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FUS (fusion involved in t (12;16) in malignant liposarcoma)

Written2004-07PA Pérez-Mancera, Isidro Sánchez-Garía
Laboratorio 13, Instituto de Biologia Molecular y Celular del Cancer (IBMCC), Centro de Investigacion del Cancer, Campus Unamuno, 37.007-Salamanca, Spain

(Note : for Links provided by Atlas : click)

Identity

Alias (NCBI)TLS (translocated in liposarcoma)
HGNC (Hugo) FUS
HGNC Alias symbTLS
FUS1
hnRNP-P2
HNRNPP2
HGNC Alias nameheterogeneous nuclear ribonucleoprotein P2
 translocated in liposarcoma
HGNC Previous nameALS6
HGNC Previous namefusion, derived from t(12;16) malignant liposarcoma
 amyotrophic lateral sclerosis 6
 fusion (involved in t(12;16) in malignant liposarcoma)
 fused in sarcoma
LocusID (NCBI) 2521
Atlas_Id 44
Location 16p11.2  [Link to chromosome band 16p11]
Location_base_pair Starts at 31180139 and ends at 31191604 bp from pter ( according to GRCh38/hg38-Dec_2013)  [Mapping FUS.png]
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ATF1 (12q13.12)::FUS (16p11.2)CEBPZ (2p22.2)::FUS (16p11.2)CREB3L1 (11p11.2)::FUS (16p11.2)
CREB3L2 (7q33)::FUS (16p11.2)DDIT3 (12q13.3)::FUS (16p11.2)EIF4A2 (3q27.3)::FUS (16p11.2)
ERBB4 (2q34)::FUS (16p11.2)ERG (21q22.2)::FUS (16p11.2)FEV (2q35)::FUS (16p11.2)
FUS (16p11.2)::ACTN4 (19q13.2)FUS (16p11.2)::ADNP2 (18q23)FUS (16p11.2)::ATF1 (12q13.12)
FUS (16p11.2)::CEBPZ (2p22.2)FUS (16p11.2)::CHD1 (5q15)FUS (16p11.2)::CREB3L1 (11p11.2)
FUS (16p11.2)::CREB3L2 (7q33)FUS (16p11.2)::DDIT3 (12q13.3)FUS (16p11.2)::ERG (21q22.2)
FUS (16p11.2)::FEV (2q35)FUS (16p11.2)::FUS (16p11.2)FUS (16p11.2)::GDNF (5p13.2)
FUS (16p11.2)::KLF17 (1p34.1)FUS (16p11.2)::LTBP3 (11q13.1)FUS (16p11.2)::MAEA (4p16.3)
FUS (16p11.2)::MARS (12q13.3)FUS (16p11.2)::NFATC2 (20q13.2)FUS (16p11.2)::NMNAT2 (1q25.3)
FUS (16p11.2)::NR4A3 (9q22.33)FUS (16p11.2)::NR4A3 (9q31.1)FUS (16p11.2)::PHLDB2 (3q13.2)
FUS (16p11.2)::POU5F1 (6p21.33)FUS (16p11.2)::PRSS36 (16p11.2)FUS (16p11.2)::PSMB7 (9q33.3)
FUS (16p11.2)::RUNX1 (21q22.12)FUS (16p11.2)::SET (9q34.11)FUS (16p11.2)::SRR (17p13.3)
GDNF (5p13.2)::FUS (16p11.2)NOVA1 (14q12)::FUS (16p11.2)SRSF11 (1p31.1)::FUS (16p11.2)
VRK2 (2p16.1)::FUS (16p11.2)

DNA/RNA

Description The gene has 15 exons, and the total genomic sequence spanning the FUS gene is approx. 12 Kb.
Transcription Transcript lenght: 1,9 Kb. There are two isoforms produced by an alternative splicing that involved the exon 4a (145 bp) or the exon 4b (142 bp).

Protein

 
Description 526 amino acids (isoform with the exon 4a) or 525 aa (isoform with the exon 4b), 68 Kda. The protein contains different domains:
  • a N-terminal SYQG-rich region;
  • a RGG-rich region;
  • a RNA binding domain;
  • a RGG-rich region;
  • a Cys2/Cys2-zinc finger motif and;
  • a C-terminal RGG-rich region.

