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FOXP2 (forkhead box P2)

Identity

Alias_namesTNRC10
SPCH1
Alias_symbol (synonym)CAGH44
HGNC (Hugo) FOXP2
LocusID (NCBI) 93986
Atlas_Id 40633
Location 7q31.1  [Link to chromosome band 7q31]
Location_base_pair Starts at 114055052 and ends at 114333827 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
COG5 (7q22.3) / FOXP2 (7q31.1)FOXP2 (7q31.1) / FOXP2 (7q31.1)FOXP2 (7q31.1) / RFC3 (13q13.2)
FOXP2 (7q31.1) / RPL36 (19p13.3)SFTPB (2p11.2) / FOXP2 (7q31.1)COG5 7q22.3 / FOXP2 7q31.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)FOXP2   13875
Cards
Entrez_Gene (NCBI)FOXP2  93986  forkhead box P2
AliasesCAGH44; SPCH1; TNRC10
GeneCards (Weizmann)FOXP2
Ensembl hg19 (Hinxton)ENSG00000128573 [Gene_View]  chr7:114055052-114333827 [Contig_View]  FOXP2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000128573 [Gene_View]  chr7:114055052-114333827 [Contig_View]  FOXP2 [Vega]
ICGC DataPortalENSG00000128573
TCGA cBioPortalFOXP2
AceView (NCBI)FOXP2
Genatlas (Paris)FOXP2
WikiGenes93986
SOURCE (Princeton)FOXP2
Genetics Home Reference (NIH)FOXP2
Genomic and cartography
GoldenPath hg19 (UCSC)FOXP2  -     chr7:114055052-114333827 +  7q31.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)FOXP2  -     7q31.1   [Description]    (hg38-Dec_2013)
EnsemblFOXP2 - 7q31.1 [CytoView hg19]  FOXP2 - 7q31.1 [CytoView hg38]
Mapping of homologs : NCBIFOXP2 [Mapview hg19]  FOXP2 [Mapview hg38]
OMIM602081   605317   
Gene and transcription
Genbank (Entrez)AF086040 AF337817 AF454830 AF467252 AF467253
RefSeq transcript (Entrez)NM_001172766 NM_001172767 NM_014491 NM_148898 NM_148899 NM_148900
RefSeq genomic (Entrez)NC_000007 NC_018918 NG_007491 NT_007933 NW_004929332
Consensus coding sequences : CCDS (NCBI)FOXP2
Cluster EST : UnigeneHs.282787 [ NCBI ]
CGAP (NCI)Hs.282787
Alternative Splicing GalleryENSG00000128573
Gene ExpressionFOXP2 [ NCBI-GEO ]   FOXP2 [ EBI - ARRAY_EXPRESS ]   FOXP2 [ SEEK ]   FOXP2 [ MEM ]
Gene Expression Viewer (FireBrowse)FOXP2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)93986
GTEX Portal (Tissue expression)FOXP2
Protein : pattern, domain, 3D structure
UniProt/SwissProtO15409   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO15409  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO15409
Splice isoforms : SwissVarO15409
PhosPhoSitePlusO15409
Domaine pattern : Prosite (Expaxy)FORK_HEAD_2 (PS00658)    FORK_HEAD_3 (PS50039)    ZINC_FINGER_C2H2_1 (PS00028)   
Domains : Interpro (EBI)Fork_head_dom    FOXP-CC    TF_fork_head_CS_2    WHTH_DNA-bd_dom    Znf_C2H2-like   
Domain families : Pfam (Sanger)Forkhead (PF00250)    FOXP-CC (PF16159)   
Domain families : Pfam (NCBI)pfam00250    pfam16159   
Domain families : Smart (EMBL)FH (SM00339)  ZnF_C2H2 (SM00355)  
Conserved Domain (NCBI)FOXP2
DMDM Disease mutations93986
Blocks (Seattle)FOXP2
PDB (SRS)2A07    2AS5   
PDB (PDBSum)2A07    2AS5   
PDB (IMB)2A07    2AS5   
PDB (RSDB)2A07    2AS5   
Structural Biology KnowledgeBase2A07    2AS5   
SCOP (Structural Classification of Proteins)2A07    2AS5   
CATH (Classification of proteins structures)2A07    2AS5   
SuperfamilyO15409
Human Protein AtlasENSG00000128573
Peptide AtlasO15409
HPRD05611
IPIIPI00940557   IPI00215632   IPI00383604   IPI00382947   IPI00454591   IPI00454592   IPI00879217   IPI00470950   IPI00784938   IPI00878144   IPI00288960   IPI00170880   IPI00853141   IPI00877946   IPI00877864   IPI00926273   IPI01008819   
Protein Interaction databases
DIP (DOE-UCLA)O15409
IntAct (EBI)O15409
FunCoupENSG00000128573
BioGRIDFOXP2
STRING (EMBL)FOXP2
ZODIACFOXP2
Ontologies - Pathways
QuickGOO15409
