FOXD3 (forkhead box D3)

2007-04-01  

Identity

HGNC
LOCATION
1p31.3
LOCUSID
ALIAS
AIS1,Genesis,HFH2,VAMAS2

Other Information

Locus ID:

NCBI: 27022
MIM: 611539
HGNC: 3804
Ensembl: ENSG00000187140

Variants:

dbSNP: 27022
ClinVar: 27022
TCGA: ENSG00000187140
COSMIC: FOXD3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000187140ENST00000371116Q9UJU5

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50

Pathways

PathwaySourceExternal ID
Developmental BiologyREACTOMER-HSA-1266738
Transcriptional regulation of pluripotent stem cellsREACTOMER-HSA-452723
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferationREACTOMER-HSA-2892247

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
235430552013Melanoma adapts to RAF/MEK inhibitors through FOXD3-mediated upregulation of ERBB3.115
203322282010FOXD3 is a mutant B-RAF-regulated inhibitor of G(1)-S progression in melanoma cells.48
249708082014FoxD3-regulated microRNA-137 suppresses tumour growth and metastasis in human hepatocellular carcinoma by targeting AKT2.48
230583212013Helicobacter pylori causes epigenetic dysregulation of FOXD3 to promote gastric carcinogenesis.45
242699922013FOXD3 is a novel tumor suppressor that affects growth, invasion, metastasis and angiogenesis of neuroblastoma.34
160980532005Candidate functional promoter variant in the FOXD3 melanoblast developmental regulator gene in autosomal dominant vitiligo.22
268989892016The aspirin-induced long non-coding RNA OLA1P2 blocks phosphorylated STAT3 homodimer formation.21
214782672011FOXD3 regulates migration properties and Rnd3 expression in melanoma cells.20
238584372013Neural crest and Schwann cell progenitor-derived melanocytes are two spatially segregated populations similarly regulated by Foxd3.20
279265032017FOXD3 is a tumor suppressor of colon cancer by inhibiting EGFR-Ras-Raf-MEK-ERK signal pathway.14

Citation

Dessen P

FOXD3 (forkhead box D3)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47419/foxd3