  • Expression FUS is expressed in a housekeeping pattern.
    Localisation Nuclear, although FUS shuttles from the nucleus to the cytoplasm in a large complex that contains mRNA and hnRNPs.
    Function FUS is a RNA-binding protein that is identical to hnRNP P2 and may be implicated in mRNA metabolism. FUS seems to have a function as a heterogeneous ribonuclear protein (hnRNP)-like chaperone of RNA. In addition, it has been suggested that FUS might have a role in the BCR/ABL-mediated leukemogenesis.
    Homology FUS forms a sub-family of RNA binding proteins with EWS and RBP56/hTAFII68. FUS has homologous in mouse (fus), rat (pigpen) and Drosophila (Cabeza/SARFH).

    Mutations

    Germinal In the mouse, germline mutation in the fus gene produces male sterility, sensitivity to radiation, defective B-lymphocyte development and activation, chromosomal instability and perinatal death.

    Implicated in

    Note
    Note The FUS gene is implicated in several chromosomal translocations associated to both solid tumors and leukemias. The result of these chromosomal translocations are gene fusions. FUS contributes to these fusions with its N-terminal part, just before the RNA-binding domain. This domain confers to the fusion protein a transcriptional activation domain. These fusion genes generated as a result of chromosomal rearragements are used to monitor diagnosis and treatment.
     
      
      
    Entity t(12;16)(q13;p11) chromosomal translocation. It produces the fusion protein FUS/ATF-1.
    Disease .
    Hybrid/Mutated Gene FUS was interrupted at codon 175 (exon 5) and fused to codon 110 (exon 5) of ATF-1, resulting in an in-frame junction with a glycine to valine (GGT to GTT) transition.
      
      
    Entity t(7;16)(q33;p11) chromosomal translocation. It produces the fusion protein FUS/CREB3L2 (also known as BBF2H7).
    Disease .
    Hybrid/Mutated Gene The breakpoints in the fusion transcripts are produced between the exons 6 or 7 of FUS and the exon 5 of CREB3L2.
      
      
    Entity t(12;16)(q13;p11) chromosomal translocation. It produces the fusion protein FUS/DDIT3 (also known as CHOP).
    Disease .
    Hybrid/Mutated Gene 9 different types of fusions between the genes FUS and DDIT3 have been reported. The most frequent rearragements join the exons 5, 7 or 8 of FUS with the exon 2 of DDIT3.
    Oncogenesis The unequivocally relation between FUS/DDIT3 and the MLS was shown by the generation of a transgenic mouse model expressing FUS/DDIT3 from a housekeeping promoter.
      
      
    Entity chromosomal translocation. It produces the fusion protein FUS/ERG.
    Disease .
    Hybrid/Mutated Gene The junction of both genes is produced between the exons 6 or 7 of FUS and the exon 9 of ERG,or between the exon 8 of FUS and the exon 7 of ERG.
      

    Breakpoints

     

    Bibliography

    Expression patterns of the human sarcoma-associated genes FUS and EWS and the genomic structure of FUS.
    Aman P, Panagopoulos I, Lassen C, Fioretos T, Mencinger M, Toresson H, Höglund M, Forster A, Rabbitts TH, Ron D, Mandahl N, Mitelman F
    Genomics. 1996 ; 37 (1) : 1-8.
    PMID 8921363
     
    Rearrangement of the transcription factor gene CHOP in myxoid liposarcomas with t(12;16)(q13;p11).
    Aman P, Ron D, Mandahl N, Fioretos T, Heim S, Arheden K, Willén H, Rydholm A, Mitelman F
    Genes, chromosomes & cancer. 1992 ; 5 (4) : 278-285.
    PMID 1283316
     
    Identification of hnRNP P2 as TLS/FUS using electrospray mass spectrometry.
    Calvio C, Neubauer G, Mann M, Lamond AI
    RNA (New York, N.Y.). 1995 ; 1 (7) : 724-733.
    PMID 7585257
     
    Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma.
    Crozat A, Aman P, Mandahl N, Ron D
    Nature. 1993 ; 363 (6430) : 640-644.
    PMID 8510758
     
    Fus deficiency in mice results in defective B-lymphocyte development and activation, high levels of chromosomal instability and perinatal death.
    Hicks GG, Singh N, Nashabi A, Mai S, Bozek G, Klewes L, Arapovic D, White EK, Koury MJ, Oltz EM, Van Kaer L, Ruley HE
    Nature genetics. 2000 ; 24 (2) : 175-179.
    PMID 10655065
     
