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FOXK2 (forkhead box K2)

Identity

Alias_namesILF
ILF1
interleukin enhancer binding factor 1
Other aliasILF-1
HGNC (Hugo) FOXK2
LocusID (NCBI) 3607
Atlas_Id 46881
Location 17q25.3  [Link to chromosome band 17q25]
Location_base_pair Starts at 82519718 and ends at 82604607 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
DNAJA4 (15q25.1) / FOXK2 (17q25.3)EIF4G2 (11p15.3) / FOXK2 (17q25.3)FOXK2 (17q25.3) / ABCA5 (17q24.3)
FOXK2 (17q25.3) / CAD (2p23.3)FOXK2 (17q25.3) / CLIP2 (7q11.23)FOXK2 (17q25.3) / FOXK2 (17q25.3)
FOXK2 (17q25.3) / HEXDC (17q25.3)FOXK2 (17q25.3) / MADCAM1 (19p13.3)FOXK2 (17q25.3) / NARF (17q25.3)
FOXK2 (17q25.3) / PITPNC1 (17q24.2)FOXK2 (17q25.3) / SKAP1 (17q21.32)FOXK2 (17q25.3) / TIAF1 (17q11.2)
TBCD (17q25.3) / FOXK2 (17q25.3)FOXK2 17q25.3 / ABCA5 17q24.3FOXK2 17q25.3 / MADCAM1 19p13.3
FOXK2 17q25.3 / NARF 17q25.3FOXK2 17q25.3 / PITPNC1 17q24.2FOXK2 17q25.3 / SKAP1 17q21.32
FOXK2 17q25.3 / TIAF1 17q11.2TBCD 17q25.3 / FOXK2 17q25.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Small Cell Carcinoma


