Atlas of Genetics and Cytogenetics in Oncology and Haematology

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FSHR (follicle stimulating hormone receptor)

Identity

Alias_namesODG1
Alias_symbol (synonym)FSHRO
LGR1
Other aliasFSHR1
HGNC (Hugo) FSHR
LocusID (NCBI) 2492
Atlas_Id 507
Location 2p16.3  [Link to chromosome band 2p16]
Location_base_pair Starts at 48962157 and ends at 49154527 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ELL3 (15q15.3) / FSHR (2p16.3)FSHR (2p16.3) / FSHR (2p16.3)FSHR (2p16.3) / TRABD (22q13.33)
TTC7A (2p21) / FSHR (2p16.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Ovary: Sex cord-stromal tumors

External links

Nomenclature
HGNC (Hugo)FSHR   3969
LRG (Locus Reference Genomic)LRG_536
Cards
Entrez_Gene (NCBI)FSHR  2492  follicle stimulating hormone receptor
AliasesFSHR1; FSHRO; LGR1; ODG1
GeneCards (Weizmann)FSHR
Ensembl hg19 (Hinxton)ENSG00000170820 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000170820 [Gene_View]  ENSG00000170820 [Sequence]  chr2:48962157-49154527 [Contig_View]  FSHR [Vega]
ICGC DataPortalENSG00000170820
TCGA cBioPortalFSHR
AceView (NCBI)FSHR
Genatlas (Paris)FSHR
WikiGenes2492
SOURCE (Princeton)FSHR
Genetics Home Reference (NIH)FSHR
Genomic and cartography
GoldenPath hg38 (UCSC)FSHR  -     chr2:48962157-49154527 -  2p16.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FSHR  -     2p16.3   [Description]    (hg19-Feb_2009)
EnsemblFSHR - 2p16.3 [CytoView hg19]  FSHR - 2p16.3 [CytoView hg38]
Mapping of homologs : NCBIFSHR [Mapview hg19]  FSHR [Mapview hg38]
OMIM136435   233300   276400   608115   
Gene and transcription
Genbank (Entrez)AK292562 AK301899 AK310367 AY429104 BC096831
RefSeq transcript (Entrez)NM_000145 NM_181446
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FSHR
Cluster EST : UnigeneHs.1428 [ NCBI ]
CGAP (NCI)Hs.1428
Alternative Splicing GalleryENSG00000170820
Gene ExpressionFSHR [ NCBI-GEO ]   FSHR [ EBI - ARRAY_EXPRESS ]   FSHR [ SEEK ]   FSHR [ MEM ]
Gene Expression Viewer (FireBrowse)FSHR [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2492
GTEX Portal (Tissue expression)FSHR
Human Protein AtlasENSG00000170820-FSHR [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP23945   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP23945  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP23945
Splice isoforms : SwissVarP23945
PhosPhoSitePlusP23945
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F1_1 (PS00237)    G_PROTEIN_RECEP_F1_2 (PS50262)   
Domains : Interpro (EBI)FSH_rcpt    GnHR_TM    GPCR_Rhodpsn    GPCR_Rhodpsn_7TM    Gphrmn_rcpt_fam    L_dom-like    LRR_5    LRRNT    TSHR/LHCGR/FSHR   
Domain families : Pfam (Sanger)7tm_1 (PF00001)    GnHR_trans (PF12369)    LRR_5 (PF13306)    LRRNT (PF01462)   
Domain families : Pfam (NCBI)pfam00001    pfam12369    pfam13306    pfam01462   
Domain families : Smart (EMBL)LRRNT (SM00013)  
Conserved Domain (NCBI)FSHR
DMDM Disease mutations2492
Blocks (Seattle)FSHR
PDB (SRS)1XUN    1XWD    4AY9    4MQW   
PDB (PDBSum)1XUN    1XWD    4AY9    4MQW   
PDB (IMB)1XUN    1XWD    4AY9    4MQW   
PDB (RSDB)1XUN    1XWD    4AY9    4MQW   
Structural Biology KnowledgeBase1XUN    1XWD    4AY9    4MQW   
SCOP (Structural Classification of Proteins)1XUN    1XWD    4AY9    4MQW   
CATH (Classification of proteins structures)1XUN    1XWD    4AY9    4MQW   
SuperfamilyP23945
Human Protein Atlas [tissue]ENSG00000170820-FSHR [tissue]
Peptide AtlasP23945
HPRD00639
IPIIPI00303575   IPI00328365   IPI01012610   IPI00807720   IPI00893331   
Protein Interaction databases
DIP (DOE-UCLA)P23945
IntAct (EBI)P23945
FunCoupENSG00000170820
BioGRIDFSHR
STRING (EMBL)FSHR
ZODIACFSHR
Ontologies - Pathways
QuickGOP23945