    Dual transforming activities of the FUS (TLS)-ERG leukemia fusion protein conferred by two N-terminal domains of FUS (TLS).
    Ichikawa H, Shimizu K, Katsu R, Ohki M
    Molecular and cellular biology. 1999 ; 19 (11) : 7639-7650.
    PMID 10523652
     
    Translocation t(12;16)(q13;p11) in myxoid liposarcoma and round cell liposarcoma: molecular and cytogenetic analysis.
    Knight JC, Renwick PJ, Cin PD, Van den Berghe H, Fletcher CD
    Cancer research. 1995 ; 55 (1) : 24-27.
    PMID 7805034
     
    Consistent detection of TLS/FUS-ERG chimeric transcripts in acute myeloid leukemia with t(16;21)(p11;q22) and identification of a novel transcript.
    Kong XT, Ida K, Ichikawa H, Shimizu K, Ohki M, Maseki N, Kaneko Y, Sako M, Kobayashi Y, Tojou A, Miura I, Kakuda H, Funabiki T, Horibe K, Hamaguchi H, Akiyama Y, Bessho F, Yanagisawa M, Hayashi Y
    Blood. 1997 ; 90 (3) : 1192-1199.
    PMID 9242552
     
    Male sterility and enhanced radiation sensitivity in TLS(-/-) mice.
    Kuroda M, Sok J, Webb L, Baechtold H, Urano F, Yin Y, Chung P, de Rooij DG, Akhmedov A, Ashley T, Ron D
    The EMBO journal. 2000 ; 19 (3) : 453-462.
    PMID 10654943
     
    Genomic structure of the human RBP56/hTAFII68 and FUS/TLS genes.
    Morohoshi F, Ootsuka Y, Arai K, Ichikawa H, Mitani S, Munakata N, Ohki M
    Gene. 1998 ; 221 (2) : 191-198.
    PMID 9795213
     
    Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia.
    Mullighan CG, Goorha S, Radtke I, Miller CB, Coustan-Smith E, Dalton JD, Girtman K, Mathew S, Ma J, Pounds SB, Su X, Pui CH, Relling MV, Evans WE, Shurtleff SA, Downing JR
    Nature. 2007 ; 446 (7137) : 758-764.
    PMID 17344859
     
    Expression of the FUS domain restores liposarcoma development in CHOP transgenic mice.
    Pérez-Mancera PA, Pérez-Losada J, Sánchez-Martín M, Rodríguez-García MA, Flores T, Battaner E, Gutiérrez-Adán A, Pintado B, Sánchez-García I
    Oncogene. 2002 ; 21 (11) : 1679-1684.
    PMID 11896599
     
    The chimeric FUS/CREB3l2 gene is specific for low-grade fibromyxoid sarcoma.
    Panagopoulos I, Storlazzi CT, Fletcher CD, Fletcher JA, Nascimento A, Domanski HA, Wejde J, Brosjö O, Rydholm A, Isaksson M, Mandahl N, Mertens F
    Genes, chromosomes & cancer. 2004 ; 40 (3) : 218-228.
    PMID 15139001
     
    TLS/FUS, a pro-oncogene involved in multiple chromosomal translocations, is a novel regulator of BCR/ABL-mediated leukemogenesis.
    Perrotti D, Bonatti S, Trotta R, Martinez R, Skorski T, Salomoni P, Grassilli E, Lozzo RV, Cooper DR, Calabretta B
    The EMBO journal. 1998 ; 17 (15) : 4442-4455.
    PMID 9687511
     
    TLS/FUS fusion domain of TLS/FUS-erg chimeric protein resulting from the t(16;21) chromosomal translocation in human myeloid leukemia functions as a transcriptional activation domain.
    Prasad DD, Ouchida M, Lee L, Rao VN, Reddy ES
    Oncogene. 1994 ; 9 (12) : 3717-3729.
    PMID 7970732
     
    Fusion of the dominant negative transcription regulator CHOP with a novel gene FUS by translocation t(12;16) in malignant liposarcoma.
    Rabbitts TH, Forster A, Larson R, Nathan P
    Nature genetics. 1993 ; 4 (2) : 175-180.
    PMID 7503811
     
    Transcriptional activation by TAL1 and FUS-CHOP proteins expressed in acute malignancies as a result of chromosomal abnormalities.
    S´nchez-Garcí I, Rabbitts TH
    Proceedings of the National Academy of Sciences of the United States of America. 1994 ; 91 (17) : 7869-7873.
    PMID 8058726
     
