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FRAS1 (Fraser extracellular matrix complex subunit 1)

Identity

Alias_namesFraser syndrome 1
Alias_symbol (synonym)FLJ22031
FLJ14927
KIAA1500
Other alias-
HGNC (Hugo) FRAS1
LocusID (NCBI) 80144
Atlas_Id 63583
Location 4q21.21  [Link to chromosome band 4q21]
Location_base_pair Starts at 78057570 and ends at 78446633 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CNOT6L (4q21.1) / FRAS1 (4q21.21)FRAS1 (4q21.21) / ARMCX3 (Xq22.1)FRAS1 (4q21.21) / CCSER1 (4q22.1)
FRAS1 (4q21.21) / DCK (4q13.3)FRAS1 (4q21.21) / HADH (4q25)FRAS1 (4q21.21) / LRRC8D (1p22.2)
FRAS1 (4q21.21) / MRPL1 (4q21.1)FRAS1 (4q21.21) / SHROOM3 (4q21.1)WDFY3 (4q21.23) / FRAS1 (4q21.21)
FRAS1 FAM190AFRAS1 DCKFRAS1 SHROOM3
FRAS1 MRPL1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)FRAS1   19185
Cards
Entrez_Gene (NCBI)FRAS1  80144  Fraser extracellular matrix complex subunit 1
Aliases
GeneCards (Weizmann)FRAS1
Ensembl hg19 (Hinxton)ENSG00000138759 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000138759 [Gene_View]  chr4:78057570-78446633 [Contig_View]  FRAS1 [Vega]
ICGC DataPortalENSG00000138759
TCGA cBioPortalFRAS1
AceView (NCBI)FRAS1
Genatlas (Paris)FRAS1
WikiGenes80144
SOURCE (Princeton)FRAS1
Genetics Home Reference (NIH)FRAS1
Genomic and cartography
GoldenPath hg38 (UCSC)FRAS1  -     chr4:78057570-78446633 +  4q21.21   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FRAS1  -     4q21.21   [Description]    (hg19-Feb_2009)
EnsemblFRAS1 - 4q21.21 [CytoView hg19]  FRAS1 - 4q21.21 [CytoView hg38]
Mapping of homologs : NCBIFRAS1 [Mapview hg19]  FRAS1 [Mapview hg38]
OMIM219000   607830   
Gene and transcription
Genbank (Entrez)AB040933 AK025684 AK027833 AK092082 AK096838
RefSeq transcript (Entrez)NM_001166133 NM_020875 NM_025074 NM_032863 NM_206841
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FRAS1
Cluster EST : UnigeneHs.369448 [ NCBI ]
CGAP (NCI)Hs.369448
Alternative Splicing GalleryENSG00000138759
Gene ExpressionFRAS1 [ NCBI-GEO ]   FRAS1 [ EBI - ARRAY_EXPRESS ]   FRAS1 [ SEEK ]   FRAS1 [ MEM ]
Gene Expression Viewer (FireBrowse)FRAS1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)80144
GTEX Portal (Tissue expression)FRAS1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ86XX4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ86XX4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ86XX4
Splice isoforms : SwissVarQ86XX4
PhosPhoSitePlusQ86XX4
Domaine pattern : Prosite (Expaxy)VWFC_1 (PS01208)    VWFC_2 (PS50184)   
Domains : Interpro (EBI)Calx_beta    EGF-like_dom    FRAS1    Furin_repeat    Growth_fac_rcpt_    VWF_dom   
Domain families : Pfam (Sanger)Calx-beta (PF03160)    VWC (PF00093)   
Domain families : Pfam (NCBI)pfam03160    pfam00093   
Domain families : Smart (EMBL)Calx_beta (SM00237)  EGF (SM00181)  FU (SM00261)  VWC (SM00214)  VWC_out (SM00215)  
Conserved Domain (NCBI)FRAS1
DMDM Disease mutations80144
Blocks (Seattle)FRAS1
SuperfamilyQ86XX4
Human Protein AtlasENSG00000138759
Peptide AtlasQ86XX4
HPRD06382
IPIIPI00943593   IPI00455318   IPI00455320   IPI00830085   IPI00983738   IPI00965614   IPI00410193   IPI00455316   IPI00455319   IPI00964426   
Protein Interaction databases
DIP (DOE-UCLA)Q86XX4
IntAct (EBI)Q86XX4
FunCoupENSG00000138759
BioGRIDFRAS1
STRING (EMBL)FRAS1
ZODIACFRAS1
Ontologies - Pathways
QuickGOQ86XX4
Ontology : AmiGOmorphogenesis of an epithelium  metanephros morphogenesis  plasma membrane  cell communication  protein transport  integral component of membrane  embryonic limb morphogenesis  extracellular matrix  skin development  metal ion binding  palate development  sublamina densa  
Ontology : EGO-EBImorphogenesis of an epithelium  metanephros morphogenesis  plasma membrane  cell communication  protein transport  integral component of membrane  embryonic limb morphogenesis  extracellular matrix  skin development  metal ion binding  palate development  sublamina densa  
NDEx NetworkFRAS1
Atlas of Cancer Signalling NetworkFRAS1
Wikipedia pathwaysFRAS1
Orthology - Evolution
OrthoDB80144
GeneTree (enSembl)ENSG00000138759
Phylogenetic Trees/Animal Genes : TreeFamFRAS1
HOVERGENQ86XX4
HOGENOMQ86XX4
Homologs : HomoloGeneFRAS1
Homology/Alignments : Family Browser (UCSC)FRAS1
Gene fusions - Rearrangements
Fusion: TCGAFRAS1 FAM190A
Fusion: TCGAFRAS1 DCK
Fusion: TCGAFRAS1 SHROOM3
Fusion: TCGAFRAS1 MRPL1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFRAS1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FRAS1
dbVarFRAS1
ClinVarFRAS1
1000_GenomesFRAS1 
Exome Variant ServerFRAS1
ExAC (Exome Aggregation Consortium)FRAS1 (select the gene name)
Genetic variants : HAPMAP80144
Genomic Variants (DGV)FRAS1 [DGVbeta]
DECIPHERFRAS1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFRAS1 
Mutations
ICGC Data PortalFRAS1 
TCGA Data PortalFRAS1 
Broad Tumor PortalFRAS1
OASIS PortalFRAS1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFRAS1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDFRAS1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FRAS1
DgiDB (Drug Gene Interaction Database)FRAS1
DoCM (Curated mutations)FRAS1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FRAS1 (select a term)
intoGenFRAS1
Cancer3DFRAS1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM219000    607830   
Orphanet1046    12163   
MedgenFRAS1
Genetic Testing Registry FRAS1
NextProtQ86XX4 [Medical]
TSGene80144
GENETestsFRAS1
Target ValidationFRAS1
Huge Navigator FRAS1 [HugePedia]
snp3D : Map Gene to Disease80144
BioCentury BCIQFRAS1
ClinGenFRAS1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD80144
Chemical/Pharm GKB GenePA134980133
Clinical trialFRAS1
Miscellaneous
canSAR (ICR)FRAS1 (select the gene name)
Probes
Litterature
PubMed22 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFRAS1
EVEXFRAS1
GoPubMedFRAS1
iHOPFRAS1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 13:08:54 CEST 2017

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