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FRAT2 (FRAT regulator of WNT signaling pathway 2)

Identity

Alias (NCBI)FRAT-2
HGNC (Hugo) FRAT2
HGNC Alias nameGSK-3 binding protein FRAT2
HGNC Previous namefrequently rearranged in advanced T-cell lymphomas 2
 FRAT2, WNT signaling pathway regulator
LocusID (NCBI) 23401
Atlas_Id 465
Location 10q24.1  [Link to chromosome band 10q24]
Location_base_pair Starts at 97332497 and ends at 97334729 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)FRAT2   16048
Cards
Entrez_Gene (NCBI)FRAT2    FRAT regulator of WNT signaling pathway 2
AliasesFRAT-2
GeneCards (Weizmann)FRAT2
Ensembl hg19 (Hinxton)ENSG00000181274 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000181274 [Gene_View]  ENSG00000181274 [Sequence]  chr10:97332497-97334729 [Contig_View]  FRAT2 [Vega]
ICGC DataPortalENSG00000181274
TCGA cBioPortalFRAT2
AceView (NCBI)FRAT2
Genatlas (Paris)FRAT2
SOURCE (Princeton)FRAT2
Genetics Home Reference (NIH)FRAT2
Genomic and cartography
GoldenPath hg38 (UCSC)FRAT2  -     chr10:97332497-97334729 -  10q24.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FRAT2  -     10q24.1   [Description]    (hg19-Feb_2009)
GoldenPathFRAT2 - 10q24.1 [CytoView hg19]  FRAT2 - 10q24.1 [CytoView hg38]
ImmunoBaseENSG00000181274
Genome Data Viewer NCBIFRAT2 [Mapview hg19]  
OMIM605006   
Gene and transcription
Genbank (Entrez)AB045118 AF062739 BC020165 BT009770 BU675503
RefSeq transcript (Entrez)NM_012083
Consensus coding sequences : CCDS (NCBI)FRAT2
Gene ExpressionFRAT2 [ NCBI-GEO ]   FRAT2 [ EBI - ARRAY_EXPRESS ]   FRAT2 [ SEEK ]   FRAT2 [ MEM ]
Gene Expression Viewer (FireBrowse)FRAT2 [ Firebrowse - Broad ]
GenevisibleExpression of FRAT2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23401
GTEX Portal (Tissue expression)FRAT2
Human Protein AtlasENSG00000181274-FRAT2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO75474   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO75474  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO75474
PhosPhoSitePlusO75474
Domains : Interpro (EBI)FRAT2    GSK3-bd   
Domain families : Pfam (Sanger)GSK-3_bind (PF05350)   
Domain families : Pfam (NCBI)pfam05350   
Conserved Domain (NCBI)FRAT2
SuperfamilyO75474
AlphaFold pdb e-kbO75474   
Human Protein Atlas [tissue]ENSG00000181274-FRAT2 [tissue]
HPRD05419
Protein Interaction databases
DIP (DOE-UCLA)O75474
IntAct (EBI)O75474
BioGRIDFRAT2
STRING (EMBL)FRAT2
ZODIACFRAT2
Ontologies - Pathways
QuickGOO75474
Ontology : AmiGOmolecular_function  cellular_component  cytoplasm  cytosol  beta-catenin destruction complex disassembly  
Ontology : EGO-EBImolecular_function  cellular_component  cytoplasm  cytosol  beta-catenin destruction complex disassembly  
Pathways : KEGGWnt signaling pathway   
NDEx NetworkFRAT2
Atlas of Cancer Signalling NetworkFRAT2
Wikipedia pathwaysFRAT2
Orthology - Evolution
OrthoDB23401
GeneTree (enSembl)ENSG00000181274
Phylogenetic Trees/Animal Genes : TreeFamFRAT2
Homologs : HomoloGeneFRAT2
Homology/Alignments : Family Browser (UCSC)FRAT2
Gene fusions - Rearrangements
Fusion : QuiverFRAT2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFRAT2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FRAT2
dbVarFRAT2
ClinVarFRAT2
MonarchFRAT2
1000_GenomesFRAT2 
Exome Variant ServerFRAT2
GNOMAD BrowserENSG00000181274
Varsome BrowserFRAT2
ACMGFRAT2 variants
VarityO75474
Genomic Variants (DGV)FRAT2 [DGVbeta]
DECIPHERFRAT2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFRAT2 
Mutations
ICGC Data PortalFRAT2 
TCGA Data PortalFRAT2 
Broad Tumor PortalFRAT2
OASIS PortalFRAT2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFRAT2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DFRAT2
Mutations and Diseases : HGMDFRAT2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaFRAT2
DgiDB (Drug Gene Interaction Database)FRAT2
DoCM (Curated mutations)FRAT2
CIViC (Clinical Interpretations of Variants in Cancer)FRAT2
Cancer3DFRAT2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605006   
Orphanet
DisGeNETFRAT2
MedgenFRAT2
Genetic Testing Registry FRAT2
NextProtO75474 [Medical]
GENETestsFRAT2
Target ValidationFRAT2
Huge Navigator FRAT2 [HugePedia]
ClinGenFRAT2
Clinical trials, drugs, therapy
MyCancerGenomeFRAT2
Protein Interactions : CTDFRAT2
Pharm GKB GenePA28362
PharosO75474
Clinical trialFRAT2
Miscellaneous
canSAR (ICR)FRAT2
HarmonizomeFRAT2
DataMed IndexFRAT2
Probes
Litterature
PubMed15 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXFRAT2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:09:56 CEST 2021

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