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FRS3 (fibroblast growth factor receptor substrate 3)

Identity

Alias_symbol (synonym)SNT-2
FRS2beta
FRS2B
Other aliasFRS2-beta
SNT2
HGNC (Hugo) FRS3
LocusID (NCBI) 10817
Atlas_Id 51593
Location 6p21.1  [Link to chromosome band 6p21]
Location_base_pair Starts at 41770176 and ends at 41779905 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
FRS3 (6p21.1) / FRS3 (6p21.1)FRS3 (6p21.1) / SMA4 (5q13.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)FRS3   16970
Cards
Entrez_Gene (NCBI)FRS3  10817  fibroblast growth factor receptor substrate 3
AliasesFRS2-beta; FRS2B; FRS2beta; SNT-2; 
SNT2
GeneCards (Weizmann)FRS3
Ensembl hg19 (Hinxton)ENSG00000137218 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000137218 [Gene_View]  ENSG00000137218 [Sequence]  chr6:41770176-41779905 [Contig_View]  FRS3 [Vega]
ICGC DataPortalENSG00000137218
TCGA cBioPortalFRS3
AceView (NCBI)FRS3
Genatlas (Paris)FRS3
WikiGenes10817
SOURCE (Princeton)FRS3
Genetics Home Reference (NIH)FRS3
Genomic and cartography
GoldenPath hg38 (UCSC)FRS3  -     chr6:41770176-41779905 -  6p21.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FRS3  -     6p21.1   [Description]    (hg19-Feb_2009)
EnsemblFRS3 - 6p21.1 [CytoView hg19]  FRS3 - 6p21.1 [CytoView hg38]
Mapping of homologs : NCBIFRS3 [Mapview hg19]  FRS3 [Mapview hg38]
OMIM607744   
Gene and transcription
Genbank (Entrez)AF036718 BC010611 BM741175 CR457026 HM005384
RefSeq transcript (Entrez)NM_006653
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FRS3
Cluster EST : UnigeneHs.194208 [ NCBI ]
CGAP (NCI)Hs.194208
Alternative Splicing GalleryENSG00000137218
Gene ExpressionFRS3 [ NCBI-GEO ]   FRS3 [ EBI - ARRAY_EXPRESS ]   FRS3 [ SEEK ]   FRS3 [ MEM ]
Gene Expression Viewer (FireBrowse)FRS3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10817
GTEX Portal (Tissue expression)FRS3
Human Protein AtlasENSG00000137218-FRS3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO43559   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO43559  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO43559
Splice isoforms : SwissVarO43559
PhosPhoSitePlusO43559
Domaine pattern : Prosite (Expaxy)IRS_PTB (PS51064)   
Domains : Interpro (EBI)IRS_PTB   
Domain families : Pfam (Sanger)IRS (PF02174)   
Domain families : Pfam (NCBI)pfam02174   
Domain families : Smart (EMBL)PTBI (SM00310)  
Conserved Domain (NCBI)FRS3
DMDM Disease mutations10817
Blocks (Seattle)FRS3
PDB (SRS)2KUP    2KUQ    2YS5    2YT2   
PDB (PDBSum)2KUP    2KUQ    2YS5    2YT2   
PDB (IMB)2KUP    2KUQ    2YS5    2YT2   
PDB (RSDB)2KUP    2KUQ    2YS5    2YT2   
Structural Biology KnowledgeBase2KUP    2KUQ    2YS5    2YT2   
SCOP (Structural Classification of Proteins)2KUP    2KUQ    2YS5    2YT2   
CATH (Classification of proteins structures)2KUP    2KUQ    2YS5    2YT2   
SuperfamilyO43559
Human Protein Atlas [tissue]ENSG00000137218-FRS3 [tissue]
Peptide AtlasO43559
HPRD06373
IPIIPI00009089   IPI00644089   IPI00852866   
Protein Interaction databases
DIP (DOE-UCLA)O43559
IntAct (EBI)O43559
FunCoupENSG00000137218
BioGRIDFRS3
STRING (EMBL)FRS3
ZODIACFRS3
Ontologies - Pathways
QuickGOO43559
Ontology : AmiGOMAPK cascade  Ras guanyl-nucleotide exchange factor activity  fibroblast growth factor receptor binding  protein binding  intracellular  plasma membrane  signal transduction  fibroblast growth factor receptor signaling pathway  identical protein binding  
Ontology : EGO-EBIMAPK cascade  Ras guanyl-nucleotide exchange factor activity  fibroblast growth factor receptor binding  protein binding  intracellular  plasma membrane  signal transduction  fibroblast growth factor receptor signaling pathway  identical protein binding  
NDEx NetworkFRS3
Atlas of Cancer Signalling NetworkFRS3
Wikipedia pathwaysFRS3
Orthology - Evolution
OrthoDB10817
GeneTree (enSembl)ENSG00000137218
Phylogenetic Trees/Animal Genes : TreeFamFRS3
HOVERGENO43559
HOGENOMO43559
Homologs : HomoloGeneFRS3
Homology/Alignments : Family Browser (UCSC)FRS3
Gene fusions - Rearrangements
Fusion : QuiverFRS3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFRS3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FRS3
dbVarFRS3
ClinVarFRS3
1000_GenomesFRS3 
Exome Variant ServerFRS3
ExAC (Exome Aggregation Consortium)ENSG00000137218
GNOMAD BrowserENSG00000137218
Varsome BrowserFRS3
Genetic variants : HAPMAP10817
Genomic Variants (DGV)FRS3 [DGVbeta]
DECIPHERFRS3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFRS3 
Mutations
ICGC Data PortalFRS3 
TCGA Data PortalFRS3 
Broad Tumor PortalFRS3
OASIS PortalFRS3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFRS3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDFRS3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FRS3
DgiDB (Drug Gene Interaction Database)FRS3
DoCM (Curated mutations)FRS3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FRS3 (select a term)
intoGenFRS3
Cancer3DFRS3(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607744   
Orphanet
DisGeNETFRS3
MedgenFRS3
Genetic Testing Registry FRS3
NextProtO43559 [Medical]
TSGene10817
GENETestsFRS3
Target ValidationFRS3
Huge Navigator FRS3 [HugePedia]
snp3D : Map Gene to Disease10817
BioCentury BCIQFRS3
ClinGenFRS3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10817
Chemical/Pharm GKB GenePA134961503
Clinical trialFRS3
Miscellaneous
canSAR (ICR)FRS3 (select the gene name)
Probes
Litterature
PubMed25 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFRS3
EVEXFRS3
GoPubMedFRS3
iHOPFRS3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 6 11:07:19 CET 2018

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