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FRAT1 (FRAT1, WNT signaling pathway regulator)

Identity

Alias_namesfrequently rearranged in advanced T-cell lymphomas
Other alias-
HGNC (Hugo) FRAT1
LocusID (NCBI) 10023
Atlas_Id 464
Location 10q24.1  [Link to chromosome band 10q24]
Location_base_pair Starts at 97319265 and ends at 97321915 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
FRAT1 (10q24.1) / FRAT1 (10q24.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)FRAT1   3944
Cards
Entrez_Gene (NCBI)FRAT1  10023  FRAT1, WNT signaling pathway regulator
Aliases
GeneCards (Weizmann)FRAT1
Ensembl hg19 (Hinxton)ENSG00000165879 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000165879 [Gene_View]  chr10:97319265-97321915 [Contig_View]  FRAT1 [Vega]
ICGC DataPortalENSG00000165879
TCGA cBioPortalFRAT1
AceView (NCBI)FRAT1
Genatlas (Paris)FRAT1
WikiGenes10023
SOURCE (Princeton)FRAT1
Genetics Home Reference (NIH)FRAT1
Genomic and cartography
GoldenPath hg38 (UCSC)FRAT1  -     chr10:97319265-97321915 +  10q24.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FRAT1  -     10q24.1   [Description]    (hg19-Feb_2009)
EnsemblFRAT1 - 10q24.1 [CytoView hg19]  FRAT1 - 10q24.1 [CytoView hg38]
Mapping of homologs : NCBIFRAT1 [Mapview hg19]  FRAT1 [Mapview hg38]
OMIM602503   
Gene and transcription
Genbank (Entrez)AB074890 AK307245 BC034476 BE041458 U58975
RefSeq transcript (Entrez)NM_005479 NM_181355
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FRAT1
Cluster EST : UnigeneHs.126057 [ NCBI ]
CGAP (NCI)Hs.126057
Alternative Splicing GalleryENSG00000165879
Gene ExpressionFRAT1 [ NCBI-GEO ]   FRAT1 [ EBI - ARRAY_EXPRESS ]   FRAT1 [ SEEK ]   FRAT1 [ MEM ]
Gene Expression Viewer (FireBrowse)FRAT1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10023
GTEX Portal (Tissue expression)FRAT1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ92837   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ92837  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ92837
Splice isoforms : SwissVarQ92837
PhosPhoSitePlusQ92837
Domains : Interpro (EBI)GSK3-bd   
Domain families : Pfam (Sanger)GSK-3_bind (PF05350)   
Domain families : Pfam (NCBI)pfam05350   
Conserved Domain (NCBI)FRAT1
DMDM Disease mutations10023
Blocks (Seattle)FRAT1
PDB (SRS)1GNG    3ZRK    3ZRL    3ZRM    4AFJ   
PDB (PDBSum)1GNG    3ZRK    3ZRL    3ZRM    4AFJ   
PDB (IMB)1GNG    3ZRK    3ZRL    3ZRM    4AFJ   
PDB (RSDB)1GNG    3ZRK    3ZRL    3ZRM    4AFJ   
Structural Biology KnowledgeBase1GNG    3ZRK    3ZRL    3ZRM    4AFJ   
SCOP (Structural Classification of Proteins)1GNG    3ZRK    3ZRL    3ZRM    4AFJ   
CATH (Classification of proteins structures)1GNG    3ZRK    3ZRL    3ZRM    4AFJ   
SuperfamilyQ92837
Human Protein AtlasENSG00000165879
Peptide AtlasQ92837
HPRD03935
IPIIPI00023762   
Protein Interaction databases
DIP (DOE-UCLA)Q92837
IntAct (EBI)Q92837
FunCoupENSG00000165879
BioGRIDFRAT1
STRING (EMBL)FRAT1
ZODIACFRAT1
Ontologies - Pathways
QuickGOQ92837
Ontology : AmiGOprotein binding  cytosol  cytosol  intracellular membrane-bounded organelle  beta-catenin destruction complex disassembly  
Ontology : EGO-EBIprotein binding  cytosol  cytosol  intracellular membrane-bounded organelle  beta-catenin destruction complex disassembly  
Pathways : BIOCARTAWNT Signaling Pathway [Genes]   
Pathways : KEGGWnt signaling pathway   
NDEx NetworkFRAT1
Atlas of Cancer Signalling NetworkFRAT1
Wikipedia pathwaysFRAT1
Orthology - Evolution
OrthoDB10023
GeneTree (enSembl)ENSG00000165879
Phylogenetic Trees/Animal Genes : TreeFamFRAT1
HOVERGENQ92837
HOGENOMQ92837
Homologs : HomoloGeneFRAT1
Homology/Alignments : Family Browser (UCSC)FRAT1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFRAT1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FRAT1
dbVarFRAT1
ClinVarFRAT1
1000_GenomesFRAT1 
Exome Variant ServerFRAT1
ExAC (Exome Aggregation Consortium)FRAT1 (select the gene name)
Genetic variants : HAPMAP10023
Genomic Variants (DGV)FRAT1 [DGVbeta]
DECIPHERFRAT1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFRAT1 
Mutations
ICGC Data PortalFRAT1 
TCGA Data PortalFRAT1 
Broad Tumor PortalFRAT1
OASIS PortalFRAT1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFRAT1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDFRAT1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FRAT1
DgiDB (Drug Gene Interaction Database)FRAT1
DoCM (Curated mutations)FRAT1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FRAT1 (select a term)
intoGenFRAT1
Cancer3DFRAT1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602503   
Orphanet
MedgenFRAT1
Genetic Testing Registry FRAT1
NextProtQ92837 [Medical]
TSGene10023
GENETestsFRAT1
Target ValidationFRAT1
Huge Navigator FRAT1 [HugePedia]
snp3D : Map Gene to Disease10023
BioCentury BCIQFRAT1
ClinGenFRAT1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10023
Chemical/Pharm GKB GenePA28361
Clinical trialFRAT1
Miscellaneous
canSAR (ICR)FRAT1 (select the gene name)
Probes
Litterature
PubMed32 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFRAT1
EVEXFRAT1
GoPubMedFRAT1
iHOPFRAT1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:34:23 CEST 2017

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