regulation of insulin secretion involved in cellular response to glucose stimulus  response to interleukin-6  dopaminergic neuron differentiation  dopaminergic neuron differentiation  dopaminergic neuron differentiation  primitive streak formation  positive regulation of cell-cell adhesion mediated by cadherin  positive regulation of gastrulation  negative regulation of detection of glucose  
Ontology : EGO-EBIpositive regulation of transcription from RNA polymerase II promoter by glucose  negative regulation of transcription from RNA polymerase II promoter by glucose  RNA polymerase II core promoter proximal region sequence-specific DNA binding  RNA polymerase II transcription factor activity, sequence-specific DNA binding  cell fate specification  DNA binding  transcription factor activity, sequence-specific DNA binding  nucleus  nucleoplasm  cytoplasm  transcription, DNA-templated  regulation of transcription from RNA polymerase II promoter  transcription factor binding  adult locomotory behavior  negative regulation of epithelial to mesenchymal transition  chromatin modification  protein domain specific binding  cell junction  regulation of blood coagulation  endocrine pancreas development  negative regulation of glucokinase activity  positive regulation of embryonic development  negative regulation of sequence-specific DNA binding transcription factor activity  transcription regulatory region DNA binding  positive regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  positive regulation of transcription from RNA polymerase II promoter  regulation of insulin secretion involved in cellular response to glucose stimulus  response to interleukin-6  dopaminergic neuron differentiation  dopaminergic neuron differentiation  dopaminergic neuron differentiation  primitive streak formation  positive regulation of cell-cell adhesion mediated by cadherin  positive regulation of gastrulation  negative regulation of detection of glucose  
Pathways : KEGGMaturity onset diabetes of the young   
NDEx NetworkFOXA2
Atlas of Cancer Signalling NetworkFOXA2
Wikipedia pathwaysFOXA2
Orthology - Evolution
OrthoDB3170
GeneTree (enSembl)ENSG00000125798
Phylogenetic Trees/Animal Genes : TreeFamFOXA2
HOVERGENQ9Y261
HOGENOMQ9Y261
Homologs : HomoloGeneFOXA2
Homology/Alignments : Family Browser (UCSC)FOXA2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFOXA2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FOXA2
dbVarFOXA2
ClinVarFOXA2
1000_GenomesFOXA2 
Exome Variant ServerFOXA2
ExAC (Exome Aggregation Consortium)FOXA2 (select the gene name)
Genetic variants : HAPMAP3170
Genomic Variants (DGV)FOXA2 [DGVbeta]
DECIPHER (Syndromes)20:22561642-22565101  ENSG00000125798
CONAN: Copy Number AnalysisFOXA2 
Mutations
ICGC Data PortalFOXA2 
TCGA Data PortalFOXA2 
Broad Tumor PortalFOXA2
OASIS PortalFOXA2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFOXA2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDFOXA2
intOGen PortalFOXA2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FOXA2
DgiDB (Drug Gene Interaction Database)FOXA2
DoCM (Curated mutations)FOXA2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FOXA2 (select a term)
intoGenFOXA2
Cancer3DFOXA2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600288   
Orphanet
MedgenFOXA2
Genetic Testing Registry FOXA2
NextProtQ9Y261 [Medical]
TSGene3170
GENETestsFOXA2
Huge Navigator FOXA2 [HugePedia]
snp3D : Map Gene to Disease3170
BioCentury BCIQFOXA2
ClinGenFOXA2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3170
Chemical/Pharm GKB GenePA201091
Clinical trialFOXA2
Miscellaneous
canSAR (ICR)FOXA2 (select the gene name)
Probes
Litterature
PubMed97 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFOXA2
EVEXFOXA2
GoPubMedFOXA2
iHOPFOXA2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Thu Mar 30 15:01:30 CEST 2017

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