FPR2 (formyl peptide receptor 2)

2008-05-01  

Identity

HGNC
LOCATION
19q13.41
LOCUSID
ALIAS
ALX,ALXR,FMLP-R-II,FMLPX,FPR2A,FPRH1,FPRH2,FPRL1,HM63,LXA4R

Other Information

Locus ID:

NCBI: 2358
MIM: 136538
HGNC: 3827
Ensembl: ENSG00000171049

Variants:

dbSNP: 2358
ClinVar: 2358
TCGA: ENSG00000171049
COSMIC: FPR2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000171049ENST00000340023P25090
ENSG00000171049ENST00000340023A0A024R4P3
ENSG00000171049ENST00000598776P25090
ENSG00000171049ENST00000598776A0A024R4P3
ENSG00000171049ENST00000598953P25090
ENSG00000171049ENST00000598953A0A024R4P3
ENSG00000171049ENST00000599326M0QXD3
ENSG00000171049ENST00000600258M0QZ89
ENSG00000171049ENST00000600722M0R222

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
Staphylococcus aureus infectionKEGGko05150
Staphylococcus aureus infectionKEGGhsa05150
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
Formyl peptide receptors bind formyl peptides and many other ligandsREACTOMER-HSA-444473
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
205422502010Human formyl peptide receptor 2 senses highly pathogenic Staphylococcus aureus.100
241083552013Ligand-specific conformational change of the G-protein-coupled receptor ALX/FPR2 determines proresolving functional responses.97
123933912003Serum amyloid A induces IL-8 secretion through a G protein-coupled receptor, FPRL1/LXA4R.94
185835752008Airway lipoxin A4 generation and lipoxin A4 receptor expression are decreased in severe asthma.65
214993102011Pleiotropic regulation of macrophage polarization and tumorigenesis by formyl peptide receptor-2.51
158090932005Serum amyloid A stimulates matrix-metalloproteinase-9 upregulation via formyl peptide receptor like-1-mediated signaling in human monocytic cells.49
151871492004An annexin 1 N-terminal peptide activates leukocytes by triggering different members of the formyl peptide receptor family.44
176876362007Cyclosporin H, Boc-MLF and Boc-FLFLF are antagonists that preferentially inhibit activity triggered through the formyl peptide receptor.43
211835932011Neutrophil responses to staphylococcal pathogens and commensals via the formyl peptide receptor 2 relates to phenol-soluble modulin release and virulence.43
151883552004Local expression of the serum amyloid A and formyl peptide receptor-like 1 genes in synovial tissue is associated with matrix metalloproteinase production in patients with inflammatory arthritis.39

Citation

Dessen P

FPR2 (formyl peptide receptor 2)

Atlas Genet Cytogenet Oncol Haematol. 2008-05-01

Online version: http://atlasgeneticsoncology.org/gene/50107/fpr2