FOXH1 (forkhead box H1)

2007-04-01  

Identity

HGNC
LOCATION
8q24.3
LOCUSID
ALIAS
FAST-1,FAST1

Other Information

Locus ID:

NCBI: 8928
MIM: 603621
HGNC: 3814
Ensembl: ENSG00000160973

Variants:

dbSNP: 8928
ClinVar: 8928
TCGA: ENSG00000160973
COSMIC: FOXH1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000160973ENST00000377317O75593

Expression (GTEx)

0
1
2

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by ActivinREACTOMER-HSA-1502540
Developmental BiologyREACTOMER-HSA-1266738
Signaling by NODALREACTOMER-HSA-1181150

References

Pubmed IDYearTitleCitations
185382932008Reduced NODAL signaling strength via mutation of several pathway members including FOXH1 is linked to human heart defects and holoprosencephaly.52
218282742011HEB and E2A function as SMAD/FOXH1 cofactors.37
157506222005Selective inhibition of TGF-beta responsive genes by Smad-interacting peptide aptamers from FoxH1, Lef1 and CBP.21
206348912010Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia.18
159826392005Transcriptional regulation of the homeobox gene Mixl1 by TGF-beta and FoxH1.12
161206112005Modulation of androgen receptor transactivation by FoxH1. A newly identified androgen receptor corepressor.7
195250212010Forkhead box H1 (FOXH1) sequence variants in ventricular septal defect.3
195250212010Forkhead box H1 (FOXH1) sequence variants in ventricular septal defect.3
197110442009PKA-mediated stabilization of FoxH1 negatively regulates ERalpha activity.3
157377492005Expression of the FAST-1 transcription factor in coronary artery transplant vasculopathy and activated vascular smooth muscle cells.2

Citation

Dessen P

FOXH1 (forkhead box H1)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46704/foxh1