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FOXK2 (forkhead box K2)

Identity

Alias (NCBI)ILF
ILF-1
ILF1
nGTBP
HGNC (Hugo) FOXK2
HGNC Previous nameILF
 ILF1
HGNC Previous nameinterleukin enhancer binding factor 1
LocusID (NCBI) 3607
Atlas_Id 46881
Location 17q25.3  [Link to chromosome band 17q25]
Location_base_pair Starts at 82519732 and ends at 82604602 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DNAJA4 (15q25.1) / FOXK2 (17q25.3)EIF4G2 (11p15.3) / FOXK2 (17q25.3)FOXK2 (17q25.3) / ABCA5 (17q24.3)
FOXK2 (17q25.3) / CAD (2p23.3)FOXK2 (17q25.3) / CLIP2 (7q11.23)FOXK2 (17q25.3) / FOXK2 (17q25.3)
FOXK2 (17q25.3) / HEXDC (17q25.3)FOXK2 (17q25.3) / MADCAM1 (19p13.3)FOXK2 (17q25.3) / NARF (17q25.3)
FOXK2 (17q25.3) / PITPNC1 (17q24.2)FOXK2 (17q25.3) / SKAP1 (17q21.32)FOXK2 (17q25.3) / TIAF1 (17q11.2)
TBCD (17q25.3) / FOXK2 (17q25.3)FOXK2 17q25.3 / ABCA5 17q24.3FOXK2 17q25.3 / MADCAM1 19p13.3
FOXK2 17q25.3 / NARF 17q25.3FOXK2 17q25.3 / PITPNC1 17q24.2FOXK2 17q25.3 / SKAP1 17q21.32
FOXK2 17q25.3 / TIAF1 17q11.2TBCD 17q25.3 / FOXK2 17q25.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(7;17)(q11;q25) FOXK2/CLIP2


External links

 

