Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

FXR2 (FMR1 autosomal homolog 2)

Identity

Alias (NCBI)FMR1L2
FXR2P
HGNC (Hugo) FXR2
HGNC Previous nameFMR1L2
HGNC Previous namefragile X mental retardation, autosomal homolog 2
LocusID (NCBI) 9513
Atlas_Id 40651
Location 17p13.1  [Link to chromosome band 17p13]
Location_base_pair Starts at 7591230 and ends at 7614897 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
FAM104A (17q25.1) / FXR2 (17p13.1)FXR2 (17p13.1) / GAS7 (17p13.1)FXR2 (17p13.1) / TARBP1 (1q42.2)
FXR2 (17p13.1) / TP53 (17p13.1)ITPR3 (6p21.31) / FXR2 (17p13.1)TP53 (17p13.1) / FXR2 (17p13.1)
FXR2 17p13.1 / TARBP1 1q42.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)FXR2   4024
LRG (Locus Reference Genomic)LRG_285
Cards
Entrez_Gene (NCBI)FXR2    FMR1 autosomal homolog 2
AliasesFMR1L2; FXR2P
GeneCards (Weizmann)FXR2
Ensembl hg19 (Hinxton)ENSG00000129245 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000129245 [Gene_View]  ENSG00000129245 [Sequence]  chr17:7591230-7614897 [Contig_View]  FXR2 [Vega]
ICGC DataPortalENSG00000129245
TCGA cBioPortalFXR2
AceView (NCBI)FXR2
Genatlas (Paris)FXR2
SOURCE (Princeton)FXR2
Genetics Home Reference (NIH)FXR2
Genomic and cartography
GoldenPath hg38 (UCSC)FXR2  -     chr17:7591230-7614897 -  17p13.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FXR2  -     17p13.1   [Description]    (hg19-Feb_2009)
GoldenPathFXR2 - 17p13.1 [CytoView hg19]  FXR2 - 17p13.1 [CytoView hg38]
ImmunoBaseENSG00000129245
Genome Data Viewer NCBIFXR2 [Mapview hg19]  
OMIM605339   
Gene and transcription
Genbank (Entrez)AA593676 AK226082 AK313836 BC020090 BC051907
RefSeq transcript (Entrez)NM_004860
Consensus coding sequences : CCDS (NCBI)FXR2
Gene ExpressionFXR2 [ NCBI-GEO ]   FXR2 [ EBI - ARRAY_EXPRESS ]   FXR2 [ SEEK ]   FXR2 [ MEM ]
Gene Expression Viewer (FireBrowse)FXR2 [ Firebrowse - Broad ]
GenevisibleExpression of FXR2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9513
GTEX Portal (Tissue expression)FXR2
Human Protein AtlasENSG00000129245-FXR2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP51116   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP51116  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP51116
PhosPhoSitePlusP51116
Domaine pattern : Prosite (Expaxy)AGENET_LIKE (PS51641)    KH_TYPE_1 (PS50084)   
Domains : Interpro (EBI)Agenet-like_dom    FMR1    FMRP_KH0    FXMRP1_C_core    FXR_C1    KH_dom    KH_dom_type_1    KH_dom_type_1_sf    Tudor_FRX1   
Domain families : Pfam (Sanger)Agenet (PF05641)    FXMRP1_C_core (PF12235)    FXR_C1 (PF16096)    KH_1 (PF00013)    KH_9 (PF17904)    Tudor_FRX1 (PF18336)   
Domain families : Pfam (NCBI)pfam05641    pfam12235    pfam16096    pfam00013    pfam17904    pfam18336   
Domain families : Smart (EMBL)KH (SM00322)  
Conserved Domain (NCBI)FXR2
PDB (RSDB)3H8Z   
PDB Europe3H8Z   
PDB (PDBSum)3H8Z   
PDB (IMB)3H8Z   
Structural Biology KnowledgeBase3H8Z   
SCOP (Structural Classification of Proteins)3H8Z   
CATH (Classification of proteins structures)3H8Z   
SuperfamilyP51116
AlphaFold pdb e-kbP51116   
Human Protein Atlas [tissue]ENSG00000129245-FXR2 [tissue]
HPRD05629
Protein Interaction databases
DIP (DOE-UCLA)P51116
IntAct (EBI)P51116
BioGRIDFXR2
STRING (EMBL)FXR2
ZODIACFXR2
Ontologies - Pathways
QuickGOP51116
