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FUCA2 (alpha-L-fucosidase 2)

Identity

Alias (NCBI)dJ20N2.5
HGNC (Hugo) FUCA2
HGNC Alias symbMGC1314
dJ20N2.5
LocusID (NCBI) 2519
Atlas_Id 63626
Location 6q24.2  [Link to chromosome band 6q24]
Location_base_pair Starts at 143494812 and ends at 143511720 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
FUCA2 (6q24.2) / SSR2 (1q22)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)FUCA2   4008
Cards
Entrez_Gene (NCBI)FUCA2    alpha-L-fucosidase 2
AliasesdJ20N2.5
GeneCards (Weizmann)FUCA2
Ensembl hg19 (Hinxton)ENSG00000001036 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000001036 [Gene_View]  ENSG00000001036 [Sequence]  chr6:143494812-143511720 [Contig_View]  FUCA2 [Vega]
ICGC DataPortalENSG00000001036
TCGA cBioPortalFUCA2
AceView (NCBI)FUCA2
Genatlas (Paris)FUCA2
SOURCE (Princeton)FUCA2
Genetics Home Reference (NIH)FUCA2
Genomic and cartography
GoldenPath hg38 (UCSC)FUCA2  -     chr6:143494812-143511720 -  6q24.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FUCA2  -     6q24.2   [Description]    (hg19-Feb_2009)
GoldenPathFUCA2 - 6q24.2 [CytoView hg19]  FUCA2 - 6q24.2 [CytoView hg38]
ImmunoBaseENSG00000001036
Genome Data Viewer NCBIFUCA2 [Mapview hg19]  
OMIM136820   
Gene and transcription
Genbank (Entrez)AK075458 AK296485 AK315475 AY358551 BC003060
RefSeq transcript (Entrez)NM_032020
Consensus coding sequences : CCDS (NCBI)FUCA2
Gene ExpressionFUCA2 [ NCBI-GEO ]   FUCA2 [ EBI - ARRAY_EXPRESS ]   FUCA2 [ SEEK ]   FUCA2 [ MEM ]
Gene Expression Viewer (FireBrowse)FUCA2 [ Firebrowse - Broad ]
GenevisibleExpression of FUCA2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2519
GTEX Portal (Tissue expression)FUCA2
Human Protein AtlasENSG00000001036-FUCA2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BTY2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9BTY2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9BTY2
Catalytic activity : Enzyme3.2.1.51 [ Enzyme-Expasy ]   3.2.1.513.2.1.51 [ IntEnz-EBI ]   3.2.1.51 [ BRENDA ]   3.2.1.51 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ9BTY2
Domaine pattern : Prosite (Expaxy)ALPHA_L_FUCOSIDASE (PS00385)   
Domains : Interpro (EBI)FUC_metazoa-typ    Fucosidase_C    Glyco_hydro_29    Glyco_hydro_29_CS    Glyco_hydro_b    Glycoside_hydrolase_SF   
Domain families : Pfam (Sanger)Alpha_L_fucos (PF01120)    Fucosidase_C (PF16757)   
Domain families : Pfam (NCBI)pfam01120    pfam16757   
Domain families : Smart (EMBL)Alpha_L_fucos (SM00812)  
Conserved Domain (NCBI)FUCA2
SuperfamilyQ9BTY2
AlphaFold pdb e-kbQ9BTY2   
Human Protein Atlas [tissue]ENSG00000001036-FUCA2 [tissue]
HPRD00649
Protein Interaction databases
DIP (DOE-UCLA)Q9BTY2
IntAct (EBI)Q9BTY2
BioGRIDFUCA2
STRING (EMBL)FUCA2
ZODIACFUCA2
Ontologies - Pathways
QuickGOQ9BTY2
Ontology : AmiGOalpha-L-fucosidase activity  alpha-L-fucosidase activity  protein binding  extracellular region  extracellular space  lysosome  endoplasmic reticulum lumen  fucose metabolic process  fucose metabolic process  response to bacterium  glycoside catabolic process  glycoside catabolic process  azurophil granule lumen  neutrophil degranulation  post-translational protein modification  cellular protein metabolic process  extracellular exosome  regulation of entry of bacterium into host cell  
Ontology : EGO-EBIalpha-L-fucosidase activity  alpha-L-fucosidase activity  protein binding  extracellular region  extracellular space  lysosome  endoplasmic reticulum lumen  fucose metabolic process  fucose metabolic process  response to bacterium  glycoside catabolic process  glycoside catabolic process  azurophil granule lumen  neutrophil degranulation  post-translational protein modification  cellular protein metabolic process  extracellular exosome  regulation of entry of bacterium into host cell  
Pathways : KEGGN-Glycan degradation    Glycan structures - degradation   
NDEx NetworkFUCA2
Atlas of Cancer Signalling NetworkFUCA2
Wikipedia pathwaysFUCA2
Orthology - Evolution
OrthoDB2519
GeneTree (enSembl)ENSG00000001036
Phylogenetic Trees/Animal Genes : TreeFamFUCA2
Homologs : HomoloGeneFUCA2
Homology/Alignments : Family Browser (UCSC)FUCA2
Gene fusions - Rearrangements
Fusion : QuiverFUCA2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFUCA2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FUCA2
dbVarFUCA2
ClinVarFUCA2
MonarchFUCA2
1000_GenomesFUCA2 
Exome Variant ServerFUCA2
GNOMAD BrowserENSG00000001036
Varsome BrowserFUCA2
ACMGFUCA2 variants
VarityQ9BTY2
Genomic Variants (DGV)FUCA2 [DGVbeta]
DECIPHERFUCA2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFUCA2 
Mutations
ICGC Data PortalFUCA2 
TCGA Data PortalFUCA2 
Broad Tumor PortalFUCA2
OASIS PortalFUCA2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFUCA2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DFUCA2
Mutations and Diseases : HGMDFUCA2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaFUCA2
DgiDB (Drug Gene Interaction Database)FUCA2
DoCM (Curated mutations)FUCA2
CIViC (Clinical Interpretations of Variants in Cancer)FUCA2
Cancer3DFUCA2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM136820   
Orphanet
DisGeNETFUCA2
MedgenFUCA2
Genetic Testing Registry FUCA2
NextProtQ9BTY2 [Medical]
GENETestsFUCA2
Target ValidationFUCA2
Huge Navigator FUCA2 [HugePedia]
ClinGenFUCA2
Clinical trials, drugs, therapy
MyCancerGenomeFUCA2
Protein Interactions : CTDFUCA2
Pharm GKB GenePA28424
PharosQ9BTY2
Clinical trialFUCA2
Miscellaneous
canSAR (ICR)FUCA2
HarmonizomeFUCA2
DataMed IndexFUCA2
Probes
Litterature
PubMed30 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXFUCA2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:50:59 CEST 2021

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