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FXYD6 (FXYD domain containing ion transport regulator 6)

Identity

Alias (NCBI)-
HGNC (Hugo) FXYD6
HGNC Alias namephosphohippolin
HGNC Previous nameFXYD domain-containing ion transport regulator 6
LocusID (NCBI) 53826
Atlas_Id 53003
Location 11q23.3  [Link to chromosome band 11q23]
Location_base_pair Starts at 117836981 and ends at 117876658 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AFF1 (4q21.3) / FXYD6 (11q23.3)FXYD6 (11q23.3) / CD3G (11q23.3)FXYD6 (11q23.3) / KMT2A (11q23.3)
FXYD6 (11q23.3) / OSBP2 (22q12.2)FXYD6 (11q23.3) / ZEB2 (2q22.3)FXYD6 11q23.3 / CD3G 11q23.3
FXYD6 11q23.3 / OSBP2 22q12.2FXYD6 11q23.3 / ZEB2 2q22.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 2 ]
  ins(4;11)(q21;q23q23) AFF1/FXYD6
ins(4;11)(q21;q23q23) FXYD6/KMT2A

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 3 ]
  t(2;11)(q22;q23) FXYD6/ZEB2
FXYD6/CD3G (11q23)
t(11;22)(q23;q12) FXYD6/OSBP2