    Fusion of the FUS and BBF2H7 genes in low grade fibromyxoid sarcoma.
    Storlazzi CT, Mertens F, Nascimento A, Isaksson M, Wejde J, Brosjo O, Mandahl N, Panagopoulos I
    Human molecular genetics. 2003 ; 12 (18) : 2349-2358.
    PMID 12915480
     
    Genetic characterization of angiomatoid fibrous histiocytoma identifies fusion of the FUS and ATF-1 genes induced by a chromosomal translocation involving bands 12q13 and 16p11.
    Waters BL, Panagopoulos I, Allen EF
    Cancer genetics and cytogenetics. 2000 ; 121 (2) : 109-116.
    PMID 11063792
     
    TLS (FUS) binds RNA in vivo and engages in nucleo-cytoplasmic shuttling.
    Zinszner H, Sok J, Immanuel D, Yin Y, Ron D
    Journal of cell science. 1997 ; 110 ( Pt 15) : 1741-1750.
    PMID 9264461
     

    Citation

    This paper should be referenced as such :
    Pérez-Mancera, PA ; Sanchez-Garia, I
    FUS (fusion involved in t(12;16) in malignant liposarcoma)
    Atlas Genet Cytogenet Oncol Haematol. 2004;8(3):236-240.
    Free journal version : [ pdf ]   [ DOI ]


    Other Leukemias implicated (Data extracted from papers in the Atlas) [ 2 ]
      t(16;21)(p11;q22) FUS::ERG
    t(9;16)(q34;p11) FUS::SET


    External links

     

