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FYB (FYN binding protein)

Identity

Alias_namesFYN-binding protein (FYB-120/130)
Alias_symbol (synonym)SLAP-130
FYB-120/130
Other aliasADAP
PRO0823
SLAP130
THC3
HGNC (Hugo) FYB
LocusID (NCBI) 2533
Atlas_Id 51500
Location 5p13.1  [Link to chromosome band 5p13]
Location_base_pair Starts at 39105252 and ends at 39270657 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CSMD2 (1p35.1) / FYB (5p13.1)EPB41L3 (18p11.31) / FYB (5p13.1)FYB (5p13.1) / FYB (5p13.1)
RICTOR (5p13.1) / FYB (5p13.1)CSMD2 1p35.1 / FYB 5p13.1RICTOR 5p13.1 / FYB 5p13.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)FYB   4036
Cards
Entrez_Gene (NCBI)FYB  2533  FYN binding protein
AliasesADAP; PRO0823; SLAP-130; SLAP130; 
THC3
GeneCards (Weizmann)FYB
Ensembl hg19 (Hinxton)ENSG00000082074 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000082074 [Gene_View]  chr5:39105252-39270657 [Contig_View]  FYB [Vega]
ICGC DataPortalENSG00000082074
TCGA cBioPortalFYB
AceView (NCBI)FYB
Genatlas (Paris)FYB
WikiGenes2533
SOURCE (Princeton)FYB
Genetics Home Reference (NIH)FYB
Genomic and cartography
GoldenPath hg38 (UCSC)FYB  -     chr5:39105252-39270657 -  5p13.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FYB  -     5p13.1   [Description]    (hg19-Feb_2009)
EnsemblFYB - 5p13.1 [CytoView hg19]  FYB - 5p13.1 [CytoView hg38]
Mapping of homologs : NCBIFYB [Mapview hg19]  FYB [Mapview hg38]
OMIM273900   602731   
Gene and transcription
Genbank (Entrez)AF001862 AF116653 AF198052 AI961953 AK123918
RefSeq transcript (Entrez)NM_001243093 NM_001349333 NM_001465 NM_199335
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FYB
Cluster EST : UnigeneHs.691768 [ NCBI ]
CGAP (NCI)Hs.691768
Alternative Splicing GalleryENSG00000082074
Gene ExpressionFYB [ NCBI-GEO ]   FYB [ EBI - ARRAY_EXPRESS ]   FYB [ SEEK ]   FYB [ MEM ]
Gene Expression Viewer (FireBrowse)FYB [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2533
GTEX Portal (Tissue expression)FYB
Protein : pattern, domain, 3D structure
UniProt/SwissProtO15117   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO15117  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO15117
Splice isoforms : SwissVarO15117
PhosPhoSitePlusO15117
Domains : Interpro (EBI)FYB    hSH3    SH3_2    SH3_domain   
Domain families : Pfam (Sanger)hSH3 (PF14603)    SH3_2 (PF07653)   
Domain families : Pfam (NCBI)pfam14603    pfam07653   
Domain families : Smart (EMBL)SH3 (SM00326)  
Conserved Domain (NCBI)FYB
DMDM Disease mutations2533
Blocks (Seattle)FYB
PDB (SRS)1RI9    2GTJ    2GTO   
PDB (PDBSum)1RI9    2GTJ    2GTO   
PDB (IMB)1RI9    2GTJ    2GTO   
PDB (RSDB)1RI9    2GTJ    2GTO   
Structural Biology KnowledgeBase1RI9    2GTJ    2GTO   
SCOP (Structural Classification of Proteins)1RI9    2GTJ    2GTO   
CATH (Classification of proteins structures)1RI9    2GTJ    2GTO   
SuperfamilyO15117
Human Protein AtlasENSG00000082074
Peptide AtlasO15117
HPRD04107
IPIIPI00446986   IPI00073110   IPI00967826   IPI00001189   IPI01012476   IPI00966351   IPI00967174   IPI00966901   
Protein Interaction databases
DIP (DOE-UCLA)O15117
IntAct (EBI)O15117
FunCoupENSG00000082074
BioGRIDFYB
STRING (EMBL)FYB
ZODIACFYB
Ontologies - Pathways
QuickGOO15117
Ontology : AmiGOreceptor binding  protein binding  nucleus  cytosol  plasma membrane  protein phosphorylation  NLS-bearing protein import into nucleus  immune response  signal transduction  biological_process  actin cytoskeleton  cell junction  protein complex binding  intracellular signal transduction  T cell receptor signaling pathway  protein localization to plasma membrane  
Ontology : EGO-EBIreceptor binding  protein binding  nucleus  cytosol  plasma membrane  protein phosphorylation  NLS-bearing protein import into nucleus  immune response  signal transduction  biological_process  actin cytoskeleton  cell junction  protein complex binding  intracellular signal transduction  T cell receptor signaling pathway  protein localization to plasma membrane  
Pathways : KEGGRap1 signaling pathway   
NDEx NetworkFYB
Atlas of Cancer Signalling NetworkFYB
Wikipedia pathwaysFYB
Orthology - Evolution
OrthoDB2533
GeneTree (enSembl)ENSG00000082074
Phylogenetic Trees/Animal Genes : TreeFamFYB
HOVERGENO15117
HOGENOMO15117
Homologs : HomoloGeneFYB
Homology/Alignments : Family Browser (UCSC)FYB
Gene fusions - Rearrangements
Fusion : MitelmanCSMD2/FYB [1p35.1/5p13.1]  [t(1;5)(p34;p13)]  
Fusion : MitelmanRICTOR/FYB [5p13.1/5p13.1]  [t(5;5)(p13;p13)]  
Fusion: TCGACSMD2 1p35.1 FYB 5p13.1 OV
Fusion: TCGARICTOR 5p13.1 FYB 5p13.1 LUAD LUSC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFYB [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FYB
dbVarFYB
ClinVarFYB
1000_GenomesFYB 
Exome Variant ServerFYB
ExAC (Exome Aggregation Consortium)FYB (select the gene name)
Genetic variants : HAPMAP2533
Genomic Variants (DGV)FYB [DGVbeta]
DECIPHERFYB [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFYB 
Mutations
ICGC Data PortalFYB 
TCGA Data PortalFYB 
Broad Tumor PortalFYB
OASIS PortalFYB [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFYB  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDFYB
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FYB
DgiDB (Drug Gene Interaction Database)FYB
DoCM (Curated mutations)FYB (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FYB (select a term)
intoGenFYB
Cancer3DFYB(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM273900    602731   
Orphanet
MedgenFYB
Genetic Testing Registry FYB
NextProtO15117 [Medical]
TSGene2533
GENETestsFYB
Target ValidationFYB
Huge Navigator FYB [HugePedia]
snp3D : Map Gene to Disease2533
BioCentury BCIQFYB
ClinGenFYB
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2533
Chemical/Pharm GKB GenePA28452
Clinical trialFYB
Miscellaneous
canSAR (ICR)FYB (select the gene name)
Probes
Litterature
PubMed55 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFYB
EVEXFYB
GoPubMedFYB
iHOPFYB
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:34:34 CEST 2017

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