Ontology : AmiGOprimary ovarian follicle growth  follicle-stimulating hormone receptor activity  protein binding  intracellular  plasma membrane  plasma membrane  integral component of plasma membrane  G-protein coupled receptor signaling pathway  adenylate cyclase-activating G-protein coupled receptor signaling pathway  activation of adenylate cyclase activity  spermatogenesis  female gamete generation  gonad development  G-protein coupled peptide receptor activity  male gonad development  female gonad development  hormone-mediated signaling pathway  regulation of protein kinase A signaling  positive regulation of phosphatidylinositol 3-kinase signaling  integral component of membrane  follicle-stimulating hormone signaling pathway  regulation of osteoclast differentiation  positive regulation of adenylate cyclase activity  positive regulation of ERK1 and ERK2 cascade  cellular response to follicle-stimulating hormone stimulus  
Ontology : EGO-EBIprimary ovarian follicle growth  follicle-stimulating hormone receptor activity  protein binding  intracellular  plasma membrane  plasma membrane  integral component of plasma membrane  G-protein coupled receptor signaling pathway  adenylate cyclase-activating G-protein coupled receptor signaling pathway  activation of adenylate cyclase activity  spermatogenesis  female gamete generation  gonad development  G-protein coupled peptide receptor activity  male gonad development  female gonad development  hormone-mediated signaling pathway  regulation of protein kinase A signaling  positive regulation of phosphatidylinositol 3-kinase signaling  integral component of membrane  follicle-stimulating hormone signaling pathway  regulation of osteoclast differentiation  positive regulation of adenylate cyclase activity  positive regulation of ERK1 and ERK2 cascade  cellular response to follicle-stimulating hormone stimulus  
Pathways : BIOCARTARegulation of Spermatogenesis by CREM [Genes]   
Pathways : KEGGNeuroactive ligand-receptor interaction   
NDEx NetworkFSHR
Atlas of Cancer Signalling NetworkFSHR
Wikipedia pathwaysFSHR
Orthology - Evolution
OrthoDB2492
GeneTree (enSembl)ENSG00000170820
Phylogenetic Trees/Animal Genes : TreeFamFSHR
HOVERGENP23945
HOGENOMP23945
Homologs : HomoloGeneFSHR
Homology/Alignments : Family Browser (UCSC)FSHR
Gene fusions - Rearrangements
Fusion : QuiverFSHR
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFSHR [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FSHR
dbVarFSHR
ClinVarFSHR
1000_GenomesFSHR 
Exome Variant ServerFSHR
ExAC (Exome Aggregation Consortium)ENSG00000170820
GNOMAD BrowserENSG00000170820
Genetic variants : HAPMAP2492
Genomic Variants (DGV)FSHR [DGVbeta]
DECIPHERFSHR [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFSHR 
Mutations
ICGC Data PortalFSHR 
TCGA Data PortalFSHR 
Broad Tumor PortalFSHR
OASIS PortalFSHR [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFSHR  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDFSHR
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FSHR
DgiDB (Drug Gene Interaction Database)FSHR
DoCM (Curated mutations)FSHR (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FSHR (select a term)
intoGenFSHR
Cancer3DFSHR(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM136435    233300    276400    608115   
Orphanet1011    10843   
DisGeNETFSHR
MedgenFSHR
Genetic Testing Registry FSHR
NextProtP23945 [Medical]
TSGene2492
GENETestsFSHR
Target ValidationFSHR
Huge Navigator FSHR [HugePedia]
snp3D : Map Gene to Disease2492
BioCentury BCIQFSHR
ClinGenFSHR
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2492
Chemical/Pharm GKB GenePA28386
Clinical trialFSHR
Miscellaneous
canSAR (ICR)FSHR (select the gene name)
Probes
Litterature
PubMed270 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFSHR
EVEXFSHR
GoPubMedFSHR
iHOPFSHR
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jun 22 16:26:22 CEST 2018
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