Atlas of Genetics and Cytogenetics in Oncology and Haematology


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FOXN3 (forkhead box N3)

Identity

Alias_namesC14orf116
CHES1
chromosome 14 open reading frame 116
checkpoint suppressor 1
Other aliasPRO1635
HGNC (Hugo) FOXN3
LocusID (NCBI) 1112
Atlas_Id 47613
Location 14q31.3  [Link to chromosome band 14q31]
Location_base_pair Starts at 89156172 and ends at 89417110 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
BRF1 (14q32.33) / FOXN3 (14q31.3)FOXN3 (14q31.3) / AUP1 (2p13.1)FOXN3 (14q31.3) / CD74 (5q32)
FOXN3 (14q31.3) / FOXN3 (14q31.3)FOXN3 (14q31.3) / KCNQ1 (11p15.5)FOXN3 (14q31.3) / MBNL1 (3q25.1)
FOXN3 (14q31.3) / RP11-944C7.1 ()FOXN3 (14q31.3) / SLC25A21 (14q13.3)FOXO3 (6q21) / FOXN3 (14q31.3)
NDUFA5 (7q31.32) / FOXN3 (14q31.3)BRF1 14q32.33 / FOXN3 14q31.3FOXN3 14q31.3 / KCNQ1 11p15.5
FOXN3 14q31.3 RP11-944C7.1FOXN3 14q31.3 / SLC25A21 14q13.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 3 ]
  t(11;14)(p15;q32) FOXN3/KCNQ1
t(14;14)(q13;q32) FOXN3/SLC25A21
BRF1/FOXN3 (14q32)


