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FOXL2 (forkhead box L2)

Identity

Other namesBPES
BPES1
PFRK
PINTO
POF3
HGNC (Hugo) FOXL2
LocusID (NCBI) 668
Location 3q22.3
Location_base_pair Starts at 138663066 and ends at 138665982 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)FOXL2   1092
Cards
Entrez_Gene (NCBI)FOXL2  668  forkhead box L2
GeneCards (Weizmann)FOXL2
Ensembl hg19 (Hinxton)ENSG00000183770 [Gene_View]  chr3:138663066-138665982 [Contig_View]  FOXL2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000183770 [Gene_View]  chr3:138663066-138665982 [Contig_View]  FOXL2 [Vega]
ICGC DataPortalENSG00000183770
cBioPortalFOXL2
AceView (NCBI)FOXL2
Genatlas (Paris)FOXL2
WikiGenes668
SOURCE (Princeton)FOXL2
Genomic and cartography
GoldenPath hg19 (UCSC)FOXL2  -     chr3:138663066-138665982 -  3q22.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)FOXL2  -     3q22.3   [Description]    (hg38-Dec_2013)
EnsemblFOXL2 - 3q22.3 [CytoView hg19]  FOXL2 - 3q22.3 [CytoView hg38]
Mapping of homologs : NCBIFOXL2 [Mapview hg19]  FOXL2 [Mapview hg38]
OMIM110100   605597   608996   
Gene and transcription
Genbank (Entrez)AF301906 AI089172 BC019896 BC062549 BF512713
RefSeq transcript (Entrez)NM_023067
RefSeq genomic (Entrez)AC_000135 NC_000003 NC_018914 NG_012454 NG_029796 NT_005612 NW_001838884 NW_004929311
Consensus coding sequences : CCDS (NCBI)FOXL2
Cluster EST : UnigeneHs.289292 [ NCBI ]
CGAP (NCI)Hs.289292
Alternative Splicing : Fast-db (Paris)GSHG0022098
Alternative Splicing GalleryENSG00000183770
Gene ExpressionFOXL2 [ NCBI-GEO ]     FOXL2 [ SEEK ]   FOXL2 [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP58012 (Uniprot)
NextProtP58012  [Medical]
With graphics : InterProP58012
Splice isoforms : SwissVarP58012 (Swissvar)
Domaine pattern : Prosite (Expaxy)FORK_HEAD_1 (PS00657)    FORK_HEAD_2 (PS00658)    FORK_HEAD_3 (PS50039)   
Domains : Interpro (EBI)TF_fork_head    TF_fork_head_CS    WHTH_DNA-bd_dom   
Related proteins : CluSTrP58012
Domain families : Pfam (Sanger)Fork_head (PF00250)   
Domain families : Pfam (NCBI)pfam00250   
Domain families : Smart (EMBL)FH (SM00339)  
DMDM Disease mutations668
Blocks (Seattle)P58012
Human Protein AtlasENSG00000183770
Peptide AtlasP58012
HPRD05723
IPIIPI01014622   IPI00010550   
Protein Interaction databases
DIP (DOE-UCLA)P58012
IntAct (EBI)P58012
FunCoupENSG00000183770
BioGRIDFOXL2
IntegromeDBFOXL2
STRING (EMBL)FOXL2
Ontologies - Pathways
QuickGOP58012
Ontology : AmiGOovarian follicle development  ovarian follicle development  extraocular skeletal muscle development  DNA binding  DNA binding  sequence-specific DNA binding transcription factor activity  sequence-specific DNA binding transcription factor activity  protein binding  nucleus  apoptotic DNA fragmentation  transcription from RNA polymerase II promoter  female somatic sex determination  cell differentiation  estrogen receptor binding  ubiquitin conjugating enzyme binding  menstruation  cysteine-type endopeptidase regulator activity involved in apoptotic process  positive regulation of apoptotic process  positive regulation of apoptotic process  positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  sequence-specific DNA binding  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  embryonic eye morphogenesis  granulosa cell differentiation  
Ontology : EGO-EBIovarian follicle development  ovarian follicle development  extraocular skeletal muscle development  DNA binding  DNA binding  sequence-specific DNA binding transcription factor activity  sequence-specific DNA binding transcription factor activity  protein binding  nucleus  apoptotic DNA fragmentation  transcription from RNA polymerase II promoter  female somatic sex determination  cell differentiation  estrogen receptor binding  ubiquitin conjugating enzyme binding  menstruation  cysteine-type endopeptidase regulator activity involved in apoptotic process  positive regulation of apoptotic process  positive regulation of apoptotic process  positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  sequence-specific DNA binding  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  embryonic eye morphogenesis  granulosa cell differentiation  
Protein Interaction DatabaseFOXL2
DoCM (Curated mutations)FOXL2
Wikipedia pathwaysFOXL2
Gene fusion - rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerFOXL2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FOXL2
dbVarFOXL2
ClinVarFOXL2
1000_GenomesFOXL2 
Exome Variant ServerFOXL2
SNP (GeneSNP Utah)FOXL2
SNP : HGBaseFOXL2
Genetic variants : HAPMAPFOXL2
Genomic VariantsFOXL2  FOXL2 [DGVbeta]
Mutations
ICGC Data PortalENSG00000183770 
Cancer Gene: CensusFOXL2 
Somatic Mutations in Cancer : COSMICFOXL2 
CONAN: Copy Number AnalysisFOXL2 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)3:138663066-138665982
Mutations and Diseases : HGMDFOXL2
OMIM110100    605597    608996   
MedgenFOXL2
NextProtP58012 [Medical]
GENETestsFOXL2
Disease Genetic AssociationFOXL2
Huge Navigator FOXL2 [HugePedia]  FOXL2 [HugeCancerGEM]
snp3D : Map Gene to Disease668
DGIdb (Drug Gene Interaction db)FOXL2
General knowledge
Homologs : HomoloGeneFOXL2
Homology/Alignments : Family Browser (UCSC)FOXL2
Phylogenetic Trees/Animal Genes : TreeFamFOXL2
Chemical/Protein Interactions : CTD668
Chemical/Pharm GKB GenePA28235
Clinical trialFOXL2
Cancer Resource (Charite)ENSG00000183770
Other databases
Probes
Litterature
PubMed129 Pubmed reference(s) in Entrez
CoreMineFOXL2
GoPubMedFOXL2
iHOPFOXL2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2014Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Dec 20 21:39:54 CET 2014

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