FUZ (fuzzy planar cell polarity protein)

2016-10-01  

Identity

HGNC
LOCATION
19q13.33
LOCUSID
ALIAS
CPLANE3,FY,NTD

Other Information

Locus ID:

NCBI: 80199
MIM: 610622
HGNC: 26219
Ensembl: ENSG00000010361

Variants:

dbSNP: 80199
ClinVar: 80199
TCGA: ENSG00000010361
COSMIC: FUZ

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000010361ENST00000313777Q9BT04
ENSG00000010361ENST00000313777A0A024QZF7
ENSG00000010361ENST00000377092G5E9A4
ENSG00000010361ENST00000525130E9PKJ4
ENSG00000010361ENST00000525370E9PKJ4
ENSG00000010361ENST00000525800M0R0M0
ENSG00000010361ENST00000526435M0QYX9
ENSG00000010361ENST00000526575E9PKJ4
ENSG00000010361ENST00000527111M0QYI7
ENSG00000010361ENST00000527585M0QZY8
ENSG00000010361ENST00000528043E9PLA3
ENSG00000010361ENST00000528094Q9BT04
ENSG00000010361ENST00000529302M0R1D4
ENSG00000010361ENST00000529634E9PS25
ENSG00000010361ENST00000533418E9PK12

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by HedgehogREACTOMER-HSA-5358351
Hedgehog 'off' stateREACTOMER-HSA-5610787

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
218409262011Mutations in the planar cell polarity gene, Fuzzy, are associated with neural tube defects in humans.33
300263072018Planar cell polarity gene Fuz triggers apoptosis in neurodegenerative disease models.2
294214382018In vitro study of FUZ as a novel potential therapeutic target in non-small-cell lung cancer.1

Citation

Dessen P

FUZ (fuzzy planar cell polarity protein)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56211/fuz