FRAP1 (FK506 binding protein 12-rapamycin associated protein 1)

Identity

Other names	FLJ44809
	FRAP
	FRAP2
	MTOR
	RAFT1
	RAPT1
HGNC	FRAP1
Location	1p36
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	FRAP1   3942
Entrez_Gene	FRAP1  2475  FK506 binding protein 12-rapamycin associated protein 1
	Cards
GeneCards	FRAP1
Ensembl	FRAP1 [Search_View]   ENSG00000198793 [Gene_View]
Genatlas	FRAP1
GeneLynx	FRAP1
eGenome	FRAP1
euGene	2475
	Genomic and cartography
GoldenPath	FRAP1  -  1p36   chr1:11089179-11245151 -  1p36.22   [Description]    (hg18-March_2006)
Ensembl	FRAP1 - 1p36.22 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	FRAP1
	Gene and transcription
Genbank	AB209995 [ ENTREZ ]
Genbank	AK126762 [ ENTREZ ]
Genbank	AK304273 [ ENTREZ ]
Genbank	BC117166 [ ENTREZ ]
Genbank	L34075 [ ENTREZ ]
RefSeq	NM_004958 [ SRS ]    NM_004958 [ ENTREZ ]
RefSeq	AC_000044 [ SRS ]    AC_000044 [ ENTREZ ]
RefSeq	AC_000133 [ SRS ]    AC_000133 [ ENTREZ ]
RefSeq	NC_000001 [ SRS ]    NC_000001 [ ENTREZ ]
RefSeq	NT_021937 [ SRS ]    NT_021937 [ ENTREZ ]
RefSeq	NW_001838534 [ SRS ]    NW_001838534 [ ENTREZ ]
RefSeq	NW_923572 [ SRS ]    NW_923572 [ ENTREZ ]
AceView	FRAP1 AceView - NCBI
Unigene	Hs.338207 [ SRS ]    Hs.338207 [ NCBI ]     HS338207 [ spliceNest ]
Fast-db	5167 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	P42345 [ SRS]    P42345 [ EXPASY ]     P42345 [ INTERPRO ]     P42345 [ UNIPROT ]
Prosite	PS51189 FAT [ SRS ]    PS51189 FAT [ Expasy ]
Prosite	PS51190 FATC [ SRS ]    PS51190 FATC [ Expasy ]
Prosite	PS50077 HEAT_REPEAT [ SRS ]    PS50077 HEAT_REPEAT [ Expasy ]
Prosite	PS00915 PI3_4_KINASE_1 [ SRS ]    PS00915 PI3_4_KINASE_1 [ Expasy ]
Prosite	PS00916 PI3_4_KINASE_2 [ SRS ]    PS00916 PI3_4_KINASE_2 [ Expasy ]
Prosite	PS50290 PI3_4_KINASE_3 [ SRS ]    PS50290 PI3_4_KINASE_3 [ Expasy ]
Interpro	IPR011989 ARM-like [ SRS ]    IPR011989 ARM-like [ EBI ]
Interpro	IPR003152 FATC [ SRS ]    IPR003152 FATC [ EBI ]
Interpro	IPR009076 FKBP_rapamycin-assoc_FKBP12-bd [ SRS ]    IPR009076 FKBP_rapamycin-assoc_FKBP12-bd [ EBI ]
Interpro	IPR000357 HEAT [ SRS ]    IPR000357 HEAT [ EBI ]
Interpro	IPR000403 PI3/4_kinase_cat [ SRS ]    IPR000403 PI3/4_kinase_cat [ EBI ]
Interpro	IPR003151 PIK-rel_kinase_FAT [ SRS ]    IPR003151 PIK-rel_kinase_FAT [ EBI ]
Interpro	IPR014009 PIK_FAT [ SRS ]    IPR014009 PIK_FAT [ EBI ]
CluSTr	P42345
Pfam	PF02259 FAT [ SRS ]    PF02259 FAT [ Sanger ]    pfam02259 [ NCBI-CDD ]
Pfam	PF02260 FATC [ SRS ]    PF02260 FATC [ Sanger ]    pfam02260 [ NCBI-CDD ]
Pfam	PF00454 PI3_PI4_kinase [ SRS ]    PF00454 PI3_PI4_kinase [ Sanger ]    pfam00454 [ NCBI-CDD ]