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  RNA polymerase II core promoter proximal region sequence-specific DNA binding  RNA polymerase II transcription factor activity, sequence-specific DNA binding  transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding  positive regulation of mesenchymal cell proliferation  DNA binding  transcription factor activity, sequence-specific DNA binding  protein binding  nucleus  transcription, DNA-templated  skeletal muscle tissue development  post-embryonic development  cerebellum development  caudate nucleus development  putamen development  cerebral cortex development  growth  vocal learning  protein homodimerization activity  camera-type eye development  sequence-specific DNA binding  negative regulation of transcription, DNA-templated  metal ion binding  protein heterodimerization activity  lung alveolus development  smooth muscle tissue development  righting reflex  positive regulation of epithelial cell proliferation involved in lung morphogenesis  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  RNA polymerase II core promoter proximal region sequence-specific DNA binding  RNA polymerase II transcription factor activity, sequence-specific DNA binding  transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding  positive regulation of mesenchymal cell proliferation  DNA binding  transcription factor activity, sequence-specific DNA binding  protein binding  nucleus  transcription, DNA-templated  skeletal muscle tissue development  post-embryonic development  cerebellum development  caudate nucleus development  putamen development  cerebral cortex development  growth  vocal learning  protein homodimerization activity  camera-type eye development  sequence-specific DNA binding  negative regulation of transcription, DNA-templated  metal ion binding  protein heterodimerization activity  lung alveolus development  smooth muscle tissue development  righting reflex  positive regulation of epithelial cell proliferation involved in lung morphogenesis  
NDEx NetworkFOXP2
Atlas of Cancer Signalling NetworkFOXP2
Wikipedia pathwaysFOXP2
Orthology - Evolution
OrthoDB93986
GeneTree (enSembl)ENSG00000128573
Phylogenetic Trees/Animal Genes : TreeFamFOXP2
HOVERGENO15409
HOGENOMO15409
Homologs : HomoloGeneFOXP2
Homology/Alignments : Family Browser (UCSC)FOXP2
Gene fusions - Rearrangements
Fusion : MitelmanCOG5/FOXP2 [7q22.3/7q31.1]  [t(7;7)(q31;q31)]  
Fusion: TCGACOG5 7q22.3 FOXP2 7q31.1 BRCA
Fusion Cancer (Beijing)SFTPB [2p11.2]  -  FOXP2 [7q31.1]  [FUSC003657]
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFOXP2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FOXP2
dbVarFOXP2
ClinVarFOXP2
1000_GenomesFOXP2 
Exome Variant ServerFOXP2
ExAC (Exome Aggregation Consortium)FOXP2 (select the gene name)
Genetic variants : HAPMAP93986
Genomic Variants (DGV)FOXP2 [DGVbeta]
DECIPHER (Syndromes)7:114055052-114333827  ENSG00000128573
CONAN: Copy Number AnalysisFOXP2 
Mutations
ICGC Data PortalFOXP2 
TCGA Data PortalFOXP2 
Broad Tumor PortalFOXP2
OASIS PortalFOXP2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFOXP2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDFOXP2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FOXP2
DgiDB (Drug Gene Interaction Database)FOXP2
DoCM (Curated mutations)FOXP2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FOXP2 (select a term)
intoGenFOXP2
Cancer3DFOXP2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602081    605317   
Orphanet19612    18667   
MedgenFOXP2
Genetic Testing Registry FOXP2
NextProtO15409 [Medical]
TSGene93986
GENETestsFOXP2
Huge Navigator FOXP2 [HugePedia]
snp3D : Map Gene to Disease93986
BioCentury BCIQFOXP2
ClinGenFOXP2 (curated)
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD93986
Chemical/Pharm GKB GenePA28242
Clinical trialFOXP2
Miscellaneous
canSAR (ICR)FOXP2 (select the gene name)
Probes
Litterature
PubMed105 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFOXP2
EVEXFOXP2
GoPubMedFOXP2
iHOPFOXP2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Nov 18 19:37:47 CET 2016

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