Nomenclature
HGNC (Hugo)FOXK2   6036
Cards
Entrez_Gene (NCBI)FOXK2    forkhead box K2
AliasesILF; ILF-1; ILF1; nGTBP
GeneCards (Weizmann)FOXK2
Ensembl hg19 (Hinxton)ENSG00000141568 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000141568 [Gene_View]  ENSG00000141568 [Sequence]  chr17:82519732-82604602 [Contig_View]  FOXK2 [Vega]
ICGC DataPortalENSG00000141568
TCGA cBioPortalFOXK2
AceView (NCBI)FOXK2
Genatlas (Paris)FOXK2
SOURCE (Princeton)FOXK2
Genetics Home Reference (NIH)FOXK2
Genomic and cartography
GoldenPath hg38 (UCSC)FOXK2  -     chr17:82519732-82604602 +  17q25.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FOXK2  -     17q25.3   [Description]    (hg19-Feb_2009)
GoldenPathFOXK2 - 17q25.3 [CytoView hg19]  FOXK2 - 17q25.3 [CytoView hg38]
ImmunoBaseENSG00000141568
Genome Data Viewer NCBIFOXK2 [Mapview hg19]  
OMIM147685   
Gene and transcription
Genbank (Entrez)AA889932 AK096800 AK098140 AL832570 BC041569
RefSeq transcript (Entrez)NM_004514 NM_181430 NM_181431
Consensus coding sequences : CCDS (NCBI)FOXK2
Gene ExpressionFOXK2 [ NCBI-GEO ]   FOXK2 [ EBI - ARRAY_EXPRESS ]   FOXK2 [ SEEK ]   FOXK2 [ MEM ]
Gene Expression Viewer (FireBrowse)FOXK2 [ Firebrowse - Broad ]
GenevisibleExpression of FOXK2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3607
GTEX Portal (Tissue expression)FOXK2
Human Protein AtlasENSG00000141568-FOXK2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ01167   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ01167  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ01167
PhosPhoSitePlusQ01167
Domaine pattern : Prosite (Expaxy)FHA_DOMAIN (PS50006)    FORK_HEAD_1 (PS00657)    FORK_HEAD_2 (PS00658)    FORK_HEAD_3 (PS50039)   
Domains : Interpro (EBI)FHA_dom    Fork_head_dom    SMAD_FHA_dom_sf    TF_fork_head_CS_1    TF_fork_head_CS_2    WH-like_DNA-bd_sf    WH_DNA-bd_sf   
Domain families : Pfam (Sanger)FHA (PF00498)    Forkhead (PF00250)   
Domain families : Pfam (NCBI)pfam00498    pfam00250   
Domain families : Smart (EMBL)FH (SM00339)  FHA (SM00240)  
Conserved Domain (NCBI)FOXK2
PDB (RSDB)1JXS    2C6Y   
PDB Europe1JXS    2C6Y   
PDB (PDBSum)1JXS    2C6Y   
PDB (IMB)1JXS    2C6Y   
Structural Biology KnowledgeBase1JXS    2C6Y   
SCOP (Structural Classification of Proteins)1JXS    2C6Y   
CATH (Classification of proteins structures)1JXS    2C6Y   
SuperfamilyQ01167
AlphaFold pdb e-kbQ01167   
Human Protein Atlas [tissue]ENSG00000141568-FOXK2 [tissue]
HPRD00982
Protein Interaction databases
DIP (DOE-UCLA)Q01167
IntAct (EBI)Q01167
BioGRIDFOXK2
STRING (EMBL)FOXK2
ZODIACFOXK2
Ontologies - Pathways
QuickGOQ01167
Ontology : AmiGOnegative regulation of transcription by RNA polymerase II  magnesium ion binding  chromatin  transcription cis-regulatory region binding  RNA polymerase II cis-regulatory region sequence-specific DNA binding  RNA polymerase II cis-regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription repressor activity, RNA polymerase II-specific  DNA-binding transcription activator activity, RNA polymerase II-specific  cellular glucose homeostasis  DNA-binding transcription factor activity  DNA-binding transcription factor activity  protein binding  nucleus  nucleus  nucleoplasm  nucleoplasm  mitochondrion  regulation of transcription, DNA-templated  regulation of transcription by RNA polymerase II  negative regulation of autophagy  regulation of glucose metabolic process  protein deubiquitination  response to starvation  intracellular membrane-bounded organelle  sequence-specific DNA binding  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  canonical glycolysis  
Ontology : EGO-EBInegative regulation of transcription by RNA polymerase II  magnesium ion binding  chromatin  transcription cis-regulatory region binding  RNA polymerase II cis-regulatory region sequence-specific DNA binding  RNA polymerase II cis-regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription repressor activity, RNA polymerase II-specific  DNA-binding transcription activator activity, RNA polymerase II-specific  cellular glucose homeostasis  DNA-binding transcription factor activity  DNA-binding transcription factor activity  protein binding  nucleus  nucleus  nucleoplasm  nucleoplasm  mitochondrion  regulation of transcription, DNA-templated  regulation of transcription by RNA polymerase II  negative regulation of autophagy  regulation of glucose metabolic process  protein deubiquitination  response to starvation  intracellular membrane-bounded organelle  sequence-specific DNA binding  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  canonical glycolysis  
NDEx NetworkFOXK2
Atlas of Cancer Signalling NetworkFOXK2
Wikipedia pathwaysFOXK2
Orthology - Evolution
OrthoDB3607
GeneTree (enSembl)ENSG00000141568
Phylogenetic Trees/Animal Genes : TreeFamFOXK2
Homologs : HomoloGeneFOXK2
Homology/Alignments : Family Browser (UCSC)FOXK2
Gene fusions - Rearrangements
Fusion : MitelmanFOXK2/ABCA5 [17q25.3/17q24.3]  
Fusion : MitelmanFOXK2/HEXDC [17q25.3/17q25.3]  
Fusion : MitelmanFOXK2/MADCAM1 [17q25.3/19p13.3]  
Fusion : MitelmanFOXK2/NARF [17q25.3/17q25.3]  
Fusion : MitelmanFOXK2/PITPNC1 [17q25.3/17q24.2]  
Fusion : MitelmanFOXK2/SKAP1 [17q25.3/17q21.32]  
Fusion : MitelmanFOXK2/TIAF1 [17q25.3/17q11.2]  
Fusion : MitelmanTBCD/FOXK2 [17q25.3/17q25.3]  
Fusion : QuiverFOXK2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFOXK2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FOXK2
dbVarFOXK2
ClinVarFOXK2
MonarchFOXK2
1000_GenomesFOXK2 
Exome Variant ServerFOXK2
GNOMAD BrowserENSG00000141568
Varsome BrowserFOXK2
ACMGFOXK2 variants
VarityQ01167
Genomic Variants (DGV)FOXK2 [DGVbeta]
DECIPHERFOXK2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFOXK2 
Mutations
ICGC Data PortalFOXK2 
TCGA Data PortalFOXK2 
Broad Tumor PortalFOXK2
OASIS PortalFOXK2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFOXK2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DFOXK2
Mutations and Diseases : HGMDFOXK2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaFOXK2
DgiDB (Drug Gene Interaction Database)FOXK2
DoCM (Curated mutations)FOXK2
CIViC (Clinical Interpretations of Variants in Cancer)FOXK2
Cancer3DFOXK2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM147685   
Orphanet
DisGeNETFOXK2
MedgenFOXK2
Genetic Testing Registry FOXK2
NextProtQ01167 [Medical]
GENETestsFOXK2
Target ValidationFOXK2
Huge Navigator FOXK2 [HugePedia]
ClinGenFOXK2
Clinical trials, drugs, therapy
MyCancerGenomeFOXK2
Protein Interactions : CTDFOXK2
Pharm GKB GenePA29851
PharosQ01167
Clinical trialFOXK2
Miscellaneous
canSAR (ICR)FOXK2
HarmonizomeFOXK2
DataMed IndexFOXK2
Probes
Litterature
PubMed67 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXFOXK2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 4 15:09:51 CEST 2021

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