External links

Nomenclature
HGNC (Hugo)FXYD6   4030
Cards
Entrez_Gene (NCBI)FXYD6    FXYD domain containing ion transport regulator 6
Aliases
GeneCards (Weizmann)FXYD6
Ensembl hg19 (Hinxton)ENSG00000137726 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000137726 [Gene_View]  ENSG00000137726 [Sequence]  chr11:117836981-117876658 [Contig_View]  FXYD6 [Vega]
ICGC DataPortalENSG00000137726
TCGA cBioPortalFXYD6
AceView (NCBI)FXYD6
Genatlas (Paris)FXYD6
SOURCE (Princeton)FXYD6
Genetics Home Reference (NIH)FXYD6
Genomic and cartography
GoldenPath hg38 (UCSC)FXYD6  -     chr11:117836981-117876658 -  11q23.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FXYD6  -     11q23.3   [Description]    (hg19-Feb_2009)
GoldenPathFXYD6 - 11q23.3 [CytoView hg19]  FXYD6 - 11q23.3 [CytoView hg38]
ImmunoBaseENSG00000137726
genome Data Viewer NCBIFXYD6 [Mapview hg19]  
OMIM606683   
Gene and transcription
Genbank (Entrez)AK055389 AK092198 AK289629 AK290757 AK311736
RefSeq transcript (Entrez)NM_001164831 NM_001164832 NM_001164836 NM_001164837 NM_022003
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FXYD6
Alternative Splicing GalleryENSG00000137726
Gene ExpressionFXYD6 [ NCBI-GEO ]   FXYD6 [ EBI - ARRAY_EXPRESS ]   FXYD6 [ SEEK ]   FXYD6 [ MEM ]
Gene Expression Viewer (FireBrowse)FXYD6 [ Firebrowse - Broad ]
GenevisibleExpression of FXYD6 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)53826
GTEX Portal (Tissue expression)FXYD6
Human Protein AtlasENSG00000137726-FXYD6 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9H0Q3   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9H0Q3  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9H0Q3
Splice isoforms : SwissVarQ9H0Q3
PhosPhoSitePlusQ9H0Q3
Domaine pattern : Prosite (Expaxy)FXYD (PS01310)   
Domains : Interpro (EBI)Ion-transport_regulator_FXYD   
Domain families : Pfam (Sanger)ATP1G1_PLM_MAT8 (PF02038)   
Domain families : Pfam (NCBI)pfam02038   
Conserved Domain (NCBI)FXYD6
Blocks (Seattle)FXYD6
SuperfamilyQ9H0Q3
Human Protein Atlas [tissue]ENSG00000137726-FXYD6 [tissue]
Peptide AtlasQ9H0Q3
HPRD09456
IPIIPI00004367   IPI00978307   IPI00978559   
Protein Interaction databases
DIP (DOE-UCLA)Q9H0Q3
IntAct (EBI)Q9H0Q3
BioGRIDFXYD6
STRING (EMBL)FXYD6
ZODIACFXYD6
Ontologies - Pathways
QuickGOQ9H0Q3
Ontology : AmiGOmolecular_function  protein binding  plasma membrane  plasma membrane  biological_process  sodium channel regulator activity  ion transmembrane transport  glutamatergic synapse  integral component of postsynaptic membrane  integral component of presynaptic membrane  ion channel regulator activity  regulation of cardiac conduction  regulation of sodium ion transmembrane transporter activity  
Ontology : EGO-EBImolecular_function  protein binding  plasma membrane  plasma membrane  biological_process  sodium channel regulator activity  ion transmembrane transport  glutamatergic synapse  integral component of postsynaptic membrane  integral component of presynaptic membrane  ion channel regulator activity  regulation of cardiac conduction  regulation of sodium ion transmembrane transporter activity  
NDEx NetworkFXYD6
Atlas of Cancer Signalling NetworkFXYD6
Wikipedia pathwaysFXYD6
Orthology - Evolution
OrthoDB53826
GeneTree (enSembl)ENSG00000137726
Phylogenetic Trees/Animal Genes : TreeFamFXYD6
HOGENOMQ9H0Q3
Homologs : HomoloGeneFXYD6
Homology/Alignments : Family Browser (UCSC)FXYD6
Gene fusions - Rearrangements
Fusion : MitelmanAFF1/FXYD6 [4q21.3/11q23.3]  
Fusion : MitelmanFXYD6/CD3G [11q23.3/11q23.3]  
Fusion : MitelmanFXYD6/OSBP2 [11q23.3/22q12.2]  
Fusion : MitelmanFXYD6/ZEB2 [11q23.3/2q22.3]  
Fusion PortalFXYD6 11q23.3 CD3G 11q23.3 LUAD
Fusion PortalFXYD6 11q23.3 OSBP2 22q12.2 LGG
Fusion PortalFXYD6 11q23.3 ZEB2 2q22.3 LGG
Fusion : QuiverFXYD6
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFXYD6 [hg38]
dbVarFXYD6
ClinVarFXYD6
MonarchFXYD6
1000_GenomesFXYD6 
Exome Variant ServerFXYD6
GNOMAD BrowserENSG00000137726
Varsome BrowserFXYD6
Genomic Variants (DGV)FXYD6 [DGVbeta]
DECIPHERFXYD6 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFXYD6 
Mutations
ICGC Data PortalFXYD6 
TCGA Data PortalFXYD6 
Broad Tumor PortalFXYD6
OASIS PortalFXYD6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFXYD6  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DFXYD6
Mutations and Diseases : HGMDFXYD6
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FXYD6
DgiDB (Drug Gene Interaction Database)FXYD6
DoCM (Curated mutations)FXYD6 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FXYD6 (select a term)
intoGenFXYD6
Cancer3DFXYD6(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606683   
Orphanet
DisGeNETFXYD6
MedgenFXYD6
Genetic Testing Registry FXYD6
NextProtQ9H0Q3 [Medical]
GENETestsFXYD6
Target ValidationFXYD6
Huge Navigator FXYD6 [HugePedia]
ClinGenFXYD6
Clinical trials, drugs, therapy
MyCancerGenomeFXYD6
Protein Interactions : CTD
Pharm GKB GenePA28446
PharosQ9H0Q3
Clinical trialFXYD6
Miscellaneous
canSAR (ICR)FXYD6 (select the gene name)
HarmonizomeFXYD6
DataMed IndexFXYD6
Probes
Litterature
PubMed29 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXFXYD6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Fri Jan 1 18:16:22 CET 2021
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