FUT5 (fucosyltransferase 5)

2007-02-01  

Identity

HGNC
LOCATION
19p13.3
LOCUSID
ALIAS
FUC-TV
FUSION GENES

Other Information

Locus ID:

NCBI: 2527
MIM: 136835
HGNC: 4016
Ensembl: ENSG00000130383

Variants:

dbSNP: 2527
ClinVar: 2527
TCGA: ENSG00000130383
COSMIC: FUT5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000130383ENST00000252675Q11128
ENSG00000130383ENST00000588525K7ENC0

Expression (GTEx)

0
1
2

Pathways

PathwaySourceExternal ID
Glycosphingolipid biosynthesis - lacto and neolacto seriesKEGGko00601
Glycosphingolipid biosynthesis - lacto and neolacto seriesKEGGhsa00601
Metabolic pathwaysKEGGhsa01100

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
287712242017miR-125a-3p/FUT5-FUT6 axis mediates colorectal cancer cell proliferation, migration, invasion and pathological angiogenesis via PI3K-Akt pathway.24
146010542003Gene transfer of alpha1,3-fucosyltransferase increases tumor growth of the PC-3 human prostate cancer cell line through enhanced adhesion to prostatic stromal cells.11
171485762007Glycodelin-A interacts with fucosyltransferase on human sperm plasma membrane to inhibit spermatozoa-zona pellucida binding.10
193496242009Activation of host antiviral RNA-sensing factors necessary for herpes simplex virus type 1-activated transcription of host cell fucosyltransferase genes FUT3, FUT5, and FUT6 and subsequent expression of sLe(x) in virus-infected cells.6
308085442019Overexpressed N-fucosylation on the cell surface driven by FUT3, 5, and 6 promotes cell motilities in metastatic pancreatic cancer cell lines.2
206771622010[The genetic diversity in the full coding region of human FUT5 gene in a Chinese Han population].0
219788302011Down-regulation of FUT3 and FUT5 by shRNA alters Lewis antigens expression and reduces the adhesion capacities of gastric cancer cells.0
226198062012[Distribution specificity of human fucosyltransferase 5 and its expression and localization in spermatids].0

Citation

Dessen P

FUT5 (fucosyltransferase 5)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45680/fut5