External links

Nomenclature
HGNC (Hugo)FOXK2   6036
Cards
Entrez_Gene (NCBI)FOXK2  3607  forkhead box K2
AliasesILF; ILF-1; ILF1
GeneCards (Weizmann)FOXK2
Ensembl hg19 (Hinxton)ENSG00000141568 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000141568 [Gene_View]  chr17:82519718-82604607 [Contig_View]  FOXK2 [Vega]
ICGC DataPortalENSG00000141568
TCGA cBioPortalFOXK2
AceView (NCBI)FOXK2
Genatlas (Paris)FOXK2
WikiGenes3607
SOURCE (Princeton)FOXK2
Genetics Home Reference (NIH)FOXK2
Genomic and cartography
GoldenPath hg38 (UCSC)FOXK2  -     chr17:82519718-82604607 +  17q25.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FOXK2  -     17q25.3   [Description]    (hg19-Feb_2009)
EnsemblFOXK2 - 17q25.3 [CytoView hg19]  FOXK2 - 17q25.3 [CytoView hg38]
Mapping of homologs : NCBIFOXK2 [Mapview hg19]  FOXK2 [Mapview hg38]
OMIM147685   
Gene and transcription
Genbank (Entrez)AA889932 AK096800 AK098140 AL832570 BC041569
RefSeq transcript (Entrez)NM_004514 NM_181430 NM_181431
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FOXK2
Cluster EST : UnigeneHs.591140 [ NCBI ]
CGAP (NCI)Hs.591140
Alternative Splicing GalleryENSG00000141568
Gene ExpressionFOXK2 [ NCBI-GEO ]   FOXK2 [ EBI - ARRAY_EXPRESS ]   FOXK2 [ SEEK ]   FOXK2 [ MEM ]
Gene Expression Viewer (FireBrowse)FOXK2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3607
GTEX Portal (Tissue expression)FOXK2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ01167   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ01167  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ01167
Splice isoforms : SwissVarQ01167
PhosPhoSitePlusQ01167
Domaine pattern : Prosite (Expaxy)FHA_DOMAIN (PS50006)    FORK_HEAD_1 (PS00657)    FORK_HEAD_2 (PS00658)    FORK_HEAD_3 (PS50039)   
Domains : Interpro (EBI)FHA_dom    Fork_head_dom    SMAD_FHA_domain    TF_fork_head_CS_1    TF_fork_head_CS_2    WHTH_DNA-bd_dom   
Domain families : Pfam (Sanger)FHA (PF00498)    Forkhead (PF00250)   
Domain families : Pfam (NCBI)pfam00498    pfam00250   
Domain families : Smart (EMBL)FH (SM00339)  FHA (SM00240)  
Conserved Domain (NCBI)FOXK2
DMDM Disease mutations3607
Blocks (Seattle)FOXK2
PDB (SRS)1JXS    2C6Y   
PDB (PDBSum)1JXS    2C6Y   
PDB (IMB)1JXS    2C6Y   
PDB (RSDB)1JXS    2C6Y   
Structural Biology KnowledgeBase1JXS    2C6Y   
SCOP (Structural Classification of Proteins)1JXS    2C6Y   
CATH (Classification of proteins structures)1JXS    2C6Y   
SuperfamilyQ01167
Human Protein AtlasENSG00000141568
Peptide AtlasQ01167
HPRD00982
IPIIPI00006029   IPI00220426   IPI00479612   IPI01013081   IPI00035361   IPI00982638   
Protein Interaction databases
DIP (DOE-UCLA)Q01167
IntAct (EBI)Q01167
FunCoupENSG00000141568
BioGRIDFOXK2
STRING (EMBL)FOXK2
ZODIACFOXK2
Ontologies - Pathways
QuickGOQ01167
Ontology : AmiGOmagnesium ion binding  RNA polymerase II core promoter proximal region sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding  transcription factor activity, sequence-specific DNA binding  protein binding  nucleus  nucleus  nucleoplasm  regulation of transcription, DNA-templated  regulation of transcription from RNA polymerase II promoter  transcription from RNA polymerase II promoter  protein deubiquitination  sequence-specific DNA binding  positive regulation of transcription from RNA polymerase II promoter  
Ontology : EGO-EBImagnesium ion binding  RNA polymerase II core promoter proximal region sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding  transcription factor activity, sequence-specific DNA binding  protein binding  nucleus  nucleus  nucleoplasm  regulation of transcription, DNA-templated  regulation of transcription from RNA polymerase II promoter  transcription from RNA polymerase II promoter  protein deubiquitination  sequence-specific DNA binding  positive regulation of transcription from RNA polymerase II promoter  
NDEx NetworkFOXK2
Atlas of Cancer Signalling NetworkFOXK2
Wikipedia pathwaysFOXK2
Orthology - Evolution
OrthoDB3607
GeneTree (enSembl)ENSG00000141568
Phylogenetic Trees/Animal Genes : TreeFamFOXK2
HOVERGENQ01167
HOGENOMQ01167
Homologs : HomoloGeneFOXK2
Homology/Alignments : Family Browser (UCSC)FOXK2
Gene fusions - Rearrangements
Fusion : MitelmanFOXK2/ABCA5 [17q25.3/17q24.3]  
Fusion : MitelmanFOXK2/HEXDC [17q25.3/17q25.3]  [t(17;17)(q25;q25)]  
Fusion : MitelmanFOXK2/MADCAM1 [17q25.3/19p13.3]  [t(17;19)(q25;p13)]  
Fusion : MitelmanFOXK2/NARF [17q25.3/17q25.3]  [t(17;17)(q25;q25)]  
Fusion : MitelmanFOXK2/PITPNC1 [17q25.3/17q24.2]  [t(17;17)(q24;q25)]  
Fusion : MitelmanFOXK2/SKAP1 [17q25.3/17q21.32]  [t(17;17)(q21;q25)]  
Fusion : MitelmanFOXK2/TIAF1 [17q25.3/17q11.2]  [t(17;17)(q11;q25)]  
Fusion : MitelmanTBCD/FOXK2 [17q25.3/17q25.3]  [t(17;17)(q25;q25)]  
Fusion: TCGAFOXK2 17q25.3 ABCA5 17q24.3 BRCA
Fusion: TCGAFOXK2 17q25.3 MADCAM1 19p13.3 BRCA
Fusion: TCGAFOXK2 17q25.3 NARF 17q25.3 OV
Fusion: TCGAFOXK2 17q25.3 PITPNC1 17q24.2 BRCA
Fusion: TCGAFOXK2 17q25.3 SKAP1 17q21.32 BRCA
Fusion: TCGAFOXK2 17q25.3 TIAF1 17q11.2 BRCA
Fusion: TCGATBCD 17q25.3 FOXK2 17q25.3 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFOXK2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FOXK2
dbVarFOXK2
ClinVarFOXK2
1000_GenomesFOXK2 
Exome Variant ServerFOXK2
ExAC (Exome Aggregation Consortium)FOXK2 (select the gene name)
Genetic variants : HAPMAP3607
Genomic Variants (DGV)FOXK2 [DGVbeta]
DECIPHERFOXK2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFOXK2 
Mutations
ICGC Data PortalFOXK2 
TCGA Data PortalFOXK2 
Broad Tumor PortalFOXK2
OASIS PortalFOXK2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFOXK2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDFOXK2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FOXK2
DgiDB (Drug Gene Interaction Database)FOXK2
DoCM (Curated mutations)FOXK2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FOXK2 (select a term)
intoGenFOXK2
Cancer3DFOXK2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM147685   
Orphanet
MedgenFOXK2
Genetic Testing Registry FOXK2
NextProtQ01167 [Medical]
TSGene3607
GENETestsFOXK2
Target ValidationFOXK2
Huge Navigator FOXK2 [HugePedia]
snp3D : Map Gene to Disease3607
BioCentury BCIQFOXK2
ClinGenFOXK2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3607
Chemical/Pharm GKB GenePA29851
Clinical trialFOXK2
Miscellaneous
canSAR (ICR)FOXK2 (select the gene name)
Probes
Litterature
PubMed35 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFOXK2
EVEXFOXK2
GoPubMedFOXK2
iHOPFOXK2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:34:18 CEST 2017

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