FUT9 (fucosyltransferase 9)

2018-11-01  

Identity

HGNC
LOCATION
6q16.1
LOCUSID
ALIAS
Fuc-TIX
FUSION GENES

Other Information

Locus ID:

NCBI: 10690
MIM: 606865
HGNC: 4020
Ensembl: ENSG00000172461

Variants:

dbSNP: 10690
ClinVar: 10690
TCGA: ENSG00000172461
COSMIC: FUT9

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000172461ENST00000302103Q9Y231

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
Glycosphingolipid biosynthesis - lacto and neolacto seriesKEGGko00601
Glycosphingolipid biosynthesis - lacto and neolacto seriesKEGGhsa00601
Glycosphingolipid biosynthesis - globo and isoglobo seriesKEGGhsa00603
Metabolic pathwaysKEGGhsa01100
Mannose type O-glycan biosynthesisKEGGko00515
Mannose type O-glycan biosynthesisKEGGhsa00515

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
231923502013Silencing α1,3-fucosyltransferases in human leukocytes reveals a role for FUT9 enzyme during E-selectin-mediated cell adhesion.39
162826042006CEACAM1, an adhesion molecule of human granulocytes, is fucosylated by fucosyltransferase IX and interacts with DC-SIGN of dendritic cells via Lewis x residues.12
230005742012Expression of glycogenes in differentiating human NT2N neurons. Downregulation of fucosyltransferase 9 leads to decreased Lewis(x) levels and impaired neurite outgrowth.7
291965082017An integrated computational and experimental study uncovers FUT9 as a metabolic driver of colorectal cancer.6
194608852009A variant in the gene FUT9 is associated with susceptibility to placental malaria infection.4
121070782002Fuc-TIX: a versatile alpha1,3-fucosyltransferase with a distinct acceptor- and site-specificity profile.3
183950132008Human fucosyltransferase IX: specificity towards N-linked glycoproteins and relevance of the cytoplasmic domain in intra-Golgi localization.2
232631992013N-glycosylations of human α1,3-fucosyltransferase IX are required for full enzyme activity.1

Citation

Dessen P

FUT9 (fucosyltransferase 9)

Atlas Genet Cytogenet Oncol Haematol. 2018-11-01

Online version: http://atlasgeneticsoncology.org/gene/57705/fut9