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FTCD (formimidoyltransferase cyclodeaminase)

Identity

Alias_namesformiminotransferase cyclodeaminase
Other aliasLCHC1
HGNC (Hugo) FTCD
LocusID (NCBI) 10841
Atlas_Id 56429
Location 21q22.3  [Link to chromosome band 21q22]
Location_base_pair Starts at 46136262 and ends at 46155567 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ECH1 (19q13.2) / FTCD (21q22.3)SETD4 (21q22.12) / FTCD (21q22.3)SPATC1L (21q22.3) / FTCD (21q22.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)FTCD   3974
Cards
Entrez_Gene (NCBI)FTCD  10841  formimidoyltransferase cyclodeaminase
AliasesLCHC1
GeneCards (Weizmann)FTCD
Ensembl hg19 (Hinxton)ENSG00000160282 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000160282 [Gene_View]  chr21:46136262-46155567 [Contig_View]  FTCD [Vega]
ICGC DataPortalENSG00000160282
TCGA cBioPortalFTCD
AceView (NCBI)FTCD
Genatlas (Paris)FTCD
WikiGenes10841
SOURCE (Princeton)FTCD
Genetics Home Reference (NIH)FTCD
Genomic and cartography
GoldenPath hg38 (UCSC)FTCD  -     chr21:46136262-46155567 -  21q22.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FTCD  -     21q22.3   [Description]    (hg19-Feb_2009)
EnsemblFTCD - 21q22.3 [CytoView hg19]  FTCD - 21q22.3 [CytoView hg38]
Mapping of homologs : NCBIFTCD [Mapview hg19]  FTCD [Mapview hg38]
OMIM229100   606806   
Gene and transcription
Genbank (Entrez)AA719282 AF169017 AF289021 AF289022 AF289023
RefSeq transcript (Entrez)NM_001320412 NM_006657 NM_206965
RefSeq genomic (Entrez)NC_000021 NC_018932 NG_016191 NT_187626
Consensus coding sequences : CCDS (NCBI)FTCD
Cluster EST : UnigeneHs.415846 [ NCBI ]
CGAP (NCI)Hs.415846
Alternative Splicing GalleryENSG00000160282
Gene ExpressionFTCD [ NCBI-GEO ]   FTCD [ EBI - ARRAY_EXPRESS ]   FTCD [ SEEK ]   FTCD [ MEM ]
Gene Expression Viewer (FireBrowse)FTCD [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10841
GTEX Portal (Tissue expression)FTCD
Protein : pattern, domain, 3D structure
UniProt/SwissProtO95954   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO95954  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO95954
Splice isoforms : SwissVarO95954
Catalytic activity : Enzyme2.1.2.5 [ Enzyme-Expasy ]   2.1.2.52.1.2.5 [ IntEnz-EBI ]   2.1.2.5 [ BRENDA ]   2.1.2.5 [ KEGG ]   
PhosPhoSitePlusO95954
Domains : Interpro (EBI)Cyclodeamin/CycHdrlase    Formiminotransferase_C    Formiminotransferase_cat    Formiminotransferase_N    FormiminoTrfase_subdom   
Domain families : Pfam (Sanger)FTCD (PF02971)    FTCD_C (PF04961)    FTCD_N (PF07837)   
Domain families : Pfam (NCBI)pfam02971    pfam04961    pfam07837   
Domain families : Smart (EMBL)FTCD (SM01221)  FTCD_N (SM01222)  
Conserved Domain (NCBI)FTCD
DMDM Disease mutations10841
Blocks (Seattle)FTCD
SuperfamilyO95954
Human Protein AtlasENSG00000160282
Peptide AtlasO95954
HPRD08430
IPIIPI00001441   IPI00218976   IPI00218977   IPI00218978   IPI00921399   IPI00792328   
Protein Interaction databases
DIP (DOE-UCLA)O95954
IntAct (EBI)O95954
FunCoupENSG00000160282
BioGRIDFTCD
STRING (EMBL)FTCD
ZODIACFTCD
Ontologies - Pathways
QuickGOO95954
Ontology : AmiGOGolgi membrane  Golgi membrane  protein binding  folic acid binding  cytoplasm  endoplasmic reticulum  endoplasmic reticulum-Golgi intermediate compartment  Golgi apparatus  centriole  cytosol  cytosol  histidine catabolic process  folic acid-containing compound metabolic process  cytoskeleton organization  microtubule binding  microtubule binding  histidine catabolic process to glutamate and formamide  histidine catabolic process to glutamate and formate  formimidoyltransferase activity  glutamate formimidoyltransferase activity  formimidoyltetrahydrofolate cyclodeaminase activity  formimidoyltetrahydrofolate cyclodeaminase activity  smooth endoplasmic reticulum membrane  tetrahydrofolate interconversion  extracellular exosome  
Ontology : EGO-EBIGolgi membrane  Golgi membrane  protein binding  folic acid binding  cytoplasm  endoplasmic reticulum  endoplasmic reticulum-Golgi intermediate compartment  Golgi apparatus  centriole  cytosol  cytosol  histidine catabolic process  folic acid-containing compound metabolic process  cytoskeleton organization  microtubule binding  microtubule binding  histidine catabolic process to glutamate and formamide  histidine catabolic process to glutamate and formate  formimidoyltransferase activity  glutamate formimidoyltransferase activity  formimidoyltetrahydrofolate cyclodeaminase activity  formimidoyltetrahydrofolate cyclodeaminase activity  smooth endoplasmic reticulum membrane  tetrahydrofolate interconversion  extracellular exosome  
Pathways : KEGGHistidine metabolism    One carbon pool by folate   
NDEx NetworkFTCD
Atlas of Cancer Signalling NetworkFTCD
Wikipedia pathwaysFTCD
Orthology - Evolution
OrthoDB10841
GeneTree (enSembl)ENSG00000160282
Phylogenetic Trees/Animal Genes : TreeFamFTCD
HOVERGENO95954
HOGENOMO95954
Homologs : HomoloGeneFTCD
Homology/Alignments : Family Browser (UCSC)FTCD
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFTCD [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FTCD
dbVarFTCD
ClinVarFTCD
1000_GenomesFTCD 
Exome Variant ServerFTCD
ExAC (Exome Aggregation Consortium)FTCD (select the gene name)
Genetic variants : HAPMAP10841
Genomic Variants (DGV)FTCD [DGVbeta]
DECIPHERFTCD [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFTCD 
Mutations
ICGC Data PortalFTCD 
TCGA Data PortalFTCD 
Broad Tumor PortalFTCD
OASIS PortalFTCD [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFTCD  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDFTCD
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FTCD
DgiDB (Drug Gene Interaction Database)FTCD
DoCM (Curated mutations)FTCD (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FTCD (select a term)
intoGenFTCD
Cancer3DFTCD(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM229100    606806   
Orphanet10673   
MedgenFTCD
Genetic Testing Registry FTCD
NextProtO95954 [Medical]
TSGene10841
GENETestsFTCD
Target ValidationFTCD
Huge Navigator FTCD [HugePedia]
snp3D : Map Gene to Disease10841
BioCentury BCIQFTCD
ClinGenFTCD
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10841
Chemical/Pharm GKB GenePA28391
Clinical trialFTCD
Miscellaneous
canSAR (ICR)FTCD (select the gene name)
Probes
Litterature
PubMed21 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFTCD
EVEXFTCD
GoPubMedFTCD
iHOPFTCD
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Tue Aug 1 17:01:34 CEST 2017

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