External links

Nomenclature
HGNC (Hugo)FOXN3   1928
Cards
Entrez_Gene (NCBI)FOXN3  1112  forkhead box N3
AliasesC14orf116; CHES1; PRO1635
GeneCards (Weizmann)FOXN3
Ensembl hg19 (Hinxton)ENSG00000053254 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000053254 [Gene_View]  ENSG00000053254 [Sequence]  chr14:89156172-89417110 [Contig_View]  FOXN3 [Vega]
ICGC DataPortalENSG00000053254
TCGA cBioPortalFOXN3
AceView (NCBI)FOXN3
Genatlas (Paris)FOXN3
WikiGenes1112
SOURCE (Princeton)FOXN3
Genetics Home Reference (NIH)FOXN3
Genomic and cartography
GoldenPath hg38 (UCSC)FOXN3  -     chr14:89156172-89417110 -  14q31.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FOXN3  -     14q31.3   [Description]    (hg19-Feb_2009)
FOXN3 - 14q31.3 [CytoView hg19]  FOXN3 - 14q31.3 [CytoView hg38]
Mapping of homologs : NCBIFOXN3 [Mapview hg19]  FOXN3 [Mapview hg38]
OMIM602628   
Gene and transcription
Genbank (Entrez)AA149521 AA938188 AF116643 AI084011 AI240081
RefSeq transcript (Entrez)NM_001085471 NM_005197
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FOXN3
Cluster EST : UnigeneHs.434286 [ NCBI ]
CGAP (NCI)Hs.434286
Alternative Splicing GalleryENSG00000053254
Gene ExpressionFOXN3 [ NCBI-GEO ]   FOXN3 [ EBI - ARRAY_EXPRESS ]   FOXN3 [ SEEK ]   FOXN3 [ MEM ]
Gene Expression Viewer (FireBrowse)FOXN3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1112
GTEX Portal (Tissue expression)FOXN3
Human Protein AtlasENSG00000053254-FOXN3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO00409   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO00409  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO00409
Splice isoforms : SwissVarO00409
PhosPhoSitePlusO00409
Domaine pattern : Prosite (Expaxy)FORK_HEAD_1 (PS00657)    FORK_HEAD_2 (PS00658)    FORK_HEAD_3 (PS50039)   
Domains : Interpro (EBI)Fork_head_dom    TF_fork_head_CS_1    TF_fork_head_CS_2    WH-like_DNA-bd_sf    WH_DNA-bd_sf   
Domain families : Pfam (Sanger)Forkhead (PF00250)   
Domain families : Pfam (NCBI)pfam00250   
Domain families : Smart (EMBL)FH (SM00339)  
Conserved Domain (NCBI)FOXN3
DMDM Disease mutations1112
Blocks (Seattle)FOXN3
SuperfamilyO00409
Human Protein Atlas [tissue]ENSG00000053254-FOXN3 [tissue]
Peptide AtlasO00409
HPRD07533
IPIIPI00011681   IPI00220563   IPI00816449   IPI01026478   IPI01024697   IPI01024731   IPI01024851   IPI01025052   IPI01025166   IPI01025307   IPI01025608   IPI01025857   
Protein Interaction databases
DIP (DOE-UCLA)O00409
IntAct (EBI)O00409
FunCoupENSG00000053254
BioGRIDFOXN3
STRING (EMBL)FOXN3
ZODIACFOXN3
Ontologies - Pathways
QuickGOO00409
Ontology : AmiGODNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  protein binding  nucleus  regulation of transcription by RNA polymerase II  mitotic G2 DNA damage checkpoint  protein C-terminus binding  sequence-specific DNA binding  negative regulation of transcription, DNA-templated  craniofacial suture morphogenesis  
Ontology : EGO-EBIDNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  protein binding  nucleus  regulation of transcription by RNA polymerase II  mitotic G2 DNA damage checkpoint  protein C-terminus binding  sequence-specific DNA binding  negative regulation of transcription, DNA-templated  craniofacial suture morphogenesis  
NDEx NetworkFOXN3
Atlas of Cancer Signalling NetworkFOXN3
Wikipedia pathwaysFOXN3
Orthology - Evolution
OrthoDB1112
GeneTree (enSembl)ENSG00000053254
Phylogenetic Trees/Animal Genes : TreeFamFOXN3
HOGENOMO00409
Homologs : HomoloGeneFOXN3
Homology/Alignments : Family Browser (UCSC)FOXN3
Gene fusions - Rearrangements
Fusion : MitelmanBRF1/FOXN3 [14q32.33/14q31.3]  [t(14;14)(q32;q32)]  
Fusion : MitelmanFOXN3/KCNQ1 [14q31.3/11p15.5]  [t(11;14)(p15;q32)]  
Fusion : MitelmanFOXN3/SLC25A21 [14q31.3/14q13.3]  [t(14;14)(q13;q32)]  
Fusion PortalBRF1 14q32.33 FOXN3 14q31.3 BRCA
Fusion PortalFOXN3 14q31.3 KCNQ1 11p15.5 PRAD
Fusion PortalFOXN3 14q31.3 RP11-944C7.1 SKCM
Fusion PortalFOXN3 14q31.3 SLC25A21 14q13.3 LUAD
Fusion : QuiverFOXN3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFOXN3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FOXN3
dbVarFOXN3
ClinVarFOXN3
1000_GenomesFOXN3 
Exome Variant ServerFOXN3
ExAC (Exome Aggregation Consortium)ENSG00000053254
GNOMAD BrowserENSG00000053254
Varsome BrowserFOXN3
Genetic variants : HAPMAP1112
Genomic Variants (DGV)FOXN3 [DGVbeta]
DECIPHERFOXN3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFOXN3 
Mutations
ICGC Data PortalFOXN3 
TCGA Data PortalFOXN3 
Broad Tumor PortalFOXN3
OASIS PortalFOXN3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFOXN3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDFOXN3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FOXN3
DgiDB (Drug Gene Interaction Database)FOXN3
DoCM (Curated mutations)FOXN3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FOXN3 (select a term)
intoGenFOXN3
Cancer3DFOXN3(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602628   
Orphanet
DisGeNETFOXN3
MedgenFOXN3
Genetic Testing Registry FOXN3
NextProtO00409 [Medical]
TSGene1112
GENETestsFOXN3
Target ValidationFOXN3
Huge Navigator FOXN3 [HugePedia]
snp3D : Map Gene to Disease1112
BioCentury BCIQFOXN3
ClinGenFOXN3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1112
Chemical/Pharm GKB GenePA26460
Clinical trialFOXN3
Miscellaneous
canSAR (ICR)FOXN3 (select the gene name)
DataMed IndexFOXN3
Probes
Litterature
PubMed35 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFOXN3
EVEXFOXN3
GoPubMedFOXN3
iHOPFOXN3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu May 2 12:49:30 CEST 2019

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