FOXL2 (forkhead box L2)

2007-04-01  

Identity

HGNC
LOCATION
3q22.3
LOCUSID
ALIAS
BPES,BPES1,PFRK,PINTO,POF3

Other Information

Locus ID:

NCBI: 668
MIM: 605597
HGNC: 1092
Ensembl: ENSG00000183770

Variants:

dbSNP: 668
ClinVar: 668
TCGA: ENSG00000183770
COSMIC: FOXL2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000183770ENST00000648323P58012
ENSG00000183770ENST00000648323Q53ZD3

Expression (GTEx)

0
50
100
150

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
195160272009Mutation of FOXL2 in granulosa-cell tumors of the ovary.167
124712062002Evolution and expression of FOXL2.55
125298552003FOXL2 and BPES: mutational hotspots, phenotypic variability, and revision of the genotype-phenotype correlation.48
191061052009FoxL2 and Smad3 coordinately regulate follistatin gene transcription.47
206939782010The FOXL2 C134W mutation is characteristic of adult granulosa cell tumors of the ovary.41
193249682009A novel role for the forkhead transcription factor FOXL2 in activin A-regulated follicle-stimulating hormone beta subunit transcription.38
207340642010A large-scale candidate gene association study of age at menarche and age at natural menopause.38
281193672017HMGA2-FOXL2 Axis Regulates Metastases and Epithelial-to-Mesenchymal Transition of Chemoresistant Gastric Cancer.38
235163772013Microhomology-mediated mechanisms underlie non-recurrent disease-causing microdeletions of the FOXL2 gene or its regulatory domain.35
121494042002Identification of novel mutations in FOXL2 associated with premature ovarian failure.34

Citation

Dessen P

FOXL2 (forkhead box L2)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47069/foxl2