FPR3 (formyl peptide receptor 3)

2014-11-01 Affiliation

Identity

HGNC

FPR3

LOCATION

19q13.41

LOCUSID

2359

ALIAS

FML2_HUMAN,FMLP-R-II,FMLPY,FPRH1,FPRH2,FPRL2,RMLP-R-I

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 2359
MIM: 136539
HGNC: 3828
Ensembl: ENSG00000187474

Variants:

dbSNP: 2359
ClinVar: 2359
TCGA: ENSG00000187474
COSMIC: FPR3

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000187474	ENST00000339223	P25089
ENSG00000187474	ENST00000339223	Q6L5J4
ENSG00000187474	ENST00000595991	P25089
ENSG00000187474	ENST00000595991	Q6L5J4

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Neuroactive ligand-receptor interaction	KEGG	ko04080
Neuroactive ligand-receptor interaction	KEGG	hsa04080
Staphylococcus aureus infection	KEGG	ko05150
Staphylococcus aureus infection	KEGG	hsa05150
Signal Transduction	REACTOME	R-HSA-162582
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR ligand binding	REACTOME	R-HSA-500792
Class A/1 (Rhodopsin-like receptors)	REACTOME	R-HSA-373076
Peptide ligand-binding receptors	REACTOME	R-HSA-375276
Formyl peptide receptors bind formyl peptides and many other ligands	REACTOME	R-HSA-444473
GPCR downstream signaling	REACTOME	R-HSA-388396
G alpha (i) signalling events	REACTOME	R-HSA-418594

References

Pubmed ID	Year	Title	Citations
15187149	2004	An annexin 1 N-terminal peptide activates leukocytes by triggering different members of the formyl peptide receptor family.	44
15465011	2004	N-Formylated humanin activates both formyl peptide receptor-like 1 and 2.	32
20237496	2010	New genetic associations detected in a host response study to hepatitis B vaccine.	27
19342677	2009	Formyl peptide receptor-like 2 is expressed and functional in plasmacytoid dendritic cells, tissue-specific macrophage subpopulations, and eosinophils.	26
21543323	2011	N-formyl peptide receptor 3 (FPR3) departs from the homologous FPR2/ALX receptor with regard to the major processes governing chemoattractant receptor regulation, expression at the cell surface, and phosphorylation.	20
19843937	2009	Functional expression of formyl peptide receptor family in human NK cells.	19
12223529	2002	Human dendritic cells express functional formyl peptide receptor-like-2 (FPRL2) throughout maturation.	15
12410796	2002	Phagocyte activation by Trp-Lys-Tyr-Met-Val-Met, acting through FPRL1/LXA4R, is not affected by lipoxin A4.	15
16002663	2005	The synthetic peptide Trp-Lys-Tyr-Met-Val-D-Met inhibits human monocyte-derived dendritic cell maturation via formyl peptide receptor and formyl peptide receptor-like 2.	14
20972812	2011	The cross-talk between the urokinase receptor and fMLP receptors regulates the activity of the CXCR4 chemokine receptor.	13

Citation

Dessen P

FPR3 (formyl peptide receptor 3)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/63581/fpr3