    Nomenclature
    HGNC (Hugo)FUS   4010
    LRG (Locus Reference Genomic)LRG_655
    Cards
    AtlasFUSID44
    Entrez_Gene (NCBI)FUS    FUS RNA binding protein
    AliasesALS6; ETM4; FUS1; HNRNPP2; 
    POMP75; TLS; altFUS
    GeneCards (Weizmann)FUS
    Ensembl hg19 (Hinxton)ENSG00000089280 [Gene_View]
    Ensembl hg38 (Hinxton)ENSG00000089280 [Gene_View]  ENSG00000089280 [Sequence]  chr16:31180139-31191604 [Contig_View]  FUS [Vega]
    ICGC DataPortalENSG00000089280
    TCGA cBioPortalFUS
    AceView (NCBI)FUS
    Genatlas (Paris)FUS
    SOURCE (Princeton)FUS
    Genetics Home Reference (NIH)FUS
    Genomic and cartography
    GoldenPath hg38 (UCSC)FUS  -     chr16:31180139-31191604 +  16p11.2   [Description]    (hg38-Dec_2013)
    GoldenPath hg19 (UCSC)FUS  -     16p11.2   [Description]    (hg19-Feb_2009)
    GoldenPathFUS - 16p11.2 [CytoView hg19]  FUS - 16p11.2 [CytoView hg38]
    ImmunoBaseENSG00000089280
    Genome Data Viewer NCBIFUS [Mapview hg19]  
    OMIM137070   608030   614782   
    Gene and transcription
    Genbank (Entrez)AB208902 AI333366 AK098774 AK130774 AK290936
    RefSeq transcript (Entrez)NM_001010850 NM_001170634 NM_001170937 NM_004960
    Consensus coding sequences : CCDS (NCBI)FUS
    Gene ExpressionFUS [ NCBI-GEO ]   FUS [ EBI - ARRAY_EXPRESS ]   FUS [ SEEK ]   FUS [ MEM ]
    Gene Expression Viewer (FireBrowse)FUS [ Firebrowse - Broad ]
    GenevisibleExpression of FUS in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
    BioGPS (Tissue expression)2521
    GTEX Portal (Tissue expression)FUS
    Human Protein AtlasENSG00000089280-FUS [pathology]   [cell]   [tissue]
    Protein : pattern, domain, 3D structure
    UniProt/SwissProtP35637   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
    NextProtP35637  [Sequence]  [Exons]  [Medical]  [Publications]
    With graphics : InterProP35637
    PhosPhoSitePlusP35637
    Domaine pattern : Prosite (Expaxy)RRM (PS50102)    ZF_RANBP2_1 (PS01358)    ZF_RANBP2_2 (PS50199)   
    Domains : Interpro (EBI)FUS    Nucleotide-bd_a/b_plait_sf    RBD_domain_sf    RRM_dom    TET_fam    Znf_RanBP2    Znf_RanBP2_sf   
    Domain families : Pfam (Sanger)RRM_1 (PF00076)    zf-RanBP (PF00641)   
    Domain families : Pfam (NCBI)pfam00076    pfam00641   
    Domain families : Smart (EMBL)RRM (SM00360)  ZnF_RBZ (SM00547)  
    Conserved Domain (NCBI)FUS
    PDB (RSDB)2LA6    2LCW    4FDD    4FQ3    5W3N    5XRR    5XSG    5YVG    5YVH    5YVI    6BWZ    6BXV    6BZP    6G99    6GBM    6KJ1    6KJ2    6KJ3    6KJ4    6SNJ    6XFM   
    PDB Europe2LA6    2LCW    4FDD    4FQ3    5W3N    5XRR    5XSG    5YVG    5YVH    5YVI    6BWZ    6BXV    6BZP    6G99    6GBM    6KJ1    6KJ2    6KJ3    6KJ4    6SNJ    6XFM   
    PDB (PDBSum)2LA6    2LCW    4FDD    4FQ3    5W3N    5XRR    5XSG    5YVG    5YVH    5YVI    6BWZ    6BXV    6BZP    6G99    6GBM    6KJ1    6KJ2    6KJ3    6KJ4    6SNJ    6XFM   
    PDB (IMB)2LA6    2LCW    4FDD    4FQ3    5W3N    5XRR    5XSG    5YVG    5YVH    5YVI    6BWZ    6BXV    6BZP    6G99    6GBM    6KJ1    6KJ2    6KJ3    6KJ4    6SNJ    6XFM   
    Structural Biology KnowledgeBase2LA6    2LCW    4FDD    4FQ3    5W3N    5XRR    5XSG    5YVG    5YVH    5YVI    6BWZ    6BXV    6BZP    6G99    6GBM    6KJ1    6KJ2    6KJ3    6KJ4    6SNJ    6XFM   
    SCOP (Structural Classification of Proteins)2LA6    2LCW    4FDD    4FQ3    5W3N    5XRR    5XSG    5YVG    5YVH    5YVI    6BWZ    6BXV    6BZP    6G99    6GBM    6KJ1    6KJ2    6KJ3    6KJ4    6SNJ    6XFM   
    CATH (Classification of proteins structures)2LA6    2LCW    4FDD    4FQ3    5W3N    5XRR    5XSG    5YVG    5YVH    5YVI    6BWZ    6BXV    6BZP    6G99    6GBM    6KJ1    6KJ2    6KJ3    6KJ4    6SNJ    6XFM   
    SuperfamilyP35637
    AlphaFold pdb e-kbP35637   
    Human Protein Atlas [tissue]ENSG00000089280-FUS [tissue]
    HPRD00660
    Protein Interaction databases
    DIP (DOE-UCLA)P35637
    IntAct (EBI)P35637
    BioGRIDFUS
    STRING (EMBL)FUS
    ZODIACFUS
    Ontologies - Pathways
    QuickGOP35637
    Ontology : AmiGOmRNA splicing, via spliceosome  DNA binding  chromatin binding  transcription coregulator activity  transcription coactivator activity  RNA binding  RNA binding  RNA binding  mRNA 3'-UTR binding  protein binding  nucleus  nucleus  nucleoplasm  nucleoplasm  polysome  regulation of transcription, DNA-templated  regulation of transcription by RNA polymerase II  RNA splicing  estrogen receptor binding  myosin V binding  ionotropic glutamate receptor binding  identical protein binding  perikaryon  regulation of RNA splicing  dendritic spine head  positive regulation of transcription, DNA-templated  metal ion binding  retinoid X receptor binding  thyroid hormone receptor binding  mRNA stabilization  perinuclear region of cytoplasm  protein homooligomerization  cellular response to calcium ion  positive regulation of double-strand break repair via homologous recombination  
