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FXYD5 (FXYD domain containing ion transport regulator 5)

Written2008-07Setsuo Hirohashi
Pathology Division, National Cancer Center Research Institute 5-1-1, Tsukiji, Chuo-ku, Tokyo 104-0045, Japan

(Note : for Links provided by Atlas : click)


HGNC Alias symbOIT2
HGNC Alias namedysadherin
HGNC Previous nameFXYD domain-containing ion transport regulator 5
LocusID (NCBI) 53827
Atlas_Id 40652
Location 19q13.12  [Link to chromosome band 19q13]
Location_base_pair Starts at 35154735 and ends at 35169881 bp from pter ( according to GRCh38/hg38-Dec_2013)  [Mapping FXYD5.png]
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
FXYD5 (19q13.12)::TSKU (11q13.5)GLMN (1p22.1)::FXYD5 (19q13.12)SFPQ (16q24.1)::FXYD5 (19q13.12)
SFPQ (1p34.3)::FXYD5 (19q13.12)TGFB1 (19q13.2)::FXYD5 (19q13.12)


Transcription 0.9 kb mRNA; 534 bp open reading frame.


  Dysadherin protein consists of 178 amino acids.
Description The deduced amino acid sequence consisted of two hydrophobic regions corresponding to a signal peptide and a transmembrane domain (146-162), a serine-, threonine-, and proline-rich extracellular domain, which is a target for O-glycosylation, anda short cytoplasmic region containing positively charged amino acid residues.
Expression Endothelial cell, T lymphocytes, basal cell of squamous epithelium.
Localisation Cell membrane
Homology The transmembrane domain of dysadherin and mouse RIC especially showed a very high degree of similarity to other ion channels such as Mat-8 chloride channel, phospholemman, which is the major plasma membrane substrate for cAMPdependent protein kinase and protein kinase C, and the subunit of Na, K-ATPase.

Implicated in

Entity Various cancers
Disease Dysadherin, newly identified cell membrane glycoprotein, downregulates E-cadherin and promotes cancer invasion and metastasis. A reverse correlation between dysadherin expression and E-cadherin expression was observed in various cancers. Increased dysadherin expression was correlated with poor prognosis with head and neck squamous cell carcinoma, esophageal carcinoma, gastric carcinoma, colorectal carcinoma, melanoma and so on. Dysadherin expression in epitheloid sarcomas could be a used as powerful diagnostic marker for distinguishing epithelioid sarcomas from malignant rabdoid tumors.


