Atlas of Genetics and Cytogenetics in Oncology and Haematology


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FOXL2 (forkhead box L2)

Identity

Other namesBPES
BPES1
PFRK
PINTO
POF3
HGNC (Hugo) FOXL2
LocusID (NCBI) 668
Atlas_Id 47069
Location 3q22.3
Location_base_pair Starts at 138663066 and ends at 138665982 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)FOXL2   1092
Cards
Entrez_Gene (NCBI)FOXL2  668  forkhead box L2
GeneCards (Weizmann)FOXL2
Ensembl hg19 (Hinxton)ENSG00000183770 [Gene_View]  chr3:138663066-138665982 [Contig_View]  FOXL2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000183770 [Gene_View]  chr3:138663066-138665982 [Contig_View]  FOXL2 [Vega]
ICGC DataPortalENSG00000183770
TCGA cBioPortalFOXL2
AceView (NCBI)FOXL2
Genatlas (Paris)FOXL2
WikiGenes668
SOURCE (Princeton)FOXL2
Genomic and cartography
GoldenPath hg19 (UCSC)FOXL2  -     chr3:138663066-138665982 -  3q22.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)FOXL2  -     3q22.3   [Description]    (hg38-Dec_2013)
EnsemblFOXL2 - 3q22.3 [CytoView hg19]  FOXL2 - 3q22.3 [CytoView hg38]
Mapping of homologs : NCBIFOXL2 [Mapview hg19]  FOXL2 [Mapview hg38]
OMIM110100   605597   608996   
Gene and transcription
Genbank (Entrez)AF301906 AI089172 BC019896 BC062549 BF512713
RefSeq transcript (Entrez)NM_023067
RefSeq genomic (Entrez)NC_000003 NC_018914 NG_012454 NG_029796 NT_005612 NW_004929311
Consensus coding sequences : CCDS (NCBI)FOXL2
Cluster EST : UnigeneHs.289292 [ NCBI ]
CGAP (NCI)Hs.289292
Alternative Splicing GalleryENSG00000183770
Gene ExpressionFOXL2 [ NCBI-GEO ]   FOXL2 [ EBI - ARRAY_EXPRESS ]   FOXL2 [ SEEK ]   FOXL2 [ MEM ]
Gene Expression Viewer (FireBrowse)FOXL2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)668
GTEX Portal (Tissue expression)FOXL2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP58012 (Uniprot)
NextProtP58012  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP58012
Splice isoforms : SwissVarP58012 (Swissvar)
PhosPhoSitePlusP58012
Domaine pattern : Prosite (Expaxy)FORK_HEAD_1 (PS00657)    FORK_HEAD_2 (PS00658)    FORK_HEAD_3 (PS50039)   
Domains : Interpro (EBI)Fork_head_dom    FoxL2    TF_fork_head_CS_1    TF_fork_head_CS_2    WHTH_DNA-bd_dom   
Domain families : Pfam (Sanger)Forkhead (PF00250)   
Domain families : Pfam (NCBI)pfam00250   
Domain families : Smart (EMBL)FH (SM00339)  
DMDM Disease mutations668
Blocks (Seattle)FOXL2
SuperfamilyP58012
Human Protein AtlasENSG00000183770
Peptide AtlasP58012
HPRD05723
IPIIPI01014622   IPI00010550   
Protein Interaction databases
DIP (DOE-UCLA)P58012
IntAct (EBI)P58012
FunCoupENSG00000183770
BioGRIDFOXL2
STRING (EMBL)FOXL2
ZODIACFOXL2
Ontologies - Pathways
QuickGOP58012
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  RNA polymerase II core promoter proximal region sequence-specific DNA binding  RNA polymerase II transcription factor activity, sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding  ovarian follicle development  ovarian follicle development  oocyte growth  extraocular skeletal muscle development  DNA binding  DNA binding  transcription factor activity, sequence-specific DNA binding  transcription factor activity, sequence-specific DNA binding  protein binding  nucleus  apoptotic DNA fragmentation  transcription from RNA polymerase II promoter  single fertilization  female somatic sex determination  cell differentiation  estrogen receptor binding  ubiquitin conjugating enzyme binding  positive regulation of luteinizing hormone secretion  menstruation  cysteine-type endopeptidase regulator activity involved in apoptotic process  positive regulation of apoptotic process  positive regulation of apoptotic process  positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  positive regulation of follicle-stimulating hormone secretion  embryonic eye morphogenesis  granulosa cell differentiation  uterus development  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  RNA polymerase II core promoter proximal region sequence-specific DNA binding  RNA polymerase II transcription factor activity, sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding  ovarian follicle development  ovarian follicle development  oocyte growth  extraocular skeletal muscle development  DNA binding  DNA binding  transcription factor activity, sequence-specific DNA binding  transcription factor activity, sequence-specific DNA binding  protein binding  nucleus  apoptotic DNA fragmentation  transcription from RNA polymerase II promoter  single fertilization  female somatic sex determination  cell differentiation  estrogen receptor binding  ubiquitin conjugating enzyme binding  positive regulation of luteinizing hormone secretion  menstruation  cysteine-type endopeptidase regulator activity involved in apoptotic process  positive regulation of apoptotic process  positive regulation of apoptotic process  positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  positive regulation of follicle-stimulating hormone secretion  embryonic eye morphogenesis  granulosa cell differentiation  uterus development  
NDEx Network
Atlas of Cancer Signalling NetworkFOXL2
Wikipedia pathwaysFOXL2
Orthology - Evolution
OrthoDB668
GeneTree (enSembl)ENSG00000183770
Phylogenetic Trees/Animal Genes : TreeFamFOXL2
Homologs : HomoloGeneFOXL2
Homology/Alignments : Family Browser (UCSC)FOXL2
Gene fusions - Rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerFOXL2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FOXL2
dbVarFOXL2
ClinVarFOXL2
1000_GenomesFOXL2 
Exome Variant ServerFOXL2
ExAC (Exome Aggregation Consortium)FOXL2 (select the gene name)
Genetic variants : HAPMAP668
Genomic Variants (DGV)FOXL2 [DGVbeta]
Mutations
ICGC Data PortalFOXL2 
TCGA Data PortalFOXL2 
Broad Tumor PortalFOXL2
OASIS PortalFOXL2 [ Somatic mutations - Copy number]
Cancer Gene: CensusFOXL2 
Somatic Mutations in Cancer : COSMICFOXL2 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FOXL2
DgiDB (Drug Gene Interaction Database)FOXL2
DoCM (Curated mutations)FOXL2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FOXL2 (select a term)
intoGenFOXL2
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)3:138663066-138665982  ENSG00000183770
CONAN: Copy Number AnalysisFOXL2 
Mutations and Diseases : HGMDFOXL2
OMIM110100    605597    608996   
MedgenFOXL2
Genetic Testing Registry FOXL2
NextProtP58012 [Medical]
TSGene668
GENETestsFOXL2
Huge Navigator FOXL2 [HugePedia]
snp3D : Map Gene to Disease668
BioCentury BCIQFOXL2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD668
Chemical/Pharm GKB GenePA28235
Clinical trialFOXL2
Miscellaneous
canSAR (ICR)FOXL2 (select the gene name)
Probes
Litterature
PubMed149 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFOXL2
EVEXFOXL2
GoPubMedFOXL2
iHOPFOXL2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sun May 8 18:46:42 CEST 2016

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