Atlas of Genetics and Cytogenetics in Oncology and Haematology

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FOXC2 (forkhead box C2 (MFH-1, mesenchyme forkhead 1))

Identity

Other namesFKHL14
LD
MFH-1
MFH1
HGNC (Hugo) FOXC2
LocusID (NCBI) 2303
Location 16q24.1
Location_base_pair Starts at 86600857 and ends at 86602537 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)FOXC2   3801
Entrez_Gene (NCBI)FOXC2  2303  forkhead box C2 (MFH-1, mesenchyme forkhead 1)
Cards
GeneCards (Weizmann)FOXC2
Ensembl (Hinxton)ENSG00000176692 [Gene_View]  chr16:86600857-86602537 [Contig_View]  FOXC2 [Vega]
AceView (NCBI)FOXC2
Genatlas (Paris)FOXC2
SOURCE (Stanford)NM_005251
Genomic and cartography
GoldenPath (UCSC)FOXC2  -  16q24.1   chr16:86600857-86602537 +  16q24.1   [Description]    (hg19-Feb_2009)
EnsemblFOXC2 - 16q24.1 [CytoView]
Mapping of homologs : NCBIFOXC2 [Mapview]
OMIM153200   153300   153400   602402   
Gene and transcription
Genbank (Entrez)BC111589 BC113437 BC113439
RefSeq transcript (SRS)NM_005251
RefSeq transcript (Entrez)NM_005251
RefSeq genomic (SRS)AC_000148 NC_000016 NC_018927 NG_012025 NT_010498 NW_001838329 NW_004078087
RefSeq genomic (Entrez)AC_000148 NC_000016 NC_018927 NG_012025 NT_010498 NW_001838329 NW_004078087
Consensus coding sequences : CCDS (NCBI)FOXC2
Cluster EST : UnigeneHs.740701 [ SRS ] Hs.740701 [ NCBI ]
CGAP (NCI)Hs.740701
Alternative Splicing : Fast-db (Paris)GSHG0011429
Alternative Splicing GalleryENSG00000176692
Gene ExpressionFOXC2 [ NCBI-GEO ]   FOXC2 [ EBI - ARRAY_EXPRESS ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ99958 (SRS) Q99958 (Uniprot)
NextProtQ99958
With graphics : InterProQ99958
Splice isoforms : SwissVarQ99958(Swissvar)
Domaine pattern : Prosite (SRS)FORK_HEAD_1 (PS00657)    FORK_HEAD_2 (PS00658)    FORK_HEAD_3 (PS50039)   
Domaine pattern : Prosite (Expaxy)FORK_HEAD_1 (PS00657)    FORK_HEAD_2 (PS00658)    FORK_HEAD_3 (PS50039)   
Domains : Interpro (SRS)TF_fork_head    TF_fork_head_CS    WHTH_trsnscrt_rep_DNA-bd   
Domains : Interpro (EBI)TF_fork_head    TF_fork_head_CS    WHTH_trsnscrt_rep_DNA-bd   
Related proteins : CluSTrQ99958
Domain families : Pfam (SRS)Fork_head (PF00250)   
Domain families : Pfam (Sanger)Fork_head (PF00250)   
Domain families : Pfam (NCBI)pfam00250   
Domain families : Smart (EMBL)FH (SM00339)  
DMDM2303
Blocks (Seattle)Q99958
PDB (SRS)1D5V   
PDB (PDBSum)1D5V   
PDB (IMB)1D5V   
PDB (RSDB)1D5V   
Human Protein AtlasENSG00000176692
HPRD03869
IPIIPI00019155   
Protein Interaction databases
DIP (DOE-UCLA)Q99958
IntAct (EBI)Q99958
FunCoupENSG00000176692
REACTOMEFOXC2
Protein Interaction Database2303
BioGRIDFOXC2
InParanoidQ99958
Interologous Interaction database Q99958
IntegromeDBFOXC2
Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)FOXC2
SNP (GeneSNP Utah)FOXC2
SNP : HGBaseFOXC2
Genetic variants : HAPMAPFOXC2
Somatic Mutations in Cancer : COSMICFOXC2 
CONAN: Copy Number AnalysisFOXC2 
Mutations and Diseases : HGMDFOXC2
OMIM153200    153300    153400    602402   
GENETests153200    153300    153400    602402   
Disease Genetic AssociationFOXC2
Huge Navigator FOXC2 [HugePedia]  FOXC2 [HugeCancerGEM]
Genomic VariantsFOXC2  FOXC2 [DGVbeta]
snp3D : Map Gene to Disease2303
General knowledge
Homologs : HomoloGeneFOXC2
Homology/Alignments : Family Browser (UCSC)FOXC2
Phylogenetic Trees/Animal Genes : TreeFamFOXC2
Chemical/Protein Interactions : CTD2303
Chemical/Pharm GKB GenePA28218
Clinical trialFOXC2
Cancer Resource (Charite)ENSG00000176692
