FTH1 (ferritin heavy chain 1)

2007-02-01  

Identity

HGNC
FTH1
LOCATION
11q12.3
LOCUSID
2495
ALIAS
FHC,FTH,FTHL6,HFE5,PIG15,PLIF
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2495
MIM: 134770
HGNC: 3976
Ensembl: ENSG00000167996

Variants:

dbSNP: 2495
ClinVar: 2495
TCGA: ENSG00000167996
COSMIC: FTH1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000167996ENST00000273550P02794
ENSG00000167996ENST00000273550A0A024R525
ENSG00000167996ENST00000526640G3V192
ENSG00000167996ENST00000529191E9PK45
ENSG00000167996ENST00000529548E9PPQ4
ENSG00000167996ENST00000529631E9PKM5
ENSG00000167996ENST00000530019E9PKY7
ENSG00000167996ENST00000532601G3V1D1
ENSG00000167996ENST00000532829E9PRK8
ENSG00000167996ENST00000534180E9PQR3
ENSG00000167996ENST00000620041P02794
ENSG00000167996ENST00000620041A0A024R525

Expression (GTEx)

0
500
1000
1500
2000
2500
3000
3500
4000
4500
5000
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Mineral absorptionKEGGko04978
Mineral absorptionKEGGhsa04978
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
trans-Golgi Network Vesicle BuddingREACTOMER-HSA-199992
Clathrin derived vesicle buddingREACTOMER-HSA-421837
Golgi Associated Vesicle BiogenesisREACTOMER-HSA-432722
Binding and Uptake of Ligands by Scavenger ReceptorsREACTOMER-HSA-2173782
Scavenging by Class A ReceptorsREACTOMER-HSA-3000480
Transmembrane transport of small moleculesREACTOMER-HSA-382551
Iron uptake and transportREACTOMER-HSA-917937
Neutrophil degranulationREACTOMER-HSA-6798695
FerroptosisKEGGko04216
FerroptosisKEGGhsa04216

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
201336742010Binding and uptake of H-ferritin are mediated by human transferrin receptor-1.82
215555182011The BTB and CNC homology 1 (BACH1) target genes are involved in the oxidative stress response and in control of the cell cycle.60
124357352003Nrf2 mediates the induction of ferritin H in response to xenobiotics and cancer chemopreventive dithiolethiones.58
203903452011Role of ferritin alterations in human breast cancer cells.57
191266852009Regulatory effects of ferritin on angiogenesis.47
241248912014Coupling heme and iron metabolism via ferritin H chain.42
157554492005Unique iron binding and oxidation properties of human mitochondrial ferritin: a comparative analysis with Human H-chain ferritin.29
177610322007The association of circulating ferritin with serum concentrations of fibroblast growth factor-23 measured by three commercial assays.28
198217642010Ferritin ferroxidase activity: a potent inhibitor of osteogenesis.26
292409472018A FTH1 gene:pseudogene:microRNA network regulates tumorigenesis in prostate cancer.24

Citation

Dessen P

FTH1 (ferritin heavy chain 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46107/fth1