FOXA3 (forkhead box A3)

2007-04-01  

Identity

HGNC
LOCATION
19q13.32
LOCUSID
ALIAS
FKHH3,HNF3G,TCF3G

Other Information

Locus ID:

NCBI: 3171
MIM: 602295
HGNC: 5023
Ensembl: ENSG00000170608

Variants:

dbSNP: 3171
ClinVar: 3171
TCGA: ENSG00000170608
COSMIC: FOXA3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000170608ENST00000302177P55318
ENSG00000170608ENST00000302177A0A024R0R3
ENSG00000170608ENST00000594297M0QZW5

Expression (GTEx)

0
5
10
15
20
25
30
35

Pathways

PathwaySourceExternal ID
Maturity onset diabetes of the youngKEGGko04950
Maturity onset diabetes of the youngKEGGhsa04950
Developmental BiologyREACTOMER-HSA-1266738
Regulation of beta-cell developmentREACTOMER-HSA-186712
Regulation of gene expression in beta cellsREACTOMER-HSA-210745

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
243928842014Foxa3 induces goblet cell metaplasia and inhibits innate antiviral immunity.45
199196812009Differential binding and co-binding pattern of FOXA1 and FOXA3 and their relation to H3K4me3 in HepG2 cells revealed by ChIP-seq.34
199344002010Genetic predictors of interindividual variability in hepatic CYP3A4 expression.27
157379872005A hepatocyte nuclear factor-3 site in the fibrinogen beta promoter is important for interleukin 6-induced expression, and its activity is influenced by the adjacent -148C/T polymorphism.13
237985562013The winged helix transcription factor Foxa3 regulates adipocyte differentiation and depot-selective fat tissue expansion.10
256729062015Analysis of variants and mutations in the human winged helix FOXA3 gene and associations with metabolic traits.4
312917592019Hepatic Forkhead Box Protein A3 Regulates ApoA-I (Apolipoprotein A-I) Expression, Cholesterol Efflux, and Atherogenesis.4
226594292012[Caloric restriction suppresses endothelial cells senescence via down-regulation of NOX4 induced by HNF3γ].1

Citation

Dessen P

FOXA3 (forkhead box A3)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47123/foxa3