Atlas of Genetics and Cytogenetics in Oncology and Haematology


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FOXC2 (forkhead box C2)

Identity

Other namesFKHL14
LD
MFH-1
MFH1
HGNC (Hugo) FOXC2
LocusID (NCBI) 2303
Atlas_Id 46819
Location 16q24.1
Location_base_pair Starts at 86600857 and ends at 86602537 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)FOXC2   3801
Cards
Entrez_Gene (NCBI)FOXC2  2303  forkhead box C2
GeneCards (Weizmann)FOXC2
Ensembl hg19 (Hinxton) [Gene_View]  chr16:86600857-86602537 [Contig_View]  FOXC2 [Vega]
Ensembl hg38 (Hinxton) [Gene_View]  chr16:86600857-86602537 [Contig_View]  FOXC2 [Vega]
TCGA cBioPortalFOXC2
AceView (NCBI)FOXC2
Genatlas (Paris)FOXC2
WikiGenes2303
SOURCE (Princeton)FOXC2
Genomic and cartography
GoldenPath hg19 (UCSC)FOXC2  -     chr16:86600857-86602537 +  16q24.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)FOXC2  -     16q24.1   [Description]    (hg38-Dec_2013)
EnsemblFOXC2 - 16q24.1 [CytoView hg19]  FOXC2 - 16q24.1 [CytoView hg38]
Mapping of homologs : NCBIFOXC2 [Mapview hg19]  FOXC2 [Mapview hg38]
OMIM153400   602402   
Gene and transcription
Genbank (Entrez)BC111589 BC113437 BC113439
RefSeq transcript (Entrez)NM_005251
RefSeq genomic (Entrez)NC_000016 NC_018927 NG_012025 NT_010498 NW_004929402
Consensus coding sequences : CCDS (NCBI)FOXC2
Cluster EST : UnigeneHs.436448 [ NCBI ]
CGAP (NCI)Hs.436448
Alternative Splicing : Fast-db (Paris)GSHG0011429
Gene ExpressionFOXC2 [ NCBI-GEO ]     FOXC2 [ SEEK ]   FOXC2 [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ99958 (Uniprot)
NextProtQ99958  [Medical]  [Publications]
With graphics : InterProQ99958
Splice isoforms : SwissVarQ99958 (Swissvar)
Domaine pattern : Prosite (Expaxy)FORK_HEAD_1 (PS00657)    FORK_HEAD_2 (PS00658)    FORK_HEAD_3 (PS50039)   
Domains : Interpro (EBI)TF_fork_head    TF_fork_head_CS_1    WHTH_DNA-bd_dom   
Related proteins : CluSTrQ99958
Domain families : Pfam (Sanger)Fork_head (PF00250)   
Domain families : Pfam (NCBI)pfam00250   
Domain families : Smart (EMBL)FH (SM00339)  
DMDM Disease mutations2303
Blocks (Seattle)Q99958
PDB (SRS)1D5V   
PDB (PDBSum)1D5V   
PDB (IMB)1D5V   
PDB (RSDB)1D5V   
Peptide AtlasQ99958
HPRD03869
IPIIPI00019155   
Protein Interaction databases
DIP (DOE-UCLA)Q99958
IntAct (EBI)Q99958
BioGRIDFOXC2
IntegromeDBFOXC2
STRING (EMBL)FOXC2
Ontologies - Pathways
QuickGOQ99958
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription  ossification  patterning of blood vessels  metanephros development  ureteric bud development  somitogenesis  lymphangiogenesis  blood vessel remodeling  sequence-specific DNA binding transcription factor activity  RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity  protein binding  nucleus  regulation of transcription from RNA polymerase II promoter  transcription from RNA polymerase II promoter  Notch signaling pathway  mesoderm development  heart development  insulin receptor signaling pathway  response to hormone  positive regulation of endothelial cell migration  neural crest cell development  cell differentiation  collagen fibril organization  chromatin DNA binding  positive regulation of cell adhesion mediated by integrin  embryonic heart tube development  positive regulation of vascular wound healing  camera-type eye development  sequence-specific DNA binding  transcription regulatory region DNA binding  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  regulation of organ growth  vascular endothelial growth factor receptor signaling pathway  paraxial mesodermal cell fate commitment  embryonic viscerocranium morphogenesis  artery morphogenesis  regulation of blood vessel size  