Prognostic significance of dysadherin expression in advanced colorectal carcinoma.
Aoki S, Shimamura T, Shibata T, Nakanishi Y, Moriya Y, Sato Y, Kitajima M, Sakamoto M, Hirohashi S.
Br J Cancer. 2003; 88(5): 726-32.
PMID 12618882
In breast carcinoma dysadherin expression is correlated with invasiveness but not with E-cadherin.
Batistatou A, Peschos D, Tsanou H, Charalabopoulos A, Nakanishi Y, Hirohashi S, Agnantis NJ, Charalabopoulos K.
Br J Cancer. 2007; 96(9): 1404-8.
PMID 17437014
Nuclear targeting of the growth hormone receptor results in dysregulation of cell proliferation and tumorigenesis.
Conway-Campbell BL, Wooh JW, Brooks AJ, Gordon D, Brown RJ, Lichanska AM, Chin HS, Barton CL, Boyle GM, Parsons PG, Jans DA, Waters MJ.
Proc Natl Acad Sci U S A. 2007; 104(33): 13331-6.
PMID 17690250
Cell adhesion system and human cancer morphogenesis.
Hirohashi S, Kanai Y.
Cancer Sci. 2003; 94(7): 575-81. (Review)
PMID 12841864
Dysadherin, a cancer-associated cell membrane glycoprotein, down-regulates E-cadherin and promotes metastasis.
Ino Y, Gotoh M, Sakamoto M, Tsukagoshi K, Hirohashi S.
Proc Natl Acad Sci USA. 2002; 99(1): 365-70.
PMID 11756660
Dysadherin expression as a significant prognostic factor and as a determinant of histologic features in synovial sarcoma: special reference to its inverse relationship with E-cadherin expression.
Izumi T, Oda Y, Hasegawa T, Nakanishi Y, Kawai A, Sonobe H, Takahira T, Kobayashi C, Yamamoto H, Tamiya S, Hirohashi S, Iwamoto Y, Tsuneyoshi M.
Am J Surg Pathol. 2007; 31(1): 85-94.
PMID 17197923
Dysadherin expression in head and neck squamous cell carcinoma: association with lymphangiogenesis and prognostic significance.
Kyzas PA, Stefanou D, Batistatou A, Agnantis NJ, Nakanishi Y, Hirohashi S, Charalabopoulos K.
Am J Surg Pathol. 2006; 30(2): 185-93.
PMID 16434892
Prognostic significance of dysadherin expression in tongue cancer: immunohistochemical analysis of 91 cases.
Nakanishi Y, Akimoto S, Sato Y, Kanai Y, Sakamoto M, Hirohashi S.
Appl Immunohistochem Mol Morphol. 2004; 12(4): 323-8.
PMID 15536331
Dysadherin: a new player in cancer progression.
Nam JS, Hirohashi S, Wakefield LM.
Cancer Lett. 2007; 255(2): 161-9. (Review)
PMID 17442482
Chemokine (C-C motif) ligand 2 mediates the prometastatic effect of dysadherin in human breast cancer cells.
Nam JS, Kang MJ, Suchar AM, Shimamura T, Kohn EA, Michalowska AM, Jordan VC, Hirohashi S, Wakefield LM.
Cancer Res. 2006; 66(14): 7176-84.
PMID 16849564
Clinicopathologic significance of dysadherin expression in cutaneous malignant melanoma: immunohistochemical analysis of 115 patients.
Nishizawa A, Nakanishi Y, Yoshimura K, Sasajima Y, Yamazaki N, Yamamoto A, Hanada K, Kanai Y, Hirohashi S.
Cancer. 2005; 103(8): 1693-700.
PMID 15751018
Dysadherin: expression and clinical significance in thyroid carcinoma.
Sato H, Ino Y, Miura A, Abe Y, Sakai H, Ito K, Hirohashi S.
J Clin Endocrinol Metab. 2003; 88(9): 4407-12.
PMID 12970317
Prognostic significance of dysadherin expression in esophageal squamous cell carcinoma.
Shimada Y, Hashimoto Y, Kan T, Kawamura J, Okumura T, Soma T, Kondo K, Teratani N, Watanabe G, Ino Y, Sakamoto M, Hirohashi S, Imamura M.
Oncology. 2004; 67(1): 73-80.
PMID 15459499
Clinical significance of dysadherin expression in gastric cancer patients.
Shimada Y, Yamasaki S, Hashimoto Y, Ito T, Kawamura J, Soma T, Ino Y, Nakanishi Y, Sakamoto M, Hirohashi S, Imamura M.
Clin Cancer Res. 2004; 10(8): 2818-23.
PMID 15102690
Dysadherin expression facilitates cell motility and metastatic potential of human pancreatic cancer cells.
Shimamura T, Yasuda J, Ino Y, Gotoh M, Tsuchiya A, Nakajima A, Sakamoto M, Kanai Y, Hirohashi S.
Cancer Res. 2004; 64(19): 6989-95.
PMID 15466191
Prognostic significance of dysadherin expression in patients with non-small cell lung cancer.
Tamura M, Ohta Y, Tsunezuka Y, Matsumoto I, Kawakami K, Oda M, Watanabe G.
J Thorac Cardiovasc Surg. 2005; 130(3): 740-5.
PMID 16153922
Aberrant O-glycosylation inhibits stable expression of dysadherin, a carcinoma-associated antigen, and facilitates cell-cell adhesion.
Tsuiji H, Takasaki S, Sakamoto M, Irimura T, Hirohashi S.
Glycobiology. 2003; 13(7): 521-7.
PMID 12672699
Prognostic significance of dysadherin expression in cervical squamous cell carcinoma.
Wu D, Qiao Y, Kristensen GB, Li S, Troen G, Holm R, Nesland JM, Suo Z.
Pathol Oncol Res. 2004; 10(4): 212-8.
PMID 15619642
Establishment of two cell lines from human gastric scirrhous carcinoma that possess the potential to metastasize spontaneously in nude mice.
Yanagihara K, Tanaka H, Takigahira M, Ino Y, Yamaguchi Y, Toge T, Sugano K, Hirohashi S.
Cancer Sci. 2004; 95(7): 575-82.
PMID 15245593


This paper should be referenced as such :
Hirohashi, S
FXYD5 (FXYD domain containing ion transport regulator 5)
Atlas Genet Cytogenet Oncol Haematol. 2009;13(6):413-414.
Free journal version : [ pdf ]   [ DOI ]

