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FOXP2 (forkhead box P2)

Identity

Other namesCAGH44
SPCH1
TNRC10
HGNC (Hugo) FOXP2
LocusID (NCBI) 93986
Location 7q31.1
Location_base_pair Starts at 114055052 and ends at 114333827 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)FOXP2   13875
Cards
Entrez_Gene (NCBI)FOXP2  93986  forkhead box P2
GeneCards (Weizmann)FOXP2
Ensembl (Hinxton)ENSG00000128573 [Gene_View]  chr7:114055052-114333827 [Contig_View]  FOXP2 [Vega]
ICGC DataPortalENSG00000128573
AceView (NCBI)FOXP2
Genatlas (Paris)FOXP2
WikiGenes93986
SOURCE (Princeton)NM_001172766 NM_001172767 NM_014491 NM_148898 NM_148899 NM_148900
Genomic and cartography
GoldenPath (UCSC)FOXP2  -  7q31.1   chr7:114055052-114333827 +  7q31.1   [Description]    (hg19-Feb_2009)
EnsemblFOXP2 - 7q31.1 [CytoView]
Mapping of homologs : NCBIFOXP2 [Mapview]
OMIM602081   605317   
Gene and transcription
Genbank (Entrez)AF086040 AF337817 AF454830 AF467252 AF467253
RefSeq transcript (Entrez)NM_001172766 NM_001172767 NM_014491 NM_148898 NM_148899 NM_148900
RefSeq genomic (Entrez)AC_000139 NC_000007 NC_018918 NG_007491 NT_007933 NW_001839071 NW_004929332
Consensus coding sequences : CCDS (NCBI)FOXP2
Cluster EST : UnigeneHs.282787 [ NCBI ]
CGAP (NCI)Hs.282787
Alternative Splicing : Fast-db (Paris)GSHG0027655
Alternative Splicing GalleryENSG00000128573
Gene ExpressionFOXP2 [ NCBI-GEO ]     FOXP2 [ SEEK ]   FOXP2 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO15409 (Uniprot)
NextProtO15409  [Medical]
With graphics : InterProO15409
Splice isoforms : SwissVarO15409 (Swissvar)
Domaine pattern : Prosite (Expaxy)FORK_HEAD_2 (PS00658)    FORK_HEAD_3 (PS50039)    ZINC_FINGER_C2H2_1 (PS00028)   
Domains : Interpro (EBI)TF_fork_head    TF_fork_head_CS    WHTH_DNA-bd_dom    Znf_C2H2-like   
Related proteins : CluSTrO15409
Domain families : Pfam (Sanger)Fork_head (PF00250)   
Domain families : Pfam (NCBI)pfam00250   
Domain families : Smart (EMBL)FH (SM00339)  ZnF_C2H2 (SM00355)  
DMDM Disease mutations93986
Blocks (Seattle)O15409
PDB (SRS)2A07    2AS5   
PDB (PDBSum)2A07    2AS5   
PDB (IMB)2A07    2AS5   
PDB (RSDB)2A07    2AS5   
Human Protein AtlasENSG00000128573
Peptide AtlasO15409
HPRD05611
IPIIPI00940557   IPI00215632   IPI00383604   IPI00382947   IPI00454591   IPI00454592   IPI00879217   IPI00470950   IPI00784938   IPI00878144   IPI00288960   IPI00170880   IPI00853141   IPI00877946   IPI00877864   IPI00926273   IPI01008819   
Protein Interaction databases
DIP (DOE-UCLA)O15409
IntAct (EBI)O15409
FunCoupENSG00000128573
BioGRIDFOXP2
IntegromeDBFOXP2
STRING (EMBL)FOXP2
Ontologies - Pathways
QuickGOO15409
Ontology : AmiGOpositive regulation of mesenchymal cell proliferation  DNA binding  sequence-specific DNA binding transcription factor activity  nucleus  transcription, DNA-templated  skeletal muscle tissue development  embryo development  post-embryonic development  cerebellum development  caudate nucleus development  putamen development  cerebral cortex development  growth  vocal learning  protein homodimerization activity  camera-type eye development  sequence-specific DNA binding  negative regulation of transcription, DNA-templated  metal ion binding  protein heterodimerization activity  lung alveolus development  smooth muscle tissue development  righting reflex  positive regulation of epithelial cell proliferation involved in lung morphogenesis  
Ontology : EGO-EBIpositive regulation of mesenchymal cell proliferation  DNA binding  sequence-specific DNA binding transcription factor activity  nucleus  transcription, DNA-templated  skeletal muscle tissue development  embryo development  post-embryonic development  cerebellum development  caudate nucleus development  putamen development  cerebral cortex development  growth  vocal learning  protein homodimerization activity  camera-type eye development  sequence-specific DNA binding  negative regulation of transcription, DNA-templated  metal ion binding  protein heterodimerization activity  lung alveolus development  smooth muscle tissue development  righting reflex  positive regulation of epithelial cell proliferation involved in lung morphogenesis  
Protein Interaction DatabaseFOXP2
Wikipedia pathwaysFOXP2
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)FOXP2
SNP (GeneSNP Utah)FOXP2
SNP : HGBaseFOXP2
Genetic variants : HAPMAPFOXP2
1000_GenomesFOXP2 
ICGC programENSG00000128573 
CONAN: Copy Number AnalysisFOXP2 
Somatic Mutations in Cancer : COSMICFOXP2 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
DECIPHER (Syndromes)7:114055052-114333827
Mutations and Diseases : HGMDFOXP2
OMIM602081    605317   
MedgenFOXP2
GENETestsFOXP2
Disease Genetic AssociationFOXP2
Huge Navigator FOXP2 [HugePedia]  FOXP2 [HugeCancerGEM]
Genomic VariantsFOXP2  FOXP2 [DGVbeta]
Exome VariantFOXP2
dbVarFOXP2
ClinVarFOXP2
snp3D : Map Gene to Disease93986
General knowledge
Homologs : HomoloGeneFOXP2
Homology/Alignments : Family Browser (UCSC)FOXP2
Phylogenetic Trees/Animal Genes : TreeFamFOXP2
Chemical/Protein Interactions : CTD93986
Chemical/Pharm GKB GenePA28242
Clinical trialFOXP2
Cancer Resource (Charite)ENSG00000128573
Other databases
Probes
Litterature
PubMed87 Pubmed reference(s) in Entrez
CoreMineFOXP2
GoPubMedFOXP2
iHOPFOXP2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Nov 8 17:26:23 CET 2014

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