ventricular cardiac muscle tissue morphogenesis  cardiac muscle cell proliferation  glomerular endothelium development  glomerular visceral epithelial cell differentiation  glomerular mesangial cell development  positive regulation of cell migration involved in sprouting angiogenesis  negative regulation of apoptotic process involved in outflow tract morphogenesis  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription  ossification  patterning of blood vessels  metanephros development  ureteric bud development  somitogenesis  lymphangiogenesis  blood vessel remodeling  sequence-specific DNA binding transcription factor activity  RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity  protein binding  nucleus  regulation of transcription from RNA polymerase II promoter  transcription from RNA polymerase II promoter  Notch signaling pathway  mesoderm development  heart development  insulin receptor signaling pathway  response to hormone  positive regulation of endothelial cell migration  neural crest cell development  cell differentiation  collagen fibril organization  chromatin DNA binding  positive regulation of cell adhesion mediated by integrin  embryonic heart tube development  positive regulation of vascular wound healing  camera-type eye development  sequence-specific DNA binding  transcription regulatory region DNA binding  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  regulation of organ growth  vascular endothelial growth factor receptor signaling pathway  paraxial mesodermal cell fate commitment  embryonic viscerocranium morphogenesis  artery morphogenesis  regulation of blood vessel size  ventricular cardiac muscle tissue morphogenesis  cardiac muscle cell proliferation  glomerular endothelium development  glomerular visceral epithelial cell differentiation  glomerular mesangial cell development  positive regulation of cell migration involved in sprouting angiogenesis  negative regulation of apoptotic process involved in outflow tract morphogenesis  
Protein Interaction DatabaseFOXC2
DoCM (Curated mutations)FOXC2
Wikipedia pathwaysFOXC2
Gene fusion - Rearrangements
Gene fusion: TCGA
Polymorphisms : SNP, variants
NCBI Variation ViewerFOXC2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FOXC2
dbVarFOXC2
ClinVarFOXC2
1000_GenomesFOXC2 
Exome Variant ServerFOXC2
SNP (GeneSNP Utah)FOXC2
SNP : HGBaseFOXC2
Genetic variants : HAPMAPFOXC2
Genomic Variants (DGV)FOXC2 [DGVbeta]
Mutations
ICGC Data PortalFOXC2 
TCGA Data PortalFOXC2 
Tumor PortalFOXC2
Somatic Mutations in Cancer : COSMICFOXC2 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Mendelian genes
LOVD (Leiden Open Variation Database)Vascular Anomaly and Lymphedema Mutation Database
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)16:86600857-86602537
CONAN: Copy Number AnalysisFOXC2 
Mutations and Diseases : HGMDFOXC2
OMIM153400    602402   
MedgenFOXC2
NextProtQ99958 [Medical]
GENETestsFOXC2
Disease Genetic AssociationFOXC2
Huge Navigator FOXC2 [HugePedia]  FOXC2 [HugeCancerGEM]
snp3D : Map Gene to Disease2303
DGIdb (Drug Gene Interaction db)FOXC2
BioCentury BCIQFOXC2
General knowledge
Homologs : HomoloGeneFOXC2
Homology/Alignments : Family Browser (UCSC)FOXC2
Phylogenetic Trees/Animal Genes : TreeFamFOXC2
Chemical/Protein Interactions : CTD2303
Chemical/Pharm GKB GenePA28218
Clinical trialFOXC2
Other databases
Probes
Litterature
PubMed90 Pubmed reference(s) in Entrez
CoreMineFOXC2
GoPubMedFOXC2
iHOPFOXC2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated02-2015Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Jun 27 11:34:46 CEST 2015

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