    Ontology : EGO-EBImRNA splicing, via spliceosome  DNA binding  chromatin binding  transcription coregulator activity  transcription coactivator activity  RNA binding  RNA binding  RNA binding  mRNA 3'-UTR binding  protein binding  nucleus  nucleus  nucleoplasm  nucleoplasm  polysome  regulation of transcription, DNA-templated  regulation of transcription by RNA polymerase II  RNA splicing  estrogen receptor binding  myosin V binding  ionotropic glutamate receptor binding  identical protein binding  perikaryon  regulation of RNA splicing  dendritic spine head  positive regulation of transcription, DNA-templated  metal ion binding  retinoid X receptor binding  thyroid hormone receptor binding  mRNA stabilization  perinuclear region of cytoplasm  protein homooligomerization  cellular response to calcium ion  positive regulation of double-strand break repair via homologous recombination  
    Pathways : KEGGTranscriptional misregulation in cancer   
    REACTOMEP35637 [protein]
    REACTOME PathwaysR-HSA-72163 [pathway]   
    NDEx NetworkFUS
    Atlas of Cancer Signalling NetworkFUS
    Wikipedia pathwaysFUS
    Orthology - Evolution
    OrthoDB2521
    GeneTree (enSembl)ENSG00000089280
    Phylogenetic Trees/Animal Genes : TreeFamFUS
    Homologs : HomoloGeneFUS
    Homology/Alignments : Family Browser (UCSC)FUS
    Gene fusions - Rearrangements
    Fusion : MitelmanFUS::ATF1 [16p11.2/12q13.12]  
    Fusion : MitelmanFUS::CHD1 [16p11.2/5q15]  
    Fusion : MitelmanFUS::CREB3L1 [16p11.2/11p11.2]  
    Fusion : MitelmanFUS::CREB3L2 [16p11.2/7q33]  
    Fusion : MitelmanFUS::DDIT3 [16p11.2/12q13.3]  
    Fusion : MitelmanFUS::ERG [16p11.2/21q22.2]  
    Fusion : MitelmanFUS::FEV [16p11.2/2q35]  
    Fusion : MitelmanFUS::KLF17 [16p11.2/1p34.1]  
    Fusion : MitelmanFUS::NFATC2 [16p11.2/20q13.2]  
    Fusion : MitelmanFUS::NR4A3 [16p11.2/9q22.33]  
    Fusion : MitelmanFUS::PRSS36 [16p11.2/16p11.2]  
    Fusion : MitelmanFUS::SET [16p11.2/9q34.11]  
    Fusion : COSMICFUS [16p11.2]  -  FEV [2q35]  [fusion_295]  
    Fusion : QuiverFUS
    Polymorphisms : SNP and Copy number variants
    NCBI Variation ViewerFUS [hg38]
    dbSNP Single Nucleotide Polymorphism (NCBI)FUS
    dbVarFUS
    ClinVarFUS
    MonarchFUS
    1000_GenomesFUS 
    Exome Variant ServerFUS
    GNOMAD BrowserENSG00000089280
    Varsome BrowserFUS
    ACMGFUS variants
    VarityP35637
    Genomic Variants (DGV)FUS [DGVbeta]
    DECIPHERFUS [patients]   [syndromes]   [variants]   [genes]  
    CONAN: Copy Number AnalysisFUS 
    Mutations
    ICGC Data PortalFUS 
    TCGA Data PortalFUS 
    Broad Tumor PortalFUS
    OASIS PortalFUS [ Somatic mutations - Copy number]
    Cancer Gene: CensusFUS 
    Somatic Mutations in Cancer : COSMICFUS  [overview]  [genome browser]  [tissue]  [distribution]  
    Somatic Mutations in Cancer : COSMIC3DFUS
    Mutations and Diseases : HGMDFUS
    intOGen PortalFUS
    LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
    BioMutaFUS
    DgiDB (Drug Gene Interaction Database)FUS
    DoCM (Curated mutations)FUS
    CIViC (Clinical Interpretations of Variants in Cancer)FUS
    OncoKBFUS
    NCG (London)FUS
    Cancer3DFUS
    Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
    Diseases
    OMIM137070    608030    614782   
    Orphanet106    20341    21137    11147    14540   
    DisGeNETFUS
    MedgenFUS
    Genetic Testing Registry FUS
    NextProtP35637 [Medical]
    GENETestsFUS
    Target ValidationFUS
    Huge Navigator FUS [HugePedia]
    ClinGenFUS
    Clinical trials, drugs, therapy
    MyCancerGenomeFUS
    Protein Interactions : CTDFUS
    Pharm GKB GenePA28425
    PharosP35637
    Clinical trialFUS
    Miscellaneous
    canSAR (ICR)FUS
    HarmonizomeFUS
    DataMed IndexFUS
    Probes
    Litterature
    PubMed499 Pubmed reference(s) in Entrez
    GeneRIFsGene References Into Functions (Entrez)
    EVEXFUS
    REVIEW articlesautomatic search in PubMed
    Last year publicationsautomatic search in PubMed

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