Pfam	PF08771 Rapamycin_bind [ SRS ]    PF08771 Rapamycin_bind [ Sanger ]    pfam08771 [ NCBI-CDD ]
Smart	SM00146 PI3Kc [EMBL]
Blocks	P42345
PDB	1AUE [ SRS ]    1AUE [ PdbSum ],   1AUE [ IMB ]   1AUE [ RSDB ]
PDB	1FAP [ SRS ]    1FAP [ PdbSum ],   1FAP [ IMB ]   1FAP [ RSDB ]
PDB	1NSG [ SRS ]    1NSG [ PdbSum ],   1NSG [ IMB ]   1NSG [ RSDB ]
PDB	2FAP [ SRS ]    2FAP [ PdbSum ],   2FAP [ IMB ]   2FAP [ RSDB ]
PDB	2GAQ [ SRS ]    2GAQ [ PdbSum ],   2GAQ [ IMB ]   2GAQ [ RSDB ]
PDB	2NPU [ SRS ]    2NPU [ PdbSum ],   2NPU [ IMB ]   2NPU [ RSDB ]
PDB	3FAP [ SRS ]    3FAP [ PdbSum ],   3FAP [ IMB ]   3FAP [ RSDB ]
PDB	4FAP [ SRS ]    4FAP [ PdbSum ],   4FAP [ IMB ]   4FAP [ RSDB ]
HPRD	03134
	Protein Interaction databases
DIP	P42345
IntAct	P42345
	Polymorphism : SNP, mutations, diseases
OMIM	601231    [ map ]
GENECLINICS	601231
SNP	FRAP1 [dbSNP-NCBI]
SNP	NM_004958 [SNP-NCI]
SNP	FRAP1 [GeneSNPs - Utah]  FRAP1] [HGBASE - SRS]
HAPMAP	FRAP1 [HAPMAP]
COSMIC	FRAP1 [Somatic mutation (COSMIC-CGP-Sanger)]
HGMD	FRAP1
	General knowledge
Family Browser	FRAP1 [UCSC Family Browser]
SOURCE	NM_004958
SMD	Hs.338207
SAGE	Hs.338207
GO	protein serine/threonine kinase activity [Amigo]  protein serine/threonine kinase activity
GO	cytoplasm [Amigo]  cytoplasm
GO	cytosol [Amigo]  cytosol
GO	phosphoinositide 3-kinase complex [Amigo]  phosphoinositide 3-kinase complex
GO	signal transduction [Amigo]  signal transduction
GO	response to nutrient [Amigo]  response to nutrient
GO	membrane [Amigo]  membrane
GO	cell growth [Amigo]  cell growth
GO	kinase activity [Amigo]  kinase activity
GO	phosphorylation [Amigo]  phosphorylation
GO	phosphotransferase activity, alcohol group as acceptor [Amigo]  phosphotransferase activity, alcohol group as acceptor
GO	protein catabolic process [Amigo]  protein catabolic process
GO	phosphoprotein binding [Amigo]  phosphoprotein binding
BIOCARTA	B Cell Survival Pathway    [Genes]
BIOCARTA	CTCF: First Multivalent Nuclear Factor    [Genes]
BIOCARTA	Regulation of eIF4e and p70 S6 Kinase    [Genes]
BIOCARTA	Skeletal muscle hypertrophy is regulated via AKT/mTOR pathway    [Genes]
BIOCARTA	mTOR Signaling Pathway    [Genes]
BIOCARTA	Stat3 Signaling Pathway    [Genes]
KEGG	mTOR signaling pathway
KEGG	Insulin signaling pathway
KEGG	Adipocytokine signaling pathway
KEGG	Type II diabetes mellitus
PubGene	FRAP1
TreeFam	FRAP1
CTD	2475 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	FRAP1 Related clones (RZPD - Berlin)
	PubMed
PubMed	203 Pubmed reference(s) in LocusLink

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

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Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Mon Aug 11 20:11:45 2008