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription  ossification  patterning of blood vessels  vasculogenesis  metanephros development  ureteric bud development  somitogenesis  lymphangiogenesis  blood vessel remodeling  double-stranded DNA binding  sequence-specific DNA binding transcription factor activity  RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity  nucleus  transcription factor complex  Notch signaling pathway  mesoderm development  heart development  transcription factor binding  insulin receptor signaling pathway  DNA binding, bending  response to hormone stimulus  positive regulation of endothelial cell migration  neural crest cell development  neural crest cell fate commitment  collagen fibril organization  chromatin DNA binding  positive regulation of cell adhesion mediated by integrin  embryonic heart tube development  positive regulation of vascular wound healing  camera-type eye development  sequence-specific DNA binding  transcription regulatory region DNA binding  positive regulation of transcription, DNA-dependent  positive regulation of transcription from RNA polymerase II promoter  positive regulation of transcription from RNA polymerase II promoter  regulation of organ growth  vascular endothelial growth factor receptor signaling pathway  paraxial mesodermal cell fate commitment  embryonic viscerocranium morphogenesis  artery morphogenesis  regulation of blood vessel size  regulation of sequence-specific DNA binding transcription factor activity  ventricular cardiac muscle tissue morphogenesis  cardiac muscle cell proliferation  glomerular endothelium development  glomerular visceral epithelial cell differentiation  glomerular mesangial cell development  positive regulation of cell migration involved in sprouting angiogenesis  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription  ossification  patterning of blood vessels  vasculogenesis  metanephros development  ureteric bud development  somitogenesis  lymphangiogenesis  blood vessel remodeling  double-stranded DNA binding  sequence-specific DNA binding transcription factor activity  RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity  nucleus  transcription factor complex  Notch signaling pathway  mesoderm development  heart development  transcription factor binding  insulin receptor signaling pathway  DNA binding, bending  response to hormone stimulus  positive regulation of endothelial cell migration  neural crest cell development  neural crest cell fate commitment  collagen fibril organization  chromatin DNA binding  positive regulation of cell adhesion mediated by integrin  embryonic heart tube development  positive regulation of vascular wound healing  camera-type eye development  sequence-specific DNA binding  transcription regulatory region DNA binding  positive regulation of transcription, DNA-dependent  positive regulation of transcription from RNA polymerase II promoter  positive regulation of transcription from RNA polymerase II promoter  regulation of organ growth  vascular endothelial growth factor receptor signaling pathway  paraxial mesodermal cell fate commitment  embryonic viscerocranium morphogenesis  artery morphogenesis  regulation of blood vessel size  regulation of sequence-specific DNA binding transcription factor activity  ventricular cardiac muscle tissue morphogenesis  cardiac muscle cell proliferation  glomerular endothelium development  glomerular visceral epithelial cell differentiation  glomerular mesangial cell development  positive regulation of cell migration involved in sprouting angiogenesis  
Other databases
Probes
Litterature
PubMed73 Pubmed reference(s) in Entrez
PubGeneFOXC2
iHOPFOXC2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated01-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed May 1 12:26:26 CEST 2013
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