External links


HGNC (Hugo)FXYD5   4029
Entrez_Gene (NCBI)FXYD5    FXYD domain containing ion transport regulator 5
AliasesDYSAD; HSPC113; IWU1; KCT1; 
OIT2; PRO6241; RIC
GeneCards (Weizmann)FXYD5
Ensembl hg19 (Hinxton)ENSG00000089327 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000089327 [Gene_View]  ENSG00000089327 [Sequence]  chr19:35154735-35169881 [Contig_View]  FXYD5 [Vega]
ICGC DataPortalENSG00000089327
TCGA cBioPortalFXYD5
Genatlas (Paris)FXYD5
SOURCE (Princeton)FXYD5
Genetics Home Reference (NIH)FXYD5
Genomic and cartography
GoldenPath hg38 (UCSC)FXYD5  -     chr19:35154735-35169881 +  19q13.12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FXYD5  -     19q13.12   [Description]    (hg19-Feb_2009)
GoldenPathFXYD5 - 19q13.12 [CytoView hg19]  FXYD5 - 19q13.12 [CytoView hg38]
Genome Data Viewer NCBIFXYD5 [Mapview hg19]  
Gene and transcription
Genbank (Entrez)AA044211 AA296696 AB072911 AF161462 AF177940
RefSeq transcript (Entrez)NM_001164605 NM_001320912 NM_001320913 NM_014164 NM_144779
Consensus coding sequences : CCDS (NCBI)FXYD5
Gene ExpressionFXYD5 [ NCBI-GEO ]   FXYD5 [ EBI - ARRAY_EXPRESS ]   FXYD5 [ SEEK ]   FXYD5 [ MEM ]
Gene Expression Viewer (FireBrowse)FXYD5 [ Firebrowse - Broad ]
GenevisibleExpression of FXYD5 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)53827
GTEX Portal (Tissue expression)FXYD5
Human Protein AtlasENSG00000089327-FXYD5 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96DB9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96DB9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96DB9
Domaine pattern : Prosite (Expaxy)FXYD (PS01310)   
Domains : Interpro (EBI)Ion-transport_regulator_FXYD   
Domain families : Pfam (Sanger)ATP1G1_PLM_MAT8 (PF02038)   
Domain families : Pfam (NCBI)pfam02038   
Conserved Domain (NCBI)FXYD5
AlphaFold pdb e-kbQ96DB9   
Human Protein Atlas [tissue]ENSG00000089327-FXYD5 [tissue]
Protein Interaction databases
IntAct (EBI)Q96DB9
Ontologies - Pathways
Ontology : AmiGOactin binding  protein binding  ion transport  integral component of membrane  sodium channel regulator activity  microvillus assembly  cadherin binding  negative regulation of calcium-dependent cell-cell adhesion  regulation of sodium ion transmembrane transporter activity  
Ontology : EGO-EBIactin binding  protein binding  ion transport  integral component of membrane  sodium channel regulator activity  microvillus assembly  cadherin binding  negative regulation of calcium-dependent cell-cell adhesion  regulation of sodium ion transmembrane transporter activity  
NDEx NetworkFXYD5
Atlas of Cancer Signalling NetworkFXYD5
Wikipedia pathwaysFXYD5
Orthology - Evolution
GeneTree (enSembl)ENSG00000089327
Phylogenetic Trees/Animal Genes : TreeFamFXYD5
Homologs : HomoloGeneFXYD5
Homology/Alignments : Family Browser (UCSC)FXYD5
Gene fusions - Rearrangements
Fusion : MitelmanTGFB1::FXYD5 [19q13.2/19q13.12]  
Fusion Cancer (Beijing)SFPQ [16q24.1]  -  FXYD5 [19q13.12]  [FUSC002256]  [FUSC002256]  [FUSC002256]
Fusion : QuiverFXYD5
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFXYD5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FXYD5
Exome Variant ServerFXYD5
GNOMAD BrowserENSG00000089327
Varsome BrowserFXYD5
ACMGFXYD5 variants
Genomic Variants (DGV)FXYD5 [DGVbeta]
DECIPHERFXYD5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFXYD5 
ICGC Data PortalFXYD5 
TCGA Data PortalFXYD5 
Broad Tumor PortalFXYD5
OASIS PortalFXYD5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFXYD5  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DFXYD5
Mutations and Diseases : HGMDFXYD5
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
DgiDB (Drug Gene Interaction Database)FXYD5
DoCM (Curated mutations)FXYD5
CIViC (Clinical Interpretations of Variants in Cancer)FXYD5
NCG (London)FXYD5
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Genetic Testing Registry FXYD5
NextProtQ96DB9 [Medical]
Target ValidationFXYD5
Huge Navigator FXYD5 [HugePedia]
Clinical trials, drugs, therapy
Protein Interactions : CTDFXYD5
Pharm GKB GenePA28445
Clinical trialFXYD5
DataMed IndexFXYD5
PubMed44 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Oct 8 21:18:28 CEST 2021

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