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FOXP4 (forkhead box P4)

Identity

Alias (NCBI)hFKHLA
HGNC (Hugo) FOXP4
HGNC Alias symbFLJ40908
LocusID (NCBI) 116113
Atlas_Id 47477
Location 6p21.1  [Link to chromosome band 6p21]
Location_base_pair Starts at 41546381 and ends at 41602384 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ASCC2 (22q12.2) / FOXP4 (6p21.1)FOXP4 (6p21.1) / DNAH8 (6p21.2)MCM3 (6p12.2) / FOXP4 (6p21.1)
FOXP4 6p21.1 / DNAH8 6p21.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(3;9)(p13;q34.1) FOXP1/ABL1

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  FOXP4/DNAH8 (6p21)

External links

Nomenclature
HGNC (Hugo)FOXP4   20842
Cards
Entrez_Gene (NCBI)FOXP4    forkhead box P4
AliaseshFKHLA
GeneCards (Weizmann)FOXP4
Ensembl hg19 (Hinxton)ENSG00000137166 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000137166 [Gene_View]  ENSG00000137166 [Sequence]  chr6:41546381-41602384 [Contig_View]  FOXP4 [Vega]
ICGC DataPortalENSG00000137166
TCGA cBioPortalFOXP4
AceView (NCBI)FOXP4
Genatlas (Paris)FOXP4
SOURCE (Princeton)FOXP4
Genetics Home Reference (NIH)FOXP4
Genomic and cartography
GoldenPath hg38 (UCSC)FOXP4  -     chr6:41546381-41602384 +  6p21.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FOXP4  -     6p21.1   [Description]    (hg19-Feb_2009)
GoldenPathFOXP4 - 6p21.1 [CytoView hg19]  FOXP4 - 6p21.1 [CytoView hg38]
ImmunoBaseENSG00000137166
genome Data Viewer NCBIFOXP4 [Mapview hg19]  
OMIM608924   
Gene and transcription
Genbank (Entrez)AB080747 AK094912 AK098227 AL832437 AW450805
RefSeq transcript (Entrez)NM_001012426 NM_001012427 NM_138457
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FOXP4
Alternative Splicing GalleryENSG00000137166
Gene ExpressionFOXP4 [ NCBI-GEO ]   FOXP4 [ EBI - ARRAY_EXPRESS ]   FOXP4 [ SEEK ]   FOXP4 [ MEM ]
Gene Expression Viewer (FireBrowse)FOXP4 [ Firebrowse - Broad ]
GenevisibleExpression of FOXP4 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)116113
GTEX Portal (Tissue expression)FOXP4
Human Protein AtlasENSG00000137166-FOXP4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8IVH2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8IVH2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8IVH2
Splice isoforms : SwissVarQ8IVH2
PhosPhoSitePlusQ8IVH2
Domaine pattern : Prosite (Expaxy)FORK_HEAD_2 (PS00658)    FORK_HEAD_3 (PS50039)    ZINC_FINGER_C2H2_1 (PS00028)   
Domains : Interpro (EBI)Fork_head_dom    FOXP-CC    TF_fork_head_CS_2    WH-like_DNA-bd_sf    WH_DNA-bd_sf   
Domain families : Pfam (Sanger)Forkhead (PF00250)    FOXP-CC (PF16159)   
Domain families : Pfam (NCBI)pfam00250    pfam16159   
Domain families : Smart (EMBL)FH (SM00339)  
Conserved Domain (NCBI)FOXP4
Blocks (Seattle)FOXP4
SuperfamilyQ8IVH2
Human Protein Atlas [tissue]ENSG00000137166-FOXP4 [tissue]
Peptide AtlasQ8IVH2
HPRD10600
IPIIPI00395554   IPI00386277   IPI00980717   IPI00554643   IPI00554470   IPI00795449   IPI00915788   
Protein Interaction databases
DIP (DOE-UCLA)Q8IVH2
IntAct (EBI)Q8IVH2
BioGRIDFOXP4
STRING (EMBL)FOXP4
ZODIACFOXP4
Ontologies - Pathways
QuickGOQ8IVH2
Ontology : AmiGOnuclear chromatin  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  protein binding  regulation of transcription by RNA polymerase II  sequence-specific DNA binding  metal ion binding  
Ontology : EGO-EBInuclear chromatin  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  protein binding  regulation of transcription by RNA polymerase II  sequence-specific DNA binding  metal ion binding  
NDEx NetworkFOXP4
Atlas of Cancer Signalling NetworkFOXP4
Wikipedia pathwaysFOXP4
Orthology - Evolution
OrthoDB116113
GeneTree (enSembl)ENSG00000137166
Phylogenetic Trees/Animal Genes : TreeFamFOXP4
HOGENOMQ8IVH2
Homologs : HomoloGeneFOXP4
Homology/Alignments : Family Browser (UCSC)FOXP4
Gene fusions - Rearrangements
Fusion : MitelmanFOXP4/DNAH8 [6p21.1/6p21.2]  
Fusion PortalFOXP4 6p21.1 DNAH8 6p21.2 PRAD
Fusion : QuiverFOXP4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFOXP4 [hg38]
dbVarFOXP4
ClinVarFOXP4
MonarchFOXP4
1000_GenomesFOXP4 
Exome Variant ServerFOXP4
GNOMAD BrowserENSG00000137166
Varsome BrowserFOXP4
Genomic Variants (DGV)FOXP4 [DGVbeta]
DECIPHERFOXP4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFOXP4 
Mutations
ICGC Data PortalFOXP4 
TCGA Data PortalFOXP4 
Broad Tumor PortalFOXP4
OASIS PortalFOXP4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFOXP4  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DFOXP4
Mutations and Diseases : HGMDFOXP4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FOXP4
DgiDB (Drug Gene Interaction Database)FOXP4
DoCM (Curated mutations)FOXP4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FOXP4 (select a term)
intoGenFOXP4
Cancer3DFOXP4(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608924   
Orphanet
DisGeNETFOXP4
MedgenFOXP4
Genetic Testing Registry FOXP4
NextProtQ8IVH2 [Medical]
GENETestsFOXP4
Target ValidationFOXP4
Huge Navigator FOXP4 [HugePedia]
ClinGenFOXP4
Clinical trials, drugs, therapy
MyCancerGenomeFOXP4
Protein Interactions : CTD
Pharm GKB GenePA134943098
PharosQ8IVH2
Clinical trialFOXP4
Miscellaneous
canSAR (ICR)FOXP4 (select the gene name)
HarmonizomeFOXP4
DataMed IndexFOXP4
Probes
Litterature
PubMed40 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXFOXP4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Jan 1 18:16:10 CET 2021
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