Ontology : AmiGOregulation of alternative mRNA splicing, via spliceosome  positive regulation of protein phosphorylation  RNA binding  mRNA 3'-UTR binding  protein binding  nucleus  cytoplasm  cytosol  polysome  postsynaptic density  membrane  membrane  negative regulation of translation  cytosolic large ribosomal subunit  axon  growth cone  cytoplasmic ribonucleoprotein granule  identical protein binding  protein homodimerization activity  protein homodimerization activity  neuronal cell body  dendritic spine  regulation of mRNA stability  dendritic spine neck  translation regulator activity  positive regulation of translation  protein heterodimerization activity  regulation of filopodium assembly  presynapse  dendritic filopodium  positive regulation of response to DNA damage stimulus  
Ontology : EGO-EBIregulation of alternative mRNA splicing, via spliceosome  positive regulation of protein phosphorylation  RNA binding  mRNA 3'-UTR binding  protein binding  nucleus  cytoplasm  cytosol  polysome  postsynaptic density  membrane  membrane  negative regulation of translation  cytosolic large ribosomal subunit  axon  growth cone  cytoplasmic ribonucleoprotein granule  identical protein binding  protein homodimerization activity  protein homodimerization activity  neuronal cell body  dendritic spine  regulation of mRNA stability  dendritic spine neck  translation regulator activity  positive regulation of translation  protein heterodimerization activity  regulation of filopodium assembly  presynapse  dendritic filopodium  positive regulation of response to DNA damage stimulus  
Pathways : KEGGRNA transport   
NDEx NetworkFXR2
Atlas of Cancer Signalling NetworkFXR2
Wikipedia pathwaysFXR2
Orthology - Evolution
OrthoDB9513
GeneTree (enSembl)ENSG00000129245
Phylogenetic Trees/Animal Genes : TreeFamFXR2
Homologs : HomoloGeneFXR2
Homology/Alignments : Family Browser (UCSC)FXR2
Gene fusions - Rearrangements
Fusion : MitelmanFXR2/TARBP1 [17p13.1/1q42.2]  
Fusion : QuiverFXR2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFXR2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FXR2
dbVarFXR2
ClinVarFXR2
MonarchFXR2
1000_GenomesFXR2 
Exome Variant ServerFXR2
GNOMAD BrowserENSG00000129245
Varsome BrowserFXR2
ACMGFXR2 variants
VarityP51116
Genomic Variants (DGV)FXR2 [DGVbeta]
DECIPHERFXR2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFXR2 
Mutations
ICGC Data PortalFXR2 
TCGA Data PortalFXR2 
Broad Tumor PortalFXR2
OASIS PortalFXR2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFXR2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DFXR2
Mutations and Diseases : HGMDFXR2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaFXR2
DgiDB (Drug Gene Interaction Database)FXR2
DoCM (Curated mutations)FXR2
CIViC (Clinical Interpretations of Variants in Cancer)FXR2
Cancer3DFXR2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605339   
Orphanet
DisGeNETFXR2
MedgenFXR2
Genetic Testing Registry FXR2
NextProtP51116 [Medical]
GENETestsFXR2
Target ValidationFXR2
Huge Navigator FXR2 [HugePedia]
ClinGenFXR2
Clinical trials, drugs, therapy
MyCancerGenomeFXR2
Protein Interactions : CTDFXR2
Pharm GKB GenePA28440
PharosP51116
Clinical trialFXR2
Miscellaneous
canSAR (ICR)FXR2
HarmonizomeFXR2
DataMed IndexFXR2
Probes
Litterature
PubMed116 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXFXR2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 4 15:10:06 CEST 2021

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.